Ausgabe 1/2018
Inhalt (349 Artikel)
Inhibition of cyclin-dependent kinase 5 affects early neuroinflammatory signalling in murine model of amyloid beta toxicity
Anna Wilkaniec, Magdalena Gąssowska-Dobrowolska, Marcin Strawski, Agata Adamczyk, Grzegorz A. Czapski
Activation of dopamine D1 receptor decreased NLRP3-mediated inflammation in intracerebral hemorrhage mice
Tian Wang, Derek Nowrangi, Lingyan Yu, Tai Lu, Jiping Tang, Bing Han, Yuxin Ding, Fenghua Fu, John H. Zhang
Role of the indoleamine-2,3-dioxygenase/kynurenine pathway of tryptophan metabolism in behavioral alterations in a hepatic encephalopathy rat model
Xi Jiang, Lexing Xu, Lin Tang, Fuhe Liu, Ziwei Chen, Jiajia Zhang, Lei Chen, Cong Pang, Xuefeng Yu
Hypercapnia induces IL-1β overproduction via activation of NLRP3 inflammasome: implication in cognitive impairment in hypoxemic adult rats
Hong-Guang Ding, Yi-Yu Deng, Ren-qiang Yang, Qiao-Sheng Wang, Wen-Qiang Jiang, Yong-Li Han, Lin-Qiang Huang, Miao-Yun Wen, Wen-Hong Zhong, Xu-Sheng Li, Fan Yang, Hong-Ke Zeng
Laquinimod ameliorates excitotoxic damage by regulating glutamate re-uptake
Antonietta Gentile, Alessandra Musella, Francesca De Vito, Diego Fresegna, Silvia Bullitta, Francesca Romana Rizzo, Diego Centonze, Georgia Mandolesi
Curcumin attenuates collagen-induced inflammatory response through the “gut-brain axis”
Yannong Dou, Jinque Luo, Xin Wu, Zhifeng Wei, Bei Tong, Juntao Yu, Ting Wang, Xinyu Zhang, Yan Yang, Xusheng Yuan, Peng Zhao, Yufeng Xia, Huijuan Hu, Yue Dai
Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex
Marianna Stamou, Ana Cristina Grodzki, Marc van Oostrum, Bernd Wollscheid, Pamela J. Lein
In vivo evidence for the contribution of peripheral circulating inflammatory exosomes to neuroinflammation
Jing Jing Li, Bin Wang, Mahesh Chandra Kodali, Chao Chen, Eunhee Kim, Benjamin John Patters, Lubin Lan, Santosh Kumar, Xinjun Wang, Junming Yue, Francesca-Fang Liao
WWL70 protects against chronic constriction injury-induced neuropathic pain in mice by cannabinoid receptor-independent mechanisms
Jie Wen, Melissa Jones, Mikiei Tanaka, Prabhuanand Selvaraj, Aviva J. Symes, Brian Cox, Yumin Zhang
Dietary fats promote functional and structural changes in the median eminence blood/spinal fluid interface—the protective role for BDNF
Albina F. Ramalho, Bruna Bombassaro, Nathalia R. Dragano, Carina Solon, Joseane Morari, Milena Fioravante, Roberta Barbizan, Licio A. Velloso, Eliana P. Araujo
Decreased microglial activation through gut-brain axis by prebiotics, probiotics, or synbiotics effectively restored cognitive function in obese-insulin resistant rats
Titikorn Chunchai, Wannipa Thunapong, Sakawdaurn Yasom, Keerati Wanchai, Sathima Eaimworawuthikul, Gabrielle Metzler, Anusorn Lungkaphin, Anchalee Pongchaidecha, Sasithorn Sirilun, Chaiyavat Chaiyasut, Wasana Pratchayasakul, Parameth Thiennimitr, Nipon Chattipakorn, Siriporn C. Chattipakorn
IL-33/ST2 signaling contributes to radicular pain by modulating MAPK and NF-κB activation and inflammatory mediator expression in the spinal cord in rat models of noncompressive lumber disk herniation
Si-Jian Huang, Jian-Qin Yan, Hui Luo, Lu-Yao Zhou, Jian-Gang Luo
MicroRNA-124 regulates the expression of MEKK3 in the inflammatory pathogenesis of Parkinson’s disease
Longping Yao, Yongyi Ye, Hengxu Mao, Fengfei Lu, Xiaozheng He, Guohui Lu, Shizhong Zhang
Correction to: Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome
Elizabeth Nance, Siva P. Kambhampati, Elizabeth S. Smith, Zhi Zhang, Fan Zhang, Sarabdeep Singh, Michael V. Johnston, Rangaramanujam M. Kannan, Mary E. Blue, Sujatha Kannan
Evidence for the activation of pyroptotic and apoptotic pathways in RPE cells associated with NLRP3 inflammasome in the rodent eye
Jiangyuan Gao, Jing Z. Cui, Eleanor To, Sijia Cao, Joanne A. Matsubara
A novel IL-1RA-PEP fusion protein alleviates blood-brain barrier disruption after ischemia-reperfusion in male rats
Dong-Dong Zhang, Chen Jin, Ya-Tao Zhang, Xiang-Dong Gan, Min-Ji Zou, Yuan-Yuan Wang, Wen-Liang Fu, Tao Xu, Wei-Wei Xing, Wen-Ron Xia, Dong-Gang Xu
Oxidative stress predicts cognitive decline with aging in healthy adults: an observational study
Ihab Hajjar, Salim S. Hayek, Felicia C. Goldstein, Greg Martin, Dean P. Jones, Arshed Quyyumi
Transcriptional profile and Epstein-Barr virus infection status of laser-cut immune infiltrates from the brain of patients with progressive multiple sclerosis
Caterina Veroni, Barbara Serafini, Barbara Rosicarelli, Corrado Fagnani, Francesca Aloisi
Benefits of VCE-003.2, a cannabigerol quinone derivative, against inflammation-driven neuronal deterioration in experimental Parkinson’s disease: possible involvement of different binding sites at the PPARγ receptor
Concepción García, María Gómez-Cañas, Sonia Burgaz, Belén Palomares, Yolanda Gómez-Gálvez, Cristina Palomo-Garo, Sara Campo, Joel Ferrer-Hernández, Carolina Pavicic, Carmen Navarrete, M. Luz Bellido, Moisés García-Arencibia, M. Ruth Pazos, Eduardo Muñoz, Javier Fernández-Ruiz
Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation
Maike Kuhn, Kurt-Wolfram Sühs, Manas K. Akmatov, Frank Klawonn, Junxi Wang, Thomas Skripuletz, Volkhard Kaever, Martin Stangel, Frank Pessler
Microglial activation mediates chronic mild stress-induced depressive- and anxiety-like behavior in adult rats
Ya-Lin Wang, Qiu-Qin Han, Wen-Qing Gong, Dong-Hui Pan, Li-Zheng Wang, Wei Hu, Min Yang, Bing Li, Jin Yu, Qiong Liu
Baló’s concentric sclerosis is immunologically distinct from multiple sclerosis: results from retrospective analysis of almost 150 lumbar punctures
S. Jarius, C. Würthwein, J. R. Behrens, J. Wanner, J. Haas, F. Paul, B. Wildemann
Unconjugated bilirubin induces pyroptosis in cultured rat cortical astrocytes
Jie Feng, Mengwen Li, Qian Wei, Shengjun Li, Sijie Song, Ziyu Hua
The role of the complement system in traumatic brain injury: a review
Adnan Hammad, Laura Westacott, Malik Zaben
Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation
Slava Rom, Viviana Zuluaga-Ramirez, Nancy L. Reichenbach, Michelle A. Erickson, Malika Winfield, Sachin Gajghate, Melpo Christofidou-Solomidou, Kelly L. Jordan-Sciutto, Yuri Persidsky
Laquinimod attenuates inflammation by modulating macrophage functions in traumatic brain injury mouse model
Atsuko Katsumoto, Aline S. Miranda, Oleg Butovsky, Antônio L. Teixeira, Richard M. Ransohoff, Bruce T. Lamb
Upregulation of HMGB1-TLR4 inflammatory pathway in focal cortical dysplasia type II
Zhongbin Zhang, Qingzhu Liu, Ming Liu, Hui Wang, Ying Dong, Taoyun Ji, Xiaoyan Liu, Yuwu Jiang, Lixin Cai, Ye Wu
Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation
Joana Costa d’Avila, Luciana Domett Siqueira, Aurélien Mazeraud, Estefania Pereira Azevedo, Debora Foguel, Hugo Caire Castro-Faria-Neto, Tarek Sharshar, Fabrice Chrétien, Fernando Augusto Bozza
miRNA-23a/CXCR4 regulates neuropathic pain via directly targeting TXNIP/NLRP3 inflammasome axis
Zhiqiang Pan, Qun Shan, Pan Gu, Xiao Min Wang, Lydia Wai Tai, Menglan Sun, Xin Luo, Liting Sun, Chi Wai Cheung
The role of HFE genotype in macrophage phenotype
Anne M. Nixon, Elizabeth Neely, Ian A. Simpson, James R. Connor
Chi3l3: a potential key orchestrator of eosinophil recruitment in meningitis induced by Angiostrongylus cantonensis
Wan Shuo, Sun Xiaoqiang, Wu Feng, Yu Zilong, Wang Lifu, Lin Datao, Li Zhengyu, Wu Zhongdao, Sun Xi
IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic–ischemic brain injury in rats
Di Chen, Brandon J. Dixon, Desislava M. Doycheva, Bo Li, Yang Zhang, Qin Hu, Yue He, Zongduo Guo, Derek Nowrangi, Jerry Flores, Valery Filippov, John H. Zhang, Jiping Tang
18F-VC701-PET and MRI in the in vivo neuroinflammation assessment of a mouse model of multiple sclerosis
Sara Belloli, Lucia Zanotti, Valentina Murtaj, Cristina Mazzon, Giuseppe Di Grigoli, Cristina Monterisi, Valeria Masiello, Leonardo Iaccarino, Andrea Cappelli, Pietro Luigi Poliani, Letterio Salvatore Politi, Rosa Maria Moresco
Correction to: AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity
Soraya Wilke Saliba, Ariel R. Marcotegui, Ellen Fortwängler, Johannes Ditrich, Juan Carlos Perazzo, Eduardo Muñoz, Antônio Carlos Pinheiro de Oliveira, Bernd L. Fiebich
Calcineurin A beta deficiency ameliorates HFD-induced hypothalamic astrocytosis in mice
Katrin Pfuhlmann, Sonja C. Schriever, Beata Legutko, Peter Baumann, Luke Harrison, Dhiraj G. Kabra, Emily Violette Baumgart, Matthias H. Tschöp, Cristina Garcia-Caceres, Paul T. Pfluger
Hyperammonemia alters membrane expression of GluA1 and GluA2 subunits of AMPA receptors in hippocampus by enhancing activation of the IL-1 receptor: underlying mechanisms
Lucas Taoro-Gonzalez, Yaiza M. Arenas, Andrea Cabrera-Pastor, Vicente Felipo
Porphyromonas gingivalis lipopolysaccharide induces cognitive dysfunction, mediated by neuronal inflammation via activation of the TLR4 signaling pathway in C57BL/6 mice
Jing Zhang, Chunbo Yu, Xuan Zhang, Huiwen Chen, Jiachen Dong, Weili Lu, Zhongchen Song, Wei Zhou
Systemic autoinflammation with intractable epilepsy managed with interleukin-1 blockade
Allen D. DeSena, Thuy Do, Grant S. Schulert
Salidroside provides neuroprotection by modulating microglial polarization after cerebral ischemia
Xiangrong Liu, Shaohong Wen, Feng Yan, Kuan Liu, Liqiang Liu, Lei Wang, Shangfeng Zhao, Xunming Ji
A clinical approach to new-onset psychosis associated with immune dysregulation: the concept of autoimmune psychosis
Souhel Najjar, Johann Steiner, Amanda Najjar, Karl Bechter
Histamine upregulates the expression of histamine receptors and increases the neuroprotective effect of astrocytes
Jiawen Xu, Xiang Zhang, Qingqing Qian, Yiwei Wang, Hongquan Dong, Nana Li, Yanning Qian, Wenjie Jin
Trovafloxacin attenuates neuroinflammation and improves outcome after traumatic brain injury in mice
