Ausgabe 1/2023
Inhalt (309 Artikel)
Extracellular vesicles from mesenchymal stem cells reduce neuroinflammation in hippocampus and restore cognitive function in hyperammonemic rats
Paula Izquierdo-Altarejos, Andrea Cabrera-Pastor, Mar Martínez-García, Carlos Sánchez-Huertas, Alberto Hernández, Victoria Moreno-Manzano, Vicente Felipo
Correction: Motor neuron survival is associated with reduced neuroinflammation and increased autophagy after brachial plexus avulsion injury in aldose reductase-deficient mice
Ke Zhong, Yu Huang, Prince last Mudenda Zilundu, Yaqiong Wang, Yingying Zhou, Guangyin Yu, Rao Fu, Sookja Kim Chung, Yamei Tang, Xiao Cheng, Lihua Zhou
Intracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function
Evangelos Konstantinidis, Benjamin Portal, Tobias Mothes, Chiara Beretta, Maria Lindskog, Anna Erlandsson
Delayed NLRP3 inflammasome inhibition ameliorates subacute stroke progression in mice
Maximilian Bellut, Michael Bieber, Peter Kraft, Alexander N. R. Weber, Guido Stoll, Michael K. Schuhmann
Protein kinase B (AKT) upregulation and Thy-1-αvβ3 integrin-induced phosphorylation of Connexin43 by activated AKT in astrogliosis
Ramón Pérez-Núñez, Alejandro Chamorro, María Fernanda González, Pamela Contreras, Rocío Artigas, Alejandro H. Corvalán, Brigitte van Zundert, Christopher Reyes, Pablo R. Moya, Ana María Avalos, Pascal Schneider, Andrew F. G. Quest, Lisette Leyton
Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization
Haojie Zhang, Yituo Chen, Feida Li, Chenyu Wu, Wanta Cai, Hantao Ye, Haohan Su, Mingjun He, Liangliang Yang, Xiangyang Wang, Kailiang Zhou, Wenfei Ni
Teriflunomide as a therapeutic means for myelin repair
Peter Göttle, Janos Groh, Laura Reiche, Joel Gruchot, Nicole Rychlik, Luisa Werner, Iria Samper Agrelo, Rainer Akkermann, Annika Zink, Alessandro Prigione, Hans-Peter Hartung, Rudolf Martini, Patrick Küry
Brain endothelial CXCL12 attracts protective natural killer cells during ischemic stroke
Shuaiwei Wang, Lauriane de Fabritus, Praveen Ashok Kumar, Yves Werner, Minglu Ma, Dan Li, Carole Siret, Milesa Simic, Bin Li, Yann M. Kerdiles, Lei Hou, Ralf Stumm, Serge A. van de Pavert
Blocking interleukin-23 ameliorates neuromuscular and thymic defects in myasthenia gravis
José A. Villegas, Jérôme Van Wassenhove, Judith Merrheim, Karen Matta, Samy Hamadache, Clémence Flaugère, Pauline Pothin, Frédérique Truffault, Sébastien Hascoët, Nicola Santelmo, Marco Alifano, Sonia Berrih-Aknin, Rozen le Panse, Nadine Dragin
The FGF/FGFR system in the microglial neuroinflammation with Borrelia burgdorferi: likely intersectionality with other neurological conditions
Geetha Parthasarathy, Melissa B. Pattison, Cecily C. Midkiff
Transplanted human iPSC-derived vascular endothelial cells promote functional recovery by recruitment of regulatory T cells to ischemic white matter in the brain
Bin Xu, Hiroya Shimauchi-Ohtaki, Yuhei Yoshimoto, Tetsushi Sadakata, Yasuki Ishizaki
Abcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced axonal injury, cytotoxic edema and cognitive dysfunction vs. wild-type in a cecal ligation and puncture model of sepsis
Jessica Cummings, Yijen L. Wu, C. Edward Dixon, Jeremy Henchir, J. Marc Simard, Ashok Panigrahy, Patrick M. Kochanek, Ruchira M. Jha, Rajesh K. Aneja
Early peripheral blood gene expression associated with good and poor 90-day ischemic stroke outcomes
Hajar Amini, Bodie Knepp, Fernando Rodriguez, Glen C. Jickling, Heather Hull, Paulina Carmona-Mora, Cheryl Bushnell, Bradley P. Ander, Frank R. Sharp, Boryana Stamova
Role of acyl-coenzyme A: cholesterol transferase 1 (ACAT1) in retinal neovascularization
Syed A. H. Zaidi, Tahira Lemtalsi, Zhimin Xu, Isabella Santana, Porsche Sandow, Leila Labazi, Robert W. Caldwell, Ruth B. Caldwell, Modesto A. Rojas
Neonatal inflammation increases hippocampal KCC2 expression through methylation-mediated TGF-β1 downregulation leading to impaired hippocampal cognitive function and synaptic plasticity in adult mice
Jing Rong, Yang Yang, Min Liang, Haiquan Zhong, Yingchun Li, Yichao Zhu, Sha Sha, Lei Chen, Rong Zhou
Nanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress
Zhenghao Li, Kefu Chen, Qi Shao, Hongtao Lu, Xin Zhang, Yingyan Pu, Xuejun Sun, Hua He, Li Cao
Inhibition of 2-arachidonoylglycerol degradation enhances glial immunity by single-cell transcriptomic analysis
Dexiao Zhu, Jian Zhang, Jack Hashem, Fei Gao, Chu Chen
The presence of cerebellar B cell aggregates is associated with a specific chemokine profile in the cerebrospinal fluid in a mouse model of multiple sclerosis
Verena Schropp, Rittika Chunder, Barbara Dietel, Sabine Tacke, Stefanie Kuerten
Patchouli alcohol attenuates the cognitive deficits in a transgenic mouse model of Alzheimer’s disease via modulating neuropathology and gut microbiota through suppressing C/EBPβ/AEP pathway
Qing-Qing Xu, Zi-Ren Su, Wen Yang, Mei Zhong, Yan-Fang Xian, Zhi-Xiu Lin
Plasma derived extracellular vesicle biomarkers of microglia activation in an experimental stroke model
A. D. Roseborough, S. J. Myers, R. Khazaee, Y. Zhu, L. Zhao, E. Iorio, F. M. Elahi, S. H. Pasternak, S. N. Whitehead
TNEA therapy promotes the autophagic degradation of NLRP3 inflammasome in a transgenic mouse model of Alzheimer’s disease via TFEB/TFE3 activation
Wenjia Lin, Zhao Li, Guangfeng Liang, Runjin Zhou, Xiaoyan Zheng, Rongrong Tao, Qingwei Huo, Chengfu Su, Min Li, Nenggui Xu, Chunzhi Tang, Ju-Xian Song
