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01.01.2013 | Original Research Paper

Interleukin-9 release from human kidney grafts and its potential protective role in renal ischemia/reperfusion injury

verfasst von: Kirsten A. Kortekaas, Dorottya K. de Vries, Marlies E. J. Reinders, Ellen Lievers, Jan Ringers, Jan H. N. Lindeman, Alexander F. M. Schaapherder

Erschienen in: Inflammation Research | Ausgabe 1/2013

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Abstract

Objective and design

The pathophysiology of ischemia/reperfusion (I/R) injury is dominated by an inflammatory response. In the identification of new therapeutic agents, the role of individual cytokines may be essential. Interleukin (IL)-9 is a pleiotropic cytokine recently identified to be involved in various immune responses. In this study, the role of IL-9 in renal I/R injury was assessed.

Methods

We performed repeated direct measurements of arteriovenous IL-9 concentration differences over the reperfused graft in human kidney transplantation.

Results

Substantial renal IL-9 release was observed from deceased donor kidneys (P = 0.006). In contrast, living donor kidneys, which have a more favourable clinical outcome, did not release IL-9 during early reperfusion (P = 0.78). Tissue expression of IL-9 did not change upon reperfusion in both living and deceased human donor kidneys. To assess the role of IL-9 in I/R injury, an experimental study comprising IL-9 inhibition in mice undergoing renal I/R was performed. Although there was no difference in kidney function, structural damage was significantly aggravated in anti-IL-9 treated mice.

Conclusions

Deceased donor grafts show a substantial IL-9 release upon reperfusion in clinical kidney transplantation. However, inhibition of IL-9 aggravated kidney damage, suggesting a regulating or minor role of IL-9 in clinical I/R injury.

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Koning OH, Ploeg RJ, van Bockel JH, Groenewegen M, van der Woude FJ, Persijn GG, European Multicenter Study Group, et al. Risk factors for delayed graft function in cadaveric kidney transplantation: a prospective study of renal function and graft survival after preservation with University of Wisconsin solution in multi-organ donors. Transplantation. 1997;63:1620–8.PubMedCrossRef

Ojo AO, Wolfe RA, Held PJ, Port FK, Schmouder RL. Delayed graft function: risk factors and implications for renal allograft survival. Transplantation. 1997;63:968–74.PubMedCrossRef

Yarlagadda SG, Coca SG, Formica RN Jr, Poggio ED, Parikh CR. Association between delayed graft function and allograft and patient survival: a systematic review and meta-analysis. Nephrol Dial Transplant. 2009;24:1039–47.PubMedCrossRef

Burne MJ, Elghandour A, Haq M, Saba SR, Norman J, Condon T, et al. IL-1 and TNF independent pathways mediate ICAM-1/VCAM-1 up-regulation in ischemia reperfusion injury. J Leukoc Biol. 2001;70(2):192–8.PubMed

Patel NS, Chatterjee PK, Di Paola R, Mazzon E, Britti D, De Sarro A, et al. Endogenous interleukin-6 enhances the renal injury, dysfunction, and inflammation caused by ischemia/reperfusion. J Pharmacol Exp Ther. 2005;312:1170–8.PubMedCrossRef

Jo SK, Sung SA, Cho WY, Go KJ, Kim HK. Macrophages contribute to the initiation of ischaemic acute renal failure in rats. Nephrol Dial Transplant. 2006;21:1231–9.PubMedCrossRef

Nijboer WN, Schuurs TA, van der Hoeven JA, Leuvenink HG, van der Heide JJ, van Goor H, et al. Effects of brain death on stress and inflammatory response in the human donor kidney. Transplant Proc. 2005;37:367–9.PubMedCrossRef

Stangl M, Zerkaulen T, Theodorakis J, Illner W, Schneeberger H, Land W, et al. Influence of brain death on cytokine release in organ donors and renal transplants. Transplant Proc. 2001;33:1284–5.PubMedCrossRef

Jassem W, Koo DD, Muiesan P, Cerundolo L, Rela M, Fuggle SV, et al. Non-heart-beating versus cadaveric and living-donor livers: differences in inflammatory markers before transplantation. Transplantation. 2003;75:1386–90.PubMedCrossRef

10.

de Vries DK, Lindeman JH, Ringers J, Reinders ME, Rabelink TJ, Schaapherder AF. Donor brain death predisposes human kidney grafts to a proinflammatory reaction after transplantation. Am J Transplant. 2011;11:1064–70.PubMedCrossRef

11.

