nach oben

Pediatric Nephrology

Erschienen in:

01.10.2013 | Educational Review

Is obesity a risk factor for chronic kidney disease in children?

verfasst von: Sujana S. Gunta, Robert H. Mak

Erschienen in: Pediatric Nephrology | Ausgabe 10/2013

Einloggen, um Zugang zu erhalten

Abstract

There is a rapid increase worldwide in the prevalence of obesity in adults and children. Obesity is not only a comorbidity for chronic kidney disease (CKD) but may also be a risk factor for CKD. Epidemiological correlations and pathophysiological changes have been observed associating obesity with CKD. Low birth weight may be associated with both obesity and low nephron mass, leading to CKD later in life. Elevated levels of adipokines, such as leptin and adiponectin, in obesity may be factors in CKD pathogenesis and progression. Furthermore, various other factors, such as hypertension, increased cardiovascular morbidity, insulin resistance, dyslipidemia, and lipotoxicity, may play significant roles in the pathogenesis of CKD in obesity. Reduction in obesity, which is a potentially modifiable risk factor, might help decrease the burden of CKD in the population. Apart from individualized options, community-based interventions have the potential to create a strong impact in this condition.

Nur mit Berechtigung zugänglich

Troiano RP, Flegal KM, Kuczmarski RJ, Campbell SM, Johnson CL (1995) Overweight prevalence and trends for children and adolescents. The National Health and Nutrition Examination Surveys, 1963 to 1991. Arch Pediatr Adolesc Med 149:1085–1091PubMedCrossRef

Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM (2006) Prevalence of overweight and obesity in the United States, 1999–2004. JAMA 295:1549–1555PubMedCrossRef

Kuczmarski RJ, Ogden CL, Guo SS, Grummer-Strawn LM, Flegal KM, Mei Z (2002) 2000 CDC Growth Charts for the United States: Methods and Development. National Center for Health Statistics. Vital Health Stat 11:1–190

Ogden CL, Carroll MD, Curtin LR, Lamb MM, Flegal KM (2010) Prevalence of high body mass index in US children and adolescents, 2007-2008. JAMA 303:242–249PubMedCrossRef

Wahba IM, Mak RH (2007) Obesity and obesity-initiated metabolic syndrome: mechanistic links to chronic kidney disease. Clin J Am Soc Nephrol 2:550–562PubMedCrossRef

Fox CS, Larson MG, Leip EP, Culleton B, Wilson PW, Levy D (2004) Predictors of new-onset kidney disease in a community-based population. JAMA 291:844–850PubMedCrossRef

Ejerblad E, Fored CM, Lindblad P, Fryzek J, McLaughlin JK, Nyren O (2006) Obesity and risk for chronic renal failure. J Am Soc Nephrol 17:1695–1702PubMedCrossRef

Savino A, Pelliccia P, Chiarelli F, Mohn A (2010) Obesity-related renal injury in childhood. Horm Res Paediatr 73:303–311PubMedCrossRef

Filler G, Reimao SM, Kathiravelu A, Grimmer J, Feber J, Drukker A (2007) Pediatric nephrology patients are overweight: 20 years’ experience in a single Canadian tertiary pediatric nephrology clinic. Int Urol Nephrol 93:1235–1240CrossRef

10.

Espinoza R, Gracida C, Cancino J, Ibarra A (2006) Effect of obese living donors on the outcome and metabolic features in recipients of kidney transplantation. Transplant Proc 38:888–889PubMedCrossRef

11.

Pantoja-Zuzuarregui JR, Mallios R, Murphy J (2009) The effect of obesity on kidney length in a healthy pediatric population. Pediatr Nephrol 24:2023–2027PubMedCrossRef

12.

Darouich S, Goucha R, Jaafoura MH, Zekri S, Ben Maiz H, Kheder A (2011) Clinicopathological characteristics of obesity-associated focal segmental glomerulosclerosis. Ultrastruct Pathol 35:176–182PubMedCrossRef

13.

Kambham N, Markowitz GS, Valeri AM, Lin J, D’Agati VD (2001) Obesity-related glomerulopathy: An emerging epidemic. Kidney Int 59:1498–1509PubMedCrossRef

14.