Hydrogen attenuates postoperative pain through Trx1/ASK1/MMP9 signaling pathway
Juan Li, Shirong Ruan, Jinhui Jia, Qian Li, Rumeng Jia, Li Wan, Xing Yang, Peng Teng, Qilin Peng, Ya-dan Shi, Pan Yu, Yinbing Pan, Man-lin Duan, Wen-Tao Liu, Li Zhang, Liang Hu
5-HT attenuates chronic stress-induced cognitive impairment in mice through intestinal flora disruption
Junxing Ma, Ran Wang, Yaoxing Chen, Zixu Wang, Yulan Dong
Pertussis toxin-induced inhibition of Wnt/β-catenin signaling in dendritic cells promotes an autoimmune response in experimental autoimmune uveitis
Zhihui Zhang, Yongtao Li, Nu Chen, Huan Li, Shuang Chen, Xuexue Cui, Hui Shao, Lai Wei, Jianxing Ma, Song Zhang, Xiaorong Li, Xiaomin Zhang
Endothelial Toll-like receptor 4 is required for microglia activation in the murine retina after systemic lipopolysaccharide exposure
Ioanna Tsioti, Beatrice L. Steiner, Pascal Escher, Martin S. Zinkernagel, Peter M. Benz, Despina Kokona
ASC specks exacerbate α‑synuclein pathology via amplifying NLRP3 inflammasome activities
Ran Zheng, Yiqun Yan, Shaobing Dai, Yang Ruan, Ying Chen, Chenjun Hu, Zhihao Lin, Naijia Xue, Zhe Song, Yi Liu, Baorong Zhang, Jiali Pu
Myeloid cells protect corneal nerves against sterile injury through negative-feedback regulation of TLR2–IL-6 axis
Hyun Ju Lee, Hyeon Ji Kim, Jung Hwa Ko, Joo Youn Oh
Melanophages give rise to hyperreflective foci in AMD, a disease-progression marker
Sebastien Augustin, Marion Lam, Sophie Lavalette, Anna Verschueren, Frédéric Blond, Valérie Forster, Lauriane Przegralek, Zhiguo He, Daniel Lewandowski, Alexis-Pierre Bemelmans, Serge Picaud, José-Alain Sahel, Thibaud Mathis, Michel Paques, Gilles Thuret, Xavier Guillonneau, Cécile Delarasse, Florian Sennlaub
Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model
Nicolau Beckmann, Anna Neuhaus, Stefan Zurbruegg, Pia Volkmer, Claudia Patino, Stefanie Joller, Dominik Feuerbach, Arno Doelemeyer, Tatjana Schweizer, Stefan Rudin, Ulf Neumann, Ramon Berth, Wilfried Frieauff, Fabrizio Gasparini, Derya R. Shimshek
The brain reacting to COVID-19: analysis of the cerebrospinal fluid proteome, RNA and inflammation
Dirk Reinhold, Vadim Farztdinov, Yan Yan, Christian Meisel, Henrik Sadlowski, Joachim Kühn, Frank H. Perschel, Matthias Endres, Emrah Düzel, Stefan Vielhaber, Karina Guttek, Alexander Goihl, Morten Venø, Bianca Teegen, Winfried Stöcker, Paula Stubbemann, Florian Kurth, Leif E. Sander, Markus Ralser, Carolin Otto, Simon Streit, Sven Jarius, Klemens Ruprecht, Helena Radbruch, Jørgen Kjems, Michael Mülleder, Frank Heppner, Peter Körtvelyessy
Morinda officinalis oligosaccharides mitigate depression-like behaviors in hypertension rats by regulating Mfn2-mediated mitophagy
Lixuan Yang, Yutian Ao, Yannan Li, Baoan Dai, Jingchun Li, Wenzhe Duan, Wei Gao, Zhonghui Zhao, Zhenyun Han, Rongjuan Guo
Inducible co-stimulatory molecule (ICOS) alleviates paclitaxel-induced neuropathic pain via an IL-10-mediated mechanism in female mice
Ishwarya Sankaranarayanan, Diana Tavares-Ferreira, Juliet M. Mwirigi, Galo L. Mejia, Michael D. Burton, Theodore J. Price
The reciprocal interactions between microglia and T cells in Parkinson’s disease: a double-edged sword
Yuxiang Xu, Yongjie Li, Changqing Wang, Tingting Han, Haixuan Liu, Lin Sun, Jun Hong, Makoto Hashimoto, Jianshe Wei
Exploring the neuroprotective effects of montelukast on brain inflammation and metabolism in a rat model of quinolinic acid-induced striatal neurotoxicity
Margherita Tassan Mazzocco, Valentina Murtaj, Daniel Martins, Roberta Schellino, Angela Coliva, Elisa Toninelli, Alessandro Vercelli, Federico Turkheimer, Sara Belloli, Rosa Maria Moresco
Siponimod ameliorates experimental autoimmune neuritis
Takafumi Uchi, Shingo Konno, Hideo Kihara, Toshiki Fujioka
α-Synuclein induces prodromal symptoms of Parkinson’s disease via activating TLR2/MyD88/NF-κB pathway in Schwann cells of vagus nerve in a rat model
Yue Cheng, Qing Tong, Yongsheng Yuan, Xinna Song, Wenwen Jiang, Yueping Wang, Wenjie Li, Yangxia Li, Kezhong Zhang
Activation of endogenous retrovirus triggers microglial immuno-inflammation and contributes to negative emotional behaviors in mice with chronic stress
Han Bao, Jinqi Yan, Jiancheng Huang, Wenjuan Deng, Ce Zhang, Cong Liu, Ailing Huang, Qiao Zhang, Ying Xiong, Qiang Wang, Huanghui Wu, Lichao Hou
Efficacy and safety of lenalidomide in HIV-associated cryptococcal meningitis patients with persistent intracranial inflammation: an open-label, single-arm, prospective interventional study
Zhikai Wan, Ran Tao, Jiangjin Hui, Xiang Liu, Xiaorong Peng, Yongzheng Guo, Xueling Zhu, Ying Huang, Biao Zhu
Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1
Chunling Huang, Lulu Sun, Chenyang Xiao, Wenjun You, Li Sun, Siye Wang, Zhijun Zhang, Su Liu
Correction: Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease
Xuesong Chen, Jeremy W. Gawryluk, John F. Wagener, Othman Ghribi, Jonathan D. Geiger
Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4/MyD88/NF-κB pathway in LPC-induced demyelination
Yao Wang, Dilinuer Sadike, Bo Huang, Ping Li, Qiao Wu, Na Jiang, Yongkang Fang, Guini Song, Li Xu, Wei Wang, Minjie Xie
Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase–NLRP3 inflammasome axis-dependent microglial activation
Liyan Hou, Jianing Liu, Fuqiang Sun, Ruixue Huang, Rui Chang, Zhengzheng Ruan, Ying Wang, Jie Zhao, Qingshan Wang
