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Zeitschrift

Journal of Neuroinflammation

Journal of Neuroinflammation 1/2018

Ausgabe 1/2018

Inhaltsverzeichnis ( 349 Artikel )

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inhibition of cyclin-dependent kinase 5 affects early neuroinflammatory signalling in murine model of amyloid beta toxicity

Anna Wilkaniec, Magdalena Gąssowska-Dobrowolska, Marcin Strawski, Agata Adamczyk, Grzegorz A. Czapski

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Activation of dopamine D1 receptor decreased NLRP3-mediated inflammation in intracerebral hemorrhage mice

Tian Wang, Derek Nowrangi, Lingyan Yu, Tai Lu, Jiping Tang, Bing Han, Yuxin Ding, Fenghua Fu, John H. Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Role of the indoleamine-2,3-dioxygenase/kynurenine pathway of tryptophan metabolism in behavioral alterations in a hepatic encephalopathy rat model

Xi Jiang, Lexing Xu, Lin Tang, Fuhe Liu, Ziwei Chen, Jiajia Zhang, Lei Chen, Cong Pang, Xuefeng Yu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Hypercapnia induces IL-1β overproduction via activation of NLRP3 inflammasome: implication in cognitive impairment in hypoxemic adult rats

Hong-Guang Ding, Yi-Yu Deng, Ren-qiang Yang, Qiao-Sheng Wang, Wen-Qiang Jiang, Yong-Li Han, Lin-Qiang Huang, Miao-Yun Wen, Wen-Hong Zhong, Xu-Sheng Li, Fan Yang, Hong-Ke Zeng

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Laquinimod ameliorates excitotoxic damage by regulating glutamate re-uptake

Antonietta Gentile, Alessandra Musella, Francesca De Vito, Diego Fresegna, Silvia Bullitta, Francesca Romana Rizzo, Diego Centonze, Georgia Mandolesi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Curcumin attenuates collagen-induced inflammatory response through the “gut-brain axis”

Yannong Dou, Jinque Luo, Xin Wu, Zhifeng Wei, Bei Tong, Juntao Yu, Ting Wang, Xinyu Zhang, Yan Yang, Xusheng Yuan, Peng Zhao, Yufeng Xia, Huijuan Hu, Yue Dai

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex

Marianna Stamou, Ana Cristina Grodzki, Marc van Oostrum, Bernd Wollscheid, Pamela J. Lein

01.12.2018 | Research | Ausgabe 1/2018 Open Access

In vivo evidence for the contribution of peripheral circulating inflammatory exosomes to neuroinflammation

Jing Jing Li, Bin Wang, Mahesh Chandra Kodali, Chao Chen, Eunhee Kim, Benjamin John Patters, Lubin Lan, Santosh Kumar, Xinjun Wang, Junming Yue, Francesca-Fang Liao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

WWL70 protects against chronic constriction injury-induced neuropathic pain in mice by cannabinoid receptor-independent mechanisms

Jie Wen, Melissa Jones, Mikiei Tanaka, Prabhuanand Selvaraj, Aviva J. Symes, Brian Cox, Yumin Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Dietary fats promote functional and structural changes in the median eminence blood/spinal fluid interface—the protective role for BDNF

Albina F. Ramalho, Bruna Bombassaro, Nathalia R. Dragano, Carina Solon, Joseane Morari, Milena Fioravante, Roberta Barbizan, Licio A. Velloso, Eliana P. Araujo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Decreased microglial activation through gut-brain axis by prebiotics, probiotics, or synbiotics effectively restored cognitive function in obese-insulin resistant rats

Titikorn Chunchai, Wannipa Thunapong, Sakawdaurn Yasom, Keerati Wanchai, Sathima Eaimworawuthikul, Gabrielle Metzler, Anusorn Lungkaphin, Anchalee Pongchaidecha, Sasithorn Sirilun, Chaiyavat Chaiyasut, Wasana Pratchayasakul, Parameth Thiennimitr, Nipon Chattipakorn, Siriporn C. Chattipakorn

01.12.2018 | Research | Ausgabe 1/2018 Open Access

IL-33/ST2 signaling contributes to radicular pain by modulating MAPK and NF-κB activation and inflammatory mediator expression in the spinal cord in rat models of noncompressive lumber disk herniation

Si-Jian Huang, Jian-Qin Yan, Hui Luo, Lu-Yao Zhou, Jian-Gang Luo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

MicroRNA-124 regulates the expression of MEKK3 in the inflammatory pathogenesis of Parkinson’s disease

Longping Yao, Yongyi Ye, Hengxu Mao, Fengfei Lu, Xiaozheng He, Guohui Lu, Shizhong Zhang

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome

Elizabeth Nance, Siva P. Kambhampati, Elizabeth S. Smith, Zhi Zhang, Fan Zhang, Sarabdeep Singh, Michael V. Johnston, Rangaramanujam M. Kannan, Mary E. Blue, Sujatha Kannan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Evidence for the activation of pyroptotic and apoptotic pathways in RPE cells associated with NLRP3 inflammasome in the rodent eye

Jiangyuan Gao, Jing Z. Cui, Eleanor To, Sijia Cao, Joanne A. Matsubara

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A novel IL-1RA-PEP fusion protein alleviates blood-brain barrier disruption after ischemia-reperfusion in male rats

Dong-Dong Zhang, Chen Jin, Ya-Tao Zhang, Xiang-Dong Gan, Min-Ji Zou, Yuan-Yuan Wang, Wen-Liang Fu, Tao Xu, Wei-Wei Xing, Wen-Ron Xia, Dong-Gang Xu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Oxidative stress predicts cognitive decline with aging in healthy adults: an observational study

Ihab Hajjar, Salim S. Hayek, Felicia C. Goldstein, Greg Martin, Dean P. Jones, Arshed Quyyumi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Transcriptional profile and Epstein-Barr virus infection status of laser-cut immune infiltrates from the brain of patients with progressive multiple sclerosis

Caterina Veroni, Barbara Serafini, Barbara Rosicarelli, Corrado Fagnani, Francesca Aloisi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Benefits of VCE-003.2, a cannabigerol quinone derivative, against inflammation-driven neuronal deterioration in experimental Parkinson’s disease: possible involvement of different binding sites at the PPARγ receptor

Concepción García, María Gómez-Cañas, Sonia Burgaz, Belén Palomares, Yolanda Gómez-Gálvez, Cristina Palomo-Garo, Sara Campo, Joel Ferrer-Hernández, Carolina Pavicic, Carmen Navarrete, M. Luz Bellido, Moisés García-Arencibia, M. Ruth Pazos, Eduardo Muñoz, Javier Fernández-Ruiz

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation

Maike Kuhn, Kurt-Wolfram Sühs, Manas K. Akmatov, Frank Klawonn, Junxi Wang, Thomas Skripuletz, Volkhard Kaever, Martin Stangel, Frank Pessler

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Microglial activation mediates chronic mild stress-induced depressive- and anxiety-like behavior in adult rats

Ya-Lin Wang, Qiu-Qin Han, Wen-Qing Gong, Dong-Hui Pan, Li-Zheng Wang, Wei Hu, Min Yang, Bing Li, Jin Yu, Qiong Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Baló’s concentric sclerosis is immunologically distinct from multiple sclerosis: results from retrospective analysis of almost 150 lumbar punctures

S. Jarius, C. Würthwein, J. R. Behrens, J. Wanner, J. Haas, F. Paul, B. Wildemann

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Unconjugated bilirubin induces pyroptosis in cultured rat cortical astrocytes

Jie Feng, Mengwen Li, Qian Wei, Shengjun Li, Sijie Song, Ziyu Hua

01.12.2018 | Review | Ausgabe 1/2018 Open Access

The role of the complement system in traumatic brain injury: a review

Adnan Hammad, Laura Westacott, Malik Zaben

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation

Slava Rom, Viviana Zuluaga-Ramirez, Nancy L. Reichenbach, Michelle A. Erickson, Malika Winfield, Sachin Gajghate, Melpo Christofidou-Solomidou, Kelly L. Jordan-Sciutto, Yuri Persidsky

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Laquinimod attenuates inflammation by modulating macrophage functions in traumatic brain injury mouse model

Atsuko Katsumoto, Aline S. Miranda, Oleg Butovsky, Antônio L. Teixeira, Richard M. Ransohoff, Bruce T. Lamb

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Upregulation of HMGB1-TLR4 inflammatory pathway in focal cortical dysplasia type II

Zhongbin Zhang, Qingzhu Liu, Ming Liu, Hui Wang, Ying Dong, Taoyun Ji, Xiaoyan Liu, Yuwu Jiang, Lixin Cai, Ye Wu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation

Joana Costa d’Avila, Luciana Domett Siqueira, Aurélien Mazeraud, Estefania Pereira Azevedo, Debora Foguel, Hugo Caire Castro-Faria-Neto, Tarek Sharshar, Fabrice Chrétien, Fernando Augusto Bozza

01.12.2018 | Research | Ausgabe 1/2018 Open Access

miRNA-23a/CXCR4 regulates neuropathic pain via directly targeting TXNIP/NLRP3 inflammasome axis

Zhiqiang Pan, Qun Shan, Pan Gu, Xiao Min Wang, Lydia Wai Tai, Menglan Sun, Xin Luo, Liting Sun, Chi Wai Cheung

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The role of HFE genotype in macrophage phenotype

Anne M. Nixon, Elizabeth Neely, Ian A. Simpson, James R. Connor

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Chi3l3: a potential key orchestrator of eosinophil recruitment in meningitis induced by Angiostrongylus cantonensis

Shuo Wan, Xiaoqiang Sun, Feng Wu, Zilong Yu, Lifu Wang, Datao Lin, Zhengyu Li, Zhongdao Wu, Xi Sun

01.12.2018 | Research | Ausgabe 1/2018 Open Access

IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic–ischemic brain injury in rats

Di Chen, Brandon J. Dixon, Desislava M. Doycheva, Bo Li, Yang Zhang, Qin Hu, Yue He, Zongduo Guo, Derek Nowrangi, Jerry Flores, Valery Filippov, John H. Zhang, Jiping Tang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

18F-VC701-PET and MRI in the in vivo neuroinflammation assessment of a mouse model of multiple sclerosis

Sara Belloli, Lucia Zanotti, Valentina Murtaj, Cristina Mazzon, Giuseppe Di Grigoli, Cristina Monterisi, Valeria Masiello, Leonardo Iaccarino, Andrea Cappelli, Pietro Luigi Poliani, Letterio Salvatore Politi, Rosa Maria Moresco

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity

Soraya Wilke Saliba, Ariel R. Marcotegui, Ellen Fortwängler, Johannes Ditrich, Juan Carlos Perazzo, Eduardo Muñoz, Antônio Carlos Pinheiro de Oliveira, Bernd L. Fiebich

01.12.2018 | Short report | Ausgabe 1/2018 Open Access

Calcineurin A beta deficiency ameliorates HFD-induced hypothalamic astrocytosis in mice

Katrin Pfuhlmann, Sonja C. Schriever, Beata Legutko, Peter Baumann, Luke Harrison, Dhiraj G. Kabra, Emily Violette Baumgart, Matthias H. Tschöp, Cristina Garcia-Caceres, Paul T. Pfluger

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Hyperammonemia alters membrane expression of GluA1 and GluA2 subunits of AMPA receptors in hippocampus by enhancing activation of the IL-1 receptor: underlying mechanisms

Lucas Taoro-Gonzalez, Yaiza M. Arenas, Andrea Cabrera-Pastor, Vicente Felipo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Porphyromonas gingivalis lipopolysaccharide induces cognitive dysfunction, mediated by neuronal inflammation via activation of the TLR4 signaling pathway in C57BL/6 mice

Jing Zhang, Chunbo Yu, Xuan Zhang, Huiwen Chen, Jiachen Dong, Weili Lu, Zhongchen Song, Wei Zhou

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Systemic autoinflammation with intractable epilepsy managed with interleukin-1 blockade

Allen D. DeSena, Thuy Do, Grant S. Schulert

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Salidroside provides neuroprotection by modulating microglial polarization after cerebral ischemia

Xiangrong Liu, Shaohong Wen, Feng Yan, Kuan Liu, Liqiang Liu, Lei Wang, Shangfeng Zhao, Xunming Ji

01.12.2018 | Short report | Ausgabe 1/2018 Open Access

A clinical approach to new-onset psychosis associated with immune dysregulation: the concept of autoimmune psychosis

Souhel Najjar, Johann Steiner, Amanda Najjar, Karl Bechter

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Histamine upregulates the expression of histamine receptors and increases the neuroprotective effect of astrocytes

Jiawen Xu, Xiang Zhang, Qingqing Qian, Yiwei Wang, Hongquan Dong, Nana Li, Yanning Qian, Wenjie Jin

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Trovafloxacin attenuates neuroinflammation and improves outcome after traumatic brain injury in mice

Charu Garg, Joon Ho Seo, Jayalakshmi Ramachandran, Ji Meng Loh, Frances Calderon, Jorge E. Contreras

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer’s disease

Brad T. Casali, Erin G. Reed-Geaghan, Gary E. Landreth

01.12.2018 | Short report | Ausgabe 1/2018 Open Access

The role of glucocorticoid, interleukin-1β, and antioxidants in prenatal stress effects on embryonic microglia

