Ausgabe 1/2022
Inhalt (319 Artikel)
SNHG15 is a negative regulator of inflammation by mediating TRAF2 ubiquitination in stroke-induced immunosuppression
Huiling Sun, Shuo Li, Zhaohan Xu, Chengfang Liu, Pengyu Gong, Qiwen Deng, Fuling Yan
Social isolation induces neuroinflammation and microglia overactivation, while dihydromyricetin prevents and improves them
Alzahra J. Al Omran, Amy S. Shao, Saki Watanabe, Zeyu Zhang, Jifeng Zhang, Chen Xue, Junji Watanabe, Daryl L. Davies, Xuesi M. Shao, Jing Liang
Diphtheria toxin induced but not CSF1R inhibitor mediated microglia ablation model leads to the loss of CSF/ventricular spaces in vivo that is independent of cytokine upregulation
Alicia Bedolla, Aleksandr Taranov, Fucheng Luo, Jiapeng Wang, Flavia Turcato, Elizabeth M. Fugate, Nigel H. Greig, Diana M. Lindquist, Steven A. Crone, June Goto, Yu Luo
Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease
Colin F. Craig, Rhiannon T. Filippone, Rhian Stavely, Joel C. Bornstein, Vasso Apostolopoulos, Kulmira Nurgali
Microbial pathogens induce neurodegeneration in Alzheimer’s disease mice: protection by microglial regulation
Tal Ganz, Nina Fainstein, Amit Elad, Marva Lachish, Smadar Goldfarb, Ofira Einstein, Tamir Ben-Hur
Dysregulated B cell differentiation towards antibody-secreting cells in neuromyelitis optica spectrum disorder
Yasunobu Hoshino, Daisuke Noto, Shuhei Sano, Yuji Tomizawa, Kazumasa Yokoyama, Nobutaka Hattori, Sachiko Miyake
Delta opioid receptors on nociceptive sensory neurons mediate peripheral endogenous analgesia in colitis
Xavier Mas-Orea, Lilian Basso, Catherine Blanpied, Claire Gaveriaux-Ruff, Nicolas Cenac, Gilles Dietrich
Nafamostat reduces systemic inflammation in TLR7-mediated virus-like illness
Abi G. Yates, Caroline M. Weglinski, Yuxin Ying, Isobel K. Dunstan, Tatyana Strekalova, Daniel C. Anthony
Anti-inflammatory role of GM1 and other gangliosides on microglia
Danny Galleguillos, Qian Wang, Noam Steinberg, Asifa Zaidi, Gaurav Shrivastava, Kamaldeep Dhami, Gour C. Daskhan, Edward N. Schmidt, Zoë Dworsky-Fried, Fabrizio Giuliani, Matthew Churchward, Christopher Power, Kathryn Todd, Anna Taylor, Matthew S. Macauley, Simonetta Sipione
MicroRNA-210 regulates the metabolic and inflammatory status of primary human astrocytes
Nicholas W. Kieran, Rahul Suresh, Marie-France Dorion, Adam MacDonald, Manon Blain, Dingke Wen, Shih-Chieh Fuh, Fari Ryan, Roberto J. Diaz, Jo Anne Stratton, Samuel K. Ludwin, Joshua A. Sonnen, Jack Antel, Luke M. Healy
Argonaute-2 protects the neurovascular unit from damage caused by systemic inflammation
Marta Machado-Pereira, Cláudia Saraiva, Liliana Bernardino, Ana C. Cristóvão, Raquel Ferreira
Innate immune stimulation by monophosphoryl lipid A prevents chronic social defeat stress-induced anxiety-like behaviors in mice
Fu Li, Haitao Xiang, Yue Gu, Ting Ye, Xu Lu, Chao Huang
Immunological status of the olfactory bulb in a murine model of Toll-like receptor 3-mediated upper respiratory tract inflammation
Ryoji Kagoya, Makiko Toma-Hirano, Junya Yamagishi, Naoyuki Matsumoto, Kenji Kondo, Ken Ito
Correction to: Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca2+-dependent PKC/p38MAPK/NF-κB pathway
Qing Liu, Yanli Zhang, Shuang Liu, Yanna Liu, Xiaohan Yang, Gang Liu, Takahiro Shimizu, Kazuhiro Ikenaka, Kai Fan, Jianmei Ma
Correction to: Transplantation of mesenchymal stem cells genetically engineered to overexpress interleukin-10 promotes alternative inflammatory response in rat model of traumatic brain injury
S. T. Peruzzaro, M. M. M. Andrews, A. Al-Gharaibeh, O. Pupiec, M. Resk, D. Story, P. Maiti, J. Rossignol, G. L. Dunbar
Sublethal enteroviral infection exacerbates disease progression in an ALS mouse model
Yuan Chao Xue, Huitao Liu, Yasir Mohamud, Amirhossein Bahreyni, Jingchun Zhang, Neil R. Cashman, Honglin Luo
Immune response and pathogen invasion at the choroid plexus in the onset of cerebral toxoplasmosis
Caio Andreeta Figueiredo, Johannes Steffen, Lorena Morton, Sushmitha Arumugam, Oliver Liesenfeld, Mária A. Deli, Andrea Kröger, Thomas Schüler, Ildiko Rita Dunay
Correction to: Chronic colitis exacerbates NLRP3-dependent neuroinflammation and cognitive impairment in middle-aged brain
Xiao-fei He, Li-li Li, Wen-biao Xian, Ming-yue Li, Li-ying Zhang, Jing-hui Xu, Zhong Pei, Hai-qing Zheng, Xi-quan Hu
Cerebrospinal fluid findings in COVID-19: a multicenter study of 150 lumbar punctures in 127 patients
Sven Jarius, Florence Pache, Peter Körtvelyessy, Ilijas Jelčić, Mark Stettner, Diego Franciotta, Emanuela Keller, Bernhard Neumann, Marius Ringelstein, Makbule Senel, Axel Regeniter, Rea Kalantzis, Jan F. Willms, Achim Berthele, Markus Busch, Marco Capobianco, Amanda Eisele, Ina Reichen, Rick Dersch, Sebastian Rauer, Katharina Sandner, Ilya Ayzenberg, Catharina C. Gross, Harald Hegen, Michael Khalil, Ingo Kleiter, Thorsten Lenhard, Jürgen Haas, Orhan Aktas, Klemens Angstwurm, Christoph Kleinschnitz, Jan Lewerenz, Hayrettin Tumani, Friedemann Paul, Martin Stangel, Klemens Ruprecht, Brigitte Wildemann
An overlooked subset of Cx3cr1wt/wt microglia in the Cx3cr1CreER-Eyfp/wt mouse has a repopulation advantage over Cx3cr1CreER-Eyfp/wt microglia following microglial depletion
Kai Zhou, Jinming Han, Harald Lund, Nageswara Rao Boggavarapu, Volker M Lauschke, Shinobu Goto, Huaitao Cheng, Yuyu Wang, Asuka Tachi, Cuicui Xie, Keying Zhu, Ying Sun, Ahmed M. Osman, Dong Liang, Wei Han, Kristina Gemzell-Danielsson, Christer Betsholtz, Xing-Mei Zhang, Changlian Zhu, Martin Enge, Bertrand Joseph, Robert A. Harris, Klas Blomgren
Nos2−/− mice infected with M. tuberculosis develop neurobehavioral changes and immunopathology mimicking human central nervous system tuberculosis
Xuan Ying Poh, Jia Mei Hong, Chen Bai, Qing Hao Miow, Pei Min Thong, Yu Wang, Ravisankar Rajarethinam, Cristine S. L. Ding, Catherine W. M. Ong
Inflammatory monocytes and microglia play independent roles in inflammatory ictogenesis
Charles L. Howe, Reghann G. LaFrance-Corey, Brittany L. Overlee, Renee K. Johnson, Benjamin D. S. Clarkson, Emma N. Goddery
Fluoxetine inhibited the activation of A1 reactive astrocyte in a mouse model of major depressive disorder through astrocytic 5-HT2BR/β-arrestin2 pathway
Yinquan Fang, Xiao Ding, Yihe Zhang, Lei Cai, Yuan Ge, Kaiyang Ma, Rong Xu, Shanshan Li, Mengmeng Song, Hong Zhu, Jiaqi Liu, Jianhua Ding, Ming Lu, Gang Hu
MORPHIOUS: an unsupervised machine learning workflow to detect the activation of microglia and astrocytes
Joseph Silburt, Isabelle Aubert
AMPK-autophagy-mediated inhibition of microRNA-30a-5p alleviates morphine tolerance via SOCS3-dependent neuroinflammation suppression
Li Wan, Ru-Meng Jia, Lu-Lu Ji, Xin-Miao Qin, Liang Hu, Fan Hu, Yuan Han, Yin-Bing Pan, Chun-Yi Jiang, Wen-Tao Liu
TRPV4 contributes to ER stress and inflammation: implications for Parkinson’s disease
Na Liu, Liping Bai, Zhipeng Lu, Rou Gu, Dongdong Zhao, Fang Yan, Jie Bai
Administration of Maresin-1 ameliorates the physiopathology of experimental autoimmune encephalomyelitis
Alba Sánchez-Fernández, Stephanie Zandee, Mauricio Mastrogiovanni, Marc Charabati, Homero Rubbo, Alexandre Prat, Rubèn López-Vales
Elevated proportion of TLR2- and TLR4-expressing Th17-like cells and activated memory B cells was associated with clinical activity of cerebral cavernous malformations
Camilla Castro, Hugo A. A. Oyamada, Marcos Octávio S. D. Cafasso, Lana M. Lopes, Clarice Monteiro, Priscila M. Sacramento, Soniza Vieira Alves-Leon, Gustavo da Fontoura Galvão, Joana Hygino, Jorge Paes Barreto Marcondes de Souza, Cleonice A. M. Bento
TNFα-mediated necroptosis in brain endothelial cells as a potential mechanism of increased seizure susceptibility in mice following systemic inflammation
Wan-Yu Huang, Yen-Ling Lai, Ko-Hung Liu, Shankung Lin, Hsuan-Ying Chen, Chih-Hung Liang, Hung-Ming Wu, Kuei-Sen Hsu
Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer’s disease
Clara Muñoz-Castro, Ayush Noori, Colin G. Magdamo, Zhaozhi Li, Jordan D. Marks, Matthew P. Frosch, Sudeshna Das, Bradley T. Hyman, Alberto Serrano-Pozo
Neurodegeneration in the centrally-projecting Edinger–Westphal nucleus contributes to the non-motor symptoms of Parkinson’s disease in the rat
Balázs Ujvári, Bence Pytel, Zsombor Márton, Máté Bognár, László Ákos Kovács, József Farkas, Tamás Gaszner, Gergely Berta, Angéla Kecskés, Viktória Kormos, Boglárka Farkas, Nóra Füredi, Balázs Gaszner
Maresin 1 promotes nerve regeneration and alleviates neuropathic pain after nerve injury
Jinhuan Wei, Wenfeng Su, Yayu Zhao, Zhongya Wei, Yuchen Hua, Peng Xue, Xiang Zhu, Ying Chen, Gang Chen
Vagus nerve stimulation modulates hippocampal inflammation caused by continuous stress in rats
Uk Namgung, Ki-Joong Kim, Byung-Gon Jo, Jong-Min Park
Long-term running exercise improves cognitive function and promotes microglial glucose metabolism and morphological plasticity in the hippocampus of APP/PS1 mice
Shan-shan Zhang, Lin Zhu, Yan Peng, Lei Zhang, Feng-lei Chao, Lin Jiang, Qian Xiao, Xin Liang, Jing Tang, Hao Yang, Qi He, Yi-jing Guo, Chun-ni Zhou, Yong Tang
Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology
Sen Liu, Min Fan, Jing-Xian Xu, Long-Jun Yang, Cong-Cong Qi, Qing-Rong Xia, Jin-Fang Ge
Mild-to-severe traumatic brain injury in children: altered cytokines reflect severity
Emer Ryan, Lynne Kelly, Catherine Stacey, Dean Huggard, Eimear Duff, Danielle McCollum, Ann Leonard, Gerard Boran, Dermot R. Doherty, Turlough Bolger, Eleanor J. Molloy
Neuroprotective effects of alisol A 24-acetate on cerebral ischaemia–reperfusion injury are mediated by regulating the PI3K/AKT pathway
Taotao Lu, Huihong Li, Yangjie Zhou, Wei Wei, Linlin Ding, Zengtu Zhan, Weilin Liu, Jing Tao, Xiehua Xue
Gas6 induces inflammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer’s disease
Laura D. Owlett, Berke Karaahmet, Linh Le, Elizabeth K. Belcher, Dawling Dionisio-Santos, John A. Olschowka, Michael R. Elliott, M. Kerry O’Banion