Amyloid-β accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism
Marlena Zyśk, Chiara Beretta, Luana Naia, Abdulkhalek Dakhel, Linnea Påvénius, Hjalmar Brismar, Maria Lindskog, Maria Ankarcrona, Anna Erlandsson
The critical role of KLF4 in regulating the activation of A1/A2 reactive astrocytes following ischemic stroke
Cong Wang, Longxuan Li
Old age promotes retinal fibrosis in choroidal neovascularization through circulating fibrocytes and profibrotic macrophages
Caijiao Yi, Jian Liu, Wen Deng, Chang Luo, Jinyan Qi, Mei Chen, Heping Xu
Supporting the differential diagnosis of connective tissue diseases with neurological involvement by blood and cerebrospinal fluid flow cytometry
Michael Heming, Louisa Müller-Miny, Leoni Rolfes, Andreas Schulte-Mecklenbeck, Tobias J. Brix, Julian Varghese, Marc Pawlitzki, Hermann Pavenstädt, Martin A. Kriegel, Catharina C. Gross, Heinz Wiendl, Gerd Meyer zu Hörste
Depletion and activation of microglia impact metabolic connectivity of the mouse brain
Johannes Gnörich, Anika Reifschneider, Karin Wind, Artem Zatcepin, Sebastian T. Kunte, Philipp Beumers, Laura M. Bartos, Thomas Wiedemann, Maximilian Grosch, Xianyuan Xiang, Maryam K. Fard, Francois Ruch, Georg Werner, Mara Koehler, Luna Slemann, Selina Hummel, Nils Briel, Tanja Blume, Yuan Shi, Gloria Biechele, Leonie Beyer, Florian Eckenweber, Maximilian Scheifele, Peter Bartenstein, Nathalie L. Albert, Jochen Herms, Sabina Tahirovic, Christian Haass, Anja Capell, Sibylle Ziegler, Matthias Brendel
Myeloid deficiency of the intrinsic clock protein BMAL1 accelerates cognitive aging by disrupting microglial synaptic pruning
Chinyere Agbaegbu Iweka, Erica Seigneur, Amira Latif Hernandez, Sur Herrera Paredes, Mica Cabrera, Eran Blacher, Connie Tsai Pasternak, Frank M. Longo, Luis de Lecea, Katrin I. Andreasson
Human umbilical cord-derived mesenchymal stem cell transplantation supplemented with curcumin improves the outcomes of ischemic stroke via AKT/GSK-3β/β-TrCP/Nrf2 axis
Yuan Li, Jialu Huang, Jie Wang, Simin Xia, Hong Ran, Lenyu Gao, Chengjian Feng, Li Gui, Zhenhua Zhou, Jichao Yuan
TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair
Jinghui Xu, Liying Zhang, Mingyue Li, Xiaofei He, Jing Luo, Rui Wu, Zhongqiu Hong, Haiqing Zheng, Xiquan Hu
Chronic kidney disease promotes cerebral microhemorrhage formation
Chuo Fang, Wei Ling Lau, Jiahong Sun, Rudy Chang, Adrian Vallejo, Donghy Lee, Jihua Liu, Han Liu, Yu-Han Hung, Yitong Zhao, Annlia Paganini-Hill, Rachita K. Sumbria, David H. Cribbs, Mark Fisher
Retraction Note to: Regulation of autophagy by the nuclear factor κB signaling pathway in the hippocampus of rats with sepsis
YunJie Su, Yi Qu, FengYan Zhao, HuaFeng Li, DeZhi Mu, XiHong Li
A short peptide exerts neuroprotective effects on cerebral ischemia–reperfusion injury by reducing inflammation via the miR-6328/IKKβ/NF-κB axis
Yilin Li, Tao Jin, Naixin Liu, Junsong Wang, Zihan Qin, Saige Yin, Yingxuan Zhang, Zhe Fu, Yutong Wu, Yinglei Wang, Yixiang Liu, Meifeng Yang, Ailan Pang, Jun Sun, Ying Wang, Xinwang Yang
Berberine ameliorates depression-like behaviors in mice via inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing neuroplasticity disruption
Zongshi Qin, Dong-Dong Shi, Wenqi Li, Dan Cheng, Ying-Dan Zhang, Sen Zhang, Bun Tsoi, Jia Zhao, Zhen Wang, Zhang-Jin Zhang
Exogenous monocyte myeloid-derived suppressor cells ameliorate immune imbalance, neuroinflammation and cognitive impairment in 5xFAD mice infected with Porphyromonas gingivalis
Xiao Cheng, Li Chi, Tianqiong Lin, Fengyin Liang, Zhong Pei, Jianbo Sun, Wei Teng
Opposing effects of β-2 and β-1 adrenergic receptor signaling on neuroinflammation and dopaminergic neuron survival in α-synuclein-mediated neurotoxicity
Daniel Torrente, Enming J. Su, Gerald P. Schielke, Mark Warnock, Kris Mann, Daniel A. Lawrence
Effects of diabetes on microglial physiology: a systematic review of in vitro, preclinical and clinical studies
María Vargas-Soria, Mónica García-Alloza, Miriam Corraliza-Gómez
IFNAR signaling of neuroectodermal cells is essential for the survival of C57BL/6 mice infected with Theiler’s murine encephalomyelitis virus
Melanie Bühler, Dandan Li, Lin Li, Sandra Runft, Inken Waltl, Andreas Pavlou, Ulrich Kalinke, Malgorzata Ciurkiewicz, Jochen Huehn, Stefan Floess, Andreas Beineke, Wolfgang Baumgärtner, Ingo Gerhauser
Endometriosis leads to central nervous system-wide glial activation in a mouse model of endometriosis
Shah Tauseef Bashir, Catherine R. Redden, Kishori Raj, Rachel B. Arcanjo, Sandra Stasiak, Quanxi Li, Andrew J. Steelman, Romana A. Nowak
Microglia specific deletion of miR-155 in Alzheimer’s disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures
Macarena S. Aloi, Katherine E. Prater, Raymond E. A. Sánchez, Asad Beck, Jasmine L. Pathan, Stephanie Davidson, Angela Wilson, C. Dirk Keene, Horacio de la Iglesia, Suman Jayadev, Gwenn A. Garden
Metabolic reprogramming and lipid droplets are involved in Zika virus replication in neural cells
Suelen Silva Gomes Dias, Tamires Cunha-Fernandes, Luciana Souza-Moreira, Vinicius Cardoso Soares, Giselle Barbosa Lima, Isaclaudia G. Azevedo-Quintanilha, Julia Santos, Filipe Pereira-Dutra, Caroline Freitas, Patricia A. Reis, Stevens Kastrup Rehen, Fernando A. Bozza, Thiago M. Lopes Souza, Cecilia J. G. de Almeida, Patricia T. Bozza
