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01.09.2015 | Neuro

Investigation of Apparent Diffusion Coefficient from Ultra-high b-Values in Parkinson’s Disease

verfasst von: Ling Xueying, Zhang Zhongping, Zhao Zhoushe, Guo Li, Tang Yongjin, Shi Changzheng, Zhou Zhifeng, Chen Peihao, Xu Hao, Huang Li

Erschienen in: European Radiology | Ausgabe 9/2015

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Abstract

Objectives

To assess brain damage in Parkinson’s disease (PD) based on apparent diffusion coefficient (ADC) data obtained from ultra-high b-values.

Methods

Eighteen PD patients and 18 controls received diffusion-weighted imaging (DWI) with standard b-values (0, 1,000 s/mm²) and 15 b-values (0–5,000 s/mm²). Standard ADC (ADC_st) maps were calculated from standard b-values, while maps of pure diffusion coefficients (D), pseudo-diffusion coefficients (D^*), and ultra-high ADCs (ADC_uh) were calculated from the 15 b-values using a tri-component model. In this model, D and D^* values were quantified with a bi-exponential equation using b-values less than 2,000 s/mm², while ADC_uh was quantified by fitting the signals at ultra-high b-values (2,000–5,000 s/mm²) to the mono-exponential equation. ADC_st, ADC_uh, D, and D^* of the globus pallidus (GP), putamen (P), and substantia nigra (SN) were compared between PD patients and normal control subjects.

Results

ADC_uh of the GP, P, and SN was significantly lower in PD patients than those in control subjects (P < 0.001), while ADC_st, D, and D^* of the GP, P and SN were not different between the two groups (P > 0.05).

Conclusions

ADC_uh may be a useful measurement for evaluating brain damage in PD patients.

Key Points

• DWI with ultra-high b-values may provide new insight into Parkinson’s disease pathology

• ADC calculated using ultra-high b-values is different between PD and controls

• ADC _uh may be associated with water transportation by aquaporins

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Titel: Investigation of Apparent Diffusion Coefficient from Ultra-high b-Values in Parkinson’s Disease
verfasst von: Ling Xueying
Zhang Zhongping
Zhao Zhoushe
Guo Li
Tang Yongjin
Shi Changzheng
Zhou Zhifeng
Chen Peihao
Xu Hao
Huang Li
Publikationsdatum: 01.09.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 9/2015
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-3678-3

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Investigation of Apparent Diffusion Coefficient from Ultra-high b-Values in Parkinson’s Disease