Charu Garg, Joon Ho Seo, Jayalakshmi Ramachandran, Ji Meng Loh, Frances Calderon, Jorge E. Contreras
Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer’s disease
Brad T. Casali, Erin G. Reed-Geaghan, Gary E. Landreth
The role of glucocorticoid, interleukin-1β, and antioxidants in prenatal stress effects on embryonic microglia
Jada Bittle, Hanna E. Stevens
Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brain
Marina S. Hernandes, Bernard Lassègue, Lula L. Hilenski, Jonathan Adams, Ning Gao, Chia-Yi Kuan, Yu-Yo Sun, Lihong Cheng, Daniel S. Kikuchi, Manuel Yepes, Kathy K. Griendling
Cerebrospinal fluid level of Nogo receptor 1 antagonist lateral olfactory tract usher substance (LOTUS) correlates inversely with the extent of neuroinflammation
Keita Takahashi, Hideyuki Takeuchi, Yuji Kurihara, Hiroshi Doi, Misako Kunii, Kenichi Tanaka, Haruko Nakamura, Ryoko Fukai, Atsuko Tomita-Katsumoto, Mikiko Tada, Yuichi Higashiyama, Hideto Joki, Shigeru Koyano, Kohtaro Takei, Fumiaki Tanaka
Effects of umbilical cord blood cells, and subtypes, to reduce neuroinflammation following perinatal hypoxic-ischemic brain injury
Courtney A. McDonald, Tayla R. Penny, Madison C. B. Paton, Amy E. Sutherland, Lakshmi Nekkanti, Tamara Yawno, Margie Castillo-Melendez, Michael C. Fahey, Nicole M. Jones, Graham Jenkin, Suzanne L. Miller
Ablation of caspase-1 protects against TBI-induced pyroptosis in vitro and in vivo
Wei Liu, Yuhua Chen, Jiao Meng, Minfei Wu, Fangfang Bi, Cuicui Chang, Hua Li, Liangjun Zhang
Lymphotoxin β receptor-mediated NFκB signaling promotes glial lineage differentiation and inhibits neuronal lineage differentiation in mouse brain neural stem/progenitor cells
Xiao Xiao, Raj Putatunda, Yonggang Zhang, Priya V. Soni, Fang Li, Ting Zhang, Mingyang Xin, Jin Jun Luo, John R. Bethea, Yuan Cheng, Wenhui Hu
Strain-dependent effects of clinical echovirus 30 outbreak isolates at the blood-CSF barrier
Tobias Dahm, Ortwin Adams, Sindy Boettcher, Sabine Diedrich, Vasily Morozov, Grant Hansman, Petra Fallier-Becker, Sebastian Schädler, Claus J. Burkhardt, Christel Weiss, Carolin Stump-Guthier, Hiroshi Ishikawa, Horst Schroten, Christian Schwerk, Tobias Tenenbaum, Henriette Rudolph
Enhanced glycolysis contributes to the pathogenesis of experimental autoimmune neuritis
Ru-Tao Liu, Min Zhang, Chun-Lin Yang, Peng Zhang, Na Zhang, Tong Du, Meng-Ru Ge, Long-Tao Yue, Xiao-Li Li, Heng Li, Rui-Sheng Duan
Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor
Duy-Khanh Dang, Eun-Joo Shin, Dae-Joong Kim, Hai-Quyen Tran, Ji Hoon Jeong, Choon-Gon Jang, Seung-Yeol Nah, Jung Hwan Jeong, Jae Kyung Byun, Sung Kwon Ko, Guoying Bing, Jau-Shyong Hong, Hyoung-Chun Kim
Neuregulin-1 elicits a regulatory immune response following traumatic spinal cord injury
Arsalan Alizadeh, Kallivalappil T. Santhosh, Hardeep Kataria, Abdelilah S. Gounni, Soheila Karimi-Abdolrezaee
Intraocular DHODH-inhibitor PP-001 suppresses relapsing experimental uveitis and cytokine production of human lymphocytes, but not of RPE cells
Maria Diedrichs-Möhring, Sandy Niesik, Claudia S. Priglinger, Stephan R. Thurau, Franz Obermayr, Stefan Sperl, Gerhild Wildner
[18F]FSPG-PET reveals increased cystine/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis
Aileen Hoehne, Michelle L. James, Israt S. Alam, John A. Ronald, Bernadette Schneider, Aloma D’Souza, Timothy H. Witney, Lauren E. Andrews, Haley C. Cropper, Deepak Behera, Gayatri Gowrishankar, Zhaoqing Ding, Tony Wyss-Coray, Frederick T. Chin, Sandip Biswal, Sanjiv S. Gambhir
The impact of metallothionein-II on microglial response to tumor necrosis factor-alpha (TNFα) and downstream effects on neuronal regeneration
Jacqueline Y. K. Leung, William R. Bennett, Anna E. King, Roger S. Chung
Toxoplasma gondii alters NMDAR signaling and induces signs of Alzheimer’s disease in wild-type, C57BL/6 mice
Luisa Torres, Sudie-Ann Robinson, Do-Geun Kim, Angela Yan, Thomas A. Cleland, Margaret S. Bynoe
Selective killing of spinal cord neural stem cells impairs locomotor recovery in a mouse model of spinal cord injury
Melania Cusimano, Elena Brambilla, Alessia Capotondo, Donatella De Feo, Antonio Tomasso, Giancarlo Comi, Patrizia D’Adamo, Luca Muzio, Gianvito Martino
Correction to: the role of the complement system in traumatic brain injury: a review
Adnan Hammad, Laura Westacott, Malik Zaben
Cellular and behavioral effects of lipopolysaccharide treatment are dependent upon neurokinin-1 receptor activation
Hannah D. Fulenwider, Britessia M. Smith, Anna S. Nichenko, Jessica M. Carpenter, Sadie E. Nennig, Kejun Cheng, Kenner C. Rice, Jesse R. Schank
Mitochondrial damage and “plugging” of transport selectively in myelinated, small-diameter axons are major early events in peripheral neuroinflammation
Marija Sajic, Keila Kazue Ida, Ryan Canning, Norman A. Gregson, Michael R Duchen, Kenneth J Smith
Differential effect of angiotensin II and blood pressure on hippocampal inflammation in mice
M. Florencia Iulita, Diane Vallerand, Mélissa Beauvillier, Nathalie Haupert, Corinne A. Ulysse, Audrey Gagné, Nathalie Vernoux, Sonia Duchemin, Michaël Boily, Marie-Ève Tremblay, Hélène Girouard
The effect of excess weight on circulating inflammatory cytokines in drug-naïve first-episode psychosis individuals
María Juncal-Ruiz, Laura Riesco-Dávila, Víctor Ortiz-García de la Foz, Mariluz Ramírez-Bonilla, Obdulia Martínez-García, Juan Irure-Ventura, Juan Carlos Leza, Marcos López-Hoyos, Benedicto Crespo-Facorro
Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy
Carmen Navarrete, Francisco Carrillo-Salinas, Belén Palomares, Miriam Mecha, Carla Jiménez-Jiménez, Leyre Mestre, Ana Feliú, Maria L. Bellido, Bernd L. Fiebich, Giovanni Appendino, Marco A. Calzado, Carmen Guaza, Eduardo Muñoz
RNS60 exerts therapeutic effects in the SOD1 ALS mouse model through protective glia and peripheral nerve rescue
Antonio Vallarola, Francesca Sironi, Massimo Tortarolo, Noemi Gatto, Roberta De Gioia, Laura Pasetto, Massimiliano De Paola, Alessandro Mariani, Supurna Ghosh, Richard Watson, Andreas Kalmes, Valentina Bonetto, Caterina Bendotti
Nitrosative damage during retrovirus infection-induced neuropathic pain
Priyanka Chauhan, Wen S. Sheng, Shuxian Hu, Sujata Prasad, James R. Lokensgard
Correction to: Protective and therapeutic role of 2-carbacyclic phosphatidic acid in demyelinating disease
Shinji Yamamoto, Kota Yamashina, Masaki Ishikawa, Mari Gotoh, Sosuke Yagishita, Kensuke Iwasa, Kei Maruyama, Kimiko Murakami-Murofushi, Keisuke Yoshikawa
Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis
Adriana Fernanda K. Vizuete, Fernanda Hansen, Elisa Negri, Marina Concli Leite, Diogo Losch de Oliveira, Carlos-Alberto Gonçalves
Aging exacerbates development of cerebral microbleeds in a mouse model
Rachita K. Sumbria, Mher Mahoney Grigoryan, Vitaly Vasilevko, Annlia Paganini-Hill, Kelley Kilday, Ronald Kim, David H. Cribbs, Mark J. Fisher
Heme oxygenase-1 promoter region (GT)n polymorphism associates with increased neuroimmune activation and risk for encephalitis in HIV infection
Alexander J. Gill, Rolando Garza, Surendra S. Ambegaokar, Benjamin B. Gelman, Dennis L. Kolson
Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model
Michael Dietrich, Niklas Helling, Alexander Hilla, Annemarie Heskamp, Andrea Issberner, Thomas Hildebrandt, Zippora Kohne, Patrick Küry, Carsten Berndt, Orhan Aktas, Dietmar Fischer, Hans-Peter Hartung, Philipp Albrecht
Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients
Ester Canto, Noriko Isobe, Alessandro Didonna, S. Baranzini, C. Bevan, R. Bove, E. Crabtree-Hartman, J. M. Gelfand, D. S. Goodin, A. J. Green, R. Henry, J. Hollenbach, L. Kanaaneh, R. Lincoln, R. O’Shea, N. Papinutto, N. Ragan, G. Rush, W. A. Stern, S. S. Zamvil, Stephen L. Hauser, Jorge R. Oksenberg
The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor
Matthew L. Neal, Alexa M. Boyle, Kevin M. Budge, Fayez F. Safadi, Jason R. Richardson
Oxysterol levels and metabolism in the course of neuroinflammation: insights from in vitro and in vivo models
Valentin Mutemberezi, Baptiste Buisseret, Julien Masquelier, Owein Guillemot-Legris, Mireille Alhouayek, Giulio G. Muccioli
Sulforaphane rescues amyloid-β peptide-mediated decrease in MerTK expression through its anti-inflammatory effect in human THP-1 macrophages
Kyoung A. Jhang, Jin-Sun Park, Hee-Sun Kim, Young Hae Chong
Teriflunomide promotes oligodendroglial differentiation and myelination
Peter Göttle, Anastasia Manousi, David Kremer, Laura Reiche, Hans-Peter Hartung, Patrick Küry
Adipose stromal vascular fraction attenuates TH1 cell-mediated pathology in a model of multiple sclerosis
Annie C. Bowles, Rachel M. Wise, Brittany Y. Gerstein, Robert C. Thomas, Roberto Ogelman, Regan C. Manayan, Bruce A. Bunnell
Celastrol treatment protects against acute ischemic stroke-induced brain injury by promoting an IL-33/ST2 axis-mediated microglia/macrophage M2 polarization
Mei Jiang, Xinghui Liu, Denghai Zhang, Ying Wang, Xiaoxia Hu, Fengxia Xu, Mingming Jin, Fanfan Cao, Limin Xu
Glutaminase 1 regulates the release of extracellular vesicles during neuroinflammation through key metabolic intermediate alpha-ketoglutarate
Beiqing Wu, Jianhui Liu, Runze Zhao, Yuju Li, Justin Peer, Alexander L. Braun, Lixia Zhao, Yi Wang, Zenghan Tong, Yunlong Huang, Jialin C. Zheng
Cell-type- and region-specific restriction of neurotropic flavivirus infection by viperin
Richard Lindqvist, Chaitanya Kurhade, Jonathan D. Gilthorpe, Anna K. Överby
CD4+ αβ T cell infiltration into the leptomeninges of lumbar dorsal roots contributes to the transition from acute to chronic mechanical allodynia after adult rat tibial nerve injuries
Bin Du, You-Quan Ding, Xia Xiao, Hong-Yi Ren, Bing-Yin Su, Jian-Guo Qi