Cannabinoids modulate the microbiota–gut–brain axis in HIV/SIV infection by reducing neuroinflammation and dysbiosis while concurrently elevating endocannabinoid and indole-3-propionate levels
Marina McDew-White, Eunhee Lee, Lakmini S. Premadasa, Xavier Alvarez, Chioma M. Okeoma, Mahesh Mohan
Microglia/macrophages require vitamin D signaling to restrain neuroinflammation and brain injury in a murine ischemic stroke model
Pan Cui, Wanting Lu, Junjie Wang, Fei Wang, Xiyue Zhang, Xiaodan Hou, Fang Xu, Yan Liang, Guoliang Chai, Junwei Hao
Regulatory T cells decrease C3-positive reactive astrocytes in Alzheimer-like pathology
Grégoire Stym-Popper, Karen Matta, Thomas Chaigneau, Roshan Rupra, Alexandros Demetriou, Stéphane Fouquet, Cira Dansokho, Cécile Toly-Ndour, Guillaume Dorothée
Peripheral inflammation in behavioural variant frontotemporal dementia: associations with central degeneration and clinical measures
Min Chu, Lulu Wen, Deming Jiang, Li Liu, Haitian Nan, Ailing Yue, Yingtao Wang, Yihao Wang, Miao Qu, Ningqun Wang, Liyong Wu
Helicobacter pylori outer membrane vesicles induce astrocyte reactivity through nuclear factor-κappa B activation and cause neuronal damage in vivo in a murine model
Esteban Palacios, Lorena Lobos-González, Simón Guerrero, Marcelo J. Kogan, Baohai Shao, Jay W. Heinecke, Andrew F. G. Quest, Lisette Leyton, Manuel Valenzuela-Valderrama
Understanding microglial responses in large animal models of traumatic brain injury: an underutilized resource for preclinical and translational research
Michael R. Grovola, Catherine von Reyn, David J. Loane, D. Kacy Cullen
[18F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data
Anna Ballweg, Carolin Klaus, Letizia Vogler, Sabrina Katzdobler, Karin Wind, Artem Zatcepin, Sibylle I. Ziegler, Birkan Secgin, Florian Eckenweber, Bernd Bohr, Alexander Bernhardt, Urban Fietzek, Boris-Stephan Rauchmann, Sophia Stoecklein, Stefanie Quach, Leonie Beyer, Maximilian Scheifele, Marcel Simmet, Emanuel Joseph, Simon Lindner, Isabella Berg, Norman Koglin, Andre Mueller, Andrew W. Stephens, Peter Bartenstein, Joerg C. Tonn, Nathalie L. Albert, Tania Kümpfel, Martin Kerschensteiner, Robert Perneczky, Johannes Levin, Lars Paeger, Jochen Herms, Matthias Brendel
HMGB1 mediates synaptic loss and cognitive impairment in an animal model of sepsis-associated encephalopathy
Xiao-Yu Yin, Xiao-Hui Tang, Shi-Xu Wang, Yong-Chang Zhao, Min Jia, Jian-Jun Yang, Mu-Huo Ji, Jin-Chun Shen
Association of admission neutrophil serine proteinases levels with the outcomes of acute ischemic stroke: a prospective cohort study
Lingzhi Li, Ziping Han, Rongliang Wang, Junfen Fan, Yangmin Zheng, Yuyou Huang, Zhenhong Yang, Feng Yan, Ping Liu, Haiping Zhao, Qingfeng Ma, Yumin Luo
IL-1β and TNF-α play an important role in modulating the risk of periodontitis and Alzheimer’s disease
Rachel Pei-Hsuan Wang, Jianpan Huang, Kannie Wai Yan Chan, Wai Keung Leung, Tetsuya Goto, Yuen-Shan Ho, Raymond Chuen-Chung Chang
TGF-β1 signalling in Alzheimer’s pathology and cytoskeletal reorganization: a specialized Tau perspective
Mahima Kapoor, Subashchandrabose Chinnathambi
Astrocytes display ultrastructural alterations and heterogeneity in the hippocampus of aged APP-PS1 mice and human post-mortem brain samples
Marie-Kim St-Pierre, Micaël Carrier, Fernando González Ibáñez, Mohammadparsa Khakpour, Marie-Josée Wallman, Martin Parent, Marie-Ève Tremblay
Decrease in naturally occurring antibodies against epitopes of Alzheimer’s disease (AD) risk gene products is associated with cognitive decline in AD
Dongmei Gu, Luchun Wang, Nan Zhang, Huali Wang, Xin Yu
Tregs dysfunction aggravates postoperative cognitive impairment in aged mice
Yile Zhou, Huihui Ju, Yan Hu, Tingting Li, Zhouyi Chen, Yuan Si, Xia Sun, Yi Shi, Hao Fang
Exercise suppresses neuroinflammation for alleviating Alzheimer’s disease
Minghui Wang, Hu Zhang, Jiling Liang, Jielun Huang, Ning Chen
Cannabinoids in traumatic brain injury and related neuropathologies: preclinical and clinical research on endogenous, plant-derived, and synthetic compounds
Brittney R. Lins, Chidozie C. Anyaegbu, Sarah C. Hellewell, Melissa Papini, Terence McGonigle, Luca De Prato, Matthew Shales, Melinda Fitzgerald
Control of the temporal development of Alzheimer’s disease pathology by the MR1/MAIT cell axis
Season K. Wyatt-Johnson, Holly N. Kersey, Juan F. Codocedo, Kathy L. Newell, Gary E. Landreth, Bruce T. Lamb, Adrian L. Oblak, Randy R. Brutkiewicz
Inflammasome inhibition protects dopaminergic neurons from α-synuclein pathology in a model of progressive Parkinson’s disease
Alexander Grotemeyer, Judith F. Fischer, James B. Koprich, Jonathan M. Brotchie, Robert Blum, Jens Volkmann, Chi Wang Ip
The short isoform of MS4A7 is a novel player in glioblastoma microenvironment, M2 macrophage polarization, and tumor progression
Bowen Ni, Guanglong Huang, Runwei Yang, Ziyu Wang, Haimin Song, Kaishu Li, Yunxiao Zhang, Kezhi Wu, Guangwei Shi, Xiran Wang, Jie Shen, Yawei Liu
Microglia sustain anterior cingulate cortex neuronal hyperactivity in nicotine-induced pain
Dan-dan Long, Yu-zhuo Zhang, An Liu, Liang Shen, Hong-rui Wei, Qian-qian Lou, Shan-shan Hu, Dan-yang Chen, Xiao-qing Chai, Di Wang
Stellate ganglion block ameliorated central post-stroke pain with comorbid anxiety and depression through inhibiting HIF-1α/NLRP3 signaling following thalamic hemorrhagic stroke