Marine fungal metabolite butyrolactone I prevents cognitive deficits by relieving inflammation and intestinal microbiota imbalance on aluminum trichloride-injured zebrafish
Yingying Nie, Jingming Yang, Longjian Zhou, Zhiyou Yang, Jinyue Liang, Yayue Liu, Xiaoxiang Ma, Zhongji Qian, Pengzhi Hong, Allan V. Kalueff, Cai Song, Yi Zhang
Neurocognitive impact of Zika virus infection in adult rhesus macaques
Denise C. Hsu, Kesara Chumpolkulwong, Michael J. Corley, Taweewun Hunsawong, Dutsadee Inthawong, Alexandra Schuetz, Rawiwan Imerbsin, Decha Silsorn, Panupat Nadee, Jumpol Sopanaporn, Yuwadee Phuang-Ngern, Chonticha Klungthong, Matthew Reed, Stefan Fernandez, Lishomwa C. Ndhlovu, Robert Paul, Luis Lugo-Roman, Nelson L. Michael, Kayvon Modjarrad, Sandhya Vasan
Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway
Ruozhi Dang, Mingyang Wang, Xinhui Li, Haiyang Wang, Lanxiang Liu, Qingyuan Wu, Jianting Zhao, Ping Ji, Lianmei Zhong, Julio Licinio, Peng Xie
Lowering blood cholesterol does not affect neuroinflammation in experimental autoimmune encephalomyelitis
Solenne Vigne, Donovan Duc, Benjamin Peter, Jessica Rebeaud, Yannick Yersin, Florian Ruiz, Valentine Bressoud, Tinh-Hai Collet, Caroline Pot
PD-L1 signaling in reactive astrocytes counteracts neuroinflammation and ameliorates neuronal damage after traumatic brain injury
Xiang Gao, Wei Li, Fahim Syed, Fang Yuan, Ping Li, Qigui Yu
Posttranslational modifications of proteins are key features in the identification of CSF biomarkers of multiple sclerosis
Ivan L. Salazar, Ana S. T. Lourenço, Bruno Manadas, Inês Baldeiras, Cláudia Ferreira, Anabela Claro Teixeira, Vera M. Mendes, Ana Margarida Novo, Rita Machado, Sónia Batista, Maria do Carmo Macário, Mário Grãos, Lívia Sousa, Maria João Saraiva, Alberto A. C. C. Pais, Carlos B. Duarte
Central nervous system macrophages in progressive multiple sclerosis: relationship to neurodegeneration and therapeutics
Emily Kamma, Wendy Lasisi, Cole Libner, Huah Shin Ng, Jason R. Plemel
The role of S100B/RAGE-enhanced ADAM17 activation in endothelial glycocalyx shedding after traumatic brain injury
Zhimin Zou, Li Li, Qin Li, Peng Zhao, Kun Zhang, Chengyong Liu, Daozhang Cai, Marc Maegele, Zhengtao Gu, Qiaobing Huang
Scavenger receptor CD36 governs recruitment of myeloid cells to the blood–CSF barrier after stroke in neonatal mice
Aditya Rayasam, Amin Mottahedin, Joel Faustino, Carina Mallard, Zinaida S. Vexler
Early-phase administration of human amnion-derived stem cells ameliorates neurobehavioral deficits of intracerebral hemorrhage by suppressing local inflammation and apoptosis
Yoji Kuramoto, Mitsugu Fujita, Toshinori Takagi, Yuki Takeda, Nobutaka Doe, Kenichi Yamahara, Shinichi Yoshimura
Correction to: A primary neural cell culture model to study neuron, astrocyte, and microglia interactions in neuroinflammation
Noah Goshi, Rhianna K. Morgan, Pamela J. Lein, Erkin Seker
Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson’s disease
Adrianne F. Pike, Francesca Longhena, Gaia Faustini, Jean-Marc van Eik, Iris Gombert, Maaike A. C. Herrebout, Mona M. H. E. Fayed, Michele Sandre, Tatiana Varanita, Charlotte E. Teunissen, Jeroen J. M. Hoozemans, Arianna Bellucci, Robert Veerhuis, Luigi Bubacco
The neuroprotective mechanism of sevoflurane in rats with traumatic brain injury via FGF2
Zhongyu Wang, Zhaoyang Wang, Anqi Wang, Juan Li, Junmin Wang, Jingjing Yuan, Xin Wei, Fei Xing, Wei Zhang, Na Xing
Choroid plexus-selective inactivation of adenosine A2A receptors protects against T cell infiltration and experimental autoimmune encephalomyelitis
Wu Zheng, Yijia Feng, Zhenhai Zeng, Mengqian Ye, Mengru Wang, Xin Liu, Ping Tang, Huiping Shang, Xiaoting Sun, Xiangxiang Lin, Muran Wang, Zhengzheng Li, Yiyun Weng, Wei Guo, Sergii Vakal, Jiang-fan Chen
α-Synuclein-containing erythrocytic extracellular vesicles: essential contributors to hyperactivation of monocytes in Parkinson’s disease
Zongran Liu, Robin Barry Chan, Zhijian Cai, Xiaodan Liu, Yufeng Wu, Zhenwei Yu, Tao Feng, Ying Yang, Jing Zhang
B cell-dependent EAE induces visual deficits in the mouse with similarities to human autoimmune demyelinating diseases
Sandrine Joly, Julius Baya Mdzomba, Léa Rodriguez, Françoise Morin, Luc Vallières, Vincent Pernet
Neuronal FcεRIα directly mediates ocular itch via IgE-immune complex in a mouse model of allergic conjunctivitis
Huan Cui, Fan Liu, Yehong Fang, Tao Wang, Bo Yuan, Chao Ma
A selective inhibitor of the NLRP3 inflammasome as a potential therapeutic approach for neuroprotection in a transgenic mouse model of Huntington’s disease
Kai-Po Chen, Kuo-Feng Hua, Fu-Ting Tsai, Ting-Yu Lin, Chih-Yuan Cheng, Ding-I. Yang, Hsien-Ta Hsu, Tz-Chuen Ju
LXR agonist improves peripheral neuropathy and modifies PNS immune cells in aged mice
Chaitanya K. Gavini, Nadia Elshareif, Gregory Aubert, Anand V. Germanwala, Nigel A. Calcutt, Virginie Mansuy-Aubert
ALS monocyte-derived microglia-like cells reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progression
Hazel Quek, Carla Cuní-López, Romal Stewart, Tiziana Colletti, Antonietta Notaro, Tam Hong Nguyen, Yifan Sun, Christine C. Guo, Michelle K. Lupton, Tara L. Roberts, Yi Chieh Lim, Lotta E. Oikari, Vincenzo La Bella, Anthony R. White
Sox2 overexpression alleviates noise-induced hearing loss by inhibiting inflammation-related hair cell apoptosis
Diyan Chen, Gaogan Jia, Yanping Zhang, Huanyu Mao, Liping Zhao, Wenyan Li, Yan Chen, Yusu Ni
Typical and atypical properties of peripheral nerve allografts enable novel strategies to repair segmental-loss injuries
George D. Bittner, Jared S. Bushman, Cameron L. Ghergherehchi, Kelly C. S. Roballo, Jaimie T. Shores, Tyler A. Smith
Microglial VPS35 deficiency impairs Aβ phagocytosis and Aβ-induced disease-associated microglia, and enhances Aβ associated pathology
Xiao Ren, Lingling Yao, YongGang Wang, Lin Mei, Wen-Cheng Xiong
Treatment regimens for neuromyelitis optica spectrum disorder attacks: a retrospective cohort study
Stanislas Demuth, Maxime Guillaume, Bertrand Bourre, Jonathan Ciron, Hélène Zephir, Yoann Sirejacob, Anne Kerbrat, Christine Lebrun-Frenay, Caroline Papeix, Laure Michel, David Laplaud, Sandra Vukusic, Elisabeth Maillart, Mikael Cohen, Bertrand Audoin, Romain Marignier, Nicolas Collongues
Evaluation of neuroprotective and immunomodulatory properties of mesenchymal stem cells in an ex vivo retinal explant model
Élodie Reboussin, Juliette Buffault, Françoise Brignole-Baudouin, Annabelle Réaux-Le Goazigo, Luisa Riancho, Céline Olmiere, José-Alain Sahel, Stéphane Mélik Parsadaniantz, Christophe Baudouin
Connexin 43 gap junction-mediated astrocytic network reconstruction attenuates isoflurane-induced cognitive dysfunction in mice
Rui Dong, Yuqiang Han, Linhao Jiang, Shuai Liu, Fujun Zhang, Liangyu Peng, Zimo Wang, Zhengliang Ma, Tianjiao Xia, Xiaoping Gu
MT5-MMP promotes neuroinflammation, neuronal excitability and Aβ production in primary neuron/astrocyte cultures from the 5xFAD mouse model of Alzheimer’s disease
Dominika Pilat, Jean-Michel Paumier, Laura García-González, Laurence Louis, Delphine Stephan, Christine Manrique, Michel Khrestchatisky, Eric Di Pasquale, Kévin Baranger, Santiago Rivera
Absence of the lectin-like domain of thrombomodulin reduces HSV-1 lethality of mice with increased microglia responses
Meng-Shan Tsai, Li-Chiu Wang, Hua-Lin Wu, Shun-Fen Tzeng, Edward M. Conway, Sheng-Min Hsu, Shun-Hua Chen
Homer1 promotes the conversion of A1 astrocytes to A2 astrocytes and improves the recovery of transgenic mice after intracerebral hemorrhage
Xiaowei Fei, Ya-nan Dou, Li Wang, Xiuquan Wu, Yu Huan, Shuang Wu, Xin He, Weihao Lv, Jialiang Wei, Zhou Fei
Motoneuronal inflammasome activation triggers excessive neuroinflammation and impedes regeneration after sciatic nerve injury
Kinga Molnár, Bernát Nógrádi, Rebeka Kristóf, Ádám Mészáros, Krisztián Pajer, László Siklós, Antal Nógrádi, Imola Wilhelm, István A. Krizbai
The innate immune receptor Nlrp12 suppresses autoimmunity to the retina
Ellen J. Lee, Ruth J. Napier, Emily E. Vance, Sydney J. Lashley, Agnieszka D. Truax, Jenny P. Ting, Holly L. Rosenzweig
Rasmussen’s encephalitis is characterized by relatively lower production of IFN-β and activated cytotoxic T cell upon herpes viruses infection
Yi-Song Wang, Dong Liu, Xin Wang, Qiao-Li Luo, Ling Ding, Dong-Ying Fan, Qi-Liang Cai, Chong-Yang Tang, Wei Yang, Yu-Guang Guan, Tian-Fu Li, Pei-Gang Wang, Guo-Ming Luan, Jing An
Hydroxychloroquine attenuates neuroinflammation following traumatic brain injury by regulating the TLR4/NF-κB signaling pathway
Jian Hu, Xue Wang, Xiongjian Chen, Yani Fang, Kun Chen, Wenshuo Peng, Zhengyi Wang, Kaiming Guo, Xianxi Tan, Fei Liang, Li Lin, Ye Xiong
Ebselen prevents cigarette smoke-induced cognitive dysfunction in mice by preserving hippocampal synaptophysin expression
Simone N. De Luca, Kurt Brassington, Stanley M. H. Chan, Aleksandar Dobric, Kevin Mou, Huei Jiunn Seow, Ross Vlahos
Recruitment of α4β7 monocytes and neutrophils to the brain in experimental colitis is associated with elevated cytokines and anxiety-like behavior
Nina L. Cluny, Kewir D. Nyuyki, Wagdi Almishri, Lateece Griffin, Benjamin H. Lee, Simon A. Hirota, Quentin J. Pittman, Mark G. Swain, Keith A. Sharkey
Changes in leukocytes and CRP in different stages of major depression
Deepti Singh, Paul C. Guest, Henrik Dobrowolny, Veronika Vasilevska, Gabriela Meyer-Lotz, Hans-Gert Bernstein, Katrin Borucki, Alexandra Neyazi, Bernhard Bogerts, Roland Jacobs, Johann Steiner
Effects of an intravenous ketamine infusion on inflammatory cytokine levels in male and female Sprague–Dawley rats
Haley F. Spencer, Rina Y. Berman, Martin Boese, Michael Zhang, Sharon Y. Kim, Kennett D. Radford, Kwang H. Choi
Gut microbiota is causally associated with poststroke cognitive impairment through lipopolysaccharide and butyrate
Huidi Wang, Mingsi Zhang, Jie Li, Jianhai Liang, Mengjia Yang, Genghong Xia, Yueran Ren, Hongwei Zhou, Qiheng Wu, Yan He, Jia Yin
Proteomic landscape subtype and clinical prognosis of patients with the cognitive impairment by Japanese encephalitis infection