Neonatal hyperglycemia induces CXCL10/CXCR3 signaling and microglial activation and impairs long-term synaptogenesis in the hippocampus and alters behavior in rats
Katherine M. Satrom, Kathleen Ennis, Brian M. Sweis, Tatyana M. Matveeva, Jun Chen, Leif Hanson, Akhil Maheshwari, Raghavendra Rao
Lentivirus-mediated overexpression of OTULIN ameliorates microglia activation and neuroinflammation by depressing the activation of the NF-κB signaling pathway in cerebral ischemia/reperfusion rats
Hongbei Xu, Wenyi Qin, Xiao Hu, Song Mu, Jun Zhu, Wenhao Lu, Yong Luo
Therapeutic time window of multipotent adult progenitor therapy after traumatic brain injury
Supinder S. Bedi, Benjamin M. Aertker, George P. Liao, Henry W. Caplan, Deepa Bhattarai, Fanni Mandy, Franciska Mandy, Luis G. Fernandez, Pamela Zelnick, Matthew B. Mitchell, Walter Schiffer, Margaret Johnson, Emma Denson, Karthik Prabhakara, Hasen Xue, Philippa Smith, Karen Uray, Scott D. Olson, Robert W. Mays, Charles S. Cox Jr
Chronic exposure to tumor necrosis factor alpha induces retinal pigment epithelium cell dedifferentiation
Sara Touhami, Fanny Beguier, Sébastien Augustin, Hugo Charles-Messance, Lucile Vignaud, Emeline F. Nandrot, Sacha Reichman, Valérie Forster, Thibaud Mathis, José-Alain Sahel, Bahram Bodaghi, Xavier Guillonneau, Florian Sennlaub
Epigenetic impacts of stress priming of the neuroinflammatory response to sarin surrogate in mice: a model of Gulf War illness
David G. Ashbrook, Benjamin Hing, Lindsay T. Michalovicz, Kimberly A. Kelly, Julie V. Miller, Wilfred C. de Vega, Diane B. Miller, Gordon Broderick, James P. O’Callaghan, Patrick O. McGowan
Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarachnoid hemorrhage
Yue Lu, Xiang-Sheng Zhang, Zi-Huan Zhang, Xiao-Ming Zhou, Yong-Yue Gao, Guang-Jie Liu, Han Wang, Ling-Yun Wu, Wei Li, Chun-Hua Hang
MOG-IgG in primary and secondary chronic progressive multiple sclerosis: a multicenter study of 200 patients and review of the literature
S. Jarius, K. Ruprecht, J. P. Stellmann, A. Huss, I. Ayzenberg, A. Willing, C. Trebst, M. Pawlitzki, A. Abdelhak, T. Grüter, F. Leypoldt, J. Haas, I. Kleiter, H. Tumani, K. Fechner, M. Reindl, F. Paul, B. Wildemann
Acute- and late-phase matrix metalloproteinase (MMP)-9 activity is comparable in female and male rats after peripheral nerve injury
Albert G. Remacle, Swathi K. Hullugundi, Jennifer Dolkas, Mila Angert, Andrei V. Chernov, Alex Y. Strongin, Veronica I. Shubayev
Perturbing chondroitin sulfate proteoglycan signaling through LAR and PTPσ receptors promotes a beneficial inflammatory response following spinal cord injury
Scott Dyck, Hardeep Kataria, Arsalan Alizadeh, Kallivalappil T. Santhosh, Bradley Lang, Jerry Silver, Soheila Karimi-Abdolrezaee
Apolipoprotein E isoform dependently affects Tat-mediated HIV-1 LTR transactivation
Nabab Khan, Gaurav Datta, Jonathan D. Geiger, Xuesong Chen
Overexpression of zinc-α2-glycoprotein suppressed seizures and seizure-related neuroflammation in pentylenetetrazol-kindled rats
Ying Liu, Teng Wang, Xi Liu, Yuetao Wen, Tao Xu, Xinyuan Yu, Xin Wei, Xueying Ding, Lijuan Mo, Maojia Yin, Xinjie Tan, Lifen Chen
Toll-like receptor 3 modulates the behavioral effects of cocaine in mice
Ruiming Zhu, Qian Bu, Dengqi Fu, Xue Shao, Linhong Jiang, Wei Guo, Bo Chen, Bin Liu, Zhengtao Hu, Jingwei Tian, Yinglan Zhao, Xiaobo Cen
HIV-1 Tat-induced diarrhea is improved by the PPARalpha agonist, palmitoylethanolamide, by suppressing the activation of enteric glia
Giovanni Sarnelli, Luisa Seguella, Marcella Pesce, Jie Lu, Stefano Gigli, Eugenia Bruzzese, Roberta Lattanzi, Alessandra D’Alessandro, Rosario Cuomo, Luca Steardo, Giuseppe Esposito
Central blockade of NLRP3 reduces blood pressure via regulating inflammation microenvironment and neurohormonal excitation in salt-induced prehypertensive rats
Mo-Lin Wang, Yu-Ming Kang, Xiao-Guang Li, Qing Su, Hong-Bao Li, Kai-Li Liu, Li-Yan Fu, Roland Osei Saahene, Ying Li, Hong Tan, Xiao-Jing Yu
Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury
Norikazu Kiguchi, Daichi Kobayashi, Fumihiro Saika, Shinsuke Matsuzaki, Shiroh Kishioka
Roles of astrocytic connexin-43, hemichannels, and gap junctions in oxygen-glucose deprivation/reperfusion injury induced neuroinflammation and the possible regulatory mechanisms of salvianolic acid B and carbenoxolone
Xiang Yin, Liangshu Feng, Di Ma, Ping Yin, Xinyu Wang, Shuai Hou, Yulei Hao, Jingdian Zhang, Meiying Xin, Jiachun Feng
The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death
Sofia Söllvander, Elisabeth Nikitidou, Linn Gallasch, Marlena Zyśk, Linda Söderberg, Dag Sehlin, Lars Lannfelt, Anna Erlandsson
Dysregulation of chemokine receptor expression and function in leukocytes from ALS patients
Caroline Perner, Florian Perner, Beatrice Stubendorff, Martin Förster, Otto W. Witte, Florian H. Heidel, Tino Prell, Julian Grosskreutz
Dimethyl fumarate attenuates reactive microglia and long-term memory deficits following systemic immune challenge
Hallel C. Paraiso, Ping-Chang Kuo, Eric T. Curfman, Haley J. Moon, Robert D. Sweazey, Jui-Hung Yen, Fen-Lei Chang, I-Chen Yu
A novel interaction between CX3CR1 and CCR2 signalling in monocytes constitutes an underlying mechanism for persistent vincristine-induced pain
Karli Montague, Raffaele Simeoli, Joao Valente, Marzia Malcangio
β-arrestin2 functions as a key regulator in the sympathetic-triggered immunodepression after stroke
Huan Wang, Qi-Wen Deng, Ai-Ni Peng, Fang-Lan Xing, Lei Zuo, Shuo Li, Zheng-Tian Gu, Fu-Ling Yan
LncRNA H19 contributes to hippocampal glial cell activation via JAK/STAT signaling in a rat model of temporal lobe epilepsy
Chun-Lei Han, Ming Ge, Yun-Peng Liu, Xue-Min Zhao, Kai-Liang Wang, Ning Chen, Wen-Jia Meng, Wei Hu, Jian-Guo Zhang, Liang Li, Fan-Gang Meng
Neuregulin-1 attenuates experimental cerebral malaria (ECM) pathogenesis by regulating ErbB4/AKT/STAT3 signaling
Mingli Liu, Wesley Solomon, Juan Carlos Cespedes, Nana O. Wilson, Byron Ford, Jonathan K. Stiles
Neuropeptide regulation of adaptive immunity in the tibia fracture model of complex regional pain syndrome
Wen-Wu Li, Tian-Zhi Guo, Xiaoyou Shi, Frank Birklein, Tanja Schlereth, Wade S. Kingery, J. David Clark
Activation of melanocortin receptor 4 with RO27-3225 attenuates neuroinflammation through AMPK/JNK/p38 MAPK pathway after intracerebral hemorrhage in mice
Shengpan Chen, Lianhua Zhao, Prativa Sherchan, Yan Ding, Jing Yu, Derek Nowrangi, Jiping Tang, Ying Xia, John H. Zhang
Platelet-derived growth factor predicts prolonged relapse-free period in multiple sclerosis
Mario Stampanoni Bassi, Ennio Iezzi, Girolama A. Marfia, Ilaria Simonelli, Alessandra Musella, Georgia Mandolesi, Diego Fresegna, Patrizio Pasqualetti, Roberto Furlan, Annamaria Finardi, Giorgia Mataluni, Doriana Landi, Luana Gilio, Diego Centonze, Fabio Buttari
Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment
Zhi Wang, Shiyu Meng, Lin Cao, Ying Chen, Zhiyi Zuo, Shuling Peng
Selective localization of IgG from cerebrospinal fluid to brain parenchyma
Marlene Thorsen Mørch, Sofie Forsberg Sørensen, Reza Khorooshi, Nasrin Asgari, Trevor Owens
Reduced ex vivo release of pro-inflammatory cytokines and elevated plasma interleukin-6 are inflammatory signatures of post-stroke delirium
Katarzyna Kowalska, Elzbieta Klimiec, Kazimierz Weglarczyk, Joanna Pera, Agnieszka Slowik, Maciej Siedlar, Tomasz Dziedzic
Galantamine improves cognition, hippocampal inflammation, and synaptic plasticity impairments induced by lipopolysaccharide in mice
Yi Liu, Yuyun Zhang, Xian Zheng, Tongyong Fang, Xia Yang, Xuan Luo, Anlei Guo, Kelly A. Newell, Xu-Feng Huang, Yinghua Yu
Chorioamnionitis, neuroinflammation, and injury: timing is key in the preterm ovine fetus
Ruth Gussenhoven, Rob J. J. Westerlaken, Daan R. M. G. Ophelders, Alan H. Jobe, Matthew W. Kemp, Suhas G. Kallapur, Luc J. Zimmermann, Per T. Sangild, Stanislava Pankratova, Pierre Gressens, Boris W. Kramer, Bobbi Fleiss, Tim G. A. M. Wolfs
Human central nervous system astrocytes support survival and activation of B cells: implications for MS pathogenesis
Hanane Touil, Antonia Kobert, Nathalie Lebeurrier, Aja Rieger, Philippe Saikali, Caroline Lambert, Lama Fawaz, Craig S. Moore, Alexandre Prat, Jennifer Gommerman, Jack P. Antel, Yasuto Itoyama, Ichiro Nakashima, Amit Bar-Or, A. Rezk, F. Jalili, L. Michel, N. Pikor, R. Li
The intrathecal expression and pathogenetic role of Th17 cytokines and CXCR2-binding chemokines in tick-borne encephalitis
Sambor Grygorczuk, Renata Świerzbińska, Maciej Kondrusik, Justyna Dunaj, Piotr Czupryna, Anna Moniuszko, Agnieszka Siemieniako, Sławomir Pancewicz
Omega-3 polyunsaturated fatty acid attenuates the inflammatory response by modulating microglia polarization through SIRT1-mediated deacetylation of the HMGB1/NF-κB pathway following experimental traumatic brain injury
Xiangrong Chen, Chunnuan Chen, Sining Fan, Shukai Wu, Fuxing Yang, Zhongning Fang, Huangde Fu, Yasong Li
Glial interleukin-1β upregulates neuronal sodium channel 1.7 in trigeminal ganglion contributing to temporomandibular joint inflammatory hypernociception in rats
Peng Zhang, Rui-Yun Bi, Ye-Hua Gan
Biliverdin reductase-A attenuated GMH-induced inflammatory response in the spleen by inhibiting toll-like receptor-4 through eNOS/NO pathway
Yiting Zhang, Yan Ding, Tai Lu, Yixin Zhang, Ningbo Xu, Devin W. McBride, Jiping Tang, John H. Zhang
Acute dose of melatonin via Nrf2 dependently prevents acute ethanol-induced neurotoxicity in the developing rodent brain
Tahir Ali, Shafiq Ur Rehman, Fawad Ali Shah, Myeong Ok Kim
Oral sensitization to whey proteins induces age- and sex-dependent behavioral abnormality and neuroinflammatory responses in a mouse model of food allergy: a potential role of mast cells
Danielle L. Germundson, Nicholas A. Smith, Lane P. Vendsel, Andrea V. Kelsch, Colin K. Combs, Kumi Nagamoto-Combs
