Anzeige
Erschienen in:
01.10.2019 | New Imaging Techniques (S Rais-Bahrami and K Porter, Section Editors)
Irreversible Electroporation for the Ablation of Prostate Cancer
Erschienen in: Current Urology Reports | Ausgabe 10/2019
Einloggen, um Zugang zu erhaltenAbstract
Purpose of Review
Although still considered experimental, focal irreversible electroporation (IRE) as a primary treatment for prostate cancer (PCa) is considered one of the most promising ablative technologies for focal therapy. This review provides a description of the principle of IRE for the treatment of PCa, combined with an overview of the recent research.
Recent Findings
It has been almost a decade since the first human studies of focal IRE for PCa were trying to demonstrate its feasibility and safety, and recently new data are emerging regarding the functional and oncological outcomes. It was shown that the expected ablation efficacy of IRE is dependent on increased safety margins of > 9 mm and an uninterrupted IRE procedure, but these findings need further investigation in larger cohorts and randomized control trials (RCT).
Summary
Recent data from larger cohorts with a longer follow-up of up to 12 months prove that focal IRE as primary treatment for localized PCa is indeed safe, has effective short-term oncological control in selected patients, and it has good functional outcomes by retaining urinary function and causing only mild erectile dysfunction.