Rong Yin, Linpeng Yang, Ying Hao, Zhiqi Yang, Tao Lu, Wanjun Jin, Meiling Dan, Liang Peng, Yingjie Zhang, Yaxuan Wei, Rong Li, Huiping Ma, Yuanyuan Shi, Pengcheng Fan
CSF sTREM2 in neurological diseases: a two-sample Mendelian randomization study
Ming-Hao Dong, Luo-Qi Zhou, Yue Tang, Man Chen, Jun Xiao, Ke Shang, Gang Deng, Chuan Qin, Dai-Shi Tian
Macrophage elastase (MMP12) critically contributes to the development of subretinal fibrosis
Caijiao Yi, Jian Liu, Wen Deng, Chang Luo, Jinyan Qi, Mei Chen, Heping Xu
Extracellular vesicles derived from mesenchymal stem cells alleviate neuroinflammation and mechanical allodynia in interstitial cystitis rats by inhibiting NLRP3 inflammasome activation
Chi Zhang, Yong Huang, Fubing Ouyang, Minzhi Su, Wenbiao Li, Jialiang Chen, Hengjun Xiao, Xiangfu Zhou, Bolong Liu
Single-cell transcriptomics of the ventral posterolateral nucleus-enriched thalamic regions from HSV-1-infected mice reveal a novel microglia/microglia-like transcriptional response
Olus Uyar, Juan Manuel Dominguez, Maude Bordeleau, Lina Lapeyre, Fernando González Ibáñez, Luc Vallières, Marie-Eve Tremblay, Jacques Corbeil, Guy Boivin
Irisin ameliorates neuroinflammation and neuronal apoptosis through integrin αVβ5/AMPK signaling pathway after intracerebral hemorrhage in mice
Yao Wang, Mi Tian, Jiaying Tan, Xu Pei, Chaocheng Lu, Yuewen Xin, Shuixiang Deng, Feng Zhao, Yanqin Gao, Ye Gong
Single-cell transcriptomic analysis of the immune cell landscape in the aged mouse brain after ischemic stroke
Xuan Li, Jingjun Lyu, Ran Li, Vaibhav Jain, Yuntian Shen, Ángela del Águila, Ulrike Hoffmann, Huaxin Sheng, Wei Yang
miR-203, fine-tunning neuroinflammation by juggling different components of NF‐κB signaling
Shufang Li, Linpeng Li, Jieli Li, Xiaosheng Liang, Chao Song, Yi Zou
Synaptic loss and progression in mice infected with Angiostrongylus cantonensis in the early stage
Kai-Yuan Jhan, Pi-Kai Chang, Chien-Ju Cheng, Shih-Ming Jung, Lian-Chen Wang
CSF GFAP levels in double seronegative neuromyelitis optica spectrum disorder: no evidence of astrocyte damage
Jae-Won Hyun, Yeseul Kim, Ki Hoon Kim, Su-Hyun Kim, Mads Nikolaj Olesen, Nasrin Asgari, Sasitorn Siritho, Friedemann Paul, Ho Jin Kim
Morphine-induced microglial immunosuppression via activation of insufficient mitophagy regulated by NLRX1
Jialing Peng, Jingrui Pan, Hongxuan Wang, Jingjing Mo, Lihuan Lan, Ying Peng
Soluble TREM2 is associated with death and cardiovascular events after acute ischemic stroke: an observational study from CATIS
Yaling Lu, Yu Zhao, Qi Zhang, Chongquan Fang, Anran Bao, Wenjing Dong, Yanbo Peng, Hao Peng, Zhong Ju, Jiang He, Yonghong Zhang, Tan Xu, Chongke Zhong
Independent risk factors for myasthenic crisis and disease exacerbation in a retrospective cohort of myasthenia gravis patients
Christopher Nelke, Frauke Stascheit, Carmen Eckert, Marc Pawlitzki, Christina B. Schroeter, Niklas Huntemann, Philipp Mergenthaler, Ercan Arat, Menekse Öztürk, Dirk Foell, Stefanie Schreiber, Stefan Vielhaber, Asmae Gassa, Henning Stetefeld, Michael Schroeter, Benjamin Berger, Andreas Totzeck, Tim Hagenacker, Sven G. Meuth, Andreas Meisel, Heinz Wiendl, Tobias Ruck
The effect of topical decorin on temporal changes to corneal immune cells after epithelial abrasion
Mengliang Wu, Laura E. Downie, Lisa J. Hill, Holly R. Chinnery
Role of SPAK–NKCC1 signaling cascade in the choroid plexus blood–CSF barrier damage after stroke
Jun Wang, Ruijia Liu, Md Nabiul Hasan, Sydney Fischer, Yang Chen, Matt Como, Victoria M. Fiesler, Mohammad Iqbal H. Bhuiyan, Shuying Dong, Eric Li, Kristopher T. Kahle, Jinwei Zhang, Xianming Deng, Arohan R. Subramanya, Gulnaz Begum, Yan Yin, Dandan Sun
Role of lipocalin-2 in surgery-induced cognitive decline in mice: a signal from neuron to microglia
Xuwu Xiang, Xiaodong Tang, Yang Yu, Shulan Xie, Lu Liu, ManLi Chen, Rong Zhang, Xianhui Kang, Yueying Zheng, Guang Yang, Shuyuan Gan, Shengmei Zhu
The smoothened agonist SAG reduces mitochondrial dysfunction and neurotoxicity of frataxin-deficient astrocytes
Andrés Vicente-Acosta, Alfredo Giménez-Cassina, Javier Díaz-Nido, Frida Loria
Microglial cell response in α7 nicotinic acetylcholine receptor-deficient mice after systemic infection with Escherichia coli
Inge C. M. Hoogland, Jutka Yik, Dunja Westhoff, Joo-Yeon Engelen-Lee, Merche Valls Seron, Wing Kit Man, Judith H. P. M. Houben-Weerts, Michael W. T. Tanck, David J. van Westerloo, Tom van der Poll, Willem A. van Gool, Diederik van de Beek
SU16f inhibits fibrotic scar formation and facilitates axon regeneration and locomotor function recovery after spinal cord injury by blocking the PDGFRβ pathway
Ziyu Li, Shuisheng Yu, Yanchang Liu, Xuyang Hu, Yiteng Li, Zhaoming Xiao, Yihao Chen, Dasheng Tian, Xinzhong Xu, Li Cheng, Meige Zheng, Juehua Jing
The cytokines interleukin-6 and interferon-α induce distinct microglia phenotypes
Phillip K. West, Andrew N. McCorkindale, Boris Guennewig, Thomas M. Ashhurst, Barney Viengkhou, Emina Hayashida, So Ri Jung, Oleg Butovsky, Iain L. Campbell, Markus J. Hofer
The macrophage: a key player in the pathophysiology of peripheral neuropathies
Zeina Msheik, Mohamed El Massry, Amandine Rovini, Fabrice Billet, Alexis Desmoulière
The role of Th17 cells/IL-17A in AD, PD, ALS and the strategic therapy targeting on IL-17A
Jiajia Fu, Yan Huang, Ting Bao, Chengcheng Liu, Xi Liu, Xueping Chen
Synthetic amyloid beta does not induce a robust transcriptional response in innate immune cell culture systems
I. Y. Quiroga, A. E. Cruikshank, M. L. Bond, K. S. M. Reed, B. A. Evangelista, J. H. Tseng, J. V. Ragusa, R. B. Meeker, H. Won, S. Cohen, T. J. Cohen, D. H. Phanstiel
Zika virus-induced TNF-α signaling dysregulates expression of neurologic genes associated with psychiatric disorders
Po-Lun Kung, Tsui-Wen Chou, Marissa Lindman, Nydia P. Chang, Irving Estevez, Benjamin D. Buckley, Colm Atkins, Brian P. Daniels
Sepsis-associated brain injury: underlying mechanisms and potential therapeutic strategies for acute and long-term cognitive impairments
Nobufumi Sekino, Magdy Selim, Amjad Shehadah
Macrophage-based delivery of interleukin-13 improves functional and histopathological outcomes following spinal cord injury
Jana Van Broeckhoven, Céline Erens, Daniela Sommer, Elle Scheijen, Selien Sanchez, Pia M. Vidal, Dearbhaile Dooley, Elise Van Breedam, Alessandra Quarta, Peter Ponsaerts, Sven Hendrix, Stefanie Lemmens
CD4+c-Met+Itgα4+ T cell subset promotes murine neuroinflammation
Mahdia Benkhoucha, Ngoc Lan Tran, Gautier Breville, Isis Senoner, Paul F. Bradfield, Thalia Papayannopoulou, Doron Merkler, Thomas Korn, Patrice H. Lalive
TLR4 mutation protects neurovascular function and cognitive decline in high-fat diet-fed mice
Nathalie Obadia, Giulia Andrade, Marina Leardini-Tristão, Letícia Albuquerque, Celina Garcia, Flavia Lima, Júlio Daleprane, Hugo C. Castro-Faria-Neto, Eduardo Tibiriçá, Vanessa Estato
An RNA-sequencing transcriptome of the rodent Schwann cell response to peripheral nerve injury
Amanda Brosius Lutz, Tawaun A. Lucas, Glenn A. Carson, Christine Caneda, Lu Zhou, Ben A. Barres, Marion S. Buckwalter, Steven A. Sloan
Association of inflammatory markers with cerebral small vessel disease in community-based population
Lingling Jiang, Xueli Cai, Dongxiao Yao, Jing Jing, Lerong Mei, Yingying Yang, Shan Li, Aoming Jin, Xia Meng, Hao Li, Tiemin Wei, Yongjun Wang, Yuesong Pan, Yilong Wang
SUN11602, a bFGF mimetic, modulated neuroinflammation, apoptosis and calcium-binding proteins in an in vivo model of MPTP-induced nigrostriatal degeneration
Alessio Ardizzone, Valentina Bova, Giovanna Casili, Alessia Filippone, Michela Campolo, Marika Lanza, Emanuela Esposito, Irene Paterniti
Adamantinomatous craniopharyngioma cyst fluid can trigger inflammatory activation of microglia to damage the hypothalamic neurons by inducing the production of β-amyloid
Yilamujiang Ainiwan, Yiguang Chen, Chaofu Mao, Junxiang Peng, Siyuan Chen, Songtao Wei, Songtao Qi, Jun Pan
Z-DNA binding protein 1 mediates necroptotic and apoptotic cell death pathways in murine astrocytes following herpes simplex virus-1 infection
Austin M. Jeffries, Alexander J. Suptela, Ian Marriott
High-fat diet exacerbates cognitive decline in mouse models of Alzheimer's disease and mixed dementia in a sex-dependent manner
Olivia J. Gannon, Lisa S. Robison, Abigail E. Salinero, Charly Abi-Ghanem, Febronia M. Mansour, Richard D. Kelly, Alvira Tyagi, Rebekah R. Brawley, Jordan D. Ogg, Kristen L. Zuloaga
Epigenetic regulation of innate immune memory in microglia
Xiaoming Zhang, Laura Kracht, Antonio M. Lerario, Marissa L. Dubbelaar, Nieske Brouwer, Evelyn M. Wesseling, Erik W. G. M. Boddeke, Bart J. L. Eggen, Susanne M. Kooistra
Interleukin 13 promotes long-term recovery after ischemic stroke by inhibiting the activation of STAT3
Di Chen, Jiaying Li, Yichen Huang, Pengju Wei, Wanying Miao, Yaomei Yang, Yanqin Gao
A breakdown in microglial metabolic reprogramming causes internalization dysfunction of α-synuclein in a mouse model of Parkinson’s disease
Jia Lu, Chenfei Wang, Xin Cheng, Ruizhi Wang, Xuehan Yan, Pengju He, Hongzhuan Chen, Zhihua Yu
A crosstalk between gut and brain in sepsis-induced cognitive decline
Vijayasree V. Giridharan, Jaqueline S. Generoso, Leonardo Lence, Gabriela Candiotto, Emílio Streck, Fabricia Petronilho, Anilkumar Pillai, Tarek Sharshar, Felipe Dal-Pizzol, Tatiana Barichello
Asperosaponin VI ameliorates the CMS-induced depressive-like behaviors by inducing a neuroprotective microglial phenotype in hippocampus via PPAR-γ pathway
Xue Jiang, Saini Yi, Qin Liu, Dapeng Su, Liangyuan Li, Chenghong Xiao, Jinqiang Zhang
Parkinson's disease peripheral immune biomarker profile: a multicentre, cross-sectional and longitudinal study
Yuanyuan Li, Yan Yang, Aonan Zhao, Ningdi Luo, Mengyue Niu, Wenyan Kang, Anmu Xie, Hong Lu, Lei Chen, Jun Liu
Agomelatine rescues lipopolysaccharide-induced neural injury and depression-like behaviors via suppression of the Gαi-2-PKA-ASK1 signaling pathway