Blockade of sustained tumor necrosis factor in a transgenic model of progressive autoimmune encephalomyelitis limits oligodendrocyte apoptosis and promotes oligodendrocyte maturation
Alice Valentin-Torres, Carine Savarin, Joslyn Barnett, Cornelia C. Bergmann
Capsaicin-enriched diet ameliorates autoimmune neuritis in rats
Jeremias Motte, Björn Ambrosius, Thomas Grüter, Hussein Bachir, Melissa Sgodzai, Xiomara Pedreiturria, Kalliopi Pitarokoili, Ralf Gold
Ischemic stroke is associated with the pro-inflammatory potential of N-glycosylated immunoglobulin G
Di Liu, Zhongyao Zhao, Anxin Wang, Siqi Ge, Hao Wang, Xiaoyu Zhang, Qi Sun, Weijie Cao, Ming Sun, Lijuan Wu, Manshu Song, Yong Zhou, Wei Wang, Youxin Wang
Anti-high mobility group box 1 antibody suppresses local inflammatory reaction and facilitates olfactory nerve recovery following injury
Masayoshi Kobayashi, Kengo Tamari, Mohammed Omar Al Salihi, Kohei Nishida, Kazuhiko Takeuchi
Cerebrospinal fluid mitochondrial DNA in neuromyelitis optica spectrum disorder
Kazuya Yamashita, Makoto Kinoshita, Katsuichi Miyamoto, Akiko Namba, Mikito Shimizu, Toru Koda, Tomoyuki Sugimoto, Yuki Mori, Yoshichika Yoshioka, Yuji Nakatsuji, Atsushi Kumanogoh, Susumu Kusunoki, Hideki Mochizuki, Tatsusada Okuno
Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysregulates neurogranin and induces synaptodendritic injury
Debjani Guha, Marc C. E. Wagner, Velpandi Ayyavoo
IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation
Liqi Tong, G. Aleph Prieto, Carl W. Cotman
Vascular adhesion protein-1 is actively involved in the development of inflammatory lesions in rat models of multiple sclerosis
Petri Elo, Sina Tadayon, Heidi Liljenbäck, Jarmo Teuho, Meeri Käkelä, Kalle Koskensalo, Virva Saunavaara, Jenni Virta, Tibor Z. Veres, Aida Kiviniemi, Antti Saraste, Päivi Marjamäki, Laura Airas, Sirpa Jalkanen, Anne Roivainen
Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
Megan F. Duffy, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, Kelvin C. Luk, Malú G. Tansey, Katrina L. Paumier, Nicholas M. Kanaan, D. Luke Fischer, Nicole K. Polinski, Olivia L. Barth, Jacob W. Howe, Nishant N. Vaikath, Nour K. Majbour, Omar M. A. El-Agnaf, Caryl E. Sortwell
Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation
Sinéad Kinsella, Michael Fichtner, Orla Watters, Hans-Georg König, Jochen H. M. Prehn
Urate inhibits microglia activation to protect neurons in an LPS-induced model of Parkinson’s disease
Li-Hui Bao, Ya-Nan Zhang, Jian-Nan Zhang, Li Gu, Hui-Min Yang, Yi-Ying Huang, Ning Xia, Hong Zhang
PM2.5 exposure aggravates oligomeric amyloid beta-induced neuronal injury and promotes NLRP3 inflammasome activation in an in vitro model of Alzheimer’s disease
Bian-Rong Wang, Jian-Quan Shi, Nian-Nian Ge, Zhou Ou, You-Yong Tian, Teng Jiang, Jun-Shan Zhou, Jun Xu, Ying-Dong Zhang
Decreased level of irisin, a skeletal muscle cell-derived myokine, is associated with post-stroke depression in the ischemic stroke population
Wen-Jun Tu, Han-Cheng Qiu, Qiang Liu, Xuemei Li, Ji-Zong Zhao, Xianwei Zeng
MOG encephalomyelitis: international recommendations on diagnosis and antibody testing
S. Jarius, F. Paul, O. Aktas, N. Asgari, R. C. Dale, J. de Seze, D. Franciotta, K. Fujihara, A. Jacob, H. J. Kim, I. Kleiter, T. Kümpfel, M. Levy, J. Palace, K. Ruprecht, A. Saiz, C. Trebst, B. G. Weinshenker, B. Wildemann
Mesenchymal stem cells attenuate blood-brain barrier leakage after cerebral ischemia in mice
Zhuo Cheng, Liping Wang, Meijie Qu, Huaibin Liang, Wanlu Li, Yongfang Li, Lidong Deng, Zhijun Zhang, Guo-Yuan Yang
IL-33/ST2 plays a critical role in endothelial cell activation and microglia-mediated neuroinflammation modulation
Kelei Cao, Xiang Liao, Jiahui Lu, Shu Yao, Fengjiao Wu, Xingxing Zhu, Dongyan Shi, Shuang Wen, Lixin Liu, Hong Zhou
URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer’s disease
Tomomi Kiyota, Jatin Machhi, Yaman Lu, Bhagyalaxmi Dyavarshetty, Maryam Nemati, Gang Zhang, R. Lee Mosley, Harris A. Gelbard, Howard E. Gendelman
Unique and shared inflammatory profiles of human brain endothelia and pericytes
Leon C. D. Smyth, Justin Rustenhoven, Thomas I.-H. Park, Patrick Schweder, Deidre Jansson, Peter A. Heppner, Simon J. O’Carroll, Edward W. Mee, Richard L. M. Faull, Maurice Curtis, Mike Dragunow
Regional microglia are transcriptionally distinct but similarly exacerbate neurodegeneration in a culture model of Parkinson’s disease
Eric Wildon Kostuk, Jingli Cai, Lorraine Iacovitti
NADPH oxidases as potential pharmacological targets against increased seizure susceptibility after systemic inflammation
Wan-Yu Huang, Shankung Lin, Hsuan-Ying Chen, Ya-Ping Chen, Ting-Yu Chen, Kuei-Sen Hsu, Hung-Ming Wu
Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis
Sergey Kalinin, Marta González-Prieto, Hannah Scheiblich, Lucia Lisi, Handojo Kusumo, Michael T. Heneka, Jose L. M. Madrigal, Subhash C. Pandey, Douglas L. Feinstein
Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury
Justin R. Piro, Georgette L. Suidan, Jie Quan, YeQing Pi, Sharon M. O’Neill, Marissa Ilardi, Nikolay Pozdnyakov, Thomas A. Lanz, Hualin Xi, Robert D. Bell, Tarek A. Samad
A potential gliovascular mechanism for microglial activation: differential phenotypic switching of microglia by endothelium versus astrocytes
Changhong Xing, Wenlu Li, Wenjun Deng, MingMing Ning, Eng H. Lo
The role of inflammation in the development of epilepsy
Amna Rana, Alberto E. Musto
Molecular and clinical characterization of PTPN2 expression from RNA-seq data of 996 brain gliomas
Peng-fei Wang, Hong-qing Cai, Chuan-bao Zhang, Yan-Michael Li, Xiang Liu, Jing-hai Wan, Tao Jiang, Shou-wei Li, Chang-Xiang Yan
Neutrophils in traumatic brain injury (TBI): friend or foe?
Yang-Wuyue Liu, Song Li, Shuang-Shuang Dai
Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model
Chunxia Huang, Michael Garnet Irwin, Gordon Tin Chun Wong, Raymond Chuen Chung Chang
Myeloid-specific TAK1 deletion results in reduced brain monocyte infiltration and improved outcomes after stroke
Anjali Chauhan, Jacob Hudobenko, Abdullah Al Mamun, Edward C. Koellhoffer, Anthony Patrizz, Rodney M. Ritzel, Bhanu P. Ganesh, Louise D. McCullough
Impaired CD8 T cell antiviral immunity following acute spinal cord injury
Diana M. Norden, John R. Bethea, Jiu Jiang
Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3
Shoubo Chen, Jingfang Ye, Xiangrong Chen, Jinnan Shi, Wenhua Wu, Wenping Lin, Weibin Lin, Yasong Li, Huangde Fu, Shun Li
Rheumatoid meningitis developed in patient with stable rheumatoid arthritis and myasthenia gravis—detailed analysis of intracranial inflammation using flow cytometry
Miki Oono, Yoshimasa Fujita, Nobuaki Uchida, Ukichiro Kawai, Michiyo Fujita-Nakata, Megumi Nakanishi, Mitsuru Sanada, Shigemi Nagayama, Makoto Matsui
Sinomenine exerts anticonvulsant profile and neuroprotective activity in pentylenetetrazole kindled rats: involvement of inhibition of NLRP1 inflammasome
Bo Gao, Yu Wu, Yuan-Jian Yang, Wei-Zu Li, Kun Dong, Jun Zhou, Yan-Yan Yin, Da-Ke Huang, Wen-Ning Wu
RNA sequencing analysis reveals quiescent microglia isolation methods from postnatal mouse brains and limitations of BV2 cells
Yingbo He, Xiang Yao, Natalie Taylor, Yuchen Bai, Timothy Lovenberg, Anindya Bhattacharya
Novel TNF receptor-1 inhibitors identified as potential therapeutic candidates for traumatic brain injury
Rachel K. Rowe, Jordan L. Harrison, Hongtao Zhang, Adam D. Bachstetter, David P. Hesson, Bruce F. O’Hara, Mark I. Greene, Jonathan Lifshitz
Ecto-5′-nucleotidase (CD73) attenuates inflammation after spinal cord injury by promoting macrophages/microglia M2 polarization in mice
Shun Xu, Wei Zhu, Minghao Shao, Fan Zhang, Ji Guo, Haocheng Xu, Jianyuan Jiang, Xiaosheng Ma, Xinlei Xia, Xiuling Zhi, Ping Zhou, Feizhou Lu
Novel insights into neuroinflammation: bacterial lipopolysaccharide, tumor necrosis factor α, and Ureaplasma species differentially modulate atypical chemokine receptor 3 responses in human brain microvascular endothelial cells
Christine Silwedel, Christian P. Speer, Axel Haarmann, Markus Fehrholz, Heike Claus, Mathias Buttmann, Kirsten Glaser
Aquaporin-4 deletion ameliorates hypoglycemia-induced BBB permeability by inhibiting inflammatory responses
Fei Zhao, Jiangshan Deng, Xiaofeng Xu, Fengya Cao, Kaili Lu, Dawei Li, Xiaojuan Cheng, Xiuzhe Wang, Yuwu Zhao
Cannabinoid CB2 receptors in the mouse brain: relevance for Alzheimer’s disease
Alicia López, Noelia Aparicio, M. Ruth Pazos, M. Teresa Grande, M. Asunción Barreda-Manso, Irene Benito-Cuesta, Carmen Vázquez, Mario Amores, Gonzalo Ruiz-Pérez, Elena García-García, Margaret Beatka, Rosa M. Tolón, Bonnie N. Dittel, Cecilia J. Hillard, Julián Romero
Inflammatory and cytotoxic effects of bifenthrin in primary microglia and organotypic hippocampal slice cultures
Brahim Gargouri, Nizar M. Yousif, Michèle Bouchard, Hamadi Fetoui, Bernd L. Fiebich
Immunophenotyping of cerebrospinal fluid cells by Chipcytometry
Martin W. Hümmert, Sascha Alvermann, Stefan Gingele, Catharina C. Gross, Heinz Wiendl, Anja Mirenska, Christian Hennig, Martin Stangel
Dual modulation on glial cells by tetrahydroxystilbene glucoside protects against dopamine neuronal loss
Yanzhen Zhou, Guoqing Wang, Daidi Li, Yanying Wang, Qin Wu, Jingshan Shi, Feng Zhang
Indomethacin promotes survival of new neurons in the adult murine hippocampus accompanied by anti-inflammatory effects following MPTP-induced dopamine depletion
Elisabeth G. Hain, Maria Sparenberg, Justyna Rasińska, Charlotte Klein, Levent Akyüz, Barbara Steiner
Dynamic changes in microglial and macrophage characteristics during degeneration and regeneration of the zebrafish retina
Diana M. Mitchell, Anna G. Lovel, Deborah L. Stenkamp
Serum amyloid A primes microglia for ATP-dependent interleukin-1β release