Zhong-Mou Shi, Jun-Jie Jing, Zheng-Jie Xue, Wen-Jun Chen, Yan-Bin Tang, Du-Juan Chen, Xin-Yi Qi, Li Huang, Yi-Qing Zou, Xiao-Zhi Wu, Fei Yang
Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination
Yumeng Wang, Jingxian Sun, Keying Zhu, Danjie Wang, Xiaoqiang Zhao, Hongyu Zhang, Shuai Wu, Yanqing Wang, Jun Wang
α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect
Huiyang Liu, Xiaomei Zhang, Peng Shi, Jiyuan Yuan, Qiang Jia, Chao Pi, Tao Chen, Linjin Xiong, Jinglin Chen, Jia Tang, Ruxu Yue, Zerong Liu, Hongping Shen, Ying Zuo, Yumeng Wei, Ling Zhao
Optical coherence tomography angiography measurements in multiple sclerosis: a systematic review and meta-analysis
Soheil Mohammadi, Mahdi Gouravani, Mohammad Amin Salehi, J. Fernando Arevalo, Steven L. Galetta, Hamid Harandi, Elliot M. Frohman, Teresa C. Frohman, Shiv Saidha, Neda Sattarnezhad, Friedemann Paul
Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models
Dewei He, Shoupeng Fu, Bojian Ye, Hefei Wang, Yuan He, Zhe Li, Jie Li, Xiyu Gao, Dianfeng Liu
Kynurenic acid blunts A1 astrocyte activation against neurodegeneration in HIV-associated neurocognitive disorders
Jingxian Lun, Yubin Li, Xuefeng Gao, Zelong Gong, Xiaoliang Chen, Jinhu Zou, Chengxing Zhou, Yuanyuan Huang, Bingliang Zhou, Pengwei Huang, Hong Cao
Septin-3 autoimmunity in patients with paraneoplastic cerebellar ataxia
Ramona Miske, Madeleine Scharf, Kathrin Borowski, Nicole Rieckhoff, Bianca Teegen, Yvonne Denno, Christian Probst, Kersten Guthke, Ieva Didrihsone, Brigitte Wildemann, Klemens Ruprecht, Lars Komorowski, Sven Jarius
TREM2 deficiency inhibits microglial activation and aggravates demyelinating injury in neuromyelitis optica spectrum disorder
Yun-Fan You, Man Chen, Yue Tang, Wen-Xiang Yu, Xiao-Wei Pang, Yun-Hui Chu, Hang Zhang, Ke Shang, Gang Deng, Luo-Qi Zhou, Sheng Yang, Wei Wang, Jun Xiao, Dai-Shi Tian, Chuan Qin
Comparisons of 25 cerebrospinal fluid cytokines in a case–control study of 106 patients with recent-onset depression and 106 individually matched healthy subjects
Nina Vindegaard Sørensen, Nis Borbye-Lorenzen, Rune Haubo Bojesen Christensen, Sonja Orlovska-Waast, Rose Jeppesen, Kristin Skogstrand, Michael Eriksen Benros
N,N-Dimethyl-3β-hydroxycholenamide attenuates neuronal death and retinal inflammation in retinal ischemia/reperfusion injury by inhibiting Ninjurin 1
Yunhong Shi, Yidan Liu, Caiqing Wu, Xiuxing Liu, Wenfei Hu, Zhenlan Yang, Zhidong Li, Yangyang Li, Caibin Deng, Kun Wei, Chenyang Gu, Xuhao Chen, Wenru Su, Yehong Zhuo
Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease
Marta Vicente-Rodríguez, Renzo Mancuso, Alba Peris-Yague, Camilla Simmons, Dominika Wlazly, Amber Dickinson, Andy Foster, Clare Knight, Claire Leckey, Paul Morgan, Angharad Morgan, Caroline O’Hagan, Samuel Touchard, Shahid Khan, Phil Murphy, Christine Parker, Jai Patel, Jill Richardson, Paul Acton, Nigel Austin, Anindya Bhattacharya, Nick Carruthers, Peter de Boer, Wayne Drevets, John Isaac, Declan Jones, John Kemp, Hartmuth Kolb, Jeff Nye, Gayle Wittenberg, Gareth Barker, Anna Bogdanova, Heidi Byrom, Annamaria Cattaneo, Daniela Enache, Tony Gee, Caitlin Hastings, Melisa Kose, Giulia Lombardo, Nicole Mariani, Anna McLaughlin, Valeria Mondelli, Maria Nettis, Naghmeh Nikkheslat, Carmine Pariante, Karen Randall, Julia Schubert, Luca Sforzini, Hannah Sheridan, Nisha Singh, Vicky Van Loo, Mattia Veronese, Toby Wood, Courtney Worrell, Zuzanna Zajkowska, Brian Campbell, Jan Egebjerg, Hans Eriksson, Francois Gastambide, Karen Husted Adams, Ross Jeggo, Thomas Moeller, Bob Nelson, Niels Plath, Christian Thomsen, Jan Torleif Pederson, Stevin Zorn, Catherine Deith, Scott Farmer, John McClean, Andrew McPherson, Nagore Penandes, Paul Scouller, Murray Sutherland, Mary Jane Attenburrow, Jithen Benjamin, Helen Jones, Fran Mada, Akintayo Oladejo, Katy Smith, Rita Balice-Gordon, Brendon Binneman, James Duerr, Terence Fullerton, Veeru Goli, Zoe Hughes, Justin Piro, Tarek Samad, Jonathan Sporn, Liz Hoskins, Charmaine Kohn, Lauren Wilcock, Franklin Aigbirhio, Junaid Bhatti, Ed Bullmore, Sam Chamberlain, Marta Correia, Anna Crofts, Tim Fryer, Martin Graves, Alex Hatton, Manfred Kitzbichler, Mary-Ellen Lynall, Christina Maurice, Ciara O’Donnell, Linda Pointon, Peter St George Hyslop, Lorinda Turner, Petra Vertes, Barry Widmer, Guy Williams, Jonathan Cavanagh, Alison McColl, Robin Shaw, Erik Boddeke, Alison Baird, Stuart Clare, Phil Cowen, I-Shu Huang, Sam Hurley, Alejo Nevado-Holgado, Elena Ribe, Anviti Vyas, Laura Winchester, Madeleine Cleal, Diego Gomez-Nicola, Hugh Perry, Mara Cercignani, Charlotte Clarke, Alessandro Colasanti, Neil Harrison, Rosemary Murray, Jason O’Connor, Howard Mount, Diego Gómez-Nicola, V. Hugh Perry, Federico Turkheimer, Simon Lovestone, Christine A. Parker, Diana Cash
The cervical lymph node contributes to peripheral inflammation related to Parkinson’s disease
Zongran Liu, Yang Huang, Xuejing Wang, Jia-Yi Li, Can Zhang, Ying Yang, Jing Zhang
Noninvasive ultrasound stimulation to treat myocarditis through splenic neuro-immune regulation
Tianshu Liu, Yanan Fu, Jiawei Shi, Shukun He, Dandan Chen, Wenqu Li, Yihan Chen, Li Zhang, Qing Lv, Yali Yang, Qiaofeng Jin, Jing Wang, Mingxing Xie
PARK7/DJ-1 in microglia: implications in Parkinson’s disease and relevance as a therapeutic target
Frida Lind-Holm Mogensen, Andrea Scafidi, Aurélie Poli, Alessandro Michelucci