Tian Lan, Yuhan Wu, Yulei Zhang, Shuhan Li, Zhanpeng Zhu, Liyan Wang, Xueqin Mao, Ye Li, Cuiqin Fan, Wenjing Wang, Shu Yan Yu
N-Oleoyl dopamine induces IL-10 via central nervous system TRPV1 and improves endotoxemia and sepsis outcomes
Jérémie Joffre, Erika Wong, Samira Lawton, Elliot Lloyd, Nina Nguyen, Fengyun Xu, Cristina Sempio, Lester Kobzik, Ivana Zlatanova, Mark Schumacher, Jost Klawitter, Hua Su, Katalin Rabl, Kevin Wilhelmsen, Che-Chung Yeh, Judith Hellman
Network alterations underlying anxiety symptoms in early multiple sclerosis
Erik Ellwardt, Muthuraman Muthuraman, Gabriel Gonzalez-Escamilla, Venkata Chaitanya Chirumamilla, Felix Luessi, Stefan Bittner, Frauke Zipp, Sergiu Groppa, Vinzenz Fleischer
Thrombin acts as inducer of proinflammatory macrophage migration inhibitory factor in astrocytes following rat spinal cord injury
Ting Yang, Haiyan Jiang, Xinye Luo, Yuxuan Hou, Aicheng Li, Bingqiang He, Xingyuan Zhang, Huifei Hao, Honghua Song, Rixin Cai, Xudong Wang, Yingjie Wang, Chun Yao, Lei Qi, Yongjun Wang
GPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome
Zhangjin Qin, Jiaqi Song, Aolei Lin, Wei Yang, Wenbo Zhang, Fuxin Zhong, Lihong Huang, Yang Lü, Weihua Yu
Intermittent fasting reduces neuroinflammation in intracerebral hemorrhage through the Sirt3/Nrf2/HO-1 pathway
Shuhui Dai, Jialiang Wei, Hongchen Zhang, Peng Luo, Yuefan Yang, Xiaofan Jiang, Zhou Fei, Wenbin Liang, Jianli Jiang, Xia Li
Activation of locus coeruleus-spinal cord noradrenergic neurons alleviates neuropathic pain in mice via reducing neuroinflammation from astrocytes and microglia in spinal dorsal horn
Juan Li, Yiyong Wei, Junli Zhou, Helin Zou, Lulin Ma, Chengxi Liu, Zhi Xiao, Xingfeng Liu, Xinran Tan, Tian Yu, Song Cao
Melatonin, an endogenous hormone, modulates Th17 cells via the reactive-oxygen species/TXNIP/HIF-1α axis to alleviate autoimmune uveitis
Jun Huang, Zhuang Li, Yunwei Hu, Zuoyi Li, Yanyan Xie, Haixiang Huang, Qian Chen, Guanyu Chen, Wenjie Zhu, Yuxi Chen, Wenru Su, Xiaoqing Chen, Dan Liang
CXCL13 expressed on inflamed cerebral blood vessels recruit IL-21 producing TFH cells to damage neurons following stroke
Aditya Rayasam, Julie A. Kijak, Lee Kissel, Yun Hwa Choi, Taehee Kim, Martin Hsu, Dinesh Joshi, Collin J. Laaker, Peter Cismaru, Anders Lindstedt, Krisztian Kovacs, Raghu Vemuganti, Shing Yan Chiu, Thanthrige Thiunuwan Priyathilaka, Matyas Sandor, Zsuzsanna Fabry
Strawberry notch homolog 2 regulates the response to interleukin-6 in the central nervous system
Taylor E. Syme, Magdalena Grill, Emina Hayashida, Barney Viengkhou, Iain L. Campbell, Markus J. Hofer
Systemic and central nervous system neuroinflammatory signatures of neuropsychiatric symptoms and related cognitive decline in older people
Christopher Clark, Jonas Richiardi, Bénédicte Maréchal, Gene L. Bowman, Loïc Dayon, Julius Popp
Pentoxifylline alleviates ischemic white matter injury through up-regulating Mertk-mediated myelin clearance
Lili Zheng, Junqiu Jia, Yan Chen, Renyuan Liu, Runjing Cao, Manlin Duan, Meijuan Zhang, Yun Xu
DKK3 ameliorates neuropathic pain via inhibiting ASK-1/JNK/p-38-mediated microglia polarization and neuroinflammation
Long-Qing Zhang, Shao-Jie Gao, Jia Sun, Dan-Yang Li, Jia-Yi Wu, Fan-He Song, Dai-Qiang Liu, Ya-Qun Zhou, Wei Mei
CEST MRI and MALDI imaging reveal metabolic alterations in the cervical lymph nodes of EAE mice
Aline M. Thomas, Ethan Yang, Matthew D. Smith, Chengyan Chu, Peter A. Calabresi, Kristine Glunde, Peter C. M. van Zijl, Jeff W. M. Bulte
Interleukin-6 and YKL-40 predicted recurrent stroke after ischemic stroke or TIA: analysis of 6 inflammation biomarkers in a prospective cohort study
Jiejie Li, Jinxi Lin, Yuesong Pan, Mengxing Wang, Xia Meng, Hao Li, Yilong Wang, Xingquan Zhao, Haiqiang Qin, Liping Liu, Yongjun Wang
Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression
Haixia Wang, Yi He, Zuoli Sun, Siyu Ren, Mingxia Liu, Gang Wang, Jian Yang
The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson’s disease via the microglial NLRP3 inflammasome
Liang Kou, Xiaosa Chi, Yadi Sun, Chao Han, Fang Wan, Junjie Hu, Sijia Yin, Jiawei Wu, Yunna Li, Qiulu Zhou, Wenkai Zou, Nian Xiong, Jinsha Huang, Yun Xia, Tao Wang
Astrocytic Nrf2 expression protects spinal cord from oxidative stress following spinal cord injury in a male mouse model
Weiyi Zhao, Natalie Gasterich, Tim Clarner, Clara Voelz, Victoria Behrens, Cordian Beyer, Athanassios Fragoulis, Adib Zendedel
The role of Toll-like receptors and neuroinflammation in Parkinson’s disease
Arash Heidari, Niloufar Yazdanpanah, Nima Rezaei
Perivascular macrophages in high-fat diet-induced hypothalamic inflammation
Natalia F. Mendes, Licio A. Velloso
Activating cGAS–STING axis contributes to neuroinflammation in CVST mouse model and induces inflammasome activation and microglia pyroptosis
Rui Ding, Haiyan Li, Yaqi Liu, Weiyang Ou, Xifang Zhang, Huihui Chai, Xiaofei Huang, Weijie Yang, Qiujing Wang
Factor VII, EPCR, aPC Modulators: novel treatment for neuroinflammation
Valery Golderman, Marina Ben-Shimon, Nicola Maggio, Amir Dori, Shany Guly Gofrit, Shani Berkowitz, Lamis Qassim, Avital Artan-Furman, Talya Zeimer, Joab Chapman, Efrat Shavit-Stein
Persistent cortical and white matter inflammation after therapeutic hypothermia for ischemia in near-term fetal sheep
Kelly Q. Zhou, Laura Bennet, Guido Wassink, Alice McDouall, Maurice A. Curtis, Blake Highet, Taylor J. Stevenson, Alistair J. Gunn, Joanne O. Davidson
Anti-IgLON5 antibodies cause progressive behavioral and neuropathological changes in mice
You Ni, Yifan Feng, Dingding Shen, Ming Chen, Xiaona Zhu, Qinming Zhou, Yining Gao, Jun Liu, Qi Zhang, Yuntian Shen, Lisheng Peng, Zike Zeng, Dou Yin, Ji Hu, Sheng Chen
Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4/NFκB/NLRP3 signaling pathway in cerebral ischemic mice
Lu Luo, Meixi Liu, Yunhui Fan, Jingjun Zhang, Li Liu, Yun Li, Qiqi Zhang, Hongyu Xie, Congyu Jiang, Junfa Wu, Xiao Xiao, Yi Wu
Effect of rottlerin on astrocyte phenotype polarization after trimethyltin insult in the dentate gyrus of mice
Yeonggwang Hwang, Hyoung-Chun Kim, Eun-Joo Shin
Neuroprotective effects of ex vivo-expanded regulatory T cells on trimethyltin-induced neurodegeneration in mice
Seon-Young Park, HyeJin Yang, Minsook Ye, Xiao Liu, Insop Shim, Young-Tae Chang, Hyunsu Bae
Adaptation of prelimbic cortex mediated by IL-6/STAT3/Acp5 pathway contributes to the comorbidity of neuropathic pain and depression in rats
Yu-Ting Zhao, Jie Deng, He-Ming Liu, Jia-You Wei, Hai-Ting Fan, Meng Liu, Ting Xu, Ting-Feng Chen, Jing-Yi He, Wei-Ming Sun, Tao-Yu Jia, Xue-Qin Zhang, Wen-Jun Xin
Far infrared light irradiation enhances Aβ clearance via increased exocytotic microglial ATP and ameliorates cognitive deficit in Alzheimer’s disease-like mice
Qingyong Li, Jun Peng, Yuelian Luo, Jiaxin Zhou, Tailin Li, Lin Cao, Shuling Peng, Zhiyi Zuo, Zhi Wang
Reduced microglia activation following metformin administration or microglia ablation is sufficient to prevent functional deficits in a mouse model of neonatal stroke
Clara Bourget, Kelsey V. Adams, Cindi M. Morshead
Microglial amyloid beta clearance is driven by PIEZO1 channels
Henna Jäntti, Valeriia Sitnikova, Yevheniia Ishchenko, Anastasia Shakirzyanova, Luca Giudice, Irene F. Ugidos, Mireia Gómez-Budia, Nea Korvenlaita, Sohvi Ohtonen, Irina Belaya, Feroze Fazaludeen, Nikita Mikhailov, Maria Gotkiewicz, Kirsi Ketola, Šárka Lehtonen, Jari Koistinaho, Katja M. Kanninen, Damian Hernández, Alice Pébay, Rosalba Giugno, Paula Korhonen, Rashid Giniatullin, Tarja Malm
Superior control of inflammatory pain by corticotropin-releasing factor receptor 1 via opioid peptides in distinct pain-relevant brain areas
Shaaban A. Mousa, Baled I. Khalefa, Mohammed Shaqura, Mohammed Al-Madol, Sascha Treskatsch, Michael Schäfer
SARS-CoV-2 productively infects human brain microvascular endothelial cells
Rui-Cheng Yang, Kun Huang, Hui-Peng Zhang, Liang Li, Yu-Fei Zhang, Chen Tan, Huan-Chun Chen, Mei-Lin Jin, Xiang-Ru Wang
Prehabilitative resistance exercise reduces neuroinflammation and improves mitochondrial health in aged mice with perioperative neurocognitive disorders
Yan Liu, John Man Tak Chu, You Ran, Yan Zhang, Raymond Chuen Chung Chang, Gordon Tin Chun Wong
Early-life stress elicits peripheral and brain immune activation differently in wild type and 5xFAD mice in a sex-specific manner
S. Bachiller, I. Hidalgo, M. G. Garcia, A. Boza-Serrano, A. Paulus, Q. Denis, C. Haikal, O. Manouchehrian, O. Klementieva, J. Y. Li, C. J. Pronk, G. K. Gouras, T. Deierborg
FKBP51 mediates resilience to inflammation-induced anxiety through regulation of glutamic acid decarboxylase 65 expression in mouse hippocampus
Yu-Ling Gan, Chen-Yu Wang, Rong-Heng He, Pei-Chien Hsu, Hsin-Hsien Yeh, Tsung-Han Hsieh, Hui-Ching Lin, Ming-Yen Cheng, Chung-Jiuan Jeng, Ming-Chyi Huang, Yi-Hsuan Lee
Sciatic nerve stimulation alleviates acute neuropathic pain via modulation of neuroinflammation and descending pain inhibition in a rodent model
Chia-En Wong, Chia-Ying Hu, Po-Hsuan Lee, Chi-Chen Huang, Han-Wei Huang, Chih-Yuan Huang, Hsin-Tien Lo, Wentai Liu, Jung-Shun Lee
The function of gut microbiota in immune-related neurological disorders: a review
Panida Sittipo, Jaeyoon Choi, Soojin Lee, Yun Kyung Lee
Electrical stimulation of the splenic nerve bundle ameliorates dextran sulfate sodium-induced colitis in mice
David J. Brinkman, Thomas Simon, Anne S. ten Hove, Konstantina Zafeiropoulou, Olaf Welting, Patricia H. P. van Hamersveld, Rose A. Willemze, Andrew Y. F. Li Yim, Caroline Verseijden, Theodorus B. M. Hakvoort, Misha D. Luyer, Margriet J. Vervoordeldonk, Philippe Blancou, Wouter J. de Jonge
Targeting choroid plexus epithelium as a novel therapeutic strategy for hydrocephalus
Yijian Yang, Jian He, Yuchang Wang, Chuansen Wang, Changwu Tan, Junbo Liao, Lei Tong, Gelei Xiao
Fatty acids role in multiple sclerosis as “metabokines”
Haojun Yu, Shuwei Bai, Yong Hao, Yangtai Guan