Jada Bittle, Hanna E. Stevens

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brain

Marina S. Hernandes, Bernard Lassègue, Lula L. Hilenski, Jonathan Adams, Ning Gao, Chia-Yi Kuan, Yu-Yo Sun, Lihong Cheng, Daniel S. Kikuchi, Manuel Yepes, Kathy K. Griendling

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Cerebrospinal fluid level of Nogo receptor 1 antagonist lateral olfactory tract usher substance (LOTUS) correlates inversely with the extent of neuroinflammation

Keita Takahashi, Hideyuki Takeuchi, Yuji Kurihara, Hiroshi Doi, Misako Kunii, Kenichi Tanaka, Haruko Nakamura, Ryoko Fukai, Atsuko Tomita-Katsumoto, Mikiko Tada, Yuichi Higashiyama, Hideto Joki, Shigeru Koyano, Kohtaro Takei, Fumiaki Tanaka

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Effects of umbilical cord blood cells, and subtypes, to reduce neuroinflammation following perinatal hypoxic-ischemic brain injury

Courtney A. McDonald, Tayla R. Penny, Madison C. B. Paton, Amy E. Sutherland, Lakshmi Nekkanti, Tamara Yawno, Margie Castillo-Melendez, Michael C. Fahey, Nicole M. Jones, Graham Jenkin, Suzanne L. Miller

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Ablation of caspase-1 protects against TBI-induced pyroptosis in vitro and in vivo

Wei Liu, Yuhua Chen, Jiao Meng, Minfei Wu, Fangfang Bi, Cuicui Chang, Hua Li, Liangjun Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Lymphotoxin β receptor-mediated NFκB signaling promotes glial lineage differentiation and inhibits neuronal lineage differentiation in mouse brain neural stem/progenitor cells

Xiao Xiao, Raj Putatunda, Yonggang Zhang, Priya V. Soni, Fang Li, Ting Zhang, Mingyang Xin, Jin Jun Luo, John R. Bethea, Yuan Cheng, Wenhui Hu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Strain-dependent effects of clinical echovirus 30 outbreak isolates at the blood-CSF barrier

Tobias Dahm, Ortwin Adams, Sindy Boettcher, Sabine Diedrich, Vasily Morozov, Grant Hansman, Petra Fallier-Becker, Sebastian Schädler, Claus J. Burkhardt, Christel Weiss, Carolin Stump-Guthier, Hiroshi Ishikawa, Horst Schroten, Christian Schwerk, Tobias Tenenbaum, Henriette Rudolph

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Enhanced glycolysis contributes to the pathogenesis of experimental autoimmune neuritis

Ru-Tao Liu, Min Zhang, Chun-Lin Yang, Peng Zhang, Na Zhang, Tong Du, Meng-Ru Ge, Long-Tao Yue, Xiao-Li Li, Heng Li, Rui-Sheng Duan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor

Duy-Khanh Dang, Eun-Joo Shin, Dae-Joong Kim, Hai-Quyen Tran, Ji Hoon Jeong, Choon-Gon Jang, Seung-Yeol Nah, Jung Hwan Jeong, Jae Kyung Byun, Sung Kwon Ko, Guoying Bing, Jau-Shyong Hong, Hyoung-Chun Kim

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Neuregulin-1 elicits a regulatory immune response following traumatic spinal cord injury

Arsalan Alizadeh, Kallivalappil T. Santhosh, Hardeep Kataria, Abdelilah S. Gounni, Soheila Karimi-Abdolrezaee

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Intraocular DHODH-inhibitor PP-001 suppresses relapsing experimental uveitis and cytokine production of human lymphocytes, but not of RPE cells

Maria Diedrichs-Möhring, Sandy Niesik, Claudia S. Priglinger, Stephan R. Thurau, Franz Obermayr, Stefan Sperl, Gerhild Wildner

01.12.2018 | Research | Ausgabe 1/2018 Open Access

[18F]FSPG-PET reveals increased cystine/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis

Aileen Hoehne, Michelle L. James, Israt S. Alam, John A. Ronald, Bernadette Schneider, Aloma D’Souza, Timothy H. Witney, Lauren E. Andrews, Haley C. Cropper, Deepak Behera, Gayatri Gowrishankar, Zhaoqing Ding, Tony Wyss-Coray, Frederick T. Chin, Sandip Biswal, Sanjiv S. Gambhir

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The impact of metallothionein-II on microglial response to tumor necrosis factor-alpha (TNFα) and downstream effects on neuronal regeneration

Jacqueline Y. K. Leung, William R. Bennett, Anna E. King, Roger S. Chung

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Toxoplasma gondii alters NMDAR signaling and induces signs of Alzheimer’s disease in wild-type, C57BL/6 mice

Luisa Torres, Sudie-Ann Robinson, Do-Geun Kim, Angela Yan, Thomas A. Cleland, Margaret S. Bynoe

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Selective killing of spinal cord neural stem cells impairs locomotor recovery in a mouse model of spinal cord injury

Melania Cusimano, Elena Brambilla, Alessia Capotondo, Donatella De Feo, Antonio Tomasso, Giancarlo Comi, Patrizia D’Adamo, Luca Muzio, Gianvito Martino

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: the role of the complement system in traumatic brain injury: a review

Adnan Hammad, Laura Westacott, Malik Zaben

01.12.2018 | Short report | Ausgabe 1/2018 Open Access

Cellular and behavioral effects of lipopolysaccharide treatment are dependent upon neurokinin-1 receptor activation

Hannah D. Fulenwider, Britessia M. Smith, Anna S. Nichenko, Jessica M. Carpenter, Sadie E. Nennig, Kejun Cheng, Kenner C. Rice, Jesse R. Schank

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Mitochondrial damage and “plugging” of transport selectively in myelinated, small-diameter axons are major early events in peripheral neuroinflammation

Marija Sajic, Keila Kazue Ida, Ryan Canning, Norman A. Gregson, Michael R Duchen, Kenneth J Smith

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Differential effect of angiotensin II and blood pressure on hippocampal inflammation in mice

M. Florencia Iulita, Diane Vallerand, Mélissa Beauvillier, Nathalie Haupert, Corinne A. Ulysse, Audrey Gagné, Nathalie Vernoux, Sonia Duchemin, Michaël Boily, Marie-Ève Tremblay, Hélène Girouard

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The effect of excess weight on circulating inflammatory cytokines in drug-naïve first-episode psychosis individuals

María Juncal-Ruiz, Laura Riesco-Dávila, Víctor Ortiz-García de la Foz, Mariluz Ramírez-Bonilla, Obdulia Martínez-García, Juan Irure-Ventura, Juan Carlos Leza, Marcos López-Hoyos, Benedicto Crespo-Facorro

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy

Carmen Navarrete, Francisco Carrillo-Salinas, Belén Palomares, Miriam Mecha, Carla Jiménez-Jiménez, Leyre Mestre, Ana Feliú, Maria L. Bellido, Bernd L. Fiebich, Giovanni Appendino, Marco A. Calzado, Carmen Guaza, Eduardo Muñoz

01.12.2018 | Research | Ausgabe 1/2018 Open Access

RNS60 exerts therapeutic effects in the SOD1 ALS mouse model through protective glia and peripheral nerve rescue

Antonio Vallarola, Francesca Sironi, Massimo Tortarolo, Noemi Gatto, Roberta De Gioia, Laura Pasetto, Massimiliano De Paola, Alessandro Mariani, Supurna Ghosh, Richard Watson, Andreas Kalmes, Valentina Bonetto, Caterina Bendotti

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Nitrosative damage during retrovirus infection-induced neuropathic pain

Priyanka Chauhan, Wen S. Sheng, Shuxian Hu, Sujata Prasad, James R. Lokensgard

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Protective and therapeutic role of 2-carbacyclic phosphatidic acid in demyelinating disease

Shinji Yamamoto, Kota Yamashina, Masaki Ishikawa, Mari Gotoh, Sosuke Yagishita, Kensuke Iwasa, Kei Maruyama, Kimiko Murakami-Murofushi, Keisuke Yoshikawa

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis

Adriana Fernanda K. Vizuete, Fernanda Hansen, Elisa Negri, Marina Concli Leite, Diogo Losch de Oliveira, Carlos-Alberto Gonçalves

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Aging exacerbates development of cerebral microbleeds in a mouse model

Rachita K. Sumbria, Mher Mahoney Grigoryan, Vitaly Vasilevko, Annlia Paganini-Hill, Kelley Kilday, Ronald Kim, David H. Cribbs, Mark J. Fisher

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Heme oxygenase-1 promoter region (GT)n polymorphism associates with increased neuroimmune activation and risk for encephalitis in HIV infection

Alexander J. Gill, Rolando Garza, Surendra S. Ambegaokar, Benjamin B. Gelman, Dennis L. Kolson

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model

Michael Dietrich, Niklas Helling, Alexander Hilla, Annemarie Heskamp, Andrea Issberner, Thomas Hildebrandt, Zippora Kohne, Patrick Küry, Carsten Berndt, Orhan Aktas, Dietmar Fischer, Hans-Peter Hartung, Philipp Albrecht

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients

Ester Canto, Noriko Isobe, Alessandro Didonna, Stephen L. Hauser, Jorge R. Oksenberg, MS-EPIC Study Group

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor

Matthew L. Neal, Alexa M. Boyle, Kevin M. Budge, Fayez F. Safadi, Jason R. Richardson

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Oxysterol levels and metabolism in the course of neuroinflammation: insights from in vitro and in vivo models

Valentin Mutemberezi, Baptiste Buisseret, Julien Masquelier, Owein Guillemot-Legris, Mireille Alhouayek, Giulio G. Muccioli

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Sulforaphane rescues amyloid-β peptide-mediated decrease in MerTK expression through its anti-inflammatory effect in human THP-1 macrophages

Kyoung A. Jhang, Jin-Sun Park, Hee-Sun Kim, Young Hae Chong

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Teriflunomide promotes oligodendroglial differentiation and myelination

Peter Göttle, Anastasia Manousi, David Kremer, Laura Reiche, Hans-Peter Hartung, Patrick Küry

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Adipose stromal vascular fraction attenuates TH1 cell-mediated pathology in a model of multiple sclerosis

Annie C. Bowles, Rachel M. Wise, Brittany Y. Gerstein, Robert C. Thomas, Roberto Ogelman, Regan C. Manayan, Bruce A. Bunnell

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Celastrol treatment protects against acute ischemic stroke-induced brain injury by promoting an IL-33/ST2 axis-mediated microglia/macrophage M2 polarization

Mei Jiang, Xinghui Liu, Denghai Zhang, Ying Wang, Xiaoxia Hu, Fengxia Xu, Mingming Jin, Fanfan Cao, Limin Xu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Glutaminase 1 regulates the release of extracellular vesicles during neuroinflammation through key metabolic intermediate alpha-ketoglutarate

Beiqing Wu, Jianhui Liu, Runze Zhao, Yuju Li, Justin Peer, Alexander L. Braun, Lixia Zhao, Yi Wang, Zenghan Tong, Yunlong Huang, Jialin C. Zheng

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Cell-type- and region-specific restriction of neurotropic flavivirus infection by viperin

Richard Lindqvist, Chaitanya Kurhade, Jonathan D. Gilthorpe, Anna K. Överby

01.12.2018 | Short report | Ausgabe 1/2018 Open Access

CD4+ αβ T cell infiltration into the leptomeninges of lumbar dorsal roots contributes to the transition from acute to chronic mechanical allodynia after adult rat tibial nerve injuries

Bin Du, You-Quan Ding, Xia Xiao, Hong-Yi Ren, Bing-Yin Su, Jian-Guo Qi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Neonatal hyperglycemia induces CXCL10/CXCR3 signaling and microglial activation and impairs long-term synaptogenesis in the hippocampus and alters behavior in rats

Katherine M. Satrom, Kathleen Ennis, Brian M. Sweis, Tatyana M. Matveeva, Jun Chen, Leif Hanson, Akhil Maheshwari, Raghavendra Rao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Lentivirus-mediated overexpression of OTULIN ameliorates microglia activation and neuroinflammation by depressing the activation of the NF-κB signaling pathway in cerebral ischemia/reperfusion rats

Hongbei Xu, Wenyi Qin, Xiao Hu, Song Mu, Jun Zhu, Wenhao Lu, Yong Luo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Therapeutic time window of multipotent adult progenitor therapy after traumatic brain injury

Supinder S. Bedi, Benjamin M. Aertker, George P. Liao, Henry W. Caplan, Deepa Bhattarai, Fanni Mandy, Franciska Mandy, Luis G. Fernandez, Pamela Zelnick, Matthew B. Mitchell, Walter Schiffer, Margaret Johnson, Emma Denson, Karthik Prabhakara, Hasen Xue, Philippa Smith, Karen Uray, Scott D. Olson, Robert W. Mays, Charles S. Cox Jr

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Chronic exposure to tumor necrosis factor alpha induces retinal pigment epithelium cell dedifferentiation

Sara Touhami, Fanny Beguier, Sébastien Augustin, Hugo Charles-Messance, Lucile Vignaud, Emeline F. Nandrot, Sacha Reichman, Valérie Forster, Thibaud Mathis, José-Alain Sahel, Bahram Bodaghi, Xavier Guillonneau, Florian Sennlaub