Laura Facci, Massimo Barbierato, Morena Zusso, Stephen D. Skaper, Pietro Giusti
Cytokine alterations in first-episode schizophrenia and bipolar disorder: relationships to brain structure and symptoms
Tyler A. Lesh, Milo Careaga, Destanie R. Rose, A. Kimberley McAllister, Judy Van de Water, Cameron S. Carter, Paul Ashwood
Abnormalities of age-related T cell senescence in Parkinson’s disease
C. H. Williams-Gray, R. S. Wijeyekoon, K. M. Scott, S. Hayat, R. A. Barker, J. L. Jones
Splenic responses play an important role in remote ischemic preconditioning-mediated neuroprotection against stroke
Chen Chen, Wei Jiang, Zongjian Liu, Fengwu Li, Jian Yang, Yanlong Zhao, Yuanyuan Ran, Yan Meng, Xunming Ji, Xiaokun Geng, Huishan Du, Xiaoming Hu
Inflammation leads to distinct populations of extracellular vesicles from microglia
Yiyi Yang, Antonio Boza-Serrano, Christopher J. R. Dunning, Bettina Hjelm Clausen, Kate Lykke Lambertsen, Tomas Deierborg
Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
Megan F. Duffy, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, Kelvin C. Luk, Malú G. Tansey, Katrina L. Paumier, Nicholas M. Kanaan, D. Luke Fischer, Nicole K. Polinski, Olivia L. Barth, Jacob W. Howe, Nishant N. Vaikath, Nour K. Majbour, Omar M. A. El-Agnaf, Caryl E. Sortwell
Neuroinflammation is increased in the parietal cortex of atypical Alzheimer’s disease
Baayla D. C. Boon, Jeroen J. M. Hoozemans, Boaz Lopuhaä, Kristel N. Eigenhuis, Philip Scheltens, Wouter Kamphorst, Annemieke J. M. Rozemuller, Femke H. Bouwman
Complement components are upregulated and correlate with disease progression in the TDP-43Q331K mouse model of amyotrophic lateral sclerosis
John D. Lee, Samantha C. Levin, Emily F. Willis, Rui Li, Trent M. Woodruff, Peter G. Noakes
Co-aggregation of pro-inflammatory S100A9 with α-synuclein in Parkinson’s disease: ex vivo and in vitro studies
Istvan Horvath, Igor A. Iashchishyn, Roman A. Moskalenko, Chao Wang, Sebastian K. T. S. Wärmländer, Cecilia Wallin, Astrid Gräslund, Gabor G. Kovacs, Ludmilla A. Morozova-Roche
Elimination of intravascular thrombi prevents early mortality and reduces gliosis in hyper-inflammatory experimental cerebral malaria
Kyle D. Wilson, Lorenzo F. Ochoa, Olivia D. Solomon, Rahul Pal, Sandra M. Cardona, Victor H. Carpio, Philip H. Keiser, Astrid E. Cardona, Gracie Vargas, Robin Stephens
Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke
Somayyeh Hamzei Taj, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Alessandra Quarta, Jelle Praet, Annemie Van der Linden, Peter Ponsaerts, Mathias Hoehn
Activin A increases phagocytosis of Escherichia coli K1 by primary murine microglial cells activated by toll-like receptor agonists
Catharina Diesselberg, Sandra Ribes, Jana Seele, Annika Kaufmann, Sandra Redlich, Stephanie Bunkowski, Uwe-Karsten Hanisch, Uwe Michel, Roland Nau, Sandra Schütze
Ammoxetine attenuates diabetic neuropathic pain through inhibiting microglial activation and neuroinflammation in the spinal cord
Ting-Ting Zhang, Rui Xue, Shi-Yong Fan, Qiong-Yin Fan, Lei An, Juan Li, Lei Zhu, Yu-Hua Ran, Li-Ming Zhang, Bo-Hua Zhong, Yun-Feng Li, Cai-Ying Ye, You-Zhi Zhang
HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway
Shalini Swaroop, Anita Mahadevan, Susarla Krishna Shankar, Yogita K. Adlakha, Anirban Basu
Aggf1 attenuates neuroinflammation and BBB disruption via PI3K/Akt/NF-κB pathway after subarachnoid hemorrhage in rats
Qiquan Zhu, Budbazar Enkhjargal, Lei Huang, Tongyu Zhang, Chengmei Sun, Zhiyi Xie, Pei Wu, Jun Mo, Jiping Tang, Zongyi Xie, John H. Zhang
Chronic constriction injury-induced microRNA-146a-5p alleviates neuropathic pain through suppression of IRAK1/TRAF6 signaling pathway
Zhiyao Wang, Fan Liu, Min Wei, Yue Qiu, Chao Ma, Le Shen, Yuguang Huang
Necrotizing enterocolitis is associated with acute brain responses in preterm pigs
Jing Sun, Xiaoyu Pan, Line I. Christiansen, Xiao-Long Yuan, Kerstin Skovgaard, Dereck E. W. Chatterton, Sanne S. Kaalund, Fei Gao, Per T. Sangild, Stanislava Pankratova
In utero electroporation induces cell death and alters embryonic microglia morphology and expression signatures in the developing hypothalamus
Jessica M. Rosin, Deborah M. Kurrasch
Longitudinal chemokine profile expression in a blood-brain barrier model from Alzheimer transgenic versus wild-type mice
J. Vérité, T. Janet, D. Chassaing, B. Fauconneau, H. Rabeony, G. Page
Laquinimod protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model
Anna T. Wilmes, Sabrina Reinehr, Sandra Kühn, Xiomara Pedreiturria, Laura Petrikowski, Simon Faissner, Ilya Ayzenberg, Gesa Stute, Ralf Gold, H. Burkhard Dick, Ingo Kleiter, Stephanie C. Joachim
JNK-mediated microglial DICER degradation potentiates inflammatory responses to induce dopaminergic neuron loss
Qing Wang, Qian He, Yifei Chen, Wei Shao, Chao Yuan, Yizheng Wang
Temporal changes in macrophage phenotype after peripheral nerve injury
Joy E. Tomlinson, Emilija Žygelytė, Jennifer K. Grenier, Michael G. Edwards, Jonathan Cheetham
Vitexin reduces epilepsy after hypoxic ischemia in the neonatal brain via inhibition of NKCC1
Wen-di Luo, Jia-wei Min, Wen-Xian Huang, Xin Wang, Yuan-yuan Peng, Song Han, Jun Yin, Wan-Hong Liu, Xiao-Hua He, Bi-Wen Peng
Procyanidins attenuate neuropathic pain by suppressing matrix metalloproteinase-9/2
Cailong Pan, Chaoyu Wang, Li Zhang, Ling Song, Yuan Chen, Bingqian Liu, Wen-Tao Liu, Liang Hu, Yinbing Pan
Carbon monoxide-releasing molecule-3 protects against ischemic stroke by suppressing neuroinflammation and alleviating blood-brain barrier disruption
Jianping Wang, Di Zhang, Xiaojie Fu, Lie Yu, Zhengfang Lu, Yufeng Gao, Xianliang Liu, Jiang Man, Sijia Li, Nan Li, Xuemei Chen, Michael Hong, Qingwu Yang, Jian Wang
Bone marrow-derived mesenchymal stem/stromal cells reverse the sensorial diabetic neuropathy via modulation of spinal neuroinflammatory cascades
Afrânio Ferreira Evangelista, Marcos André Vannier-Santos, Gessica Sabrina de Assis Silva, Daniela Nascimento Silva, Paulo José Lima Juiz, Carolina Kymie Vasques Nonaka, Ricardo Ribeiro dos Santos, Milena Botelho Pereira Soares, Cristiane Flora Villarreal
Effects of chronic noise exposure on the microbiome-gut-brain axis in senescence-accelerated prone mice: implications for Alzheimer’s disease
Bo Cui, Donghong Su, Wenlong Li, Xiaojun She, Ming Zhang, Rui Wang, Qingfeng Zhai
Cytokine production pattern of T lymphocytes in neonatal arterial ischemic stroke during the first month of life—a case study
Anna Bajnok, László Berta, Csaba Orbán, Tivadar Tulassay, Gergely Toldi
Molecular and cellular identification of the immune response in peripheral ganglia following nerve injury
Jane A. Lindborg, Jon P. Niemi, Madeline A. Howarth, Kevin W. Liu, Christian Z. Moore, Deepti Mahajan, Richard E. Zigmond
Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson’s disease
Chen Qiao, Qian Zhang, Qingling Jiang, Ting Zhang, Miaomiao Chen, Yi Fan, Jianhua Ding, Ming Lu, Gang Hu
Teriflunomide attenuates neuroinflammation-related neural damage in mice carrying human PLP1 mutations
Janos Groh, Michaela Hörner, Rudolf Martini
The splenic response to stroke: from rodents to stroke subjects
Hilary A. Seifert, Halina Offner
The inhibitory effect of LPS on the expression of GPR81 lactate receptor in blood-brain barrier model in vitro
Elizaveta B. Boitsova, Andrey V. Morgun, Elena D. Osipova, Elena A. Pozhilenkova, Galina P. Martinova, Olga V. Frolova, Raissa Ya Olovannikova, Abolghasem Tohidpour, Yana V. Gorina, Yulia A. Panina, Alla B. Salmina
Role of MCP-1 and CCR2 in ethanol-induced neuroinflammation and neurodegeneration in the developing brain
Kai Zhang, Haiping Wang, Mei Xu, Jacqueline A. Frank, Jia Luo
Astrocytic gap junction inhibition by carbenoxolone enhances the protective effects of ischemic preconditioning following cerebral ischemia
Di Ma, Liangshu Feng, Yingying Cheng, Meiying Xin, Jiulin You, Xiang Yin, Yulei Hao, Li Cui, Jiachun Feng
Necroptosis: a regulated inflammatory mode of cell death
Yogesh K. Dhuriya, Divakar Sharma
Increased hypothalamic microglial activation after viral-induced pneumococcal lung infection is associated with excess serum amyloid A production
Hao Wang, Melissa Blackall, Luba Sominsky, Sarah J. Spencer, Ross Vlahos, Melissa Churchill, Steven Bozinovski
Inflammation and blood-brain barrier breach remote from the primary injury following neurotrauma
Nicole M. Smith, Marcus K. Giacci, Alexander Gough, Charlotte Bailey, Terence McGonigle, Anna M. B. Black, Thomas O. Clarke, Carole A. Bartlett, K. Swaminathan Iyer, Sarah A. Dunlop, Melinda Fitzgerald
Unveiling anti-oxidative and anti-inflammatory effects of docosahexaenoic acid and its lipid peroxidation product on lipopolysaccharide-stimulated BV-2 microglial cells
Bo Yang, Runting Li, C. Michael Greenlief, Kevin L. Fritsche, Zezong Gu, Jiankun Cui, James C. Lee, David Q. Beversdorf, Grace Y. Sun
Ex vivo model of epilepsy in organotypic slices—a new tool for drug screening
Daniela M. Magalhães, Noémia Pereira, Diogo M. Rombo, Cláudia Beltrão-Cavacas, Ana M. Sebastião, Cláudia A. Valente
Long noncoding RNA MALAT1 in exosomes drives regenerative function and modulates inflammation-linked networks following traumatic brain injury
Niketa A. Patel, Lauren Daly Moss, Jea-Young Lee, Naoki Tajiri, Sandra Acosta, Charles Hudson, Sajan Parag, Denise R. Cooper, Cesario V. Borlongan, Paula C. Bickford
Parkinson’s disease patients have a complex phenotypic and functional Th1 bias: cross-sectional studies of CD4+ Th1/Th2/T17 and Treg in drug-naïve and drug-treated patients
Natasa Kustrimovic, Cristoforo Comi, Luca Magistrelli, Emanuela Rasini, Massimiliano Legnaro, Raffaella Bombelli, Iva Aleksic, Fabio Blandini, Brigida Minafra, Giulio Riboldazzi, Andrea Sturchio, Marco Mauri, Giorgio Bono, Franca Marino, Marco Cosentino