NOD-like receptor NLRC5 promotes neuroinflammation and inhibits neuronal survival in Parkinson’s disease models
Zhaolin Liu, Chenye Shen, Heng Li, Jiabin Tong, Yufei Wu, Yuanyuan Ma, Jinghui Wang, Zishan Wang, Qing Li, Xiaoshuang Zhang, Hongtian Dong, Yufang Yang, Mei Yu, Jian Wang, Renyuan Zhou, Jian Fei, Fang Huang
A breakdown of metabolic reprogramming in microglia induced by CKLF1 exacerbates immune tolerance in ischemic stroke
Wen-yu Ma, Qing-lin Wu, Sha-sha Wang, Hong-yun Wang, Jun-rui Ye, Hong-shuo Sun, Zhong-ping Feng, Wen-bin He, Shi-feng Chu, Zhao Zhang, Nai-hong Chen
Prominent epigenetic and transcriptomic changes in CD4+ and CD8+ T cells during and after pregnancy in women with multiple sclerosis and controls
Alberto Zenere, Sandra Hellberg, Georgia Papapavlou Lingehed, Maria Svenvik, Johan Mellergård, Charlotte Dahle, Magnus Vrethem, Johanna Raffetseder, Mohsen Khademi, Tomas Olsson, Marie Blomberg, Maria C. Jenmalm, Claudio Altafini, Mika Gustafsson, Jan Ernerudh
PLPP/CIN-mediated NF2 S10 dephosphorylation distinctly regulates kainate-induced seizure susceptibility and neuronal death through PAK1-NF-κB-COX-2-PTGES2 signaling pathway
Ji-Eun Kim, Duk-Shin Lee, Tae-Hyun Kim, Hana Park, Min-Ju Kim, Tae-Cheon Kang
Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis
Timon Fiedler, Richard Fairless, Kira Pichi, Roman Fischer, Fabian Richter, Roland E. Kontermann, Klaus Pfizenmaier, Ricarda Diem, Sarah K. Williams
STING controls opioid-induced itch and chronic itch via spinal tank-binding kinase 1-dependent type I interferon response in mice
Nan Li, Chunyan Wang, Yuying Zhao, Yigang Wang, Tianyu Gao, Yonghao Yu, Guolin Wang, Linlin Zhang
Role of macrophage autophagy in postoperative pain and inflammation in mice
Kazuha Mitsui, Sohei Hishiyama, Aakanksha Jain, Yumi Kotoda, Masako Abe, Takashi Matsukawa, Masakazu Kotoda
Correction: Association of dimethylarginines and mediators of inflammation after acute ischemic stroke
Shufen Chen, Jens Martens-Lobenhoffer, Karin Weissenborn, Jan T. Kielstein, Ralf Lichtinghagen, Milani Deb-Chatterji, Na Li, Anita B. Tryc, Annemarie Goldbecker, Qiang Dong, Stefanie M. Bode-Böger, Hans Worthmann
The effects of aerobic exercise on neuroimmune responses in animals with traumatic peripheral nerve injury: a systematic review with meta-analyses
Marije L. S. Sleijser-Koehorst, Meghan A. Koop, Michel W. Coppieters, Ivo J. Lutke Schipholt, Nemanja Radisic, Carlijn R. Hooijmans, Gwendolyne G. M. Scholten-Peeters
Astrocytic CXCL5 hinders microglial phagocytosis of myelin debris and aggravates white matter injury in chronic cerebral ischemia
Qian Cao, Jian Chen, Zhi Zhang, Shu Shu, Yi Qian, Lixuan Yang, Lushan Xu, Yuxin Zhang, Xinyu Bao, Shengnan Xia, Haiyan Yang, Yun Xu, Shuwei Qiu
Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS
Valentina Pegoretti, Jan Bauer, Roman Fischer, Iskra Paro, Wanda Douwenga, Roland E. Kontermann, Klaus Pfizenmaier, Evelien Houben, Bieke Broux, Niels Hellings, Wia Baron, Jon D. Laman, Ulrich L. M. Eisel
Neuroinflammatory CSF biomarkers MIF, sTREM1, and sTREM2 show dynamic expression profiles in Alzheimer’s disease
Yanaika S. Hok-A-Hin, Marta del Campo, Walter A. Boiten, Erik Stoops, Melanie Vanhooren, Afina W. Lemstra, Wiesje M. van der Flier, Charlotte E. Teunissen
Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice
Irene Santos-García, Carmen Rodríguez-Cueto, Patricia Villegas, Fabiana Piscitelli, Anna Lauritano, Che-Kun J. Shen, Vincenzo Di Marzo, Javier Fernández-Ruiz, Eva de Lago
CXCL13 contributes to chronic pain of a mouse model of CRPS-I via CXCR5-mediated NF-κB activation and pro-inflammatory cytokine production in spinal cord dorsal horn
Jie Wang, Chengyu Yin, Yushuang Pan, Yunqin Yang, Wei Li, Huadong Ni, Boyu Liu, Huimin Nie, Ruoyao Xu, Huina Wei, Yunwen Zhang, Yuanyuan Li, Qimiao Hu, Yan Tai, Xiaomei Shao, Jianqiao Fang, Boyi Liu
SARS-CoV-2 envelope protein triggers depression-like behaviors and dysosmia via TLR2-mediated neuroinflammation in mice
Wenliang Su, Jiahang Ju, Minghui Gu, Xinrui Wang, Shaozhuang Liu, Jiawen Yu, Dongliang Mu
Inflammatory panel cytokines are elevated in the neocortex of late-stage Alzheimer’s disease but not Lewy body dementias
Yuek Ling Chai, Jasinda H. Lee, Joyce R. Chong, Clive Ballard, Paul T. Francis, Brian K. Kennedy, Thiruma V. Arumugam, Christopher P. Chen, Dag Aarsland, Mitchell K. P. Lai
The involvement of NLRP3 inflammasome in CUMS-induced AD-like pathological changes and related cognitive decline in mice
Jia-Mei Li, Ting Hu, Xiao-Na Zhou, Ting Zhang, Jia-Hui Guo, Min-Yuan Wang, Yi-Lin Wu, Wen-Jun Su, Chun-Lei Jiang
β-arrestin1 regulates astrocytic reactivity via Drp1-dependent mitochondrial fission: implications in postoperative delirium
Fuzhou Hua, Hong Zhu, Wen Yu, Qingcui Zheng, Lieliang Zhang, Weidong Liang, Yue Lin, Fan Xiao, Pengcheng Yi, Yanhong Xiong, Yao Dong, Hua Li, Lanran Fang, Hailin Liu, Jun Ying, Xifeng Wang
IL-10 production by granulocytes promotes Staphylococcus aureus craniotomy infection
Gunjan Kak, Zachary Van Roy, Cortney E. Heim, Rachel W. Fallet, Wen Shi, Axel Roers, Bin Duan, Tammy Kielian
Novel CH25H+ and OASL+ microglia subclusters play distinct roles in cerebral ischemic stroke
Yueman Zhang, Yunlu Guo, Ruqi Li, Tingting Huang, Yan Li, Wanqin Xie, Chen Chen, Weijie Chen, Jieqing Wan, Weifeng Yu, Peiying Li
Inhibition of discoidin domain receptor (DDR)-1 with nilotinib alters CSF miRNAs and is associated with reduced inflammation and vascular fibrosis in Alzheimer’s disease