Abitbol CL, Chandar J, Rodríguez MM, Berho M, Seeherunvong W, Freundlich M, Zilleruelo G (2009) Obesity and preterm birth: additive risks in the progression of kidney disease in children. Pediatr Nephrol 24:1363–1370PubMedCrossRef

15.

Fowler SM, Kon V, Ma L, Richards WO, Fogo AB, Hunley TE (2009) Obesity-related focal and segmental glomerulosclerosis: normalization of proteinuria in an adolescent after bariatric surgery. Pediatr Nephrol 24:851–855PubMedCrossRef

16.

Wong CS, Gipson DS, Gillen DL, Emerson S, Koepsell T, Sherrard DJ, Watkins SL, Stehman-Breen C (2000) Anthropometric measures and risk of death in children with end-stage renal disease. Am J Kidney Dis 36:811–819PubMedCrossRef

17.

Hanevold CD, Ho PL, Talley L, Mitsnefes M (2005) Obesity and renal transplant outcome: a report of the North American Pediatric Renal Transplant Cooperative Study. Pediatrics 115:352–356PubMedCrossRef

18.

Hoogeveen EK, Aalten J, Rothman KJ, Roodnat JI, Mallat MJ, Borm G, Weimar W, Hoitsma AJ, de Fijter JW (2011) Effect of obesity on the outcome of kidney transplantation: a 20-year follow-up. Transplantation 91:869–874PubMedCrossRef

19.

Mitsnefes M, Khoury P, McEnery PT (2002) Body mass index and allograft function in pediatric renal transplantation. Pediatr Nephrol 7:535–539CrossRef

20.

Hoy WE, Rees M, Kile E, Mathews JD, Wang Z (1999) A new dimension to the Barker hypothesis: low birthweight and susceptibility to renal disease. Kidney Int 56:1072–1077PubMedCrossRef

21.

Phillips DI, Jones A, Goulden PA (2006) Birth weight, stress, and the metabolic syndrome in adult life. Ann N Y Acad Sci 1083:28–36PubMedCrossRef

22.

Lackland DT, Egan BM, Fan ZJ, Syddall HE (2001) Low birth weight contributes to the excess prevalence of end-stage renal disease in African Americans. J Clin Hypertens 3:29–31CrossRef

23.

Vikse BE, Irgens LM, Leivestad T, Hallan S, Iversen BM (2008) Low birth weight increases risk for end-stage renal disease. J Am Soc Nephrol 19:151–157PubMedCrossRef

24.

Greenbaum LA, Muñoz A, Schneider MF, Kaskel FJ, Askenazi DJ, Jenkins R, Hotchkiss H, Moxey-Mims M, Furth SL, Warady BA (2011) The association between abnormal birth history and growth in children with CKD. Clin J Am Soc Nephrol 6:14–21PubMedCrossRef

25.

Bacchetta J, Harambat J, Dubourg L, Guy B, Liutkus A, Canterino I, Kassaï B, Putet G, Cochat P (2009) Both extrauterine and intrauterine growth restriction impair renal function in children born very preterm. Kidney Int 76:445–452PubMedCrossRef

26.

Hinchliffe SA, Lynch MR, Sargent PH, Howard CV, van Velzen D (1992) The effect of intrauterine growth retardation on the development of renal nephrons. Br J Obstet Gynaecol 99:296–301PubMedCrossRef

27.

Bagby SP (2004) Obesity-initiated metabolic syndrome and the kidney: A recipe for chronic kidney disease? J Am Soc Nephrol 15:2775–2791PubMedCrossRef

28.

Vehaskari VM, Aviles DH, Manning J (2001) Prenatal programming of adult hypertension in the rat. Kidney Int 59:238–245PubMedCrossRef

29.

Celsi G, Kistner A, Aizman R, Eklöf AC, Ceccatelli S, de Santiago A, Jacobson SH (1998) Prenatal dexamethasone causes oligonephronia, sodium retention, and higher blood pressure in the offspring. Pediatr Res 44:317–322PubMedCrossRef

30.

Nguyen S, McCulloch C, Brakeman P, Portale A, Hsu CY (2008) Being overweight modifies the association between cardiovascular risk factors and microalbuminuria in adolescents. Pediatrics 121:37–45PubMedCrossRef

31.

Chen J, Munter P, Hamm LL, Jones DW, Batuman V, Fonseca V, Whelton PK, He J (2004) The metabolic syndrome and chronic kidney disease in US adults. Ann Intern Med 140:167–174PubMedCrossRef

32.