The novel estrogenic receptor GPR30 alleviates ischemic injury by inhibiting TLR4-mediated microglial inflammation
Zengli Zhang, Pei Qin, Youliang Deng, Zhi Ma, Hang Guo, Haiyun Guo, Yushu Hou, Shiquan Wang, Wangyuan Zou, Yanyuan Sun, Yulong Ma, Wugang Hou
Brain 18F-FDG PET of SIV-infected macaques after treatment interruption or initiation
William Schreiber-Stainthorp, Sanhita Sinharay, Sharat Srinivasula, Swati Shah, Jing Wang, Lori Dodd, H. Clifford Lane, Michele Di Mascio, Dima A. Hammoud
An IFNγ/CXCL2 regulatory pathway determines lesion localization during EAE
Joshua S. Stoolman, Patrick C. Duncker, Amanda K. Huber, David A. Giles, Jesse M. Washnock-Schmid, Athena M. Soulika, Benjamin M. Segal
Neurofilament levels, disease activity and brain volume during follow-up in multiple sclerosis
Irene Håkansson, Anders Tisell, Petra Cassel, Kaj Blennow, Henrik Zetterberg, Peter Lundberg, Charlotte Dahle, Magnus Vrethem, Jan Ernerudh
The adhesion and migration of microglia to β-amyloid (Aβ) is decreased with aging and inhibited by Nogo/NgR pathway
Yinquan Fang, Jianing Wang, Lemeng Yao, Chenhui Li, Jing Wang, Yuan Liu, Xia Tao, Hao Sun, Hong Liao
Increased expression of matrix metalloproteinase 3 can be attenuated by inhibition of microRNA-155 in cultured human astrocytes
Anatoly Korotkov, Diede W. M. Broekaart, Jackelien van Scheppingen, Jasper J. Anink, Johannes C. Baayen, Sander Idema, Jan A. Gorter, Eleonora Aronica, Erwin A. van Vliet
Effects of rapamycin and curcumin on inflammation and oxidative stress in vitro and in vivo — in search of potential anti-epileptogenic strategies for temporal lobe epilepsy
C. M. Drion, J. van Scheppingen, A. Arena, K. W. Geijtenbeek, L. Kooijman, E. A. van Vliet, E. Aronica, J. A. Gorter
Levels of ADAM10 are reduced in Alzheimer’s disease CSF
Aitana Sogorb-Esteve, María-Salud García-Ayllón, Johan Gobom, Jordi Alom, Henrik Zetterberg, Kaj Blennow, Javier Sáez-Valero
Effect of hypothermia on interleukin-1 receptor antagonist pharmacodynamics in inflammatory-sensitized hypoxic-ischemic encephalopathy of term newborns
Mathilde Chevin, Clémence Guiraut, Guillaume Sébire
Recombinant CTRP9 administration attenuates neuroinflammation via activating adiponectin receptor 1 after intracerebral hemorrhage in mice
Lianhua Zhao, Shengpan Chen, Prativa Sherchan, Yan Ding, Wei Zhao, Zaiyu Guo, Jing Yu, Jiping Tang, John H. Zhang
Chronic Toxoplasma infection is associated with distinct alterations in the synaptic protein composition
Daniel Lang, Björn H. Schott, Marco van Ham, Lorena Morton, Leonora Kulikovskaja, Rodrigo Herrera-Molina, Rainer Pielot, Frank Klawonn, Dirk Montag, Lothar Jänsch, Eckart D. Gundelfinger, Karl Heinz Smalla, Ildiko Rita Dunay
Trapped in the epineurium: early entry into the endoneurium is restricted to neuritogenic T cells in experimental autoimmune neuritis
Anne K. Mausberg, Fabian Szepanowski, Francesca Odoardi, Alexander Flügel, Christoph Kleinschnitz, Mark Stettner, Bernd C. Kieseier
Fibronectin aggregates promote features of a classically and alternatively activated phenotype in macrophages
Arend H. Sikkema, Josephine M. J. Stoffels, Peng Wang, Frederike J. Basedow, Robbert Bulsink, Jeffrey J. Bajramovic, Wia Baron
Splenic involvement in umbilical cord matrix-derived mesenchymal stromal cell-mediated effects following traumatic spinal cord injury
Anna Badner, Justin Hacker, James Hong, Mirriam Mikhail, Reaz Vawda, Michael G. Fehlings
2-arachidonyl glycerol modulates astrocytic glutamine synthetase via p38 and ERK1/2 pathways
Shenghong Wang, Hua Zhang, Bin Geng, Qiqi Xie, Wenzhou Li, Yajun Deng, Weidong Shi, Yunyan Pan, Xuewen Kang, Jing Wang
Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation
Xinjian Zhu, Xiaolin Li, Mengyi Zhu, Kangni Xu, Li Yang, Bing Han, Rongrong Huang, Aifeng Zhang, Honghong Yao
Methylprednisolone treatment enhances early recovery following surgical decompression for degenerative cervical myelopathy without compromise to the systemic immune system
Pia M. Vidal, Antigona Ulndreaj, Anna Badner, James Hong, Michael G. Fehlings
Fas-ligand and interleukin-6 in the cerebrospinal fluid are early predictors of hypoxic-ischemic encephalopathy and long-term outcomes after birth asphyxia in term infants
Kristin Leifsdottir, Huseyin Mehmet, Staffan Eksborg, Eric Herlenius
K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression
Ji Yeon Choi, In Jun Yeo, Ki Cheon Kim, Won Rack Choi, Jae-Kyung Jung, Sang-Bae Han, Jin Tae Hong
Anti-CD52 antibody treatment depletes B cell aggregates in the central nervous system in a mouse model of multiple sclerosis
Micha Simon, Rojda Ipek, György A. Homola, Damiano M. Rovituso, Andrea Schampel, Christoph Kleinschnitz, Stefanie Kuerten
The plasticity of primary microglia and their multifaceted effects on endogenous neural stem cells in vitro and in vivo
Sabine Ulrike Vay, Lea Jessica Flitsch, Monika Rabenstein, Rebecca Rogall, Stefan Blaschke, Judith Kleinhaus, Noémie Reinert, Annika Bach, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger
Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model
Atsushi Fujita, Hiroo Yamaguchi, Ryo Yamasaki, Yiwen Cui, Yuta Matsuoka, Ken-ichi Yamada, Jun-ichi Kira
Prenatal influenza vaccination rescues impairments of social behavior and lamination in a mouse model of autism
Yingying Wu, Fangfang Qi, Dan Song, Zitian He, Zejie Zuo, Yunjie Yang, Qiongliang Liu, Saisai Hu, Xiao Wang, Xiaona Zheng, Junhua Yang, Qunfang Yuan, Juntao Zou, Kaihua Guo, Zhibin Yao
RAS modulation prevents progressive cognitive impairment after experimental stroke: a randomized, blinded preclinical trial
Heba A. Ahmed, Tauheed Ishrat, Bindu Pillai, Abdelrahman Y. Fouda, Mohammed A. Sayed, Wael Eldahshan, Jennifer L. Waller, Adviye Ergul, Susan C. Fagan
Neuroprotection and immunomodulation following intraspinal axotomy of motoneurons by treatment with adult mesenchymal stem cells
A. B. Spejo, G. B. Chiarotto, A. D. F. Ferreira, D. A. Gomes, R. S. Ferreira Jr, B. Barraviera, A. L. R. Oliveira
TSG-6 attenuates inflammation-induced brain injury via modulation of microglial polarization in SAH rats through the SOCS3/STAT3 pathway
Ran Li, Wenchao Liu, Jian Yin, Yunchang Chen, Shenquan Guo, Haiyan Fan, Xifeng Li, Xin Zhang, Xuying He, Chuanzhi Duan
High-dose intravenous immunoglobulins reduce nerve macrophage infiltration and the severity of bortezomib-induced peripheral neurotoxicity in rats
Cristina Meregalli, Ivan Marjanovic, Carla Scali, Laura Monza, Nadia Spinoni, Cristina Galliani, Rinaldo Brivio, Alessia Chiorazzi, Elisa Ballarini, Virginia Rodriguez-Menendez, Valentina Alda Carozzi, Paola Alberti, Giulia Fumagalli, Eleonora Pozzi, Annalisa Canta, Marina Quartu, Chiara Briani, Norberto Oggioni, Paola Marmiroli, Guido Cavaletti
Combined effect of non-bacteriolytic antibiotic and inhibition of matrix metalloproteinases prevents brain injury and preserves learning, memory and hearing function in experimental paediatric pneumococcal meningitis
Lukas Muri, Denis Grandgirard, Michelle Buri, Michael Perny, Stephen L. Leib
Effect of tumor necrosis factor-α on the expression of the ammonia transporter Rhcg in the brain in mice with acute liver failure
Wen Wang, Hui Lu, Xu Lu, Donglei Wang, Zhaohan Wang, Wenying Dai, Jinyong Wang, Pei Liu
Perioperative use of cefazolin ameliorates postoperative cognitive dysfunction but induces gut inflammation in mice
Peng Liang, Weiran Shan, Zhiyi Zuo
Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus
Johanna Breuer, Eva Korpos, Melanie-Jane Hannocks, Tilman Schneider-Hohendorf, Jian Song, Lisa Zondler, Sebastian Herich, Ken Flanagan, Thomas Korn, Alexander Zarbock, Tanja Kuhlmann, Lydia Sorokin, Heinz Wiendl, Nicholas Schwab
Cell permeable HMGB1-binding heptamer peptide ameliorates neurovascular complications associated with thrombolytic therapy in rats with transient ischemic stroke
Miaodan Li, Shumin Chen, Xue Shi, Chenfei Lyu, Yongfang Zhang, Miaoqin Tan, Chen Wang, Nailiang Zang, Xiaoxi Liu, Yafang Hu, Jiangang Shen, Liang Zhou, Yong Gu
Activation of neuronal N-methyl-d-aspartate receptor plays a pivotal role in Japanese encephalitis virus-induced neuronal cell damage
Zheng Chen, Xugang Wang, Usama Ashraf, Bohan Zheng, Jing Ye, Dengyuan Zhou, Hao Zhang, Yunfeng Song, Huanchun Chen, Shuhong Zhao, Shengbo Cao
Extracellular vesicles are increased in the serum of children with autism spectrum disorder, contain mitochondrial DNA, and stimulate human microglia to secrete IL-1β
Irene Tsilioni, Theoharis C. Theoharides
The role of neutrophil granule proteins in neuroinflammation and Alzheimer’s disease
Amanda J. Stock, Anne Kasus-Jacobi, H. Anne Pereira
APP21 transgenic rats develop age-dependent cognitive impairment and microglia accumulation within white matter tracts
Nina Weishaupt, Qingfan Liu, Sheojung Shin, Ramandeep Singh, Yuksel Agca, Cansu Agca, Vladimir Hachinski, Shawn Narain Whitehead
Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia/reperfusion injury
Zhe Gong, Jingrui Pan, Qingyu Shen, Mei Li, Ying Peng
NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson’s disease
Li Cheng, Lin Chen, Xinbing Wei, Yimeng Wang, Zhiping Ren, Shenglan Zeng, Xiumei Zhang, Haitao Wen, Chengjiang Gao, Huiqing Liu
Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson’s disease
Gregory P. Williams, Aubrey M. Schonhoff, Asta Jurkuvenaite, Aaron D. Thome, David G. Standaert, Ashley S. Harms
Microglia P2X4 receptor contributes to central sensitization following recurrent nitroglycerin stimulation
Ting Long, Wei He, Qi Pan, Shanshan Zhang, Yixin Zhang, Chaoyang Liu, Qing Liu, Guangcheng Qin, Lixue Chen, Jiying Zhou
ITGB4 deficiency in bronchial epithelial cells directs airway inflammation and bipolar disorder-related behavior