Max Stevenson, Rency Varghese, Michaeline L. Hebron, Xiaoguang Liu, Nick Ratliff, Amelia Smith, R. Scott Turner, Charbel Moussa
Dysbiosis of gut microbiota inhibits NMNAT2 to promote neurobehavioral deficits and oxidative stress response in the 6-OHDA-lesioned rat model of Parkinson’s disease
Jianjun Yu, Jianhong Meng, Zhengwei Qin, Yuan Yu, Yingxin Liang, Yanjun Wang, Dongmei Min
Pathological hemodynamic changes and leukocyte transmigration disrupt the blood–spinal cord barrier after spinal cord injury
Rubing Zhou, Junzhao Li, Zhengyang Chen, Ruideng Wang, Yin Shen, Rong Zhang, Fang Zhou, Yong Zhang
The BET PROTAC inhibitor dBET6 protects against retinal degeneration and inhibits the cGAS-STING in response to light damage
Xingfei Zhu, Wei Liu, Xiangcheng Tang, Yulin Chen, Xiangyu Ge, Qin Ke, Xingmiao Liang, Yuwen Gan, Yingfeng Zheng, Ming Zou, Mi Deng, Yizhi Liu, David Wan-Cheng Li, Lili Gong
An ocular Th1 immune response promotes corneal nerve damage independently of the development of corneal epitheliopathy
Alexia Vereertbrugghen, Manuela Pizzano, Florencia Sabbione, Irene Angelica Keitelman, Carolina Maiumi Shiromizu, Douglas Vera Aguilar, Federico Fuentes, Cintia S. de Paiva, Mirta Giordano, Analía Trevani, Jeremías G. Galletti
Circular RNA Tmcc1 improves astrocytic glutamate metabolism and spatial memory via NF-κB and CREB signaling in a bile duct ligation mouse model: transcriptional and cellular analyses
Danbi Jo, Yeong-Hwan Lim, Yoon Seok Jung, Young-Kook Kim, Juhyun Song
Lactobacillus paracasei L9 affects disease progression in experimental autoimmune neuritis by regulating intestinal flora structure and arginine metabolism
Yuting Meng, Xiangjie Qiu, Zhongxiang Tang, Yu Mao, Yurong Tan
High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro
Sasha Soldati, Alexander Bär, Mykhailo Vladymyrov, Dale Glavin, James L. McGrath, Fabien Gosselet, Hideaki Nishihara, Susan Goelz, Britta Engelhardt
Progressive inflammation reduces high-frequency EEG activity and cortical dendritic arborisation in late gestation fetal sheep
Sharmony B. Kelly, Justin M. Dean, Valerie A. Zahra, Ingrid Dudink, Alison Thiel, Graeme R. Polglase, Suzanne L. Miller, Stuart B. Hooper, Laura Bennet, Alistair J. Gunn, Robert Galinsky
Meningeal immunity and neurological diseases: new approaches, new insights
Yun Su, Huimin Zheng, Changhe Shi, Xinwei Li, Shuyu Zhang, Guangyu Guo, Wenkai Yu, Shuo Zhang, Zhengwei Hu, Jing Yang, Zongping Xia, Chengyuan Mao, Yuming Xu
Reactive Bergmann glia play a central role in spinocerebellar ataxia inflammation via the JNK pathway
Chandrakanth Reddy Edamakanti, Vishwa Mohan, Puneet Opal
Lung infection by Pseudomonas aeruginosa induces neuroinflammation and blood–brain barrier dysfunction in mice
Nuria Villalba, Yonggang Ma, Sarah A. Gahan, Aurelie Joly-Amado, Sam Spence, Xiaoyuan Yang, Kevin R. Nash, Sarah Y. Yuan
Stressor control and regional inflammatory responses in the brain: regulation by the basolateral amygdala
Austin M. Adkins, Emily M. Colby, Woong-Ki Kim, Laurie L. Wellman, Larry D. Sanford
The neuroprotective N-terminal amyloid-β core hexapeptide reverses reactive gliosis and gliotoxicity in Alzheimer’s disease pathology models
Megan J. Lantz, Alyssa M. Roberts, Donovan D. Delgado, Robert A. Nichols
Experimental hepatic encephalopathy causes early but sustained glial transcriptional changes
Wouter Claeys, Lien Van Hoecke, Hannah Lernout, Clint De Nolf, Griet Van Imschoot, Elien Van Wonterghem, Daan Verhaege, Jonas Castelein, Anja Geerts, Christophe Van Steenkiste, Roosmarijn E. Vandenbroucke
miRNA 548a-3p as biomarker of NEDA-3 at 2 years in multiple sclerosis patients treated with fingolimod
Alicia Gonzalez-Martinez, Rohit Patel, Brian C. Healy, Hrishikesh Lokhande, Anu Paul, Shrishti Saxena, Mariann Polgar-Turcsanyi, Howard L. Weiner, Tanuja Chitnis
Analysis of the microglia transcriptome across the human lifespan using single cell RNA sequencing
Moein Yaqubi, Adam M. R. Groh, Marie-France Dorion, Elia Afanasiev, Julia Xiao Xuan Luo, Hadi Hashemi, Sarthak Sinha, Nicholas W. Kieran, Manon Blain, Qiao-Ling Cui, Jeff Biernaskie, Myriam Srour, Roy Dudley, Jeffery A. Hall, Joshua A. Sonnen, Nathalie Arbour, Alexandre Prat, Jo Anne Stratton, Jack Antel, Luke M. Healy
B cell treatment promotes a neuroprotective microenvironment after traumatic brain injury through reciprocal immunomodulation with infiltrating peripheral myeloid cells
Liam J. Dwyer, Saumya Maheshwari, Emily Levy, Mark C. Poznansky, Michael J. Whalen, Ruxandra F. Sîrbulescu
Minocycline protects against microgliopathy in a Csf1r haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)
Xin Li, Banglian Hu, Xiaoyan Guan, Ziwei Wang, Yuhang Zhou, Hao Sun, Xian Zhang, Yanfang Li, Xiaohua Huang, Yingjun Zhao, Xin Wang, Huaxi Xu, Yun-Wu Zhang, Zhanxiang Wang, Honghua Zheng
GPR43 stimulation on TCRαβ+ intraepithelial colonic lymphocytes inhibits the recruitment of encephalitogenic T-cells into the central nervous system and attenuates the development of autoimmunity
Carolina Prado, Alexandra Espinoza, J. Eduardo Martínez-Hernández, Joseph Petrosino, Erick Riquelme, Alberto J. M. Martin, Rodrigo Pacheco
Early miR-320b and miR-25-3p miRNA levels correlate with multiple sclerosis severity at 10 years: a cohort study