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Epigenetic impacts of stress priming of the neuroinflammatory response to sarin surrogate in mice: a model of Gulf War illness

David G. Ashbrook, Benjamin Hing, Lindsay T. Michalovicz, Kimberly A. Kelly, Julie V. Miller, Wilfred C. de Vega, Diane B. Miller, Gordon Broderick, James P. O’Callaghan, Patrick O. McGowan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarachnoid hemorrhage

Yue Lu, Xiang-Sheng Zhang, Zi-Huan Zhang, Xiao-Ming Zhou, Yong-Yue Gao, Guang-Jie Liu, Han Wang, Ling-Yun Wu, Wei Li, Chun-Hua Hang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

MOG-IgG in primary and secondary chronic progressive multiple sclerosis: a multicenter study of 200 patients and review of the literature

S. Jarius, K. Ruprecht, J. P. Stellmann, A. Huss, I. Ayzenberg, A. Willing, C. Trebst, M. Pawlitzki, A. Abdelhak, T. Grüter, F. Leypoldt, J. Haas, I. Kleiter, H. Tumani, K. Fechner, M. Reindl, F. Paul, B. Wildemann

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Acute- and late-phase matrix metalloproteinase (MMP)-9 activity is comparable in female and male rats after peripheral nerve injury

Albert G. Remacle, Swathi K. Hullugundi, Jennifer Dolkas, Mila Angert, Andrei V. Chernov, Alex Y. Strongin, Veronica I. Shubayev

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Perturbing chondroitin sulfate proteoglycan signaling through LAR and PTPσ receptors promotes a beneficial inflammatory response following spinal cord injury

Scott Dyck, Hardeep Kataria, Arsalan Alizadeh, Kallivalappil T. Santhosh, Bradley Lang, Jerry Silver, Soheila Karimi-Abdolrezaee

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Apolipoprotein E isoform dependently affects Tat-mediated HIV-1 LTR transactivation

Nabab Khan, Gaurav Datta, Jonathan D. Geiger, Xuesong Chen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Overexpression of zinc-α2-glycoprotein suppressed seizures and seizure-related neuroflammation in pentylenetetrazol-kindled rats

Ying Liu, Teng Wang, Xi Liu, Yuetao Wen, Tao Xu, Xinyuan Yu, Xin Wei, Xueying Ding, Lijuan Mo, Maojia Yin, Xinjie Tan, Lifen Chen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Toll-like receptor 3 modulates the behavioral effects of cocaine in mice

Ruiming Zhu, Qian Bu, Dengqi Fu, Xue Shao, Linhong Jiang, Wei Guo, Bo Chen, Bin Liu, Zhengtao Hu, Jingwei Tian, Yinglan Zhao, Xiaobo Cen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

HIV-1 Tat-induced diarrhea is improved by the PPARalpha agonist, palmitoylethanolamide, by suppressing the activation of enteric glia

Giovanni Sarnelli, Luisa Seguella, Marcella Pesce, Jie Lu, Stefano Gigli, Eugenia Bruzzese, Roberta Lattanzi, Alessandra D’Alessandro, Rosario Cuomo, Luca Steardo, Giuseppe Esposito

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Central blockade of NLRP3 reduces blood pressure via regulating inflammation microenvironment and neurohormonal excitation in salt-induced prehypertensive rats

Mo-Lin Wang, Yu-Ming Kang, Xiao-Guang Li, Qing Su, Hong-Bao Li, Kai-Li Liu, Li-Yan Fu, Roland Osei Saahene, Ying Li, Hong Tan, Xiao-Jing Yu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury

Norikazu Kiguchi, Daichi Kobayashi, Fumihiro Saika, Shinsuke Matsuzaki, Shiroh Kishioka

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Roles of astrocytic connexin-43, hemichannels, and gap junctions in oxygen-glucose deprivation/reperfusion injury induced neuroinflammation and the possible regulatory mechanisms of salvianolic acid B and carbenoxolone

Xiang Yin, Liangshu Feng, Di Ma, Ping Yin, Xinyu Wang, Shuai Hou, Yulei Hao, Jingdian Zhang, Meiying Xin, Jiachun Feng

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death

Sofia Söllvander, Elisabeth Nikitidou, Linn Gallasch, Marlena Zyśk, Linda Söderberg, Dag Sehlin, Lars Lannfelt, Anna Erlandsson

01.12.2018 | Letter to the Editor | Ausgabe 1/2018 Open Access

Dysregulation of chemokine receptor expression and function in leukocytes from ALS patients

Caroline Perner, Florian Perner, Beatrice Stubendorff, Martin Förster, Otto W. Witte, Florian H. Heidel, Tino Prell, Julian Grosskreutz

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Dimethyl fumarate attenuates reactive microglia and long-term memory deficits following systemic immune challenge

Hallel C. Paraiso, Ping-Chang Kuo, Eric T. Curfman, Haley J. Moon, Robert D. Sweazey, Jui-Hung Yen, Fen-Lei Chang, I-Chen Yu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A novel interaction between CX3CR1 and CCR2 signalling in monocytes constitutes an underlying mechanism for persistent vincristine-induced pain

Karli Montague, Raffaele Simeoli, Joao Valente, Marzia Malcangio

01.12.2018 | Research | Ausgabe 1/2018 Open Access

β-arrestin2 functions as a key regulator in the sympathetic-triggered immunodepression after stroke

Huan Wang, Qi-Wen Deng, Ai-Ni Peng, Fang-Lan Xing, Lei Zuo, Shuo Li, Zheng-Tian Gu, Fu-Ling Yan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

LncRNA H19 contributes to hippocampal glial cell activation via JAK/STAT signaling in a rat model of temporal lobe epilepsy

Chun-Lei Han, Ming Ge, Yun-Peng Liu, Xue-Min Zhao, Kai-Liang Wang, Ning Chen, Wen-Jia Meng, Wei Hu, Jian-Guo Zhang, Liang Li, Fan-Gang Meng

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Neuregulin-1 attenuates experimental cerebral malaria (ECM) pathogenesis by regulating ErbB4/AKT/STAT3 signaling

Mingli Liu, Wesley Solomon, Juan Carlos Cespedes, Nana O. Wilson, Byron Ford, Jonathan K. Stiles

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Neuropeptide regulation of adaptive immunity in the tibia fracture model of complex regional pain syndrome

Wen-Wu Li, Tian-Zhi Guo, Xiaoyou Shi, Frank Birklein, Tanja Schlereth, Wade S. Kingery, J. David Clark

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Activation of melanocortin receptor 4 with RO27-3225 attenuates neuroinflammation through AMPK/JNK/p38 MAPK pathway after intracerebral hemorrhage in mice

Shengpan Chen, Lianhua Zhao, Prativa Sherchan, Yan Ding, Jing Yu, Derek Nowrangi, Jiping Tang, Ying Xia, John H. Zhang

01.12.2018 | Review | Ausgabe 1/2018 Open Access

TREM2 regulates innate immunity in Alzheimer’s disease

Jiang-Tao Li, Ying Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Platelet-derived growth factor predicts prolonged relapse-free period in multiple sclerosis

Mario Stampanoni Bassi, Ennio Iezzi, Girolama A. Marfia, Ilaria Simonelli, Alessandra Musella, Georgia Mandolesi, Diego Fresegna, Patrizio Pasqualetti, Roberto Furlan, Annamaria Finardi, Giorgia Mataluni, Doriana Landi, Luana Gilio, Diego Centonze, Fabio Buttari

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment

Zhi Wang, Shiyu Meng, Lin Cao, Ying Chen, Zhiyi Zuo, Shuling Peng

01.12.2018 | Short report | Ausgabe 1/2018 Open Access

Selective localization of IgG from cerebrospinal fluid to brain parenchyma

Marlene Thorsen Mørch, Sofie Forsberg Sørensen, Reza Khorooshi, Nasrin Asgari, Trevor Owens

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Reduced ex vivo release of pro-inflammatory cytokines and elevated plasma interleukin-6 are inflammatory signatures of post-stroke delirium

Katarzyna Kowalska, Elzbieta Klimiec, Kazimierz Weglarczyk, Joanna Pera, Agnieszka Slowik, Maciej Siedlar, Tomasz Dziedzic

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Galantamine improves cognition, hippocampal inflammation, and synaptic plasticity impairments induced by lipopolysaccharide in mice

Yi Liu, Yuyun Zhang, Xian Zheng, Tongyong Fang, Xia Yang, Xuan Luo, Anlei Guo, Kelly A. Newell, Xu-Feng Huang, Yinghua Yu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Chorioamnionitis, neuroinflammation, and injury: timing is key in the preterm ovine fetus

Ruth Gussenhoven, Rob J. J. Westerlaken, Daan R. M. G. Ophelders, Alan H. Jobe, Matthew W. Kemp, Suhas G. Kallapur, Luc J. Zimmermann, Per T. Sangild, Stanislava Pankratova, Pierre Gressens, Boris W. Kramer, Bobbi Fleiss, Tim G. A. M. Wolfs

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Human central nervous system astrocytes support survival and activation of B cells: implications for MS pathogenesis

Hanane Touil, Antonia Kobert, Nathalie Lebeurrier, Aja Rieger, Philippe Saikali, Caroline Lambert, Lama Fawaz, Craig S. Moore, Alexandre Prat, Jennifer Gommerman, Jack P. Antel, Yasuto Itoyama, Ichiro Nakashima, Amit Bar-Or, for the Canadian B Cell Team in MS

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The intrathecal expression and pathogenetic role of Th17 cytokines and CXCR2-binding chemokines in tick-borne encephalitis

Sambor Grygorczuk, Renata Świerzbińska, Maciej Kondrusik, Justyna Dunaj, Piotr Czupryna, Anna Moniuszko, Agnieszka Siemieniako, Sławomir Pancewicz

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Omega-3 polyunsaturated fatty acid attenuates the inflammatory response by modulating microglia polarization through SIRT1-mediated deacetylation of the HMGB1/NF-κB pathway following experimental traumatic brain injury

Xiangrong Chen, Chunnuan Chen, Sining Fan, Shukai Wu, Fuxing Yang, Zhongning Fang, Huangde Fu, Yasong Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Glial interleukin-1β upregulates neuronal sodium channel 1.7 in trigeminal ganglion contributing to temporomandibular joint inflammatory hypernociception in rats

Peng Zhang, Rui-Yun Bi, Ye-Hua Gan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Biliverdin reductase-A attenuated GMH-induced inflammatory response in the spleen by inhibiting toll-like receptor-4 through eNOS/NO pathway

Yiting Zhang, Yan Ding, Tai Lu, Yixin Zhang, Ningbo Xu, Devin W. McBride, Jiping Tang, John H. Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Acute dose of melatonin via Nrf2 dependently prevents acute ethanol-induced neurotoxicity in the developing rodent brain

Tahir Ali, Shafiq Ur Rehman, Fawad Ali Shah, Myeong Ok Kim

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Oral sensitization to whey proteins induces age- and sex-dependent behavioral abnormality and neuroinflammatory responses in a mouse model of food allergy: a potential role of mast cells

Danielle L. Germundson, Nicholas A. Smith, Lane P. Vendsel, Andrea V. Kelsch, Colin K. Combs, Kumi Nagamoto-Combs

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Blockade of sustained tumor necrosis factor in a transgenic model of progressive autoimmune encephalomyelitis limits oligodendrocyte apoptosis and promotes oligodendrocyte maturation

Alice Valentin-Torres, Carine Savarin, Joslyn Barnett, Cornelia C. Bergmann

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Capsaicin-enriched diet ameliorates autoimmune neuritis in rats

Jeremias Motte, Björn Ambrosius, Thomas Grüter, Hussein Bachir, Melissa Sgodzai, Xiomara Pedreiturria, Kalliopi Pitarokoili, Ralf Gold

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Ischemic stroke is associated with the pro-inflammatory potential of N-glycosylated immunoglobulin G

Di Liu, Zhongyao Zhao, Anxin Wang, Siqi Ge, Hao Wang, Xiaoyu Zhang, Qi Sun, Weijie Cao, Ming Sun, Lijuan Wu, Manshu Song, Yong Zhou, Wei Wang, Youxin Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Anti-high mobility group box 1 antibody suppresses local inflammatory reaction and facilitates olfactory nerve recovery following injury

Masayoshi Kobayashi, Kengo Tamari, Mohammed Omar Al Salihi, Kohei Nishida, Kazuhiko Takeuchi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Cerebrospinal fluid mitochondrial DNA in neuromyelitis optica spectrum disorder

Kazuya Yamashita, Makoto Kinoshita, Katsuichi Miyamoto, Akiko Namba, Mikito Shimizu, Toru Koda, Tomoyuki Sugimoto, Yuki Mori, Yoshichika Yoshioka, Yuji Nakatsuji, Atsushi Kumanogoh, Susumu Kusunoki, Hideki Mochizuki, Tatsusada Okuno

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysregulates neurogranin and induces synaptodendritic injury

Debjani Guha, Marc C. E. Wagner, Velpandi Ayyavoo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation

Liqi Tong, G. Aleph Prieto, Carl W. Cotman

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Vascular adhesion protein-1 is actively involved in the development of inflammatory lesions in rat models of multiple sclerosis