Li Han, Leyuan Wang, Sha Tang, Lin Yuan, Shuangyan Wu, Xizi Du, Yang Xiang, Xiangping Qu, Huijun Liu, Huaiqing Luo, Xiaoqun Qin, Chi Liu
Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid
Ana Rubio-Araiz, Orla M. Finucane, Samuel Keogh, Marina A. Lynch
Effect of tryptase on mouse brain microvascular endothelial cells via protease-activated receptor 2
Qin Zhou, Yi-wei Wang, Peng-fei Ni, Yi-nan Chen, Hong-quan Dong, Yan-ning Qian
Vitamin D protects dopaminergic neurons against neuroinflammation and oxidative stress in hemiparkinsonian rats
Ludmila A R Lima, Maria Janice P Lopes, Roberta O Costa, Francisco Arnaldo V Lima, Kelly Rose T Neves, Iana B F Calou, Geanne M Andrade, Glauce S B Viana
Inhibiting aberrant p53-PUMA feedback loop activation attenuates ischaemia reperfusion-induced neuroapoptosis and neuroinflammation in rats by downregulating caspase 3 and the NF-κB cytokine pathway
Xiao-Qian Li, Qian Yu, Feng-Shou Chen, Wen-Fei Tan, Zai-Li Zhang, Hong Ma
Intracellular inflammatory and antioxidant pathways in postmortem frontal cortex of subjects with major depression: effect of antidepressants
David Martín-Hernández, Javier R. Caso, J. Javier Meana, Luis F. Callado, José L. M. Madrigal, Borja García-Bueno, Juan C. Leza
Hippocampal Mrp8/14 signaling plays a critical role in the manifestation of depressive-like behaviors in mice
Hong Gong, Wen-Jun Su, Zhi-Yong Cao, Yong-Jie Lian, Wei Peng, Yun-Zi Liu, Yi Zhang, Lin-Lin Liu, Ran Wu, Bo Wang, Ting Zhang, Yun-Xia Wang, Chun-Lei Jiang
Macrophage migration inhibitory factor facilitates production of CCL5 in astrocytes following rat spinal cord injury
Yue Zhou, Wei Guo, Zhenjie Zhu, Yuming Hu, Yingjie Wang, Xuejie Zhang, Wenjuan Wang, Nan Du, Tiancheng Song, Kaini Yang, Zongyu Guan, Yongjun Wang, Aisong Guo
Complement activation contributes to perioperative neurocognitive disorders in mice
Chao Xiong, Jinhu Liu, Dandan Lin, Juxia Zhang, Niccolò Terrando, Anshi Wu
A comparison of brain magnetic resonance imaging lesions in multiple sclerosis by race with reference to disability progression
Yuri Nakamura, Laura Gaetano, Takuya Matsushita, Altermatt Anna, Till Sprenger, Ernst-Wilhelm Radue, Jens Wuerfel, Lorena Bauer, Michael Amann, Koji Shinoda, Noriko Isobe, Ryo Yamasaki, Takahiko Saida, Ludwig Kappos, Jun-ichi Kira
Human Alzheimer’s disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aβ plaque pathology
Sarah M. Rothman, Keith Q. Tanis, Pallavi Gandhi, Vladislav Malkov, Jacob Marcus, Michelle Pearson, Richard Stevens, Jason Gilliland, Christopher Ware, Veeravan Mahadomrongkul, Elaine O’Loughlin, Gonzalo Zeballos, Roger Smith, Bonnie J. Howell, Joel Klappenbach, Matthew Kennedy, Christian Mirescu
Characterization of a Listeria monocytogenes meningitis mouse model
Merel M. Koopmans, JooYeon Engelen-Lee, Matthijs C. Brouwer, Valery Jaspers, Wing Kit Man, Mercedes Vall Seron, Diederik van de Beek
α-Synuclein disrupts the anti-inflammatory role of Drd2 via interfering β-arrestin2-TAB1 interaction in astrocytes
Ren-Hong Du, Yan Zhou, Mei-Ling Xia, Ming Lu, Jian-Hua Ding, Gang Hu
The human microglial HMC3 cell line: where do we stand? A systematic literature review
Cinzia Dello Russo, Natalia Cappoli, Isabella Coletta, Daniele Mezzogori, Fabiola Paciello, Giacomo Pozzoli, Pierluigi Navarra, Alessandra Battaglia
Inflammation-induced Gro1 triggers senescence in neuronal progenitors: effects of estradiol
Svetlana Zonis, Joshua J. Breunig, Adam Mamelak, Kolja Wawrowsky, Catherine Bresee, Nadiya Ginzburg, Vera Chesnokova
Inhibition of NF-κB in astrocytes is sufficient to delay neurodegeneration induced by proteotoxicity in neurons
Y. X. Li, O. C. M. Sibon, P. F. Dijkers
Environmental enrichment reduces adolescent anxiety- and depression-like behaviors of rats subjected to infant nerve injury
Xingrui Gong, Yongmei Chen, Jing Chang, Yue Huang, Meihau Cai, Mazhong Zhang
Intraventricular infusion of quinolinic acid impairs spatial learning and memory in young rats: a novel mechanism of lead-induced neurotoxicity
Abdur Rahman, Muddanna S. Rao, Khalid M. Khan
Effect of PEA-OXA on neuropathic pain and functional recovery after sciatic nerve crush
Enrico Gugliandolo, Ramona D’amico, Marika Cordaro, Roberta Fusco, Rosalba Siracusa, Rosalia Crupi, Daniela Impellizzeri, Salvatore Cuzzocrea, Rosanna Di Paola
Exome sequencing study in patients with multiple sclerosis reveals variants associated with disease course
Elia Gil-Varea, Elena Urcelay, Carles Vilariño-Güell, Carme Costa, Luciana Midaglia, Fuencisla Matesanz, Alfredo Rodríguez-Antigüedad, Jorge Oksenberg, Laura Espino-Paisan, A. Dessa Sadovnick, Albert Saiz, Luisa M. Villar, Juan Antonio García-Merino, Lluís Ramió-Torrentà, Juan Carlos Triviño, Ester Quintana, René Robles, Antonio Sánchez-López, Rafael Arroyo, Jose C. Alvarez-Cermeño, Angela Vidal-Jordana, Sunny Malhotra, Nicolas Fissolo, Xavier Montalban, Manuel Comabella
NLRP3 inflammasome-dependent pyroptosis is proposed to be involved in the mechanism of age-dependent isoflurane-induced cognitive impairment
Lei Yin, Fangping Bao, Jing Wu, Kuanyu Li
A response to readers’ comments
Zhiyi Zuo, Zhi Wang, Shiyu Meng, Shuling Peng
Netrin-1 attenuates brain injury after middle cerebral artery occlusion via downregulation of astrocyte activation in mice
Xiaosong He, Yanqun Liu, Xiaohong Lin, Falei Yuan, Dahong Long, Zhijun Zhang, Yongting Wang, Aiguo Xuan, Guo-Yuan Yang
The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer’s disease
Sarah C. Hopp, Yang Lin, Derek Oakley, Allyson D. Roe, Sarah L. DeVos, David Hanlon, Bradley T. Hyman
Expression of the neuroprotective protein aryl hydrocarbon receptor nuclear translocator 2 correlates with neuronal stress and disability in models of multiple sclerosis
Tissa Rahim, Pierre Becquart, Maria-Elizabeth Baeva, Jacqueline Quandt
Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice
Hye Yeon Nam, Jin Han Nam, Gwangho Yoon, Ju-Young Lee, Youngpyo Nam, Hye-Jin Kang, Hyun-Ji Cho, Jeongyeon Kim, Hyang-Sook Hoe
Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets
Chuhyon Corwin, Anastasia Nikolopoulou, Allen L. Pan, Mariela Nunez-Santos, Shankar Vallabhajosula, Peter Serrano, John Babich, Maria E. Figueiredo-Pereira
Moderate hypothermia inhibits microglial activation after traumatic brain injury by modulating autophagy/apoptosis and the MyD88-dependent TLR4 signaling pathway
Fengchen Zhang, Haiping Dong, Tao Lv, Ke Jin, Yichao Jin, Xiaohua Zhang, Jiyao Jiang
Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice
M. S. Unger, P. Schernthaner, J. Marschallinger, H. Mrowetz, L. Aigner
ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells
Zhongyuan Tan, Wanpo Zhang, Jianhong Sun, Zuquan Fu, Xianliang Ke, Caishang Zheng, Yuan Zhang, Penghui Li, Yan Liu, Qinxue Hu, Hanzhong Wang, Zhenhua Zheng
Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease
Estella A. Newcombe, Judith Camats-Perna, Mallone L. Silva, Nicholas Valmas, Tee Jong Huat, Rodrigo Medeiros
Impact of nutrition on inflammation, tauopathy, and behavioral outcomes from chronic traumatic encephalopathy
Jin Yu, Hong Zhu, Saeid Taheri, William Mondy, Stephen Perry, Mark S. Kindy
Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy
Shane M. Bemiller, Nicole M. Maphis, Shane V. Formica, Gina N. Wilson, Crystal M. Miller, Guixiang Xu, Olga N. Kokiko-Cochran, Ki-Wook Kim, Steffen Jung, Judy L. Cannon, Samuel D. Crish, Astrid E. Cardona, Bruce T. Lamb, Kiran Bhaskar
LGI1 expression and human brain asymmetry: insights from patients with LGI1-antibody encephalitis
Yoonhyuk Jang, Soon-Tae Lee, Ji-Yeon Bae, Tae-Joon Kim, Jin-Sun Jun, Jangsup Moon, Keun-Hwa Jung, Kyung-Il Park, Sarosh R. Irani, Kon Chu, Sang Kun Lee
Analyses of gene expression profiles in the rat dorsal horn of the spinal cord using RNA sequencing in chronic constriction injury rats
Hui Du, Juan Shi, Ming Wang, Shuhong An, Xingjing Guo, Zhaojin Wang
Interaction of systemic oxidative stress and mesial temporal network degeneration in Parkinson’s disease with and without cognitive impairment
Pi-Ling Chiang, Hsiu-Ling Chen, Cheng-Hsien Lu, Yueh-Sheng Chen, Kun-Hsien Chou, Tun-Wei Hsu, Meng-Hsiang Chen, Nai-Wen Tsai, Shau-Hsuan Li, Wei-Che Lin
α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes
Taraneh Ebrahimi, Marcus Rust, Sarah Nele Kaiser, Alexander Slowik, Cordian Beyer, Andreas Rembert Koczulla, Jörg B. Schulz, Pardes Habib, Jan Philipp Bach
Effects of methylprednisolone on blood-brain barrier and cerebral inflammation in cardiac surgery—a randomized trial
Mattias Danielson, Björn Reinsfelt, Anne Westerlind, Henrik Zetterberg, Kaj Blennow, Sven-Erik Ricksten
Sphingosine 1-phosphate receptor subtype 3 (S1P3) contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarization
Bhakta Prasad Gaire, Mi-Ryoung Song, Ji Woong Choi
A central role for glial CCR5 in directing the neuropathological interactions of HIV-1 Tat and opiates
Sarah Kim, Yun Kyung Hahn, Elizabeth M Podhaizer, Virginia D McLane, Shiping Zou, Kurt F Hauser, Pamela E Knapp
The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD
Ju-Young Lee, Jin Han Nam, Youngpyo Nam, Hye Yeon Nam, Gwangho Yoon, Eunhwa Ko, Sang-Bum Kim, Mahealani R Bautista, Christina C Capule, Takaoki Koyanagi, Geoffray Leriche, Hwan Geun Choi, Jerry Yang, Jeongyeon Kim, Hyang-Sook Hoe
Adult neurogenic deficits in HIV-1 Tg26 transgenic mice
Raj Putatunda, Yonggang Zhang, Fang Li, Xiao-Feng Yang, Mary F Barbe, Wenhui Hu
Leukemia inhibitory factor modulates the peripheral immune response in a rat model of emergent large vessel occlusion
Stephanie M. Davis, Lisa A. Collier, Edric D. Winford, Christopher C. Leonardo, Craig T. Ajmo Jr, Elspeth A. Foran, Timothy J. Kopper, John C. Gensel, Keith R. Pennypacker
Central intracrine DHEA synthesis in ageing-related neuroinflammation and neurodegeneration: therapeutic potential?