Cellular inhibitor of apoptosis 2 (cIAP2) restricts neuroinflammation during experimental autoimmune encephalomyelitis
Debolina D. Biswas, Rebecca K. Martin, LaShardai N. Brown, Karli Mockenhaupt, Angela S. Gupta, Michael J. Surace, Anuj Tharakan, Jessie W. Yester, Reetika Bhardwaj, Daniel H. Conrad, Tomasz Kordula
Complement C3a activates astrocytes to promote medulloblastoma progression through TNF-α
Biao Gong, Duancheng Guo, Chaonan Zheng, Zhen Ma, Jie Zhang, Yanghui Qu, Xinhua Li, Gen Li, Li Zhang, Yuan Wang
Apelin alleviated neuroinflammation and promoted endogenous neural stem cell proliferation and differentiation after spinal cord injury in rats
Qing Liu, Shuai Zhou, Xiao Wang, Chengxu Gu, Qixuan Guo, Xikai Li, Chunlei Zhang, Naili Zhang, Luping Zhang, Fei Huang
An imbalance between RAGE/MR/HMGB1 and ATP1α3 is associated with inflammatory changes in rat brain harboring cerebral aneurysms prone to rupture
Eiji Shikata, Takeshi Miyamoto, Tadashi Yamaguchi, Izumi Yamaguchi, Hiroshi Kagusa, Daiki Gotoh, Kenji Shimada, Yoshiteru Tada, Kenji Yagi, Keiko T. Kitazato, Yasuhisa Kanematsu, Yasushi Takagi
Neuroinflammation in the anterior cingulate cortex: the potential supraspinal mechanism underlying the mirror-image pain following motor fiber injury
Qiao-Yun Li, Shao-Xia Chen, Jin-Yu Liu, Pei-Wen Yao, Yi-Wen Duan, Yong-Yong Li, Ying Zang
NLRP3 inflammasome-mediated choroid plexus hypersecretion contributes to hydrocephalus after intraventricular hemorrhage via phosphorylated NKCC1 channels
Zhaoqi Zhang, Qiang Tan, Peiwen Guo, Suna Huang, Zhengcai Jia, Xin Liu, Hua Feng, Yujie Chen
Positive interaction between GPER and β-alanine in the dorsal root ganglion uncovers potential mechanisms: mediating continuous neuronal sensitization and neuroinflammation responses in neuropathic pain
Zhenzhen Xu, Wanli Xie, Yiqi Feng, Yanting Wang, Xia Li, Jie Liu, Yue Xiong, Yuyao He, Lu Chen, Guoyang Liu, Qingping Wu
Potential biomarkers of spinal dural arteriovenous fistula: C4BPA and C1QA
Yinqing Wang, Yongjie Ma, Chengbin Yang, Xiahe Huang, Kun Yang, Fei Lan, Jingxuan Fu, Zihao Song, An Tian, Yueshan Feng, Tianqi Tu, Haifeng Li, Tao Hong, Yingchun Wang, Hongqi Zhang
Astrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors
Gang Yu, Feng Cao, Tingting Hou, Yunsheng Cheng, Benli Jia, Liang Yu, Wanjing Chen, Yanyan Xu, Mingming Chen, Yong Wang
A tale of two transmitters: serotonin and histamine as in vivo biomarkers of chronic stress in mice
Melinda Hersey, Melissa Reneaux, Shane N. Berger, Sergio Mena, Anna Marie Buchanan, Yangguang Ou, Navid Tavakoli, Lawrence P. Reagan, Claudia Clopath, Parastoo Hashemi
Targeted BRD4 protein degradation by dBET1 ameliorates acute ischemic brain injury and improves functional outcomes associated with reduced neuroinflammation and oxidative stress and preservation of blood–brain barrier integrity
Lei Liu, Changjun Yang, Bianca P. Lavayen, Ryland J. Tishko, Jonathan Larochelle, Eduardo Candelario-Jalil
Using zebrafish to understand reciprocal interactions between the nervous and immune systems and the microbial world
Jean-Pierre Levraud, John F. Rawls, Anne E. Clatworthy
Gut microbiota depletion by antibiotics ameliorates somatic neuropathic pain induced by nerve injury, chemotherapy, and diabetes in mice
Pingchuan Ma, Rufan Mo, Huabao Liao, Chengjie Qiu, Genhao Wu, Caixia Yang, Yunxiao Zhang, Yiran Zhao, Xue-Jun Song
Transient post-operative overexpression of CXCR2 on monocytes of traumatic brain injury patients drives monocyte chemotaxis toward cerebrospinal fluid and enhances monocyte-mediated immunogenic cell death of neurons in vitro
Huayang Wang, Qibing Huang, Zhijie Zhang, Jian Ji, Tao Sun, Donghai Wang
Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model
Kiara Freitag, Nele Sterczyk, Sarah Wendlinger, Benedikt Obermayer, Julia Schulz, Vadim Farztdinov, Michael Mülleder, Markus Ralser, Judith Houtman, Lara Fleck, Caroline Braeuning, Roberto Sansevrino, Christian Hoffmann, Dragomir Milovanovic, Stephan J. Sigrist, Thomas Conrad, Dieter Beule, Frank L. Heppner, Marina Jendrach
Repopulated microglia induce expression of Cxcl13 with differential changes in Tau phosphorylation but do not impact amyloid pathology
Berke Karaahmet, Linh Le, Monique S. Mendes, Ania K. Majewska, M. Kerry O’Banion
Spatial and temporal variation of routine parameters: pitfalls in the cerebrospinal fluid analysis in central nervous system infections
Marija Djukic, Peter Lange, Frank Erbguth, Roland Nau
Correction to: Vagus nerve stimulation modulates hippocampal inflammation caused by continuous stress in rats
Uk Namgung, Ki-Joong Kim, Byung-Gon Jo, Jong-Min Park
The immunometabolite S-2-hydroxyglutarate exacerbates perioperative ischemic brain injury and cognitive dysfunction by enhancing CD8+ T lymphocyte-mediated neurotoxicity
Faqiang Zhang, Mu Niu, Kaikai Guo, Yulong Ma, Qiang Fu, Yanhong Liu, Zeguo Feng, Weidong Mi, Long Wang
A cannabidiol aminoquinone derivative activates the PP2A/B55α/HIF pathway and shows protective effects in a murine model of traumatic brain injury
Carmen Navarrete, Adela García-Martín, Alejandro Correa-Sáez, María E. Prados, Francisco Fernández, Rafael Pineda, Massimiliano Mazzone, Marina Álvarez-Benito, Marco A. Calzado, Eduardo Muñoz
Modulation of C5a–C5aR1 signaling alters the dynamics of AD progression
Klebea Carvalho, Nicole D. Schartz, Gabriela Balderrama-Gutierrez, Heidi Y. Liang, Shu-Hui Chu, Purnika Selvan, Angela Gomez-Arboledas, Tiffany J. Petrisko, Maria I. Fonseca, Ali Mortazavi, Andrea J. Tenner
The primary macrophage chemokine, CCL2, is not necessary after a peripheral nerve injury for macrophage recruitment and activation or for conditioning lesion enhanced peripheral regeneration
Aaron D. Talsma, Jon P. Niemi, Joel S. Pachter, Richard E. Zigmond
MicroRNA-22-3p ameliorates Alzheimer’s disease by targeting SOX9 through the NF-κB signaling pathway in the hippocampus
Pengcheng Xia, Jing Chen, Yingchao Liu, Xiaolin Cui, Cuicui Wang, Shuai Zong, Le Wang, Zhiming Lu
Transient neuroinflammation following surgery contributes to long-lasting cognitive decline in elderly rats via dysfunction of synaptic NMDA receptor
Bo Chen, Guangcheng Qin, Jingyu Xiao, Xiaoyuan Deng, Aolei Lin, Hongliang Liu
Complement activation contributes to subretinal fibrosis through the induction of epithelial-to-mesenchymal transition (EMT) in retinal pigment epithelial cells
María Llorián-Salvador, Eimear M. Byrne, Manon Szczepan, Karis Little, Mei Chen, Heping Xu
Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases
Meini Chen, Rong Rong, Xiaobo Xia
NOX2-mediated reactive oxygen species are double-edged swords in focal cerebral ischemia in mice
Ye Yingze, Jian Zhihong, Jin Tong, Li Yina, Zeng Zhi, Zhang Xu, Xiong Xiaoxing, Gu Lijuan
Mesenchymal stromal cell treatment attenuates repetitive mild traumatic brain injury-induced persistent cognitive deficits via suppressing ferroptosis
Dong Wang, Shishuang Zhang, Xintong Ge, Zhenyu Yin, Meimei Li, Mengtian Guo, Tianpeng Hu, Zhaoli Han, Xiaodong Kong, Dai Li, Jing Zhao, Lu Wang, Qiang Liu, Fanglian Chen, Ping Lei
Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain
Zhuang Peng, Sha Peng, Kangguang Lin, Bin Zhao, Lai Wei, Qinhui Tuo, Duanfang Liao, Tifei Yuan, Zhe Shi
Nilotinib modulates LPS-induced cognitive impairment and neuroinflammatory responses by regulating P38/STAT3 signaling
Jieun Kim, Hyun-ju Lee, Jin-Hee Park, Byung-Yoon Cha, Hyang-Sook Hoe
Increased levels of a pro-inflammatory IgG receptor in the midbrain of people with schizophrenia
A. Petty, L. J. Glass, D. A. Rothmond, T. Purves-Tyson, A. Sweeney, Y. Kondo, S. Kubo, M. Matsumoto, C. Shannon Weickert
Delayed administration of nafamostat mesylate inhibits thrombin-mediated blood–spinal cord barrier breakdown during acute spinal cord injury in rats
Chenxi Zhao, Tiangang Zhou, Xiaoqing Zhao, Yilin Pang, Wenxiang Li, Baoyou Fan, Ming Li, Xinjie Liu, Lei Ma, Jiawei Zhang, Chao Sun, Wenyuan Shen, Xiaohong Kong, Xue Yao, Shiqing Feng
Phagocytosis converts infiltrated monocytes to microglia-like phenotype in experimental brain ischemia
Hyunwoo Ju, Keun Woo Park, Il-doo Kim, John W. Cave, Sunghee Cho
Ablation of Siglec-E augments brain inflammation and ischemic injury
Lexiao Li, Yu Chen, Madison N. Sluter, Ruida Hou, Jiukuan Hao, Yin Wu, Guo-Yun Chen, Ying Yu, Jianxiong Jiang
Activation of peripheral TRPM8 mitigates ischemic stroke by topically applied menthol
Shiang-Suo Huang, Hsing-Hui Su, Szu-Yu Chien, Hsin-Yi Chung, Sih-Ting Luo, Yu-Ting Chu, Yi-Hsin Wang, Iona J. MacDonald, Hsun-Hua Lee, Yi-Hung Chen
Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNFα: implications for neurodegenerative disorders
Joanna K. Winstone, Khyatiben V. Pathak, Wendy Winslow, Ignazio S. Piras, Jennifer White, Ritin Sharma, Matthew J. Huentelman, Patrick Pirrotte, Ramon Velazquez
Transforming growth factor-β1 protects against LPC-induced cognitive deficit by attenuating pyroptosis of microglia via NF-κB/ERK1/2 pathways
Yi Xie, Xuejiao Chen, Ying Li, Simiao Chen, Shuai Liu, Zhiyuan Yu, Wei Wang
A CCR5 antagonist, maraviroc, alleviates neural circuit dysfunction and behavioral disorders induced by prenatal valproate exposure
Yasuhiro Ishihara, Tatsuya Honda, Nami Ishihara, Kaede Namba, Makiko Taketoshi, Yoko Tominaga, Mayumi Tsuji, Christoph F. A. Vogel, Takeshi Yamazaki, Kouichi Itoh, Takashi Tominaga
Inositol 1,4,5-trisphosphate receptor type 1 autoantibody (ITPR1-IgG/anti-Sj)-associated autoimmune cerebellar ataxia, encephalitis and peripheral neuropathy: review of the literature
Sven Jarius, Stefan Bräuninger, Ha-Yeun Chung, Christian Geis, Jürgen Haas, Lars Komorowski, Brigitte Wildemann, Christian Roth
Correction to: Nos2−/− mice infected with M. tuberculosis develop neurobehavioral changes and immunopathology mimicking human central nervous system tuberculosis
Xuan Ying Poh, Jia Mei Hong, Chen Bai, Qing Hao Miow, Pei Min Thong, Yu Wang, Ravisankar Rajarethinam, Cristine S. L. Ding, Catherine W. M. Ong