Petri Elo, Sina Tadayon, Heidi Liljenbäck, Jarmo Teuho, Meeri Käkelä, Kalle Koskensalo, Virva Saunavaara, Jenni Virta, Tibor Z. Veres, Aida Kiviniemi, Antti Saraste, Päivi Marjamäki, Laura Airas, Sirpa Jalkanen, Anne Roivainen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

Megan F. Duffy, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, Kelvin C. Luk, Malú G. Tansey, Katrina L. Paumier, Nicholas M. Kanaan, D. Luke Fischer, Nicole K. Polinski, Olivia L. Barth, Jacob W. Howe, Nishant N. Vaikath, Nour K. Majbour, Omar M. A. El-Agnaf, Caryl E. Sortwell

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation

Sinéad Kinsella, Michael Fichtner, Orla Watters, Hans-Georg König, Jochen H. M. Prehn

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Urate inhibits microglia activation to protect neurons in an LPS-induced model of Parkinson’s disease

Li-Hui Bao, Ya-Nan Zhang, Jian-Nan Zhang, Li Gu, Hui-Min Yang, Yi-Ying Huang, Ning Xia, Hong Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

PM2.5 exposure aggravates oligomeric amyloid beta-induced neuronal injury and promotes NLRP3 inflammasome activation in an in vitro model of Alzheimer’s disease

Bian-Rong Wang, Jian-Quan Shi, Nian-Nian Ge, Zhou Ou, You-Yong Tian, Teng Jiang, Jun-Shan Zhou, Jun Xu, Ying-Dong Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Decreased level of irisin, a skeletal muscle cell-derived myokine, is associated with post-stroke depression in the ischemic stroke population

Wen-Jun Tu, Han-Cheng Qiu, Qiang Liu, Xuemei Li, Ji-Zong Zhao, Xianwei Zeng

01.12.2018 | Review | Ausgabe 1/2018 Open Access

MOG encephalomyelitis: international recommendations on diagnosis and antibody testing

S. Jarius, F. Paul, O. Aktas, N. Asgari, R. C. Dale, J. de Seze, D. Franciotta, K. Fujihara, A. Jacob, H. J. Kim, I. Kleiter, T. Kümpfel, M. Levy, J. Palace, K. Ruprecht, A. Saiz, C. Trebst, B. G. Weinshenker, B. Wildemann

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Mesenchymal stem cells attenuate blood-brain barrier leakage after cerebral ischemia in mice

Zhuo Cheng, Liping Wang, Meijie Qu, Huaibin Liang, Wanlu Li, Yongfang Li, Lidong Deng, Zhijun Zhang, Guo-Yuan Yang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

IL-33/ST2 plays a critical role in endothelial cell activation and microglia-mediated neuroinflammation modulation

Kelei Cao, Xiang Liao, Jiahui Lu, Shu Yao, Fengjiao Wu, Xingxing Zhu, Dongyan Shi, Shuang Wen, Lixin Liu, Hong Zhou

01.12.2018 | Research | Ausgabe 1/2018 Open Access

URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer’s disease

Tomomi Kiyota, Jatin Machhi, Yaman Lu, Bhagyalaxmi Dyavarshetty, Maryam Nemati, Gang Zhang, R. Lee Mosley, Harris A. Gelbard, Howard E. Gendelman

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Unique and shared inflammatory profiles of human brain endothelia and pericytes

Leon C. D. Smyth, Justin Rustenhoven, Thomas I.-H. Park, Patrick Schweder, Deidre Jansson, Peter A. Heppner, Simon J. O’Carroll, Edward W. Mee, Richard L. M. Faull, Maurice Curtis, Mike Dragunow

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Regional microglia are transcriptionally distinct but similarly exacerbate neurodegeneration in a culture model of Parkinson’s disease

Eric Wildon Kostuk, Jingli Cai, Lorraine Iacovitti

01.12.2018 | Research | Ausgabe 1/2018 Open Access

NADPH oxidases as potential pharmacological targets against increased seizure susceptibility after systemic inflammation

Wan-Yu Huang, Shankung Lin, Hsuan-Ying Chen, Ya-Ping Chen, Ting-Yu Chen, Kuei-Sen Hsu, Hung-Ming Wu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis

Sergey Kalinin, Marta González-Prieto, Hannah Scheiblich, Lucia Lisi, Handojo Kusumo, Michael T. Heneka, Jose L. M. Madrigal, Subhash C. Pandey, Douglas L. Feinstein

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury

Justin R. Piro, Georgette L. Suidan, Jie Quan, YeQing Pi, Sharon M. O’Neill, Marissa Ilardi, Nikolay Pozdnyakov, Thomas A. Lanz, Hualin Xi, Robert D. Bell, Tarek A. Samad

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A potential gliovascular mechanism for microglial activation: differential phenotypic switching of microglia by endothelium versus astrocytes

Changhong Xing, Wenlu Li, Wenjun Deng, MingMing Ning, Eng H. Lo

01.12.2018 | Review | Ausgabe 1/2018 Open Access

The role of inflammation in the development of epilepsy

Amna Rana, Alberto E. Musto

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Molecular and clinical characterization of PTPN2 expression from RNA-seq data of 996 brain gliomas

Peng-fei Wang, Hong-qing Cai, Chuan-bao Zhang, Yan-Michael Li, Xiang Liu, Jing-hai Wan, Tao Jiang, Shou-wei Li, Chang-Xiang Yan

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Neutrophils in traumatic brain injury (TBI): friend or foe?

Yang-Wuyue Liu, Song Li, Shuang-Shuang Dai

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model

Chunxia Huang, Michael Garnet Irwin, Gordon Tin Chun Wong, Raymond Chuen Chung Chang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Myeloid-specific TAK1 deletion results in reduced brain monocyte infiltration and improved outcomes after stroke

Anjali Chauhan, Jacob Hudobenko, Abdullah Al Mamun, Edward C. Koellhoffer, Anthony Patrizz, Rodney M. Ritzel, Bhanu P. Ganesh, Louise D. McCullough

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Impaired CD8 T cell antiviral immunity following acute spinal cord injury

Diana M. Norden, John R. Bethea, Jiu Jiang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3

Shoubo Chen, Jingfang Ye, Xiangrong Chen, Jinnan Shi, Wenhua Wu, Wenping Lin, Weibin Lin, Yasong Li, Huangde Fu, Shun Li

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Rheumatoid meningitis developed in patient with stable rheumatoid arthritis and myasthenia gravis—detailed analysis of intracranial inflammation using flow cytometry

Miki Oono, Yoshimasa Fujita, Nobuaki Uchida, Ukichiro Kawai, Michiyo Fujita-Nakata, Megumi Nakanishi, Mitsuru Sanada, Shigemi Nagayama, Makoto Matsui

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Sinomenine exerts anticonvulsant profile and neuroprotective activity in pentylenetetrazole kindled rats: involvement of inhibition of NLRP1 inflammasome

Bo Gao, Yu Wu, Yuan-Jian Yang, Wei-Zu Li, Kun Dong, Jun Zhou, Yan-Yan Yin, Da-Ke Huang, Wen-Ning Wu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

RNA sequencing analysis reveals quiescent microglia isolation methods from postnatal mouse brains and limitations of BV2 cells

Yingbo He, Xiang Yao, Natalie Taylor, Yuchen Bai, Timothy Lovenberg, Anindya Bhattacharya

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Novel TNF receptor-1 inhibitors identified as potential therapeutic candidates for traumatic brain injury

Rachel K. Rowe, Jordan L. Harrison, Hongtao Zhang, Adam D. Bachstetter, David P. Hesson, Bruce F. O’Hara, Mark I. Greene, Jonathan Lifshitz

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Ecto-5′-nucleotidase (CD73) attenuates inflammation after spinal cord injury by promoting macrophages/microglia M2 polarization in mice

Shun Xu, Wei Zhu, Minghao Shao, Fan Zhang, Ji Guo, Haocheng Xu, Jianyuan Jiang, Xiaosheng Ma, Xinlei Xia, Xiuling Zhi, Ping Zhou, Feizhou Lu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Novel insights into neuroinflammation: bacterial lipopolysaccharide, tumor necrosis factor α, and Ureaplasma species differentially modulate atypical chemokine receptor 3 responses in human brain microvascular endothelial cells

Christine Silwedel, Christian P. Speer, Axel Haarmann, Markus Fehrholz, Heike Claus, Mathias Buttmann, Kirsten Glaser

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Aquaporin-4 deletion ameliorates hypoglycemia-induced BBB permeability by inhibiting inflammatory responses

Fei Zhao, Jiangshan Deng, Xiaofeng Xu, Fengya Cao, Kaili Lu, Dawei Li, Xiaojuan Cheng, Xiuzhe Wang, Yuwu Zhao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Cannabinoid CB2 receptors in the mouse brain: relevance for Alzheimer’s disease

Alicia López, Noelia Aparicio, M. Ruth Pazos, M. Teresa Grande, M. Asunción Barreda-Manso, Irene Benito-Cuesta, Carmen Vázquez, Mario Amores, Gonzalo Ruiz-Pérez, Elena García-García, Margaret Beatka, Rosa M. Tolón, Bonnie N. Dittel, Cecilia J. Hillard, Julián Romero

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inflammatory and cytotoxic effects of bifenthrin in primary microglia and organotypic hippocampal slice cultures

Brahim Gargouri, Nizar M. Yousif, Michèle Bouchard, Hamadi Fetoui, Bernd L. Fiebich

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Immunophenotyping of cerebrospinal fluid cells by Chipcytometry

Martin W. Hümmert, Sascha Alvermann, Stefan Gingele, Catharina C. Gross, Heinz Wiendl, Anja Mirenska, Christian Hennig, Martin Stangel

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Dual modulation on glial cells by tetrahydroxystilbene glucoside protects against dopamine neuronal loss

Yanzhen Zhou, Guoqing Wang, Daidi Li, Yanying Wang, Qin Wu, Jingshan Shi, Feng Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Indomethacin promotes survival of new neurons in the adult murine hippocampus accompanied by anti-inflammatory effects following MPTP-induced dopamine depletion

Elisabeth G. Hain, Maria Sparenberg, Justyna Rasińska, Charlotte Klein, Levent Akyüz, Barbara Steiner

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Dynamic changes in microglial and macrophage characteristics during degeneration and regeneration of the zebrafish retina

Diana M. Mitchell, Anna G. Lovel, Deborah L. Stenkamp

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Serum amyloid A primes microglia for ATP-dependent interleukin-1β release

Laura Facci, Massimo Barbierato, Morena Zusso, Stephen D. Skaper, Pietro Giusti

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Cytokine alterations in first-episode schizophrenia and bipolar disorder: relationships to brain structure and symptoms

Tyler A. Lesh, Milo Careaga, Destanie R. Rose, A. Kimberley McAllister, Judy Van de Water, Cameron S. Carter, Paul Ashwood

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Abnormalities of age-related T cell senescence in Parkinson’s disease

C. H. Williams-Gray, R. S. Wijeyekoon, K. M. Scott, S. Hayat, R. A. Barker, J. L. Jones

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Splenic responses play an important role in remote ischemic preconditioning-mediated neuroprotection against stroke

Chen Chen, Wei Jiang, Zongjian Liu, Fengwu Li, Jian Yang, Yanlong Zhao, Yuanyuan Ran, Yan Meng, Xunming Ji, Xiaokun Geng, Huishan Du, Xiaoming Hu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inflammation leads to distinct populations of extracellular vesicles from microglia

Yiyi Yang, Antonio Boza-Serrano, Christopher J. R. Dunning, Bettina Hjelm Clausen, Kate Lykke Lambertsen, Tomas Deierborg

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

Megan F. Duffy, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, Kelvin C. Luk, Malú G. Tansey, Katrina L. Paumier, Nicholas M. Kanaan, D. Luke Fischer, Nicole K. Polinski, Olivia L. Barth, Jacob W. Howe, Nishant N. Vaikath, Nour K. Majbour, Omar M. A. El-Agnaf, Caryl E. Sortwell

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Neuroinflammation is increased in the parietal cortex of atypical Alzheimer’s disease

Baayla D. C. Boon, Jeroen J. M. Hoozemans, Boaz Lopuhaä, Kristel N. Eigenhuis, Philip Scheltens, Wouter Kamphorst, Annemieke J. M. Rozemuller, Femke H. Bouwman

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Complement components are upregulated and correlate with disease progression in the TDP-43Q331K mouse model of amyotrophic lateral sclerosis

John D. Lee, Samantha C. Levin, Emily F. Willis, Rui Li, Trent M. Woodruff, Peter G. Noakes

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Co-aggregation of pro-inflammatory S100A9 with α-synuclein in Parkinson’s disease: ex vivo and in vitro studies

Istvan Horvath, Igor A. Iashchishyn, Roman A. Moskalenko, Chao Wang, Sebastian K. T. S. Wärmländer, Cecilia Wallin, Astrid Gräslund, Gabor G. Kovacs, Ludmilla A. Morozova-Roche

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Elimination of intravascular thrombi prevents early mortality and reduces gliosis in hyper-inflammatory experimental cerebral malaria

Kyle D. Wilson, Lorenzo F. Ochoa, Olivia D. Solomon, Rahul Pal, Sandra M. Cardona, Victor H. Carpio, Philip H. Keiser, Astrid E. Cardona, Gracie Vargas, Robin Stephens

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke

Somayyeh Hamzei Taj, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Alessandra Quarta, Jelle Praet, Annemie Van der Linden, Peter Ponsaerts, Mathias Hoehn

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Activin A increases phagocytosis of Escherichia coli K1 by primary murine microglial cells activated by toll-like receptor agonists

Catharina Diesselberg, Sandra Ribes, Jana Seele, Annika Kaufmann, Sandra Redlich, Stephanie Bunkowski, Uwe-Karsten Hanisch, Uwe Michel, Roland Nau, Sandra Schütze

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Ammoxetine attenuates diabetic neuropathic pain through inhibiting microglial activation and neuroinflammation in the spinal cord

Ting-Ting Zhang, Rui Xue, Shi-Yong Fan, Qiong-Yin Fan, Lei An, Juan Li, Lei Zhu, Yu-Hua Ran, Li-Ming Zhang, Bo-Hua Zhong, Yun-Feng Li, Cai-Ying Ye, You-Zhi Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway

Shalini Swaroop, Anita Mahadevan, Susarla Krishna Shankar, Yogita K. Adlakha, Anirban Basu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Aggf1 attenuates neuroinflammation and BBB disruption via PI3K/Akt/NF-κB pathway after subarachnoid hemorrhage in rats

Qiquan Zhu, Budbazar Enkhjargal, Lei Huang, Tongyu Zhang, Chengmei Sun, Zhiyi Xie, Pei Wu, Jun Mo, Jiping Tang, Zongyi Xie, John H. Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Chronic constriction injury-induced microRNA-146a-5p alleviates neuropathic pain through suppression of IRAK1/TRAF6 signaling pathway

Zhiyao Wang, Fan Liu, Min Wei, Yue Qiu, Chao Ma, Le Shen, Yuguang Huang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Necrotizing enterocolitis is associated with acute brain responses in preterm pigs

Jing Sun, Xiaoyu Pan, Line I. Christiansen, Xiao-Long Yuan, Kerstin Skovgaard, Dereck E. W. Chatterton, Sanne S. Kaalund, Fei Gao, Per T. Sangild, Stanislava Pankratova

01.12.2018 | Research | Ausgabe 1/2018 Open Access

In utero electroporation induces cell death and alters embryonic microglia morphology and expression signatures in the developing hypothalamus

Jessica M. Rosin, Deborah M. Kurrasch

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Longitudinal chemokine profile expression in a blood-brain barrier model from Alzheimer transgenic versus wild-type mice

J. Vérité, T. Janet, D. Chassaing, B. Fauconneau, H. Rabeony, G. Page

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Laquinimod protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model

Anna T. Wilmes, Sabrina Reinehr, Sandra Kühn, Xiomara Pedreiturria, Laura Petrikowski, Simon Faissner, Ilya Ayzenberg, Gesa Stute, Ralf Gold, H. Burkhard Dick, Ingo Kleiter, Stephanie C. Joachim

01.12.2018 | Research | Ausgabe 1/2018 Open Access

JNK-mediated microglial DICER degradation potentiates inflammatory responses to induce dopaminergic neuron loss

Qing Wang, Qian He, Yifei Chen, Wei Shao, Chao Yuan, Yizheng Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Temporal changes in macrophage phenotype after peripheral nerve injury

Joy E. Tomlinson, Emilija Žygelytė, Jennifer K. Grenier, Michael G. Edwards, Jonathan Cheetham

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Vitexin reduces epilepsy after hypoxic ischemia in the neonatal brain via inhibition of NKCC1

Wen-di Luo, Jia-wei Min, Wen-Xian Huang, Xin Wang, Yuan-yuan Peng, Song Han, Jun Yin, Wan-Hong Liu, Xiao-Hua He, Bi-Wen Peng

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Procyanidins attenuate neuropathic pain by suppressing matrix metalloproteinase-9/2

Cailong Pan, Chaoyu Wang, Li Zhang, Ling Song, Yuan Chen, Bingqian Liu, Wen-Tao Liu, Liang Hu, Yinbing Pan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Carbon monoxide-releasing molecule-3 protects against ischemic stroke by suppressing neuroinflammation and alleviating blood-brain barrier disruption

Jianping Wang, Di Zhang, Xiaojie Fu, Lie Yu, Zhengfang Lu, Yufeng Gao, Xianliang Liu, Jiang Man, Sijia Li, Nan Li, Xuemei Chen, Michael Hong, Qingwu Yang, Jian Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Bone marrow-derived mesenchymal stem/stromal cells reverse the sensorial diabetic neuropathy via modulation of spinal neuroinflammatory cascades

Afrânio Ferreira Evangelista, Marcos André Vannier-Santos, Gessica Sabrina de Assis Silva, Daniela Nascimento Silva, Paulo José Lima Juiz, Carolina Kymie Vasques Nonaka, Ricardo Ribeiro dos Santos, Milena Botelho Pereira Soares, Cristiane Flora Villarreal

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Effects of chronic noise exposure on the microbiome-gut-brain axis in senescence-accelerated prone mice: implications for Alzheimer’s disease

Bo Cui, Donghong Su, Wenlong Li, Xiaojun She, Ming Zhang, Rui Wang, Qingfeng Zhai

01.12.2018 | Case study | Ausgabe 1/2018 Open Access

Cytokine production pattern of T lymphocytes in neonatal arterial ischemic stroke during the first month of life—a case study

Anna Bajnok, László Berta, Csaba Orbán, Tivadar Tulassay, Gergely Toldi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Molecular and cellular identification of the immune response in peripheral ganglia following nerve injury

Jane A. Lindborg, Jon P. Niemi, Madeline A. Howarth, Kevin W. Liu, Christian Z. Moore, Deepti Mahajan, Richard E. Zigmond

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson’s disease

Chen Qiao, Qian Zhang, Qingling Jiang, Ting Zhang, Miaomiao Chen, Yi Fan, Jianhua Ding, Ming Lu, Gang Hu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Teriflunomide attenuates neuroinflammation-related neural damage in mice carrying human PLP1 mutations

Janos Groh, Michaela Hörner, Rudolf Martini

01.12.2018 | Review | Ausgabe 1/2018 Open Access

The splenic response to stroke: from rodents to stroke subjects

Hilary A. Seifert, Halina Offner

01.12.2018 | Short report | Ausgabe 1/2018 Open Access

The inhibitory effect of LPS on the expression of GPR81 lactate receptor in blood-brain barrier model in vitro

Elizaveta B. Boitsova, Andrey V. Morgun, Elena D. Osipova, Elena A. Pozhilenkova, Galina P. Martinova, Olga V. Frolova, Raissa Ya Olovannikova, Abolghasem Tohidpour, Yana V. Gorina, Yulia A. Panina, Alla B. Salmina

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Role of MCP-1 and CCR2 in ethanol-induced neuroinflammation and neurodegeneration in the developing brain

Kai Zhang, Haiping Wang, Mei Xu, Jacqueline A. Frank, Jia Luo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Astrocytic gap junction inhibition by carbenoxolone enhances the protective effects of ischemic preconditioning following cerebral ischemia

Di Ma, Liangshu Feng, Yingying Cheng, Meiying Xin, Jiulin You, Xiang Yin, Yulei Hao, Li Cui, Jiachun Feng

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Necroptosis: a regulated inflammatory mode of cell death

Yogesh K. Dhuriya, Divakar Sharma

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Increased hypothalamic microglial activation after viral-induced pneumococcal lung infection is associated with excess serum amyloid A production

Hao Wang, Melissa Blackall, Luba Sominsky, Sarah J. Spencer, Ross Vlahos, Melissa Churchill, Steven Bozinovski

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inflammation and blood-brain barrier breach remote from the primary injury following neurotrauma

Nicole M. Smith, Marcus K. Giacci, Alexander Gough, Charlotte Bailey, Terence McGonigle, Anna M. B. Black, Thomas O. Clarke, Carole A. Bartlett, K. Swaminathan Iyer, Sarah A. Dunlop, Melinda Fitzgerald

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Unveiling anti-oxidative and anti-inflammatory effects of docosahexaenoic acid and its lipid peroxidation product on lipopolysaccharide-stimulated BV-2 microglial cells

Bo Yang, Runting Li, C. Michael Greenlief, Kevin L. Fritsche, Zezong Gu, Jiankun Cui, James C. Lee, David Q. Beversdorf, Grace Y. Sun

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Ex vivo model of epilepsy in organotypic slices—a new tool for drug screening

Daniela M. Magalhães, Noémia Pereira, Diogo M. Rombo, Cláudia Beltrão-Cavacas, Ana M. Sebastião, Cláudia A. Valente

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Long noncoding RNA MALAT1 in exosomes drives regenerative function and modulates inflammation-linked networks following traumatic brain injury

Niketa A. Patel, Lauren Daly Moss, Jea-Young Lee, Naoki Tajiri, Sandra Acosta, Charles Hudson, Sajan Parag, Denise R. Cooper, Cesario V. Borlongan, Paula C. Bickford

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Parkinson’s disease patients have a complex phenotypic and functional Th1 bias: cross-sectional studies of CD4+ Th1/Th2/T17 and Treg in drug-naïve and drug-treated patients

Natasa Kustrimovic, Cristoforo Comi, Luca Magistrelli, Emanuela Rasini, Massimiliano Legnaro, Raffaella Bombelli, Iva Aleksic, Fabio Blandini, Brigida Minafra, Giulio Riboldazzi, Andrea Sturchio, Marco Mauri, Giorgio Bono, Franca Marino, Marco Cosentino

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The novel estrogenic receptor GPR30 alleviates ischemic injury by inhibiting TLR4-mediated microglial inflammation

Zengli Zhang, Pei Qin, Youliang Deng, Zhi Ma, Hang Guo, Haiyun Guo, Yushu Hou, Shiquan Wang, Wangyuan Zou, Yanyuan Sun, Yulong Ma, Wugang Hou

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Brain 18F-FDG PET of SIV-infected macaques after treatment interruption or initiation

William Schreiber-Stainthorp, Sanhita Sinharay, Sharat Srinivasula, Swati Shah, Jing Wang, Lori Dodd, H. Clifford Lane, Michele Di Mascio, Dima A. Hammoud

01.12.2018 | Research | Ausgabe 1/2018 Open Access

An IFNγ/CXCL2 regulatory pathway determines lesion localization during EAE

Joshua S. Stoolman, Patrick C. Duncker, Amanda K. Huber, David A. Giles, Jesse M. Washnock-Schmid, Athena M. Soulika, Benjamin M. Segal

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Neurofilament levels, disease activity and brain volume during follow-up in multiple sclerosis

Irene Håkansson, Anders Tisell, Petra Cassel, Kaj Blennow, Henrik Zetterberg, Peter Lundberg, Charlotte Dahle, Magnus Vrethem, Jan Ernerudh

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The adhesion and migration of microglia to β-amyloid (Aβ) is decreased with aging and inhibited by Nogo/NgR pathway

Yinquan Fang, Jianing Wang, Lemeng Yao, Chenhui Li, Jing Wang, Yuan Liu, Xia Tao, Hao Sun, Hong Liao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Increased expression of matrix metalloproteinase 3 can be attenuated by inhibition of microRNA-155 in cultured human astrocytes

Anatoly Korotkov, Diede W. M. Broekaart, Jackelien van Scheppingen, Jasper J. Anink, Johannes C. Baayen, Sander Idema, Jan A. Gorter, Eleonora Aronica, Erwin A. van Vliet

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Effects of rapamycin and curcumin on inflammation and oxidative stress in vitro and in vivo — in search of potential anti-epileptogenic strategies for temporal lobe epilepsy

C. M. Drion, J. van Scheppingen, A. Arena, K. W. Geijtenbeek, L. Kooijman, E. A. van Vliet, E. Aronica, J. A. Gorter

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Levels of ADAM10 are reduced in Alzheimer’s disease CSF

Aitana Sogorb-Esteve, María-Salud García-Ayllón, Johan Gobom, Jordi Alom, Henrik Zetterberg, Kaj Blennow, Javier Sáez-Valero

01.12.2018 | Short report | Ausgabe 1/2018 Open Access

Effect of hypothermia on interleukin-1 receptor antagonist pharmacodynamics in inflammatory-sensitized hypoxic-ischemic encephalopathy of term newborns

Mathilde Chevin, Clémence Guiraut, Guillaume Sébire

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Recombinant CTRP9 administration attenuates neuroinflammation via activating adiponectin receptor 1 after intracerebral hemorrhage in mice

Lianhua Zhao, Shengpan Chen, Prativa Sherchan, Yan Ding, Wei Zhao, Zaiyu Guo, Jing Yu, Jiping Tang, John H. Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Chronic Toxoplasma infection is associated with distinct alterations in the synaptic protein composition

Daniel Lang, Björn H. Schott, Marco van Ham, Lorena Morton, Leonora Kulikovskaja, Rodrigo Herrera-Molina, Rainer Pielot, Frank Klawonn, Dirk Montag, Lothar Jänsch, Eckart D. Gundelfinger, Karl Heinz Smalla, Ildiko Rita Dunay

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Trapped in the epineurium: early entry into the endoneurium is restricted to neuritogenic T cells in experimental autoimmune neuritis

Anne K. Mausberg, Fabian Szepanowski, Francesca Odoardi, Alexander Flügel, Christoph Kleinschnitz, Mark Stettner, Bernd C. Kieseier

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Fibronectin aggregates promote features of a classically and alternatively activated phenotype in macrophages

Arend H. Sikkema, Josephine M. J. Stoffels, Peng Wang, Frederike J. Basedow, Robbert Bulsink, Jeffrey J. Bajramovic, Wia Baron

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Splenic involvement in umbilical cord matrix-derived mesenchymal stromal cell-mediated effects following traumatic spinal cord injury

Anna Badner, Justin Hacker, James Hong, Mirriam Mikhail, Reaz Vawda, Michael G. Fehlings

01.12.2018 | Research | Ausgabe 1/2018 Open Access

2-arachidonyl glycerol modulates astrocytic glutamine synthetase via p38 and ERK1/2 pathways

Shenghong Wang, Hua Zhang, Bin Geng, Qiqi Xie, Wenzhou Li, Yajun Deng, Weidong Shi, Yunyan Pan, Xuewen Kang, Jing Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation

Xinjian Zhu, Xiaolin Li, Mengyi Zhu, Kangni Xu, Li Yang, Bing Han, Rongrong Huang, Aifeng Zhang, Honghong Yao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Methylprednisolone treatment enhances early recovery following surgical decompression for degenerative cervical myelopathy without compromise to the systemic immune system

Pia M. Vidal, Antigona Ulndreaj, Anna Badner, James Hong, Michael G. Fehlings

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Fas-ligand and interleukin-6 in the cerebrospinal fluid are early predictors of hypoxic-ischemic encephalopathy and long-term outcomes after birth asphyxia in term infants

Kristin Leifsdottir, Huseyin Mehmet, Staffan Eksborg, Eric Herlenius

01.12.2018 | Research | Ausgabe 1/2018 Open Access

K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression

Ji Yeon Choi, In Jun Yeo, Ki Cheon Kim, Won Rack Choi, Jae-Kyung Jung, Sang-Bae Han, Jin Tae Hong

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Anti-CD52 antibody treatment depletes B cell aggregates in the central nervous system in a mouse model of multiple sclerosis

Micha Simon, Rojda Ipek, György A. Homola, Damiano M. Rovituso, Andrea Schampel, Christoph Kleinschnitz, Stefanie Kuerten

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The plasticity of primary microglia and their multifaceted effects on endogenous neural stem cells in vitro and in vivo

Sabine Ulrike Vay, Lea Jessica Flitsch, Monika Rabenstein, Rebecca Rogall, Stefan Blaschke, Judith Kleinhaus, Noémie Reinert, Annika Bach, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model

Atsushi Fujita, Hiroo Yamaguchi, Ryo Yamasaki, Yiwen Cui, Yuta Matsuoka, Ken-ichi Yamada, Jun-ichi Kira

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Prenatal influenza vaccination rescues impairments of social behavior and lamination in a mouse model of autism

Yingying Wu, Fangfang Qi, Dan Song, Zitian He, Zejie Zuo, Yunjie Yang, Qiongliang Liu, Saisai Hu, Xiao Wang, Xiaona Zheng, Junhua Yang, Qunfang Yuan, Juntao Zou, Kaihua Guo, Zhibin Yao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

RAS modulation prevents progressive cognitive impairment after experimental stroke: a randomized, blinded preclinical trial

Heba A. Ahmed, Tauheed Ishrat, Bindu Pillai, Abdelrahman Y. Fouda, Mohammed A. Sayed, Wael Eldahshan, Jennifer L. Waller, Adviye Ergul, Susan C. Fagan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Neuroprotection and immunomodulation following intraspinal axotomy of motoneurons by treatment with adult mesenchymal stem cells

A. B. Spejo, G. B. Chiarotto, A. D. F. Ferreira, D. A. Gomes, R. S. Ferreira Jr, B. Barraviera, A. L. R. Oliveira

01.12.2018 | Research | Ausgabe 1/2018 Open Access

TSG-6 attenuates inflammation-induced brain injury via modulation of microglial polarization in SAH rats through the SOCS3/STAT3 pathway

Ran Li, Wenchao Liu, Jian Yin, Yunchang Chen, Shenquan Guo, Haiyan Fan, Xifeng Li, Xin Zhang, Xuying He, Chuanzhi Duan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

High-dose intravenous immunoglobulins reduce nerve macrophage infiltration and the severity of bortezomib-induced peripheral neurotoxicity in rats

Cristina Meregalli, Ivan Marjanovic, Carla Scali, Laura Monza, Nadia Spinoni, Cristina Galliani, Rinaldo Brivio, Alessia Chiorazzi, Elisa Ballarini, Virginia Rodriguez-Menendez, Valentina Alda Carozzi, Paola Alberti, Giulia Fumagalli, Eleonora Pozzi, Annalisa Canta, Marina Quartu, Chiara Briani, Norberto Oggioni, Paola Marmiroli, Guido Cavaletti

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Combined effect of non-bacteriolytic antibiotic and inhibition of matrix metalloproteinases prevents brain injury and preserves learning, memory and hearing function in experimental paediatric pneumococcal meningitis

Lukas Muri, Denis Grandgirard, Michelle Buri, Michael Perny, Stephen L. Leib

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Effect of tumor necrosis factor-α on the expression of the ammonia transporter Rhcg in the brain in mice with acute liver failure

Wen Wang, Hui Lu, Xu Lu, Donglei Wang, Zhaohan Wang, Wenying Dai, Jinyong Wang, Pei Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Perioperative use of cefazolin ameliorates postoperative cognitive dysfunction but induces gut inflammation in mice

Peng Liang, Weiran Shan, Zhiyi Zuo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus

Johanna Breuer, Eva Korpos, Melanie-Jane Hannocks, Tilman Schneider-Hohendorf, Jian Song, Lisa Zondler, Sebastian Herich, Ken Flanagan, Thomas Korn, Alexander Zarbock, Tanja Kuhlmann, Lydia Sorokin, Heinz Wiendl, Nicholas Schwab

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Cell permeable HMGB1-binding heptamer peptide ameliorates neurovascular complications associated with thrombolytic therapy in rats with transient ischemic stroke

Miaodan Li, Shumin Chen, Xue Shi, Chenfei Lyu, Yongfang Zhang, Miaoqin Tan, Chen Wang, Nailiang Zang, Xiaoxi Liu, Yafang Hu, Jiangang Shen, Liang Zhou, Yong Gu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Activation of neuronal N-methyl-d-aspartate receptor plays a pivotal role in Japanese encephalitis virus-induced neuronal cell damage

Zheng Chen, Xugang Wang, Usama Ashraf, Bohan Zheng, Jing Ye, Dengyuan Zhou, Hao Zhang, Yunfeng Song, Huanchun Chen, Shuhong Zhao, Shengbo Cao

01.12.2018 | Short report | Ausgabe 1/2018 Open Access

Extracellular vesicles are increased in the serum of children with autism spectrum disorder, contain mitochondrial DNA, and stimulate human microglia to secrete IL-1β

Irene Tsilioni, Theoharis C. Theoharides

01.12.2018 | Review | Ausgabe 1/2018 Open Access

The role of neutrophil granule proteins in neuroinflammation and Alzheimer’s disease

Amanda J. Stock, Anne Kasus-Jacobi, H. Anne Pereira

01.12.2018 | Research | Ausgabe 1/2018 Open Access

APP21 transgenic rats develop age-dependent cognitive impairment and microglia accumulation within white matter tracts

Nina Weishaupt, Qingfan Liu, Sheojung Shin, Ramandeep Singh, Yuksel Agca, Cansu Agca, Vladimir Hachinski, Shawn Narain Whitehead

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia/reperfusion injury

Zhe Gong, Jingrui Pan, Qingyu Shen, Mei Li, Ying Peng

01.12.2018 | Research | Ausgabe 1/2018 Open Access

NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson’s disease

Li Cheng, Lin Chen, Xinbing Wei, Yimeng Wang, Zhiping Ren, Shenglan Zeng, Xiumei Zhang, Haitao Wen, Chengjiang Gao, Huiqing Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson’s disease

Gregory P. Williams, Aubrey M. Schonhoff, Asta Jurkuvenaite, Aaron D. Thome, David G. Standaert, Ashley S. Harms

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Microglia P2X4 receptor contributes to central sensitization following recurrent nitroglycerin stimulation

Ting Long, Wei He, Qi Pan, Shanshan Zhang, Yixin Zhang, Chaoyang Liu, Qing Liu, Guangcheng Qin, Lixue Chen, Jiying Zhou

01.12.2018 | Research | Ausgabe 1/2018 Open Access

ITGB4 deficiency in bronchial epithelial cells directs airway inflammation and bipolar disorder-related behavior

Li Han, Leyuan Wang, Sha Tang, Lin Yuan, Shuangyan Wu, Xizi Du, Yang Xiang, Xiangping Qu, Huijun Liu, Huaiqing Luo, Xiaoqun Qin, Chi Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid

Ana Rubio-Araiz, Orla M. Finucane, Samuel Keogh, Marina A. Lynch

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Effect of tryptase on mouse brain microvascular endothelial cells via protease-activated receptor 2

Qin Zhou, Yi-wei Wang, Peng-fei Ni, Yi-nan Chen, Hong-quan Dong, Yan-ning Qian

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Vitamin D protects dopaminergic neurons against neuroinflammation and oxidative stress in hemiparkinsonian rats

Ludmila A R Lima, Maria Janice P Lopes, Roberta O Costa, Francisco Arnaldo V Lima, Kelly Rose T Neves, Iana B F Calou, Geanne M Andrade, Glauce S B Viana

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inhibiting aberrant p53-PUMA feedback loop activation attenuates ischaemia reperfusion-induced neuroapoptosis and neuroinflammation in rats by downregulating caspase 3 and the NF-κB cytokine pathway

Xiao-Qian Li, Qian Yu, Feng-Shou Chen, Wen-Fei Tan, Zai-Li Zhang, Hong Ma

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Intracellular inflammatory and antioxidant pathways in postmortem frontal cortex of subjects with major depression: effect of antidepressants

David Martín-Hernández, Javier R. Caso, J. Javier Meana, Luis F. Callado, José L. M. Madrigal, Borja García-Bueno, Juan C. Leza

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Hippocampal Mrp8/14 signaling plays a critical role in the manifestation of depressive-like behaviors in mice

Hong Gong, Wen-Jun Su, Zhi-Yong Cao, Yong-Jie Lian, Wei Peng, Yun-Zi Liu, Yi Zhang, Lin-Lin Liu, Ran Wu, Bo Wang, Ting Zhang, Yun-Xia Wang, Chun-Lei Jiang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Macrophage migration inhibitory factor facilitates production of CCL5 in astrocytes following rat spinal cord injury

Yue Zhou, Wei Guo, Zhenjie Zhu, Yuming Hu, Yingjie Wang, Xuejie Zhang, Wenjuan Wang, Nan Du, Tiancheng Song, Kaini Yang, Zongyu Guan, Yongjun Wang, Aisong Guo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Complement activation contributes to perioperative neurocognitive disorders in mice

Chao Xiong, Jinhu Liu, Dandan Lin, Juxia Zhang, Niccolò Terrando, Anshi Wu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A comparison of brain magnetic resonance imaging lesions in multiple sclerosis by race with reference to disability progression

Yuri Nakamura, Laura Gaetano, Takuya Matsushita, Altermatt Anna, Till Sprenger, Ernst-Wilhelm Radue, Jens Wuerfel, Lorena Bauer, Michael Amann, Koji Shinoda, Noriko Isobe, Ryo Yamasaki, Takahiko Saida, Ludwig Kappos, Jun-ichi Kira

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Human Alzheimer’s disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aβ plaque pathology

Sarah M. Rothman, Keith Q. Tanis, Pallavi Gandhi, Vladislav Malkov, Jacob Marcus, Michelle Pearson, Richard Stevens, Jason Gilliland, Christopher Ware, Veeravan Mahadomrongkul, Elaine O’Loughlin, Gonzalo Zeballos, Roger Smith, Bonnie J. Howell, Joel Klappenbach, Matthew Kennedy, Christian Mirescu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Characterization of a Listeria monocytogenes meningitis mouse model

Merel M. Koopmans, JooYeon Engelen-Lee, Matthijs C. Brouwer, Valery Jaspers, Wing Kit Man, Mercedes Vall Seron, Diederik van de Beek

01.12.2018 | Research | Ausgabe 1/2018 Open Access

α-Synuclein disrupts the anti-inflammatory role of Drd2 via interfering β-arrestin2-TAB1 interaction in astrocytes

Ren-Hong Du, Yan Zhou, Mei-Ling Xia, Ming Lu, Jian-Hua Ding, Gang Hu

01.12.2018 | Review | Ausgabe 1/2018 Open Access

The human microglial HMC3 cell line: where do we stand? A systematic literature review

Cinzia Dello Russo, Natalia Cappoli, Isabella Coletta, Daniele Mezzogori, Fabiola Paciello, Giacomo Pozzoli, Pierluigi Navarra, Alessandra Battaglia

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inflammation-induced Gro1 triggers senescence in neuronal progenitors: effects of estradiol

Svetlana Zonis, Joshua J. Breunig, Adam Mamelak, Kolja Wawrowsky, Catherine Bresee, Nadiya Ginzburg, Vera Chesnokova

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inhibition of NF-κB in astrocytes is sufficient to delay neurodegeneration induced by proteotoxicity in neurons

Y. X. Li, O. C. M. Sibon, P. F. Dijkers

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Environmental enrichment reduces adolescent anxiety- and depression-like behaviors of rats subjected to infant nerve injury

Xingrui Gong, Yongmei Chen, Jing Chang, Yue Huang, Meihau Cai, Mazhong Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Intraventricular infusion of quinolinic acid impairs spatial learning and memory in young rats: a novel mechanism of lead-induced neurotoxicity

Abdur Rahman, Muddanna S. Rao, Khalid M. Khan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Effect of PEA-OXA on neuropathic pain and functional recovery after sciatic nerve crush

Enrico Gugliandolo, Ramona D’amico, Marika Cordaro, Roberta Fusco, Rosalba Siracusa, Rosalia Crupi, Daniela Impellizzeri, Salvatore Cuzzocrea, Rosanna Di Paola

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Exome sequencing study in patients with multiple sclerosis reveals variants associated with disease course

Elia Gil-Varea, Elena Urcelay, Carles Vilariño-Güell, Carme Costa, Luciana Midaglia, Fuencisla Matesanz, Alfredo Rodríguez-Antigüedad, Jorge Oksenberg, Laura Espino-Paisan, A. Dessa Sadovnick, Albert Saiz, Luisa M. Villar, Juan Antonio García-Merino, Lluís Ramió-Torrentà, Juan Carlos Triviño, Ester Quintana, René Robles, Antonio Sánchez-López, Rafael Arroyo, Jose C. Alvarez-Cermeño, Angela Vidal-Jordana, Sunny Malhotra, Nicolas Fissolo, Xavier Montalban, Manuel Comabella

01.12.2018 | Letter to the Editor | Ausgabe 1/2018 Open Access

NLRP3 inflammasome-dependent pyroptosis is proposed to be involved in the mechanism of age-dependent isoflurane-induced cognitive impairment

Lei Yin, Fangping Bao, Jing Wu, Kuanyu Li

01.12.2018 | Letter to the Editor | Ausgabe 1/2018 Open Access

A response to readers’ comments

Zhiyi Zuo, Zhi Wang, Shiyu Meng, Shuling Peng

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Netrin-1 attenuates brain injury after middle cerebral artery occlusion via downregulation of astrocyte activation in mice

Xiaosong He, Yanqun Liu, Xiaohong Lin, Falei Yuan, Dahong Long, Zhijun Zhang, Yongting Wang, Aiguo Xuan, Guo-Yuan Yang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer’s disease

Sarah C. Hopp, Yang Lin, Derek Oakley, Allyson D. Roe, Sarah L. DeVos, David Hanlon, Bradley T. Hyman

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Expression of the neuroprotective protein aryl hydrocarbon receptor nuclear translocator 2 correlates with neuronal stress and disability in models of multiple sclerosis

Tissa Rahim, Pierre Becquart, Maria-Elizabeth Baeva, Jacqueline Quandt

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice

Hye Yeon Nam, Jin Han Nam, Gwangho Yoon, Ju-Young Lee, Youngpyo Nam, Hye-Jin Kang, Hyun-Ji Cho, Jeongyeon Kim, Hyang-Sook Hoe

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets

Chuhyon Corwin, Anastasia Nikolopoulou, Allen L. Pan, Mariela Nunez-Santos, Shankar Vallabhajosula, Peter Serrano, John Babich, Maria E. Figueiredo-Pereira

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Moderate hypothermia inhibits microglial activation after traumatic brain injury by modulating autophagy/apoptosis and the MyD88-dependent TLR4 signaling pathway

Fengchen Zhang, Haiping Dong, Tao Lv, Ke Jin, Yichao Jin, Xiaohua Zhang, Jiyao Jiang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice

M. S. Unger, P. Schernthaner, J. Marschallinger, H. Mrowetz, L. Aigner

01.12.2018 | Research | Ausgabe 1/2018 Open Access

ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells

Zhongyuan Tan, Wanpo Zhang, Jianhong Sun, Zuquan Fu, Xianliang Ke, Caishang Zheng, Yuan Zhang, Penghui Li, Yan Liu, Qinxue Hu, Hanzhong Wang, Zhenhua Zheng

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease

Estella A. Newcombe, Judith Camats-Perna, Mallone L. Silva, Nicholas Valmas, Tee Jong Huat, Rodrigo Medeiros

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Impact of nutrition on inflammation, tauopathy, and behavioral outcomes from chronic traumatic encephalopathy

Jin Yu, Hong Zhu, Saeid Taheri, William Mondy, Stephen Perry, Mark S. Kindy

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy

Shane M. Bemiller, Nicole M. Maphis, Shane V. Formica, Gina N. Wilson, Crystal M. Miller, Guixiang Xu, Olga N. Kokiko-Cochran, Ki-Wook Kim, Steffen Jung, Judy L. Cannon, Samuel D. Crish, Astrid E. Cardona, Bruce T. Lamb, Kiran Bhaskar

01.12.2018 | Research | Ausgabe 1/2018 Open Access

LGI1 expression and human brain asymmetry: insights from patients with LGI1-antibody encephalitis

Yoonhyuk Jang, Soon-Tae Lee, Ji-Yeon Bae, Tae-Joon Kim, Jin-Sun Jun, Jangsup Moon, Keun-Hwa Jung, Kyung-Il Park, Sarosh R. Irani, Kon Chu, Sang Kun Lee

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Analyses of gene expression profiles in the rat dorsal horn of the spinal cord using RNA sequencing in chronic constriction injury rats

Hui Du, Juan Shi, Ming Wang, Shuhong An, Xingjing Guo, Zhaojin Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Interaction of systemic oxidative stress and mesial temporal network degeneration in Parkinson’s disease with and without cognitive impairment

Pi-Ling Chiang, Hsiu-Ling Chen, Cheng-Hsien Lu, Yueh-Sheng Chen, Kun-Hsien Chou, Tun-Wei Hsu, Meng-Hsiang Chen, Nai-Wen Tsai, Shau-Hsuan Li, Wei-Che Lin

01.12.2018 | Research | Ausgabe 1/2018 Open Access

α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

Taraneh Ebrahimi, Marcus Rust, Sarah Nele Kaiser, Alexander Slowik, Cordian Beyer, Andreas Rembert Koczulla, Jörg B. Schulz, Pardes Habib, Jan Philipp Bach

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Effects of methylprednisolone on blood-brain barrier and cerebral inflammation in cardiac surgery—a randomized trial

Mattias Danielson, Björn Reinsfelt, Anne Westerlind, Henrik Zetterberg, Kaj Blennow, Sven-Erik Ricksten

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Sphingosine 1-phosphate receptor subtype 3 (S1P3) contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarization

Bhakta Prasad Gaire, Mi-Ryoung Song, Ji Woong Choi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A central role for glial CCR5 in directing the neuropathological interactions of HIV-1 Tat and opiates

Sarah Kim, Yun Kyung Hahn, Elizabeth M Podhaizer, Virginia D McLane, Shiping Zou, Kurt F Hauser, Pamela E Knapp

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD

Ju-Young Lee, Jin Han Nam, Youngpyo Nam, Hye Yeon Nam, Gwangho Yoon, Eunhwa Ko, Sang-Bum Kim, Mahealani R Bautista, Christina C Capule, Takaoki Koyanagi, Geoffray Leriche, Hwan Geun Choi, Jerry Yang, Jeongyeon Kim, Hyang-Sook Hoe

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Adult neurogenic deficits in HIV-1 Tg26 transgenic mice

Raj Putatunda, Yonggang Zhang, Fang Li, Xiao-Feng Yang, Mary F Barbe, Wenhui Hu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Leukemia inhibitory factor modulates the peripheral immune response in a rat model of emergent large vessel occlusion

Stephanie M. Davis, Lisa A. Collier, Edric D. Winford, Christopher C. Leonardo, Craig T. Ajmo Jr, Elspeth A. Foran, Timothy J. Kopper, John C. Gensel, Keith R. Pennypacker

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Central intracrine DHEA synthesis in ageing-related neuroinflammation and neurodegeneration: therapeutic potential?

Y S L Powrie, C Smith

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The IFN-γ/PD-L1 axis between T cells and tumor microenvironment: hints for glioma anti-PD-1/PD-L1 therapy

Jiawen Qian, Chen Wang, Bo Wang, Jiao Yang, Yuedi Wang, Feifei Luo, Junying Xu, Chujun Zhao, Ronghua Liu, Yiwei Chu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

New insights into meningitic Escherichia coli infection of brain microvascular endothelial cells from quantitative proteomics analysis

Wen-Tong Liu, Yu-Jin Lv, Rui-Cheng Yang, Ji-Yang Fu, Lu Liu, Huan Wang, Qi Cao, Chen Tan, Huan-Chun Chen, Xiang-Ru Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Reduction of SIRT1 epigenetically upregulates NALP1 expression and contributes to neuropathic pain induced by chemotherapeutic drug bortezomib

Kun Chen, Jing Fan, Zhao-Fan Luo, Ying Yang, Wen-Jun Xin, Cui-Cui Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Distinct contributions of hyperglycemia and high-fat feeding in metabolic syndrome-induced neuroinflammation

Brooke J. Wanrooy, Kathryn Prame Kumar, Shu Wen Wen, Cheng Xue Qin, Rebecca H. Ritchie, Connie H. Y. Wong

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica

Tianjiao Duan, Alex J. Smith, Alan S. Verkman

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3

Shinnosuke Yamada, Norimichi Itoh, Taku Nagai, Tsuyoshi Nakai, Daisuke Ibi, Akira Nakajima, Toshitaka Nabeshima, Kiyofumi Yamada

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Circulating EZH2-positive T cells are decreased in multiple sclerosis patients

Sunny Malhotra, Luisa M. Villar, Carme Costa, Luciana Midaglia, Marta Cubedo, Silvia Medina, Nicolás Fissolo, Jordi Río, Joaquín Castilló, José C. Álvarez-Cermeño, Alex Sánchez, Xavier Montalban, Manuel Comabella

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4

Isabella Russo, Giulietta Di Benedetto, Alice Kaganovich, Jinhui Ding, Daniela Mercatelli, Michele Morari, Mark R. Cookson, Luigi Bubacco, Elisa Greggio

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Reduced gut microbiome protects from alcohol-induced neuroinflammation and alters intestinal and brain inflammasome expression

Patrick P. Lowe, Benedek Gyongyosi, Abhishek Satishchandran, Arvin Iracheta-Vellve, Yeonhee Cho, Aditya Ambade, Gyongyi Szabo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Hashimoto’s thyroiditis induces neuroinflammation and emotional alterations in euthyroid mice

Yao-Jun Cai, Fen Wang, Zhang-Xiang Chen, Li Li, Hua Fan, Zhang-Bi Wu, Jin-Fang Ge, Wen Hu, Qu-Nan Wang, De-Fa Zhu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Restoration of regulatory B cell deficiency following alemtuzumab therapy in patients with relapsing multiple sclerosis

Yeseul Kim, Gayoung Kim, Hyun-June Shin, Jae-Won Hyun, Su-Hyun Kim, Eunjig Lee, Ho Jin Kim

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Peripheral myeloid cells contribute to brain injury in male neonatal mice

Peter L. P. Smith, Amin Mottahedin, Pernilla Svedin, Carl-Johan Mohn, Henrik Hagberg, Joakim Ek, Carina Mallard

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Chronic relapsing inflammatory optic neuropathy (CRION): a manifestation of myelin oligodendrocyte glycoprotein antibodies

Haeng-Jin Lee, Boram Kim, Patrick Waters, Mark Woodhall, Sarosh Irani, Sohyun Ahn, Seong-Joon Kim, Sung-Min Kim

01.12.2018 | Research | Ausgabe 1/2018 Open Access

HIV-1 Nef-induced lncRNA AK006025 regulates CXCL9/10/11 cluster gene expression in astrocytes through interaction with CBP/P300

Feng Zhou, Xiaomei Liu, Dongjiao Zuo, Min Xue, Lin Gao, Ying Yang, Jing Wang, Liping Niu, Qianwen Cao, Xiangyang Li, Hui Hua, Bo Zhang, Minmin Hu, Dianshuai Gao, Kuiyang Zheng, Yoshihiro Izumiya, Renxian Tang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

CSF sTREM2 in delirium—relation to Alzheimer’s disease CSF biomarkers Aβ42, t-tau and p-tau

Kristi Henjum, Else Quist-Paulsen, Henrik Zetterberg, Kaj Blennow, Lars N. G. Nilsson, Leiv Otto Watne

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Cerebrospinal fluid pro-inflammatory cytokines differentiate parkinsonian syndromes