Y S L Powrie, C Smith
The IFN-γ/PD-L1 axis between T cells and tumor microenvironment: hints for glioma anti-PD-1/PD-L1 therapy
Jiawen Qian, Chen Wang, Bo Wang, Jiao Yang, Yuedi Wang, Feifei Luo, Junying Xu, Chujun Zhao, Ronghua Liu, Yiwei Chu
New insights into meningitic Escherichia coli infection of brain microvascular endothelial cells from quantitative proteomics analysis
Wen-Tong Liu, Yu-Jin Lv, Rui-Cheng Yang, Ji-Yang Fu, Lu Liu, Huan Wang, Qi Cao, Chen Tan, Huan-Chun Chen, Xiang-Ru Wang
Reduction of SIRT1 epigenetically upregulates NALP1 expression and contributes to neuropathic pain induced by chemotherapeutic drug bortezomib
Kun Chen, Jing Fan, Zhao-Fan Luo, Ying Yang, Wen-Jun Xin, Cui-Cui Liu
Distinct contributions of hyperglycemia and high-fat feeding in metabolic syndrome-induced neuroinflammation
Brooke J. Wanrooy, Kathryn Prame Kumar, Shu Wen Wen, Cheng Xue Qin, Rebecca H. Ritchie, Connie H. Y. Wong
Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica
Tianjiao Duan, Alex J. Smith, Alan S. Verkman
Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3
Shinnosuke Yamada, Norimichi Itoh, Taku Nagai, Tsuyoshi Nakai, Daisuke Ibi, Akira Nakajima, Toshitaka Nabeshima, Kiyofumi Yamada
Circulating EZH2-positive T cells are decreased in multiple sclerosis patients
Sunny Malhotra, Luisa M. Villar, Carme Costa, Luciana Midaglia, Marta Cubedo, Silvia Medina, Nicolás Fissolo, Jordi Río, Joaquín Castilló, José C. Álvarez-Cermeño, Alex Sánchez, Xavier Montalban, Manuel Comabella
Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4
Isabella Russo, Giulietta Di Benedetto, Alice Kaganovich, Jinhui Ding, Daniela Mercatelli, Michele Morari, Mark R. Cookson, Luigi Bubacco, Elisa Greggio
Reduced gut microbiome protects from alcohol-induced neuroinflammation and alters intestinal and brain inflammasome expression
Patrick P. Lowe, Benedek Gyongyosi, Abhishek Satishchandran, Arvin Iracheta-Vellve, Yeonhee Cho, Aditya Ambade, Gyongyi Szabo
Hashimoto’s thyroiditis induces neuroinflammation and emotional alterations in euthyroid mice
Yao-Jun Cai, Fen Wang, Zhang-Xiang Chen, Li Li, Hua Fan, Zhang-Bi Wu, Jin-Fang Ge, Wen Hu, Qu-Nan Wang, De-Fa Zhu
Restoration of regulatory B cell deficiency following alemtuzumab therapy in patients with relapsing multiple sclerosis
Yeseul Kim, Gayoung Kim, Hyun-June Shin, Jae-Won Hyun, Su-Hyun Kim, Eunjig Lee, Ho Jin Kim
Peripheral myeloid cells contribute to brain injury in male neonatal mice
Peter L. P. Smith, Amin Mottahedin, Pernilla Svedin, Carl-Johan Mohn, Henrik Hagberg, Joakim Ek, Carina Mallard
Chronic relapsing inflammatory optic neuropathy (CRION): a manifestation of myelin oligodendrocyte glycoprotein antibodies
Haeng-Jin Lee, Boram Kim, Patrick Waters, Mark Woodhall, Sarosh Irani, Sohyun Ahn, Seong-Joon Kim, Sung-Min Kim
HIV-1 Nef-induced lncRNA AK006025 regulates CXCL9/10/11 cluster gene expression in astrocytes through interaction with CBP/P300
Feng Zhou, Xiaomei Liu, Dongjiao Zuo, Min Xue, Lin Gao, Ying Yang, Jing Wang, Liping Niu, Qianwen Cao, Xiangyang Li, Hui Hua, Bo Zhang, Minmin Hu, Dianshuai Gao, Kuiyang Zheng, Yoshihiro Izumiya, Renxian Tang
CSF sTREM2 in delirium—relation to Alzheimer’s disease CSF biomarkers Aβ42, t-tau and p-tau
Kristi Henjum, Else Quist-Paulsen, Henrik Zetterberg, Kaj Blennow, Lars N. G. Nilsson, Leiv Otto Watne
Cerebrospinal fluid pro-inflammatory cytokines differentiate parkinsonian syndromes
C. Starhof, K. Winge, N. H. H. Heegaard, K. Skogstrand, S. Friis, A. Hejl
TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity
V. Alexandra Moser, Mariana F. Uchoa, Christian J. Pike
Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study
Tanja Blume, Carola Focke, Finn Peters, Maximilian Deussing, Nathalie L. Albert, Simon Lindner, Franz-Josef Gildehaus, Barbara von Ungern-Sternberg, Laurence Ozmen, Karlheinz Baumann, Peter Bartenstein, Axel Rominger, Jochen Herms, Matthias Brendel
Ibuprofen prevents progression of ataxia telangiectasia symptoms in ATM-deficient mice
Chin Wai Hui, Xuan Song, Fulin Ma, Xuting Shen, Karl Herrup
Protein kinase C-delta inhibition protects blood-brain barrier from sepsis-induced vascular damage
Yuan Tang, Fariborz Soroush, Shuang Sun, Elisabetta Liverani, Jordan C. Langston, Qingliang Yang, Laurie E. Kilpatrick, Mohammad F. Kiani
Omega-3 polyunsaturated fatty acid attenuates traumatic brain injury-induced neuronal apoptosis by inducing autophagy through the upregulation of SIRT1-mediated deacetylation of Beclin-1
Xiangrong Chen, Zhigang Pan, Zhongning Fang, Weibin Lin, Shukai Wu, Fuxing Yang, Yasong Li, Huangde Fu, Hongzhi Gao, Shun Li
Partial reduction of microglia does not affect tau pathology in aged mice
Rachel E. Bennett, Annie Bryant, Miwei Hu, Ashley B. Robbins, Sarah C. Hopp, Bradley T. Hyman
Age-related deregulation of TDP-43 after stroke enhances NF-κB-mediated inflammation and neuronal damage
Sai Sampath Thammisetty, Jordi Pedragosa, Yuan Cheng Weng, Frédéric Calon, Anna Planas, Jasna Kriz
Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma
Mohammad Harun-Or-Rashid, Denise M. Inman
In vivo assessment of neuroinflammation in progressive multiple sclerosis: a proof of concept study with [18F]DPA714 PET
Marloes H. J. Hagens, Sandeep V. Golla, Martijn T. Wijburg, Maqsood Yaqub, Dennis Heijtel, Martijn D. Steenwijk, Patrick Schober, John J. P. Brevé, Robert C. Schuit, Tristan A. Reekie, Michael Kassiou, Anne-Marie van Dam, Albert D. Windhorst, Joep Killestein, Frederik Barkhof, Bart N. M. van Berckel, Adriaan A. Lammertsma
Human neural stem cell-derived neuron/astrocyte co-cultures respond to La Crosse virus infection with proinflammatory cytokines and chemokines
Brian E. Dawes, Junling Gao, Colm Atkins, Jacob T. Nelson, Kendra Johnson, Ping Wu, Alexander N. Freiberg
Ca2+-dependent endoplasmic reticulum stress correlation with astrogliosis involves upregulation of KCa3.1 and inhibition of AKT/mTOR signaling
Zhihua Yu, Fangfang Dou, Yanxia Wang, Lina Hou, Hongzhuan Chen
Correction to: HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway
Shalini Swaroop, Anita Mahadevan, Susarla Krishna Shankar, Yogita K. Adlakha, Anirban Basu
Varicella zoster virus differentially alters morphology and suppresses proinflammatory cytokines in primary human spinal cord and hippocampal astrocytes
Andrew N. Bubak, Christina N. Como, Anna M. Blackmon, Dallas Jones, Maria A. Nagel
Neutrophil to lymphocyte ratio predicts intracranial hemorrhage after endovascular thrombectomy in acute ischemic stroke
Slaven Pikija, Laszlo K. Sztriha, Monika Killer-Oberpfalzer, Friedrich Weymayr, Constantin Hecker, Christian Ramesmayer, Larissa Hauer, Johann Sellner
Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines
Ting Zhang, Nan Zhang, Run Zhang, Weidong Zhao, Yong Chen, Zilong Wang, Biao Xu, Mengna Zhang, Xuerui Shi, Qinqin Zhang, Yuanyuan Guo, Jian Xiao, Dan Chen, Quan Fang
Anti-inflammatory effects induced by pharmaceutical substances on inflammatory active brain astrocytes—promising treatment of neuroinflammation
Elisabeth Hansson, Ulrika Björklund, Eva Skiöldebrand, Lars Rönnbäck
Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells
Soraya Wilke Saliba, Hannah Jauch, Brahim Gargouri, Albrecht Keil, Thomas Hurrle, Nicole Volz, Florian Mohr, Mario van der Stelt, Stefan Bräse, Bernd L. Fiebich
STING-mediated type-I interferons contribute to the neuroinflammatory process and detrimental effects following traumatic brain injury
Amar Abdullah, Moses Zhang, Tony Frugier, Sammy Bedoui, Juliet M. Taylor, Peter J. Crack
Glial-neuronal signaling mechanisms underlying the neuroinflammatory effects of manganese
Katriana A. Popichak, Maryam F. Afzali, Kelly S. Kirkley, Ronald B. Tjalkens
A central role for P2X7 receptors in human microglia
Laura Janks, Cristian V. R. Sharma, Terrance M. Egan
Anti-inflammatory and anti-oxidant mechanisms of an MMP-8 inhibitor in lipoteichoic acid-stimulated rat primary astrocytes: involvement of NF-κB, Nrf2, and PPAR-γ signaling pathways
Eun-Jung Lee, Jin-Sun Park, Yu-Young Lee, Do-Yeon Kim, Jihee Lee Kang, Hee-Sun Kim
High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections
Else Quist-Paulsen, Pål Aukrust, Anne-Marte Bakken Kran, Oona Dunlop, Vidar Ormaasen, Birgitte Stiksrud, Øivind Midttun, Thor Ueland, Per Magne Ueland, Tom Eirik Mollnes, Anne Ma Dyrhol-Riise
Effect of NAC treatment and physical activity on neuroinflammation in subchronic Parkinsonism; is physical activity essential?
Ana-Luisa Gil-Martínez, Lorena Cuenca, Consuelo Sánchez, Cristina Estrada, Emiliano Fernández-Villalba, María Trinidad Herrero
Inflammation is correlated with severity and outcome of cerebral venous thrombosis
Liyan Wang, Jiangang Duan, Tingting Bian, Ran Meng, Longfei Wu, Zhen Zhang, Xuxiang Zhang, Chunxiu Wang, Xunming Ji
Lipocalin 2 contributes to brain iron dysregulation but does not affect cognition, plaque load, and glial activation in the J20 Alzheimer mouse model
Doortje W. Dekens, Petrus J. W. Naudé, Jan N. Keijser, Ate S. Boerema, Peter P. De Deyn, Ulrich L. M. Eisel
Profiling the proteomic inflammatory state of human astrocytes using DIA mass spectrometry
Vito Dozio, Jean-Charles Sanchez
IL-17A contributes to perioperative neurocognitive disorders through blood-brain barrier disruption in aged mice
Pengfei Ni, Hongquan Dong, Yiwei Wang, Qin Zhou, Mengmeng Xu, Yanning Qian, Jie Sun
Counteracting neuroinflammation in experimental Parkinson’s disease favors recovery of function: effects of Er-NPCs administration
Stephana Carelli, Toniella Giallongo, Zuzana Gombalova, Federica Rey, Maria Carlotta F. Gorio, Massimiliano Mazza, Anna Maria Di Giulio
Phosphatidylserine-microbubble targeting-activated microglia/macrophage in inflammation combined with ultrasound for breaking through the blood–brain barrier
Ranran Zhao, Jie Jiang, Huiwen Li, Min Chen, Renfa Liu, Sujuan Sun, De Ma, Xiaolong Liang, Shumin Wang
Regulatory role of capsaicin-sensitive peptidergic sensory nerves in the proteoglycan-induced autoimmune arthritis model of the mouse
Ádám Horváth, Éva Borbély, Kata Bölcskei, Nikolett Szentes, Tamás Kiss, Mátyás Belák, Tibor Rauch, Tibor Glant, Róza Zákány, Tamás Juhász, Edina Karanyicz, Ferenc Boldizsár, Zsuzsanna Helyes, Bálint Botz
Persistent reduction in sialylation of cerebral glycoproteins following postnatal inflammatory exposure
Ekaterina P. Demina, Wyston C. Pierre, Annie L. A. Nguyen, Irene Londono, Bela Reiz, Chunxia Zou, Radhika Chakraberty, Christopher W. Cairo, Alexey V. Pshezhetsky, Gregory A. Lodygensky
The GLP-1 analog, liraglutide prevents the increase of proinflammatory mediators in the hippocampus of male rat pups submitted to maternal perinatal food restriction
Y. Diz-Chaves, L. Toba, J. Fandiño, L. C. González-Matías, L. M. Garcia-Segura, F. Mallo
Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression
Qiqi Song, Cuiqin Fan, Peng Wang, Ye Li, Mu Yang, Shu Yan Yu
Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke
Liang Zhao, Qiutang Xiong, Creed M. Stary, Omer Kamal Mahgoub, Yingze Ye, Lijuan Gu, Xiaoxing Xiong, Shengmei Zhu
Colony-stimulating factor 1 receptor inhibition prevents disruption of the blood-retina barrier during chronic inflammation
Despina Kokona, Andreas Ebneter, Pascal Escher, Martin S. Zinkernagel
Methamphetamine neurotoxicity, microglia, and neuroinflammation
Fatemeh Shaerzadeh, Wolfgang J. Streit, Soomaayeh Heysieattalab, Habibeh Khoshbouei
Circulating levels of IL-1 family cytokines and receptors in Alzheimer’s disease: new markers of disease progression?
Paola Italiani, Ilaria Puxeddu, Sabrina Napoletano, Emanuele Scala, Daniela Melillo, Simone Manocchio, Antonella Angiolillo, Paola Migliorini, Diana Boraschi, Emilia Vitale, Alfonso Di Costanzo
The atypical RhoGTPase RhoE/Rnd3 is a key molecule to acquire a neuroprotective phenotype in microglia
Veronika E. Neubrand, Irene Forte-Lago, Marta Caro, Mario Delgado
Monocyte infiltration rather than microglia proliferation dominates the early immune response to rapid photoreceptor degeneration
Sarah J. Karlen, Eric B. Miller, Xinlei Wang, Emily S. Levine, Robert J. Zawadzki, Marie E. Burns
A mathematical model of neuroinflammation in severe clinical traumatic brain injury
Leah E. Vaughan, Prerna R. Ranganathan, Raj G. Kumar, Amy K. Wagner, Jonathan E. Rubin
Imaging glial activation in patients with post-treatment Lyme disease symptoms: a pilot study using [11C]DPA-713 PET
Jennifer M. Coughlin, Ting Yang, Alison W. Rebman, Kathleen T. Bechtold, Yong Du, William B. Mathews, Wojciech G. Lesniak, Erica A. Mihm, Sarah M. Frey, Erica S. Marshall, Hailey B. Rosenthal, Tristan A. Reekie, Michael Kassiou, Robert F. Dannals, Mark J. Soloski, John N. Aucott, Martin G. Pomper
Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NF-κB signaling pathway
Fu-yi Liu, Jing Cai, Chun Wang, Wu Ruan, Guo-ping Guan, Hai-zhou Pan, Jian-ru Li, Cong Qian, Jing-sen Chen, Lin Wang, Gao Chen
A review of the role of cav-1 in neuropathology and neural recovery after ischemic stroke
Qianyi Huang, Wei Zhong, Zhiping Hu, Xiangqi Tang
Sequential alteration of microglia and astrocytes in the rat thalamus following spinal nerve ligation
Lucie Blaszczyk, Marlène Maître, Thierry Lesté-Lasserre, Samantha Clark, Daniela Cota, Stéphane H. R. Oliet, Valérie S. Fénelon