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09.11.2017 | Original Article

Heterogeneity of longitudinal and circumferential contraction in relation to late gadolinium enhancement in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction

verfasst von: Keita Sakamoto, Noriko Oyama-Manabe, Osamu Manabe, Tadao Aikawa, Yasuka Kikuchi, Harue Sasai-Masuko, Masanao Naya, Kohsuke Kudo, Fumi Kato, Nagara Tamaki, Hiroki Shirato

Erschienen in: Japanese Journal of Radiology | Ausgabe 2/2018

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Abstract

Purpose

To evaluate heterogeneity of myocardial contraction in relation to extensive late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM) patients with preserved left ventricular ejection fraction, using fast strain-encoded magnetic resonance imaging.

Materials and methods

Twenty-two HCM patients and 24 age-matched control subjects were included in this retrospective study. The regional and global peak values of longitudinal and circumferential strain (LS_regional, LS_global, CS_regional, CS_global), and their regional heterogeneities were evaluated using coefficients of variation (LS_CoV, CS_CoV) in relation to LGE. Receiver operating characteristic curve analysis was performed to identify patients with a total left ventricular myocardial LGE ≥ 15%.

Results

LS_global in HCM patients was significantly decreased compared to that in controls (− 14.4 ± 2.4% vs − 17.2 ± 2.0%; p = 0.0004), while CS_global was not (p = 1.0). Negative LGE segments demonstrated decreased LS_regional in HCM patients compared to in controls (p < 0.0001), while CS_regional was not decreased. CS_CoV demonstrated the largest area under the curve (AUC) (0.91), with high sensitivity (83%) and specificity (94%) for detection of HCM patients with extensive LGE, while the AUC of LS_CoV was low (0.49).

Conclusion

The heterogeneity in CS_regional has a high diagnostic value for detection of HCM patients with extensive LGE.

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Titel: Heterogeneity of longitudinal and circumferential contraction in relation to late gadolinium enhancement in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction
verfasst von: Keita Sakamoto
Noriko Oyama-Manabe
Osamu Manabe
Tadao Aikawa
Yasuka Kikuchi
Harue Sasai-Masuko
Masanao Naya
Kohsuke Kudo
Fumi Kato
Nagara Tamaki
Hiroki Shirato
Publikationsdatum: 09.11.2017
Verlag: Springer Japan
Erschienen in: Japanese Journal of Radiology / Ausgabe 2/2018
Print ISSN: 1867-1071
Elektronische ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-017-0700-5

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Heterogeneity of longitudinal and circumferential contraction in relation to late gadolinium enhancement in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction