Erschienen in:
Open Access
01.09.2012 | Meeting abstract
High score on PREDICTS is associated with 10-fold increased odds for the progression of subclinical atherosclerosis in SLE
verfasst von:
M McMahon, Lori Sahakian, J Grossman, B Skaggs, J Fitzgerald, C Charles-Schoeman, N Ragavendra, A Gorn, G Karpouzas, M Weisman, D Wallace, B Hahn
Erschienen in:
Arthritis Research & Therapy
|
Sonderheft 3/2012
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Excerpt
Increased oxidative stress is a major contributor to atherosclerosis (ATH). Patients with SLE demonstrate high oxidative stress and increased ATH. Our group and others have reported several biomarkers and demographic variables associated with increased oxidative stress, including proinflammatory HDL (piHDL), elevated leptin, homocysteine, and increased age - each associated with subclinical ATH in SLE. Can these biomarkers of oxidative stress be combined into a risk profile that better predicts progression of atherosclerosis? …