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NeuroMolecular Medicine

Erschienen in:

01.12.2008 | Review Paper

Impact of Energy Intake and Expenditure on Neuronal Plasticity

verfasst von: Alexis M. Stranahan, Mark P. Mattson

Erschienen in: NeuroMolecular Medicine | Ausgabe 4/2008

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Abstract

The Roman poet Horace was among the first to recognize that when “clogged with yesterday’s excess, the body drags the mind down with it.” Although considerable attention has been paid in neuroscience to the enhancement of neuronal function by wheel running and caloric restriction, far less is known about the other side of this issue. What are the consequences of unhealthy habits to central nervous system function? Prolonged exposure to excessive caloric intake impairs neuronal function and also contributes to obesity and other risk factors for diabetes. Diabetes, a disease characterized by reduced sensitivity to glucose and insulin, is also associated with deficits in brain structure and function. In contrast, enhancement of somatic metabolism by wheel running or caloric restriction improves central neuroplasticity. Generalizing across studies reveals a relationship between global metabolic efficiency and neuroplasticity in the hippocampus, a brain region that is essential for learning and memory. The specific principles upheld by these findings are suggestive of a continuum, with global metabolic alterations fluctuating in concert with neuroplasticity in the hippocampus.

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Titel: Impact of Energy Intake and Expenditure on Neuronal Plasticity
verfasst von: Alexis M. Stranahan
Mark P. Mattson
Publikationsdatum: 01.12.2008
Verlag: Humana Press Inc
Erschienen in: NeuroMolecular Medicine / Ausgabe 4/2008
Print ISSN: 1535-1084
Elektronische ISSN: 1559-1174
DOI: https://doi.org/10.1007/s12017-008-8043-0

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BACE1 Polymorphisms Do Not Influence Platelet Membrane β-secretase Activity or Genetic Susceptibility for Alzheimer’s Disease in the Northern Irish Population

The Nonsynonymous Thr105Ile Polymorphism of the Histamine N-Methyltransferase is Associated to the Risk of Developing Essential Tremor

Mutual Stimulation of Beta-Amyloid Fibrillogenesis by Clioquinol and Divalent Metals