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Clinical Reviews in Allergy & Immunology

Erschienen in:

18.09.2021

Immunology of Aging: the Birth of Inflammaging

verfasst von: T. Fulop, A. Larbi, G. Pawelec, A. Khalil, A. A. Cohen, K. Hirokawa, J. M. Witkowski, C. Franceschi

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 2/2023

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Abstract

The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an evolutionary or rather a revolutionary conceptualization of the immune changes in response to a lifelong stress. This conceptualization permitted to consider the lifelong proinflammatory process as an adaptation which could eventually lead to either beneficial or detrimental consequences. This dichotomy is influenced by both the genetics and the environment. Depending on which way prevails in an individual, the outcome may be healthy longevity or pathological aging burdened with aging-related diseases. The concept of inflammaging has also revealed the complex, systemic nature of aging. Thus, this conceptualization opens the way to consider age-related processes in their complexity, meaning that not only the process but also all counter-processes should be considered. It has also opened the way to add new concepts to the original one, leading to better understanding of the nature of inflammaging and of aging itself. Finally, it showed the way towards potential multimodal interventions involving a holistic approach to optimize the aging process towards a healthy longevity.

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Titel: Immunology of Aging: the Birth of Inflammaging
verfasst von: T. Fulop
A. Larbi
G. Pawelec
A. Khalil
A. A. Cohen
K. Hirokawa
J. M. Witkowski
C. Franceschi
Publikationsdatum: 18.09.2021
Verlag: Springer US
Erschienen in: Clinical Reviews in Allergy & Immunology / Ausgabe 2/2023
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-021-08899-6

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Springer Medizin

Immunology of Aging: the Birth of Inflammaging

Abstract

Neu im Fachgebiet HNO

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

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Springer Medizin

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