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Clinical Reviews in Allergy & Immunology

Erschienen in:

15.01.2022

Role of Inflammaging on the Reproductive Function and Pregnancy

verfasst von: Alice Zavatta, Francesca Parisi, Chiara Mandò, Chiara Scaccabarozzi, Valeria M. Savasi, Irene Cetin

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 2/2023

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Abstract

During female lifetime and pregnancy, inflammation and cellular senescence are implicated in physiological processes, from ovulation and menstruation, to placental homeostasis and delivery. Several lifestyles, nutritional, and environmental insults, as well as long-lasting pregestational inflammatory diseases may lead to detrimental effects in promoting and sustaining a chronic excessive inflammatory response and inflammaging, which finally contribute to the decay of fertility and pregnancy outcome, with a negative effect on placental function, fetal development, and future health risk profile in the offspring. Maladaptation to pregnancy and obstetric disease may in turn increase maternal inflammaging in a feedback loop, speeding up aging processes and outbreak of chronic diseases. Maternal inflammaging may also impact, through transgenerational effects, on future adult health. Hence, efficacious interventions should be implemented by physicians and healthcare professionals involved in prevention activities to reduce the modifiable factors contributing to the inflammaging process in order to improve public health.

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Titel: Role of Inflammaging on the Reproductive Function and Pregnancy
verfasst von: Alice Zavatta
Francesca Parisi
Chiara Mandò
Chiara Scaccabarozzi
Valeria M. Savasi
Irene Cetin
Publikationsdatum: 15.01.2022
Verlag: Springer US
Erschienen in: Clinical Reviews in Allergy & Immunology / Ausgabe 2/2023
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-021-08907-9

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Springer Medizin

Role of Inflammaging on the Reproductive Function and Pregnancy

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Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

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Bilateraler Hörsturz hat eine schlechte Prognose

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