Batsis JA, Romero-Corral A, Collazo-Clavell ML, Sarr MG, Somers VK, Lopez-Jimenez F (2008) Effect of bariatric surgery on the metabolic syndrome: a population-based, long-term controlled study. Mayo Clin Proc 83:897–907PubMed

33.

Wisse BE (2004) The inflammatory syndrome: The role of adipose tissue cytokines in metabolic disorders linked to obesity. J Am Soc Nephrol 15:2792–2800PubMedCrossRef

34.

Tilg H, Moschen AR (2006) Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6:772–783PubMedCrossRef

35.

Venner AA, Lyon ME, Doyle-Baker PK (2006) Leptin: a potential biomarker for childhood obesity? Clin Biochem 39:1047–1056PubMedCrossRef

36.

Belin de Chantemèle EJ, Mintz JD, Rainey WE, Stepp DW (2011) Impact of leptin-mediated sympatho-activation on cardiovascular function in obese mice. Hypertension 58:271–279PubMedCrossRef

37.

Hasty AH, Shimano H, Osuga J, Namatame I, Takahashi A, Yahagi N, Perrey S, Iizuka Y, Tamura Y, Amemiya-Kudo M, Yoshikawa T, Okazaki H, Ohashi K, Harada K, Matsuzaka T, Sone H, Gotoda T, Nagai R, Ishibashi S, Yamada N (2001) Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor. J Biol Chem 276:37402–37408PubMedCrossRef

38.

Daschner M, Tönshoff B, Blum WF, Englaro P, Wingen AM, Schaefer F, Wühl E, Rascher W, Mehls O (1998) Inappropriate elevation of serum leptin levels in children with chronic renal failure. European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood. J Am Soc Nephrol 9:1074–1079PubMed

39.

Wolf G, Ziyadeh FN (2006) Leptin and renal fibrosis. Contrib Nephrol 151:175–183PubMedCrossRef

40.

Tarzi RM, Cook HT, Jackson I, Pusey CD, Lord GM (2004) Leptin-deficient mice are protected from accelerated nephrotoxic nephritis. Am J Pathol 164:385–390PubMedCrossRef

41.

Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7:941–946PubMedCrossRef

42.

Sharma K, Ramachandrarao S, Qiu G, Usui HK, Zhu Y, Dunn SR, Ouedraogo R, Hough K, McCue P, Chan L, Falkner B, Goldstein BJ (2008) Adiponectin regulates albuminuria and podocyte function in mice. J Clin Invest 118:1645–1656PubMed

43.

Kumada M, Kihara S, Sumitsuji S, Kawamoto T, Matsumoto S, Ouchi N, Arita Y, Okamoto Y, Shimomura I, Hiraoka H, Nakamura T, Funahashi T, Matsuzawa Y, Osaka CAD Study Group. Coronary artery disease (2003) Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 23:85–89PubMedCrossRef

44.

Yoshinaga M, Sameshima K, Tanaka Y, Wada A, Hashiguchi J, Tahara H, Kono Y (2008) Adipokines and the prediction of the accumulation of cardiovascular risk factors or the presence of metabolic syndrome in elementary school children. Circ J 72:1874–1878PubMedCrossRef

45.

Mitsnefes M, Kartal J, Khoury P, Daniels S (2007) Adiponectin in children with chronic kidney disease: role of adiposity and kidney dysfunction. Clin J Am Soc Nephrol 2:46–50PubMedCrossRef

46.

Falkner B, Gidding S (2011) Childhood obesity and blood pressure: Back to the future? Hypertension 58:754–755PubMedCrossRef

47.

Staples AO, Greenbaum LA, Smith JM, Gipson DS, Filler G, Warady BA, Martz K, Wong CS (2010) Association between clinical risk factors and progression of chronic kidney disease in children. Clin J Am Soc Nephrol 5:2172–2179PubMedCrossRef

48.

Tu W, Eckert GJ, DiMeglio LA, Yu Z, Jung J, Pratt JH (2011) Intensified effect of adiposity on blood pressure in overweight and obese children. Hypertension 58:818–824PubMedCrossRef

49.

Sorof JM, Lai D, Turner J, Poffenbarger T, Portman RJ (2004) Overweight, ethnicity, and the prevalence of hypertension in school-aged children. Pediatrics 113:475–482PubMedCrossRef

50.