Aprepitant attenuates NLRC4-dependent neuronal pyroptosis via NK1R/PKCδ pathway in a mouse model of intracerebral hemorrhage
Peng Jin, Dongqing Qi, Yuhui Cui, Cameron Lenahan, John H. Zhang, Xiaogen Tao, Shuixiang Deng, Jiping Tang
Systemic inflammatory markers of persistent cerebral edema after aneurysmal subarachnoid hemorrhage
Sung-Ho Ahn, Angela Burkett, Atzhiry Paz, Jude P. Savarraj, Sarah Hinds, Georgene Hergenroeder, Aaron M. Gusdon, Xuefeng Ren, Jeong-Ho Hong, Huimahn A. Choi
Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity
Elizabeth E. Evans, Vikas Mishra, Crystal Mallow, Elaine M. Gersz, Leslie Balch, Alan Howell, Christine Reilly, Ernest S. Smith, Terrence L. Fisher, Maurice Zauderer
Microglia-specific deletion of histone deacetylase 3 promotes inflammation resolution, white matter integrity, and functional recovery in a mouse model of traumatic brain injury
Yongfang Zhao, Hongfeng Mu, Yichen Huang, Sicheng Li, Yangfan Wang, R. Anne Stetler, Michael V. L. Bennett, C. Edward Dixon, Jun Chen, Yejie Shi
Conditional knockout of ASK1 in microglia/macrophages attenuates epileptic seizures and long-term neurobehavioural comorbidities by modulating the inflammatory responses of microglia/macrophages
Yiying Zhang, Zhangyang Wang, Rongrong Wang, Lu Xia, Yiying Cai, Fangchao Tong, Yanqin Gao, Jing Ding, Xin Wang
Macrophages in close proximity to the vitreoretinal interface are potential biomarkers of inflammation during retinal vascular disease
Amrita Rajesh, Steven Droho, Jeremy A. Lavine
Sensory neuron dysfunction in orthotopic mouse models of colon cancer
Mihály Balogh, Jixiang Zhang, Caitlyn M. Gaffney, Neha Kalakuntla, Nicholas T. Nguyen, Ronnie T. Trinh, Clarissa Aguilar, Hoang Vu Pham, Bojana Milutinovic, James M. Nichols, Rajasekaran Mahalingam, Andrew J. Shepherd
Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer’s disease
Yue Dong, Hanqiao Yu, Xueqi Li, Kelong Bian, Yayuan Zheng, Mingrui Dai, Xuejian Feng, Yao Sun, Yu He, Bin Yu, Haihong Zhang, Jiaxin Wu, Xianghui Yu, Hui Wu, Wei Kong
Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer’s disease
Deepali Singh
Modulation of the proteoglycan receptor PTPσ promotes white matter integrity and functional recovery after intracerebral hemorrhage stroke in mice
Min Yao, Jie Fang, Jiewei Li, Anson Cho Kiu Ng, Jiaxin Liu, Gilberto Ka Kit Leung, Fanglai Song, Jian Zhang, Chunqi Chang
Psychological stress induces depressive-like behavior associated with bone marrow-derived monocyte infiltration into the hippocampus independent of blood–brain barrier disruption
Huiling Hu, Xue Yang, Yuqing He, Chaohui Duan, Nannan Sun
Brain microglia activation and peripheral adaptive immunity in Parkinson’s disease: a multimodal PET study
Shu-Ying Liu, Hong-Wen Qiao, Tian-Bin Song, Xiu-Lin Liu, Yun-Xia Yao, Chun-Song Zhao, Olivier Barret, Sheng-Li Xu, Yan-Ning Cai, Gilles D. Tamagnan, Vesna Sossi, Jie Lu, Piu Chan
Chronic allergic lung inflammation negatively influences neurobehavioral outcomes in mice
Akihiro Kanaya, Mu Yang, Charles Emala, Maya Mikami
Transcriptome profiling of microRNAs reveals potential mechanisms of manual therapy alleviating neuropathic pain through microRNA-547-3p-mediated Map4k4/NF-κb signaling pathway
Chongjie Yao, Jun Ren, Ruixin Huang, Cheng Tang, Yanbin Cheng, Zhizhen Lv, Lingjun Kong, Sitong Fang, Jiming Tao, Yangyang Fu, Qingguang Zhu, Min Fang
IL-27 shapes the immune properties of human astrocytes and their impact on encountered human T lymphocytes
Florent Lemaître, Negar Farzam-kia, Ana Carmena Moratalla, Yves Carpentier Solorio, Marie-Laure Clenet, Olivier Tastet, Aurélie Cleret-Buhot, Jean Victor Guimond, Elie Haddad, Pierre Duquette, J. Marc Girard, Alexandre Prat, Catherine Larochelle, Nathalie Arbour
Drp1 activates ROS/HIF-1α/EZH2 and triggers mitochondrial fragmentation to deteriorate hypercalcemia-associated neuronal injury in mouse model of chronic kidney disease
Hongming Sun, Xitong Li, Xin Chen, Yingquan Xiong, Yaochen Cao, Ziqiang Wang
Flufenamic acid improves survival and neurologic outcome after successful cardiopulmonary resuscitation in mice
Jiancong Chen, Yuan Chang, Juan Zhu, Yuqin Peng, Zheqi Li, Kunxue Zhang, Yuzhen Zhang, Chuman Lin, Zhenzhou Lin, Suyue Pan, Kaibin Huang
Pathogenesis, therapeutic strategies and biomarker development based on “omics” analysis related to microglia in Alzheimer’s disease
Chao Gao, Xin Shen, Yuyan Tan, Shengdi Chen
The cytokine IL-27 reduces inflammation and protects photoreceptors in a mouse model of retinal degeneration
Andrea Nortey, Kimberly Garces, Tal Carmy-Bennun, Abigail S. Hackam
Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study
Emma L. van der Ende, Carolin Heller, Aitana Sogorb-Esteve, Imogen J. Swift, David McFall, Georgia Peakman, Arabella Bouzigues, Jackie M. Poos, Lize C. Jiskoot, Jessica L. Panman, Janne M. Papma, Lieke H. Meeter, Elise G. P. Dopper, Martina Bocchetta, Emily Todd, David Cash, Caroline Graff, Matthis Synofzik, Fermin Moreno, Elizabeth Finger, Raquel Sanchez-Valle, Rik Vandenberghe, Robert Laforce Jr, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Chris Butler, Simon Ducharme, Alexander Gerhard, Adrian Danek, Johannes Levin, Yolande A. L. Pijnenburg, Markus Otto, Barbara Borroni, Fabrizio Tagliavini, Alexandre de Mendonça, Isabel Santana, Daniela Galimberti, Sandro Sorbi, Henrik Zetterberg, Eric Huang, John C. van Swieten, Jonathan D. Rohrer, Harro Seelaar, Sónia Afonso, Maria Rosario Almeida, Sarah Anderl-Straub, Christin Andersson, Anna Antonell, Silvana Archetti, Andrea Arighi, Mircea Balasa, Myriam Barandiaran, Nuria Bargalló, Robart Bartha, Benjamin Bender, Alberto Benussi, Luisa Benussi, Valentina Bessi, Giuliano Binetti, Sandra Black, Martina Bocchetta, Sergi Borrego-Ecija, Jose Bras, Rose Bruffaerts, Marta Cañada, Valentina Cantoni, Paola Caroppo, David Cash, Miguel Castelo-Branco, Rhian Convery, Thomas Cope, Giuseppe Di Fede, Alina Díez, Diana Duro, Chiara Fenoglio, Camilla Ferrari, Catarina B. Ferreira, Nick Fox, Morris Freedman, Giorgio Fumagalli, Alazne Gabilondo, Roberto Gasparotti, Serge Gauthier, Stefano Gazzina, Giorgio Giaccone, Ana Gorostidi, Caroline Greaves, Rita Guerreiro, Tobias Hoegen, Begoña Indakoetxea, Vesna Jelic, Hans-Otto Karnath, Ron Keren, Tobias Langheinrich, Maria João Leitão, Albert Lladó, Gemma Lombardi, Sandra Loosli, Carolina Maruta, Simon Mead, Gabriel Miltenberger, Rick van Minkelen, Sara Mitchell, Katrina Moore, Benedetta Nacmias, Jennifer Nicholas, Linn Öijerstedt, Jaume Olives, Sebastien Ourselin, Alessandro Padovani, Georgia Peakman, Michela Pievani, Cristina Polito, Enrico Premi, Sara Prioni, Catharina Prix, Rosa Rademakers, Veronica Redaelli, Tim Rittman, Ekaterina Rogaeva, Pedro Rosa-Neto, Giacomina Rossi, Martin Rosser, Beatriz Santiago, Elio Scarpini, Sonja Schönecker, Elisa Semler, Rachelle Shafei, Christen Shoesmith, Miguel Tábuas-Pereira, Mikel Tainta, Ricardo Taipa, David Tang-Wai, David L. Thomas, Paul Thompson, Hakan Thonberg, Carolyn Timberlake, Pietro Tiraboschi, Emily Todd, Philip Van Damme, Mathieu Vandenbulcke, Michele Veldsman, Ana Verdelho, Jorge Villanua, Jason Warren, Carlo Wilke, Ione Woollacott, Elisabeth Wlasich, Miren Zulaica
The associations between plasma soluble Trem1 and neurological diseases: a Mendelian randomization study
Xiaolei Shi, Tao Wei, Yachun Hu, Meng Wang, Yi Tang
Ferroptosis is involved in regulating perioperative neurocognitive disorders: emerging perspectives
Yanhong Song, Ziyi Wu, Hang Xue, Ping Zhao
Immunoadsorption versus double-dose methylprednisolone in refractory multiple sclerosis relapses
Steffen Pfeuffer, Leoni Rolfes, Timo Wirth, Falk Steffen, Marc Pawlitzki, Andreas Schulte-Mecklenbeck, Catharina C. Gross, Marcus Brand, Stefan Bittner, Tobias Ruck, Luisa Klotz, Heinz Wiendl, Sven G. Meuth
Human PMSCs-derived small extracellular vesicles alleviate neuropathic pain through miR-26a-5p/Wnt5a in SNI mice model
Yitian Lu, Jintao Zhang, Fanning Zeng, Peng Wang, Xiangna Guo, Haitao Wang, Zaisheng Qin, Tao Tao
COVID-19 and cognitive impairment: neuroinvasive and blood‒brain barrier dysfunction
Yanting Chen, Wenren Yang, Feng Chen, Lili Cui
Neuroinflammation represents a common theme amongst genetic and environmental risk factors for Alzheimer and Parkinson diseases
Rachel J. Boyd, Dimitri Avramopoulos, Lauren L. Jantzie, Andrew S. McCallion
Chronic suppurative otitis media causes macrophage-associated sensorineural hearing loss
Anping Xia, Anthony Thai, Zhixin Cao, Xiaohua Chen, Jing Chen, Brian Bacacao, Laurent A. Bekale, Viktoria Schiel, Paul L. Bollyky, Peter L. Santa Maria
Chronic delta-9-tetrahydrocannabinol (THC) treatment counteracts SIV-induced modulation of proinflammatory microRNA cargo in basal ganglia-derived extracellular vesicles
Hussein Kaddour, Marina McDew-White, Miguel M. Madeira, Malik A. Tranquille, Stella E. Tsirka, Mahesh Mohan, Chioma M. Okeoma
Captopril alleviates epilepsy and cognitive impairment by attenuation of C3-mediated inflammation and synaptic phagocytosis
Xinyan Dong, Jianchen Fan, Donghui Lin, Xuehui Wang, Haoyu Kuang, Lifen Gong, Chen Chen, Jie Jiang, Ningxiao Xia, Dahong He, Weida Shen, Peifang Jiang, Rong Kuang, Linghui Zeng, Yicheng Xie
Correction to: Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress
Dan Zhao, Xulin Xu, Linna Pan, Wei Zhu, Xiaopei Fu, Lianjun Guo, Qing Lu, Jian Wang
Investigation and modulation of interleukin-6 following subarachnoid hemorrhage: targeting inflammatory activation for cerebral vasospasm
Brandon Lucke-Wold, William Dodd, Kartik Motwani, Koji Hosaka, Dimitri Laurent, Melanie Martinez, Victoria Dugan, Nohra Chalouhi, Noelle Lucke-Wold, Arnav Barpujari, Christina von Roemeling, Chenglong Li, Richard D. Johnson, Brian Hoh
Genetic targeting or pharmacological inhibition of galectin-3 dampens microglia reactivity and delays retinal degeneration
Mona Tabel, Anne Wolf, Manon Szczepan, Heping Xu, Herbert Jägle, Christoph Moehle, Mei Chen, Thomas Langmann