Soussi-Gounni A, Kontolemos M, Hamid Q. Role of IL-9 in the pathophysiology of allergic diseases. J Allergy Clin Immunol. 2001;107:575–82.PubMedCrossRef

12.

Noelle RJ, Nowak EC. Cellular sources and immune functions of interleukin-9. Nat Rev Immunol. 2010;10:683–7.PubMedCrossRef

13.

Gessner A, Blum H, Rollinghoff M. Differential regulation of IL-9-expression after infection with Leishmania major in susceptible and resistant mice. Immunobiology. 1993;189:419–35.PubMedCrossRef

14.

Lu LF, Lind EF, Gondek DC, Bennett KA, Gleeson MW, Pino-Lagos K, et al. Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature. 2006;442:997–1002.PubMedCrossRef

15.

Stassen M, Arnold M, Hultner L, Muller C, Neudorfl C, Reineke T, et al. Murine bone marrow-derived mast cells as potent producers of IL-9: costimulatory function of IL-10 and kit ligand in the presence of IL-1. J Immunol. 2000;164:5549–55.PubMed

16.

de Vries DK, Lindeman JH, Tsikas D, de Heer E, Roos A, de Fijter JW, et al. Early renal ischemia-reperfusion injury in humans is dominated by IL-6 release from the allograft. Am J Transplant. 2009;9:1574–84.PubMedCrossRef

17.

Haslinger B, Kleemann R, Toet KH, Kooistra T. Simvastatin suppresses tissue factor expression and increases fibrinolytic activity in tumor necrosis factor-alpha-activated human peritoneal mesothelial cells. Kidney Int. 2003;63:2065–74.PubMedCrossRef

18.

Kleemann R, Verschuren L, van Erk MJ, Nikolsky Y, Cnubben NH, Verheij ER, et al. Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis. Genome Biol. 2007;8:200–15.CrossRef

19.

Jones TG, Hallgren J, Humbles A, Burwell T, Finkelman FD, Alcaide P, et al. Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells. J Immunol. 2009;183:5251–60.PubMedCrossRef

20.

Eller K, Wolf D, Huber JM, Metz M, Mayer G, McKenzie AN, et al. IL-9 production by regulatory T cells recruits mast cells that are essential for regulatory T cell-induced immune suppression. J Immunol. 2011;186:83–91.PubMedCrossRef

21.

Lu L, Leemhuis T, Srour EF, Yang YC. Human interleukin (IL)-9 specifically stimulates proliferation of CD34 +++DR+ CD33- erythroid progenitors in normal human bone marrow in the absence of serum. Exp Hematol. 1992;20:418–24.PubMed

22.

Donahue RE, Yang YC, Clark SC. Human P40 T-cell growth factor (interleukin-9) supports erythroid colony formation. Blood. 1990;75:2271–5.PubMed

23.

Fontaine RH, Cases O, Lelievre V, Mesples B, Renauld JC, Loron G, et al. IL-9/IL-9 receptor signaling selectively protects cortical neurons against developmental apoptosis. Cell Death Differ. 2008;15:1542–52.PubMedCrossRef

24.

Poulin LF, Richard M, Le Moine A, Kiss R, McKenzie AN, Goldman M, et al. Interleukin-9 promotes eosinophilic rejection of mouse heart allografts. Transplantation. 2003;76:572–7.PubMedCrossRef

25.

Li XC, Schachter AD, Zand MS, Li Y, Zheng XX, Harmon WE, et al. Differential expression of T-cell growth factors in rejecting murine islet and human renal allografts: conspicuous absence of interleukin (IL)-9 despite expression of IL-2, IL-4, IL-7, and IL-15. Transplantation. 1998;66:265–8.PubMedCrossRef

Titel: Interleukin-9 release from human kidney grafts and its potential protective role in renal ischemia/reperfusion injury
verfasst von: Kirsten A. Kortekaas
Dorottya K. de Vries
Marlies E. J. Reinders
Ellen Lievers
Jan Ringers
Jan H. N. Lindeman
Alexander F. M. Schaapherder
Publikationsdatum: 01.01.2013
Verlag: SP Birkhäuser Verlag Basel
Erschienen in: Inflammation Research / Ausgabe 1/2013
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-012-0550-7

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