Lubrano R, Travasso E, Raggi C, Guido G, Masciangelo R, Elli P (2009) Blood pressure load, proteinuria and renal function in prehypertensive children. Pediatr Nephrol 24:823–831PubMedCrossRef

51.

Mitsnefes M, Flynn J, Cohn S, Samuels J, Blydt-Hansen T, Saland J, Kimball T, Furth S, Warady B, CKiD Study Group (2010) Masked hypertension associates with left ventricular hypertrophy in children with CKD. J Am Soc Nephrol 21:137–144PubMedCrossRef

52.

Shatat IF, Flynn JT (2011) Relationships between renin, aldosterone, and 24-hour ambulatory blood pressure in obese adolescents. Pediatr Res 69:336–340PubMedCrossRef

53.

Holl RW, Hoffmeister U, Thamm M, Stachow R, Keller KM, L’Allemand D, Widhalm K, Flechtner-Mors M, Wiegand S (2011) Does obesity lead to a specific lipid disorder? Analysis from the German/Austrian/Swiss APV registry. Int J Pediatr Obes 6(Suppl 1):53–58PubMedCrossRef

54.

Saland JM, Pierce CB, Mitsnefes MM, Flynn JT, Goebel J, Kupferman JC, Warady BA, Furth SL (2010) Dyslipidemia in children with chronic kidney disease. Kidney Int 78:1154–1163PubMedCrossRef

55.

Sandhu S, Wiebe N, Fried LF, Tonelli M (2006) Statins for improving renal outcomes: a meta-analysis. J Am Soc Nephrol 17:2006–2016PubMedCrossRef

56.

Butani L (2005) Prospective monitoring of lipid profiles in children receiving pravastatin preemptively after renal transplantation. Pediatr Transplant 9:746–753PubMedCrossRef

57.

Weinberg JM (2006) Lipotoxicity. Kidney Int 70:1560–1566PubMedCrossRef

58.

Moorhead JF, Chan MK, El-Nahas M, Varghese Z (1982) Lipid nephrotoxicity in chronic progressive glomerular and tubulo- interstitial disease. Lancet 2:1309–1311PubMedCrossRef

59.

Thomas ME, Harris KP, Walls J, Furness PN, Brunskill NJ (2002) Fatty acids exacerbate tubulointerstitial injury in proteinoverload proteinuria. Am J Physiol Renal Physiol 283:F640–F647PubMedCrossRef

60.

Economos CD, Hyatt RR, Goldberg JP, Must A, Naumova EN, Collins JJ, Nelson ME (2007) A community intervention reduces BMI z-score in children: Shape Up Somerville first year results. Obesity (Silver Spring) 15:1325–1336CrossRef

61.

Demattia L, Denney SL (2008) Childhood obesity prevention: successful community-based efforts. Ann Am Acad Pol Soc Sci 615:83–99CrossRef

Titel: Is obesity a risk factor for chronic kidney disease in children?
verfasst von: Sujana S. Gunta
Robert H. Mak
Publikationsdatum: 01.10.2013
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 10/2013
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-012-2353-z

Neu im Fachgebiet Pädiatrie

23.04.2024 | Typ-1-Diabetes | Nachrichten

Update Pädiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Is obesity a risk factor for chronic kidney disease in children?

Abstract

Neu im Fachgebiet Pädiatrie

Neuer Typ-1-Diabetes bei Kindern am Wochenende eher übersehen

Neue Studienergebnisse zur Myopiekontrolle mit Atropin

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Update Pädiatrie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 10/2013

Growth and maturation improvement in children on renal replacement therapy over the past 20 years

Chronic cyclosporine-induced nephrotoxicity in children with steroid-resistant nephrotic syndrome

Nephrotic syndrome in an 18-year-old boy with congenital myelomeningocele: Questions

Midaortic syndrome: 30 years of experience with medical, endovascular and surgical management

HDAC inhibitors in kidney development and disease

Nephrotic syndrome in an 18-year-old boy with congenital myelomeningocele: Answers

Neu im Fachgebiet Pädiatrie

Neuer Typ-1-Diabetes bei Kindern am Wochenende eher übersehen

Neue Studienergebnisse zur Myopiekontrolle mit Atropin

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Update Pädiatrie