Correction to: BET protein inhibition regulates cytokine production and promotes neuroprotection after spinal cord injury
Judith Sánchez-Ventura, Jesús Amo-Aparicio, Xavier Navarro, Clara Penas
Pregabalin mitigates microglial activation and neuronal injury by inhibiting HMGB1 signaling pathway in radiation-induced brain injury
Zhan Zhang, Jingru Jiang, Yong He, Jinhua Cai, Jiatian Xie, Minyi Wu, Mengdan Xing, Zhenzhen Zhang, Haocai Chang, Pei Yu, Siqi Chen, Yuhua Yang, Zhongshan Shi, Qiang Liu, Haohui Sun, Baixuan He, Junbo Zeng, Jialin Huang, Jiongxue Chen, Honghong Li, Yi Li, Wei-Jye Lin, Yamei Tang
Nicotinamide reverses deficits in puberty-born neurons and cognitive function after maternal separation
Keke Hao, Huiling Wang, Yuejin Zhang, Xinhui Xie, Huan Huang, Cheng Chen, Shilin Xu, Rui Xu, Chang Shu, Zhongchun Liu, Yuan Zhou, Gavin P. Reynolds, Gaohua Wang
The effects of splenectomy in murine models of ischemic stroke: a systematic review and meta-analysis
Marko Sternak, Anton Glasnović, Paula Josić, Dominik Romić, Srećko Gajović
Comparative analysis of transcriptome remodeling in plaque-associated and plaque-distant microglia during amyloid-β pathology progression in mice
Anne-Laure Hemonnot-Girard, Cédric Meersseman, Manuela Pastore, Valentin Garcia, Nathalie Linck, Catherine Rey, Amine Chebbi, Freddy Jeanneteau, Stephen D. Ginsberg, Joël Lachuer, Christelle Reynes, François Rassendren, Hélène Hirbec
Ultrastructural characterization of dark microglia during aging in a mouse model of Alzheimer’s disease pathology and in human post-mortem brain samples
Marie-Kim St-Pierre, Micaël Carrier, Fernando González Ibáñez, Eva Šimončičová, Marie-Josée Wallman, Luc Vallières, Martin Parent, Marie-Ève Tremblay
Injection of amyloid-β to lateral ventricle induces gut microbiota dysbiosis in association with inhibition of cholinergic anti-inflammatory pathways in Alzheimer’s disease
Xiao-hang Qian, Xiao-li Liu, Guang Chen, Sheng-di Chen, Hui-dong Tang
Erbin protects against sepsis-associated encephalopathy by attenuating microglia pyroptosis via IRE1α/Xbp1s-Ca2+ axis
Guoqing Jing, Jing Zuo, Qing Fang, Min Yuan, Yun Xia, Qiyan Jin, Yuping Liu, Yanlin Wang, Zongze Zhang, Wanhong Liu, Xiaojing Wu, Xuemin Song
Traumatic brain injury alters dendritic cell differentiation and distribution in lymphoid and non-lymphoid organs
Orest Tsymbalyuk, Volodymyr Gerzanich, J. Marc Simard, Chozha Vendan Rathinam
Impaired response of blood neutrophils to cell-death stimulus differentiates AQP4-IgG-seropositive NMOSD from MOGAD
Maria Schroeder-Castagno, Alba Del Rio-Serrato, Andreas Wilhelm, Silvina Romero-Suárez, Patrick Schindler, Cesar Alvarez-González, Ankelien-Solveig Duchow, Judith Bellmann-Strobl, Klemens Ruprecht, Maria Hastermann, Gerald Grütz, Brigitte Wildemann, Sven Jarius, Tanja Schmitz-Hübsch, Friedemann Paul, Carmen Infante-Duarte
β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression
Yang Liu, Nanshan Song, Hang Yao, Siyuan Jiang, Yueping Wang, Ying Zheng, Yuanzhang Zhou, Jianhua Ding, Gang Hu, Ming Lu
SLAMF7 modulates B cells and adaptive immunity to regulate susceptibility to CNS autoimmunity
Patrick O’Connell, Maja K. Blake, Sarah Godbehere, Andrea Amalfitano, Yasser A. Aldhamen
Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis
Xinli Hu, Haojie Zhang, Qianxin Zhang, Xue Yao, Wenfei Ni, Kailiang Zhou
Treadmill exercise promotes E3 ubiquitin ligase to remove amyloid β and P-tau and improve cognitive ability in APP/PS1 transgenic mice
Longfei Xu, Mingzhe Li, Aili Wei, Miaomiao Yang, Chao Li, Ran Liu, Yuejun Zheng, Yuxin Chen, Zixi Wang, Kun Wang, Tianhui Wang
Inhibition of Schwann cell pannexin 1 attenuates neuropathic pain through the suppression of inflammatory responses
Qian Wang, Han-yang Li, Zhuo-min Ling, Gang Chen, Zhong-Ya Wei
Different gender-derived gut microbiota influence stroke outcomes by mitigating inflammation
Jinchen Wang, Yi Zhong, Hua Zhu, Omer Kamal Mahgoub, Zhihong Jian, Lijuan Gu, Xiaoxing Xiong
Microglial–oligodendrocyte interactions in myelination and neurological function recovery after traumatic brain injury
Shanshan Song, Md Nabiul Hasan, Lauren Yu, Satya S. Paruchuri, John P. Bielanin, Shamseldin Metwally, Helena C. M. Oft, Sydney G. Fischer, Victoria M. Fiesler, Tanusree Sen, Rajaneesh K. Gupta, Lesley M. Foley, T. Kevin Hitchens, C. Edward Dixon, Franca Cambi, Nilkantha Sen, Dandan Sun
Alzheimer’s disease-related transcriptional sex differences in myeloid cells
Isabelle Coales, Stergios Tsartsalis, Nurun Fancy, Maria Weinert, Daniel Clode, David Owen, Paul M. Matthews
Mitochondrial dysfunction in microglia: a novel perspective for pathogenesis of Alzheimer’s disease
Yun Li, Xiaohuan Xia, Yi Wang, Jialin C. Zheng
T-cells in human trigeminal ganglia express canonical tissue-resident memory T-cell markers
Peter-Paul A. Unger, Anna E. Oja, Tamana Khemai-Mehraban, Werner J. D. Ouwendijk, Pleun Hombrink, Georges M. G. M. Verjans
Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection
Chase E. Hawes, Sonny R. Elizaldi, Danielle Beckman, Giovanne B. Diniz, Yashavanth Shaan Lakshmanappa, Sean Ott, Blythe P. Durbin-Johnson, Ashok R. Dinasarapu, Andrea Gompers, John H. Morrison, Smita S. Iyer
The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases
Alexa DeMaio, Shikhar Mehrotra, Kumar Sambamurti, Shahid Husain
Metabolomics detects clinically silent neuroinflammatory lesions earlier than neurofilament-light chain in a focal multiple sclerosis animal model
Tianrong Yeo, Halwan Bayuangga, Marcus Augusto-Oliveira, Megan Sealey, Timothy D. W. Claridge, Rachel Tanner, David Leppert, Jacqueline Palace, Jens Kuhle, Fay Probert, Daniel C. Anthony
Promoted CD4+ T cell-derived IFN-γ/IL-10 by photobiomodulation therapy modulates neurogenesis to ameliorate cognitive deficits in APP/PS1 and 3xTg-AD mice
Xiaolei Wu, Qi Shen, Haocai Chang, Junyu Li, Da Xing
SAFit2 reduces neuroinflammation and ameliorates nerve injury-induced neuropathic pain
Saskia Wedel, Praveen Mathoor, Oliver Rauh, Tim Heymann, Cosmin I. Ciotu, Dominik C. Fuhrmann, Michael J. M. Fischer, Andreas Weigert, Natasja de Bruin, Felix Hausch, Gerd Geisslinger, Marco Sisignano
Early effects of LPS-induced neuroinflammation on the rat hippocampal glycolytic pathway
Adriana Fernanda K. Vizuete, Fernanda Fróes, Marina Seady, Caroline Zanotto, Larissa Daniele Bobermin, Ana Cristina Roginski, Moacir Wajner, André Quincozes-Santos, Carlos Alberto Gonçalves
Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions
Maximilian Wilmes, Carolina Pinto Espinoza, Peter Ludewig, Joschi Stabernack, Arthur Liesz, Annette Nicke, Mathias Gelderblom, Christian Gerloff, Simonetta Falzoni, Eva Tolosa, Francesco Di Virgilio, Björn Rissiek, Nikolaus Plesnilla, Friedrich Koch-Nolte, Tim Magnus
TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway
Rong Li, Jing Zhang, Qiong Wang, Meng Cheng, Bin Lin
ISGylation is induced in neurons by demyelination driving ISG15-dependent microglial activation
Benjamin D. S. Clarkson, Ethan Grund, Kenneth David, Renee K. Johnson, Charles L. Howe
Simplified regimen of combined low-dose rituximab for autoimmune encephalitis with neuronal surface antibodies
Ying Du, Chao Zhao, Juntong Liu, Chuan Li, Qi Yan, Lin Li, Yunfeng Hao, Dan Yao, Huaxing Si, Yingjun Zhao, Wei Zhang
FoxP3 expression by retinal pigment epithelial cells: transcription factor with potential relevance for the pathology of age-related macular degeneration
Ahmad Samir Alfaar, Lucas Stürzbecher, Maria Diedrichs-Möhring, Marion Lam, Christophe Roubeix, Julia Ritter, Kathrin Schumann, Balasubramaniam Annamalai, Inga-Marie Pompös, Bärbel Rohrer, Florian Sennlaub, Nadine Reichhart, Gerhild Wildner, Olaf Strauß
Single-cell RNA sequencing reveals a landscape and targeted treatment of ferroptosis in retinal ischemia/reperfusion injury
Yangyang Li, Yuwen Wen, Xiuxing Liu, Zhuang Li, Bingying Lin, Caibin Deng, Ziyu Yu, Yingting Zhu, Ling Zhao, Wenru Su, Yehong Zhuo
GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis through inhibition of RIP1/RIP3/MLKL pathway in glutamate-induced retinal excitotoxic model of glaucoma
Mengyuan Liu, Haibo Li, Rongliang Yang, Dan Ji, Xiaobo Xia
A novel aquaporin-4-associated optic neuritis rat model with severe pathological and functional manifestations
Yuko Morita, Takahide Itokazu, Toru Nakanishi, Shin-ichiro Hiraga, Toshihide Yamashita
Coexistence of chronic hyperalgesia and multilevel neuroinflammatory responses after experimental SCI: a systematic approach to profiling neuropathic pain
Lei Wang, Mehmet A. Gunduz, Ana T. Semeano, Enis C. Yılmaz, Feras A. H. Alanazi, Ozan B. Imir, Ulas Yener, Christian A. Arbelaez, Esteban Usuga, Yang D. Teng
Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity
Abi G. Yates, Elena Kislitsyna, Carla Alfonso Martin, Jiaying Zhang, Amy L. Sewell, Ane Goikolea-Vives, Valerie Cai, Lama F. Alkhader, Aleksander Skaland, Basil Hammond, Ralica Dimitrova, Dafnis Batalle, Cathy Fernandes, A. David Edwards, Pierre Gressens, Claire Thornton, Helen B. Stolp
Single cell profiling of CD45+ spinal cord cells reveals microglial and B cell heterogeneity and crosstalk following spinal cord injury
Elizabeth S. Fisher, Matthew A. Amarante, Natasha Lowry, Steven Lotz, Farhad Farjood, Sally Temple, Caitlin E. Hill, Thomas R. Kiehl
Trem2 deficiency impairs recovery and phagocytosis and dysregulates myeloid gene expression during virus-induced demyelination
Mihyun Hwang, Carine Savarin, Jihye Kim, Jennifer Powers, Natasha Towne, Hyunsuk Oh, Cornelia C. Bergmann
Mitochondrial protective effects caused by the administration of mefenamic acid in sepsis
Diogo Dominguini, Monique Michels, Leticia B. Wessler, Emilio L. Streck, Tatiana Barichello, Felipe Dal-Pizzol
Fetuin-A alleviates neuroinflammation against traumatic brain injury-induced microglial necroptosis by regulating Nrf-2/HO-1 pathway
Pengzhan Zhao, Yutian Wei, Guangchi Sun, Lei Xu, Tian Wang, Yufei Tian, Honglu Chao, Yiming Tu, Jing Ji
Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis
Christina B. Schroeter, Leoni Rolfes, K. S. Sophie Gothan, Joel Gruchot, Alexander M. Herrmann, Stefanie Bock, Luca Fazio, Antonia Henes, Venu Narayanan, Steffen Pfeuffer, Christopher Nelke, Saskia Räuber, Niklas Huntemann, Eduardo Duarte-Silva, Vera Dobelmann, Petra Hundehege, Heinz Wiendl, Katharina Raba, Patrick Küry, David Kremer, Tobias Ruck, Thomas Müntefering, Thomas Budde, Manuela Cerina, Sven G. Meuth
Motor neuron survival is associated with reduced neuroinflammation and increased autophagy after brachial plexus avulsion injury in aldose reductase-deficient mice
Ke Zhong, Yu Huang, Prince last Mudenda Zilundu, Yaqiong Wang, Yingying Zhou, Guangyin Yu, Rao Fu, Sookja Kim Chung, Yamei Tang, Xiao Cheng, Lihua Zhou
Neuroinflammation regulates the balance between hippocampal neuron death and neurogenesis in an ex vivo model of thiamine deficiency
Larissa M. G. Cassiano, Marina S. Oliveira, Jeanne Pioline, Anna C. M. Salim, Roney S. Coimbra
Microglia dynamics in aging-related neurobehavioral and neuroinflammatory diseases
Nima Javanmehr, Kiarash Saleki, Parsa Alijanizadeh, Nima Rezaei
The neuropeptide PACAP alleviates T. gondii infection-induced neuroinflammation and neuronal impairment
Caio Andreeta Figueiredo, Henning Peter Düsedau, Johannes Steffen, Stefanie Ehrentraut, Miklos P. Dunay, Gabor Toth, Dora Reglödi, Markus M. Heimesaat, Ildiko Rita Dunay
The role of the ZEB1–neuroinflammation axis in CNS disorders
Elham Poonaki, Ulf Dietrich Kahlert, Sven G. Meuth, Ali Gorji
Current perspectives on diffuse midline glioma and a different role for the immune microenvironment compared to glioblastoma
Casper J. Pachocki, Elly M. Hol
Peripheral myeloid-derived suppressor cells are good biomarkers of the efficacy of fingolimod in multiple sclerosis
Celia Camacho-Toledano, Isabel Machín-Díaz, Leticia Calahorra, María Cabañas-Cotillas, David Otaegui, Tamara Castillo-Triviño, Luisa María Villar, Lucienne Costa-Frossard, Manuel Comabella, Luciana Midaglia, José Manuel García-Domínguez, Jennifer García-Arocha, María Cristina Ortega, Diego Clemente
Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury
Albrecht Fröhlich, Florian Olde Heuvel, Rida Rehman, Sruthi Sankari Krishnamurthy, Shun Li, Zhenghui Li, David Bayer, Alison Conquest, Anna M. Hagenston, Albert Ludolph, Markus Huber-Lang, Tobias Boeckers, Bernd Knöll, Maria Cristina Morganti-Kossmann, Hilmar Bading, Francesco Roselli
Neuroimmune proteins can differentiate between tauopathies
Jonathan D. Cherry, Zach H. Baucom, Kaleb G. Eppich, Daniel Kirsch, Erin R. Dixon, Yorghos Tripodis, Kevin F. Bieniek, Kurt Farrell, Kristen Whitney, Madeline Uretsky, John F. Crary, Dennis Dickson, Ann C. McKee
Constitutively active microglial populations limit anorexia induced by the food contaminant deoxynivalenol
Stéphanie Gaige, Rym Barbouche, Manon Barbot, Sarah Boularand, Michel Dallaporta, Anne Abysique, Jean-Denis Troadec
Genetic deletion of Krüppel-like factor 11 aggravates traumatic brain injury
Chao Zhou, Ping Sun, Milton H. Hamblin, Ke-Jie Yin
Recombinant human plasma gelsolin reverses increased permeability of the blood–brain barrier induced by the spike protein of the SARS-CoV-2 virus
Łukasz Suprewicz, Kiet A. Tran, Ewelina Piktel, Krzysztof Fiedoruk, Paul A. Janmey, Peter A. Galie, Robert Bucki
Hippocampal microRNA-26a-3p deficit contributes to neuroinflammation and behavioral disorders via p38 MAPK signaling pathway in rats
Changmin Wang, Ye Li, Yuhang Yi, Guiyu Liu, Ruojing Guo, Liyan Wang, Tian Lan, Wenjing Wang, Xiao Chen, Shihong Chen, Shu Yan Yu
Scorpion venom peptide HsTx2 suppressed PTZ-induced seizures in mice via the circ_0001293/miR-8114/TGF-β2 axis
Yan Hu, Buliang Meng, Saige Yin, Meifeng Yang, Yilin Li, Naixin Liu, Shanshan Li, Yixiang Liu, Dandan Sun, Siyu Wang, Yinglei Wang, Zhe Fu, Yutong Wu, Ailan Pang, Jun Sun, Ying Wang, Xinwang Yang
An AGS-associated mutation in ADAR1 catalytic domain results in early-onset and MDA5-dependent encephalopathy with IFN pathway activation in the brain
Xinfeng Guo, Richard A. Steinman, Yi Sheng, Guodong Cao, Clayton A. Wiley, Qingde Wang
APOE genotype and biological sex regulate astroglial interactions with amyloid plaques in Alzheimer’s disease mice
T. L. Stephen, B. Breningstall, S. Suresh, C. J. McGill, C. J. Pike
Evidence of innate immune dysfunction in first-episode psychosis patients with accompanying mood disorder
Heather K. Hughes, Houa Yang, Tyler A. Lesh, Cameron S. Carter, Paul Ashwood
The dynorphin/kappa opioid receptor mediates adverse immunological and behavioral outcomes induced by repetitive blast trauma
Suhjung Janet Lee, Aric F. Logsdon, Mayumi Yagi, Britahny M. Baskin, Elaine. R. Peskind, Murray M. Raskind, David G. Cook, Abigail. G. Schindler
TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice
Jin Yan, Yuan Zhang, Lin Wang, Zhao Li, Shuang Tang, Yingwen Wang, Nina Gu, Xiaochuan Sun, Lin Li
MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and secondary brain edema in a mouse model of intracerebral hemorrhage
Kevin Akeret, Raphael M. Buzzi, Bart R. Thomson, Nina Schwendinger, Jan Klohs, Nadja Schulthess-Lutz, Livio Baselgia, Kerstin Hansen, Luca Regli, Florence Vallelian, Michael Hugelshofer, Dominik J. Schaer
Temporal proteomics of human cerebrospinal fluid after severe traumatic brain injury
Sandy R. Shultz, Anup D. Shah, Cheng Huang, Larissa K. Dill, Ralf B. Schittenhelm, M. Cristina Morganti-Kossmann, Bridgette D. Semple
Microglial diversity along the hippocampal longitudinal axis impacts synaptic plasticity in adult male mice under homeostatic conditions
E. De Felice, E. Gonçalves de Andrade, M. T. Golia, F. González Ibáñez, M. Khakpour, M. A. Di Castro, S. Garofalo, E. Di Pietro, C. Benatti, N. Brunello, F. Tascedda, B. Kaminska, C. Limatola, D. Ragozzino, M. E. Tremblay, S. Alboni, L. Maggi
Systemic cytokines and GlycA discriminate disease status and predict corticosteroid response in HTLV-1-associated neuroinflammation
Tatiane Assone, Soraya Maria Menezes, Fernanda de Toledo Gonçalves, Victor Angelo Folgosi, Gabriela da Silva Prates, Tim Dierckx, Marcos Braz, Jerusa Smid, Michel E. Haziot, Rosa M. N. Marcusso, Flávia E. Dahy, Evelien Vanderlinden, Sandra Claes, Dominique Schols, Roberta Bruhn, Edward L. Murphy, Augusto César Penalva de Oliveira, Dirk Daelemans, Jurgen Vercauteren, Jorge Casseb, Johan Van Weyenbergh
Effects of nasal inflammation on the olfactory bulb
Brandon J. LaFever, Fumiaki Imamura
Parabiosis reveals the correlation between the recruitment of circulating antigen presenting cells to the retina and the induction of spontaneous autoimmune uveoretinitis
Scott W. McPherson, Neal D. Heuss, Md. Abedin, Heidi Roehrich, Mark J. Pierson, Dale S. Gregerson
Upregulated complement receptors correlate with Fc gamma receptor 3A-positive natural killer and natural killer-T cells in neuromyelitis optica spectrum disorder
Shuhei Nishiyama, Amy E. Wright, Itay Lotan, Takahisa Mikami, Friedemann Paul, Masashi Aoki, Michael Levy
Targeting neuroinflammation as a preventive and therapeutic approach for perioperative neurocognitive disorders
Chun Cheng, Hanxi Wan, Peilin Cong, Xinwei Huang, Tingmei Wu, Mengfan He, Qian Zhang, Lize Xiong, Li Tian
Impact of disease-modifying therapy on dendritic cells and exploring their immunotherapeutic potential in multiple sclerosis
Caiyun Liu, Jie Zhu, Yan Mi, Tao Jin
Structural and functional distinctions of co-resident microglia and monocyte-derived macrophages after retinal degeneration
Kaitryn E. Ronning, Sarah J. Karlen, Marie E. Burns
Models of microglia depletion and replenishment elicit protective effects to alleviate vascular and neuronal damage in the diabetic murine retina
Kaira A. Church, Derek Rodriguez, Difernando Vanegas, Irene L. Gutierrez, Sandra M. Cardona, José L. M. Madrigal, Tejbeer Kaur, Astrid E. Cardona
Sirtuin 5 aggravates microglia-induced neuroinflammation following ischaemic stroke by modulating the desuccinylation of Annexin-A1
Qian Xia, Shuai Gao, Tangrui Han, Meng Mao, Gaofeng Zhan, Yonghong Wang, Xing Li
The upregulation of NLRP3 inflammasome in dorsal root ganglion by ten-eleven translocation methylcytosine dioxygenase 2 (TET2) contributed to diabetic neuropathic pain in mice
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Correction: Simplified regimen of combined low-dose rituximab for autoimmune encephalitis with neuronal surface antibodies
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Qi Tian, Yujia Guo, Shi Feng, Chengli Liu, Peibang He, Jianfeng Wang, Wenrui Han, Chen Yang, Zhan Zhang, Mingchang Li
Fecal microbiota transplantation and replenishment of short-chain fatty acids protect against chronic cerebral hypoperfusion-induced colonic dysfunction by regulating gut microbiota, differentiation of Th17 cells, and mitochondrial energy metabolism
Shao-Hua Su, Yi-Fang Wu, Qi Lin, Lin Zhang, Da-Peng Wang, Jian Hai
Lactate attenuates astrocytic inflammation by inhibiting ubiquitination and degradation of NDRG2 under oxygen–glucose deprivation conditions
Jinying Xu, Tong Ji, Guichen Li, Haiying Zhang, Yangyang Zheng, Meiying Li, Jie Ma, Yulin Li, Guangfan Chi
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Chen Chen, YuWei Zhou, XinPeng Ning, ShengLong Li, DongDong Xue, CaiLv Wei, Zhu Zhu, LongXiang Sheng, BingZheng Lu, Yuan Li, XiaoYuan Ye, YunZhao Fu, Chuan Bai, Wei Cai, YuXuan Ding, SuiZhen Lin, GuangMei Yan, YiJun Huang, Wei Yin
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Zhi-Bo Wang, Ya-Hui Ma, Yan Sun, Lan Tan, Hui-Fu Wang, Jin-Tai Yu
Correction: Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression
Weifen Li, Tahir Ali, Chengyou Zheng, Zizhen Liu, Kaiwu He, Fawad Ali Shah, Qingguo Ren, Shafiq Ur Rahman, Ningning Li, Zhi-Jian Yu, Shupeng Li
Progranulin from different gliocytes in the nucleus accumbens exerts distinct roles in FTD- and neuroinflammation-induced depression-like behaviors
Jing Wang, Simin Lai, Ting Zhou, Zhihao Xia, Weina Li, Wenqi Sha, Jingjie Liu, Yanjiong Chen
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