C. Starhof, K. Winge, N. H. H. Heegaard, K. Skogstrand, S. Friis, A. Hejl

01.12.2018 | Research | Ausgabe 1/2018 Open Access

TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity

V. Alexandra Moser, Mariana F. Uchoa, Christian J. Pike

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study

Tanja Blume, Carola Focke, Finn Peters, Maximilian Deussing, Nathalie L. Albert, Simon Lindner, Franz-Josef Gildehaus, Barbara von Ungern-Sternberg, Laurence Ozmen, Karlheinz Baumann, Peter Bartenstein, Axel Rominger, Jochen Herms, Matthias Brendel

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Ibuprofen prevents progression of ataxia telangiectasia symptoms in ATM-deficient mice

Chin Wai Hui, Xuan Song, Fulin Ma, Xuting Shen, Karl Herrup

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Protein kinase C-delta inhibition protects blood-brain barrier from sepsis-induced vascular damage

Yuan Tang, Fariborz Soroush, Shuang Sun, Elisabetta Liverani, Jordan C. Langston, Qingliang Yang, Laurie E. Kilpatrick, Mohammad F. Kiani

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Omega-3 polyunsaturated fatty acid attenuates traumatic brain injury-induced neuronal apoptosis by inducing autophagy through the upregulation of SIRT1-mediated deacetylation of Beclin-1

Xiangrong Chen, Zhigang Pan, Zhongning Fang, Weibin Lin, Shukai Wu, Fuxing Yang, Yasong Li, Huangde Fu, Hongzhi Gao, Shun Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Partial reduction of microglia does not affect tau pathology in aged mice

Rachel E. Bennett, Annie Bryant, Miwei Hu, Ashley B. Robbins, Sarah C. Hopp, Bradley T. Hyman

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Age-related deregulation of TDP-43 after stroke enhances NF-κB-mediated inflammation and neuronal damage

Sai Sampath Thammisetty, Jordi Pedragosa, Yuan Cheng Weng, Frédéric Calon, Anna Planas, Jasna Kriz

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma

Mohammad Harun-Or-Rashid, Denise M. Inman

01.12.2018 | Research | Ausgabe 1/2018 Open Access

In vivo assessment of neuroinflammation in progressive multiple sclerosis: a proof of concept study with [18F]DPA714 PET

Marloes H. J. Hagens, Sandeep V. Golla, Martijn T. Wijburg, Maqsood Yaqub, Dennis Heijtel, Martijn D. Steenwijk, Patrick Schober, John J. P. Brevé, Robert C. Schuit, Tristan A. Reekie, Michael Kassiou, Anne-Marie van Dam, Albert D. Windhorst, Joep Killestein, Frederik Barkhof, Bart N. M. van Berckel, Adriaan A. Lammertsma

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Human neural stem cell-derived neuron/astrocyte co-cultures respond to La Crosse virus infection with proinflammatory cytokines and chemokines

Brian E. Dawes, Junling Gao, Colm Atkins, Jacob T. Nelson, Kendra Johnson, Ping Wu, Alexander N. Freiberg

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Ca2+-dependent endoplasmic reticulum stress correlation with astrogliosis involves upregulation of KCa3.1 and inhibition of AKT/mTOR signaling

Zhihua Yu, Fangfang Dou, Yanxia Wang, Lina Hou, Hongzhuan Chen

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway

Shalini Swaroop, Anita Mahadevan, Susarla Krishna Shankar, Yogita K. Adlakha, Anirban Basu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Varicella zoster virus differentially alters morphology and suppresses proinflammatory cytokines in primary human spinal cord and hippocampal astrocytes

Andrew N. Bubak, Christina N. Como, Anna M. Blackmon, Dallas Jones, Maria A. Nagel

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Neutrophil to lymphocyte ratio predicts intracranial hemorrhage after endovascular thrombectomy in acute ischemic stroke

Slaven Pikija, Laszlo K. Sztriha, Monika Killer-Oberpfalzer, Friedrich Weymayr, Constantin Hecker, Christian Ramesmayer, Larissa Hauer, Johann Sellner

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines

Ting Zhang, Nan Zhang, Run Zhang, Weidong Zhao, Yong Chen, Zilong Wang, Biao Xu, Mengna Zhang, Xuerui Shi, Qinqin Zhang, Yuanyuan Guo, Jian Xiao, Dan Chen, Quan Fang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Anti-inflammatory effects induced by pharmaceutical substances on inflammatory active brain astrocytes—promising treatment of neuroinflammation

Elisabeth Hansson, Ulrika Björklund, Eva Skiöldebrand, Lars Rönnbäck

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells

Soraya Wilke Saliba, Hannah Jauch, Brahim Gargouri, Albrecht Keil, Thomas Hurrle, Nicole Volz, Florian Mohr, Mario van der Stelt, Stefan Bräse, Bernd L. Fiebich

01.12.2018 | Research | Ausgabe 1/2018 Open Access

STING-mediated type-I interferons contribute to the neuroinflammatory process and detrimental effects following traumatic brain injury

Amar Abdullah, Moses Zhang, Tony Frugier, Sammy Bedoui, Juliet M. Taylor, Peter J. Crack

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Glial-neuronal signaling mechanisms underlying the neuroinflammatory effects of manganese

Katriana A. Popichak, Maryam F. Afzali, Kelly S. Kirkley, Ronald B. Tjalkens

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A central role for P2X7 receptors in human microglia

Laura Janks, Cristian V. R. Sharma, Terrance M. Egan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Anti-inflammatory and anti-oxidant mechanisms of an MMP-8 inhibitor in lipoteichoic acid-stimulated rat primary astrocytes: involvement of NF-κB, Nrf2, and PPAR-γ signaling pathways

Eun-Jung Lee, Jin-Sun Park, Yu-Young Lee, Do-Yeon Kim, Jihee Lee Kang, Hee-Sun Kim

01.12.2018 | Research | Ausgabe 1/2018 Open Access

High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections

Else Quist-Paulsen, Pål Aukrust, Anne-Marte Bakken Kran, Oona Dunlop, Vidar Ormaasen, Birgitte Stiksrud, Øivind Midttun, Thor Ueland, Per Magne Ueland, Tom Eirik Mollnes, Anne Ma Dyrhol-Riise

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Effect of NAC treatment and physical activity on neuroinflammation in subchronic Parkinsonism; is physical activity essential?

Ana-Luisa Gil-Martínez, Lorena Cuenca, Consuelo Sánchez, Cristina Estrada, Emiliano Fernández-Villalba, María Trinidad Herrero

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inflammation is correlated with severity and outcome of cerebral venous thrombosis

Liyan Wang, Jiangang Duan, Tingting Bian, Ran Meng, Longfei Wu, Zhen Zhang, Xuxiang Zhang, Chunxiu Wang, Xunming Ji

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Lipocalin 2 contributes to brain iron dysregulation but does not affect cognition, plaque load, and glial activation in the J20 Alzheimer mouse model

Doortje W. Dekens, Petrus J. W. Naudé, Jan N. Keijser, Ate S. Boerema, Peter P. De Deyn, Ulrich L. M. Eisel

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Profiling the proteomic inflammatory state of human astrocytes using DIA mass spectrometry

Vito Dozio, Jean-Charles Sanchez

01.12.2018 | Research | Ausgabe 1/2018 Open Access

IL-17A contributes to perioperative neurocognitive disorders through blood-brain barrier disruption in aged mice

Pengfei Ni, Hongquan Dong, Yiwei Wang, Qin Zhou, Mengmeng Xu, Yanning Qian, Jie Sun

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Counteracting neuroinflammation in experimental Parkinson’s disease favors recovery of function: effects of Er-NPCs administration

Stephana Carelli, Toniella Giallongo, Zuzana Gombalova, Federica Rey, Maria Carlotta F. Gorio, Massimiliano Mazza, Anna Maria Di Giulio

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Phosphatidylserine-microbubble targeting-activated microglia/macrophage in inflammation combined with ultrasound for breaking through the blood–brain barrier

Ranran Zhao, Jie Jiang, Huiwen Li, Min Chen, Renfa Liu, Sujuan Sun, De Ma, Xiaolong Liang, Shumin Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Regulatory role of capsaicin-sensitive peptidergic sensory nerves in the proteoglycan-induced autoimmune arthritis model of the mouse

Ádám Horváth, Éva Borbély, Kata Bölcskei, Nikolett Szentes, Tamás Kiss, Mátyás Belák, Tibor Rauch, Tibor Glant, Róza Zákány, Tamás Juhász, Edina Karanyicz, Ferenc Boldizsár, Zsuzsanna Helyes, Bálint Botz

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Persistent reduction in sialylation of cerebral glycoproteins following postnatal inflammatory exposure

Ekaterina P. Demina, Wyston C. Pierre, Annie L. A. Nguyen, Irene Londono, Bela Reiz, Chunxia Zou, Radhika Chakraberty, Christopher W. Cairo, Alexey V. Pshezhetsky, Gregory A. Lodygensky

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The GLP-1 analog, liraglutide prevents the increase of proinflammatory mediators in the hippocampus of male rat pups submitted to maternal perinatal food restriction

Y. Diz-Chaves, L. Toba, J. Fandiño, L. C. González-Matías, L. M. Garcia-Segura, F. Mallo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression

Qiqi Song, Cuiqin Fan, Peng Wang, Ye Li, Mu Yang, Shu Yan Yu

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke

Liang Zhao, Qiutang Xiong, Creed M. Stary, Omer Kamal Mahgoub, Yingze Ye, Lijuan Gu, Xiaoxing Xiong, Shengmei Zhu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Colony-stimulating factor 1 receptor inhibition prevents disruption of the blood-retina barrier during chronic inflammation

Despina Kokona, Andreas Ebneter, Pascal Escher, Martin S. Zinkernagel

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Methamphetamine neurotoxicity, microglia, and neuroinflammation

Fatemeh Shaerzadeh, Wolfgang J. Streit, Soomaayeh Heysieattalab, Habibeh Khoshbouei

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Circulating levels of IL-1 family cytokines and receptors in Alzheimer’s disease: new markers of disease progression?

Paola Italiani, Ilaria Puxeddu, Sabrina Napoletano, Emanuele Scala, Daniela Melillo, Simone Manocchio, Antonella Angiolillo, Paola Migliorini, Diana Boraschi, Emilia Vitale, Alfonso Di Costanzo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The atypical RhoGTPase RhoE/Rnd3 is a key molecule to acquire a neuroprotective phenotype in microglia

Veronika E. Neubrand, Irene Forte-Lago, Marta Caro, Mario Delgado

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Monocyte infiltration rather than microglia proliferation dominates the early immune response to rapid photoreceptor degeneration

Sarah J. Karlen, Eric B. Miller, Xinlei Wang, Emily S. Levine, Robert J. Zawadzki, Marie E. Burns

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A mathematical model of neuroinflammation in severe clinical traumatic brain injury

Leah E. Vaughan, Prerna R. Ranganathan, Raj G. Kumar, Amy K. Wagner, Jonathan E. Rubin

01.12.2018 | Short report | Ausgabe 1/2018 Open Access

Imaging glial activation in patients with post-treatment Lyme disease symptoms: a pilot study using [11C]DPA-713 PET

Jennifer M. Coughlin, Ting Yang, Alison W. Rebman, Kathleen T. Bechtold, Yong Du, William B. Mathews, Wojciech G. Lesniak, Erica A. Mihm, Sarah M. Frey, Erica S. Marshall, Hailey B. Rosenthal, Tristan A. Reekie, Michael Kassiou, Robert F. Dannals, Mark J. Soloski, John N. Aucott, Martin G. Pomper

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NF-κB signaling pathway

Fu-yi Liu, Jing Cai, Chun Wang, Wu Ruan, Guo-ping Guan, Hai-zhou Pan, Jian-ru Li, Cong Qian, Jing-sen Chen, Lin Wang, Gao Chen

01.12.2018 | Review | Ausgabe 1/2018 Open Access

A review of the role of cav-1 in neuropathology and neural recovery after ischemic stroke

Qianyi Huang, Wei Zhong, Zhiping Hu, Xiangqi Tang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Sequential alteration of microglia and astrocytes in the rat thalamus following spinal nerve ligation

Lucie Blaszczyk, Marlène Maître, Thierry Lesté-Lasserre, Samantha Clark, Daniela Cota, Stéphane H. R. Oliet, Valérie S. Fénelon

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    Facharztwissen Psychiatrie, Psychosomatik und Psychotherapie

    Leitsymptome, Untersuchungsmethoden, Krankheitsbilder, Notfälle & Co. – mit der Neuauflage des "Facharztwissens" sind Sie auf die Facharztprüfung in Psychiatrie und Psychotherapie optimal vorbereitet. In dieser 2. Auflage sind die Kapitel zu psychosomatischen Störungen deutlich ausgebaut.

    Herausgeber:
    Prof. Dr. Dr. Frank Schneider
  • 2012 | Buch

    Kompendium der Psychotherapie

    Für Ärzte und Psychologen

    Wer in den vorhandenen Lehrbüchern der Psychotherapie den Brückenschlag zur täglichen praktischen Arbeit vermissen – ist mit diesem Werk gut bedient. In knapper, manualisierter Form werden verständlich und übersichtlich die Schritte, Techniken und konkreten, evidenzbasierten Vorgehensweisen beschrieben.

    Herausgeber:
    Prof. Dr. med. Tilo Kircher