Alicia Gonzalez-Martinez, Gauruv Bose, Hrishikesh Lokhande, Shrishti Saxena, Brian C. Healy, Mariann Polgar-Turcsanyi, Howard L. Weiner, Tanuja Chitnis
Microglia-derived TNF-α contributes to RVLM neuronal mitochondrial dysfunction via blocking the AMPK–Sirt3 pathway in stress-induced hypertension
Linping Wang, Tianfeng Liu, Xueping Wang, Lei Tong, Gaojun Chen, Shumin Zhou, Haili Zhang, Haisheng Liu, Wen Lu, Guohua Wang, Shuai Zhang, Dongshu Du
Granzyme B + CD8 + T cells with terminal differentiated effector signature determine multiple sclerosis progression
Ziyan Shi, Xiaofei Wang, Jiancheng Wang, Hongxi Chen, Qin Du, Yanlin Lang, Lingyao Kong, Wenqin Luo, Yuhan Qiu, Ying Zhang, Chen Li, Dingke Wen, Jie Yao, Xia Cheng, Linjun Cai, Xue Lin, Rui Wang, Zichao Mou, Shuangjie Li, Duanya Liu, Hong Zhou, Hongyu Zhou, Mu Yang
Kinesin-5 inhibition improves neural regeneration in experimental autoimmune neuritis
Felix Kohle, Robin Ackfeld, Franziska Hommen, Ines Klein, Martin K. R. Svačina, Christian Schneider, Gereon R. Fink, Mohammed Barham, David Vilchez, Helmar C. Lehmann
Organotypic hippocampal culture model reveals differential responses to highly similar Zika virus isolates
Marina da Silva Oliveira, Larissa Marcely Gomes Cassiano, Jeanne Pioline, Ketyllen Reis Andrade de Carvalho, Anna Christina de Matos Salim, Pedro Augusto Alves, Gabriel da Rocha Fernandes, Alexandre de Magalhães Vieira Machado, Roney Santos Coimbra
Varicella-zoster virus proteome-wide T-cell screening demonstrates low prevalence of virus-specific CD8 T-cells in latently infected human trigeminal ganglia
Michiel van Gent, Werner J. D. Ouwendijk, Victoria L. Campbell, Kerry J. Laing, Georges M. G. M. Verjans, David M. Koelle
Microglial cell response to experimental periodontal disease
Rawan Almarhoumi, Carla Alvarez, Theodore Harris, Christina M. Tognoni, Bruce J. Paster, Isabel Carreras, Alpaslan Dedeoglu, Alpdogan Kantarci
A role for P-selectin and complement in the pathological sequelae of germinal matrix hemorrhage
Devin Hatchell, Mohammed Alshareef, Tyler Vasas, Silvia Guglietta, Davis Borucki, Chunfang Guo, Khalil Mallah, Ramin Eskandari, Stephen Tomlinson
Progesterone attenuates Th17-cell pathogenicity in autoimmune uveitis via Id2/Pim1 axis
Xiuxing Liu, Chenyang Gu, Jianjie Lv, Qi Jiang, Wen Ding, Zhaohao Huang, Yidan Liu, Yuhan Su, Chun Zhang, Zhuping Xu, Xianggui Wang, Wenru Su
HIF1α-dependent hypoxia response in myeloid cells requires IRE1α
Gaëlle Mawambo, Malika Oubaha, Yusuke Ichiyama, Guillaume Blot, Sergio Crespo-Garcia, Agnieszka Dejda, François Binet, Roberto Diaz-Marin, Christina Sawchyn, Mikhail Sergeev, Rachel Juneau, Randal J. Kaufman, El Bachir Affar, Frédérick A. Mallette, Ariel M. Wilson, Przemyslaw Sapieha
Ogt-mediated O-GlcNAcylation inhibits astrocytes activation through modulating NF-κB signaling pathway
Xiaoxue Dong, Liqi Shu, Jinyu Zhang, Xu Yang, Xuejun Cheng, Xingsen Zhao, Wenzheng Qu, Qiang Zhu, Yikai Shou, Guoping Peng, Binggui Sun, Wen Yi, Qiang Shu, Xuekun Li
Pharmacologic inhibition of NLRP3 reduces the levels of α-synuclein and protects dopaminergic neurons in a model of Parkinson’s disease
Jesus Amo-Aparicio, Jonathan Daly, Jesper Falkesgaard Højen, Charles A. Dinarello
Lipocalin-2-mediated astrocyte pyroptosis promotes neuroinflammatory injury via NLRP3 inflammasome activation in cerebral ischemia/reperfusion injury
Juanji Li, Pengfei Xu, Ye Hong, Yi Xie, Mengna Peng, Rui Sun, Hongquan Guo, Xiaohao Zhang, Wusheng Zhu, Junjun Wang, Xinfeng Liu
SAFit2 ameliorates paclitaxel-induced neuropathic pain by reducing spinal gliosis and elevating pro-resolving lipid mediators
Saskia Wedel, Lisa Hahnefeld, Yannick Schreiber, Christian Namendorf, Tim Heymann, Manfred Uhr, Mathias V. Schmidt, Natasja de Bruin, Felix Hausch, Dominique Thomas, Gerd Geisslinger, Marco Sisignano
Disturbance of neuron–microglia crosstalk mediated by GRP78 in Neuropsychiatric systemic lupus erythematosus mice
Jingyi Xu, Chunshu Yang, Siyuan Zeng, Xuejiao Wang, Pingting Yang, Ling Qin
Identification of TIMP1 as an inflammatory biomarker associated with temporal lobe epilepsy based on integrated bioinformatics and experimental analyses
Ya He, Hongxia Zhang, Limin Ma, Jingang Li, Fei Wang, Hui Zhou, Guangliang Zhang, Yuetao Wen
Ambient RNAs removal of cortex-specific snRNA-seq reveals Apoe+ microglia/macrophage after deeper cerebral hypoperfusion in mice
Yuan Zhang, Jinyun Tan, Kai Yang, Weijian Fan, Bo Yu, Weihao Shi
Age- and sex-related differences of periodontal bone resorption, cognitive function, and immune state in APP/PS1 murine model of Alzheimer’s disease
Huiwen Chen, Yue Liao, Xu Zhang, Hui Shen, Dihua Shang, Zhiyan He, Wei Zhou, Zhongchen Song
Chronic social defeat alters brain vascular-associated cell gene expression patterns leading to vascular dysfunction and immune system activation
Joshua D. Samuels, Madison L. Lotstein, Michael L. Lehmann, Abdel G. Elkahloun, Subhadra Banerjee, Miles Herkenham
Neuroprotective effects of GSK-343 in an in vivo model of MPTP-induced nigrostriatal degeneration
Deborah Mannino, Sarah Adriana Scuderi, Giovanna Casili, Valentina Bova, Laura Cucinotta, Marika Lanza, Alessia Filippone, Emanuela Esposito, Irene Paterniti
Endothelial progenitor cell-derived exosomes promote anti-inflammatory macrophages via SOCS3/JAK2/STAT3 axis and improve the outcome of spinal cord injury
Feifei Yuan, Wei Peng, Yuying Yang, Jiaqi Xu, Yudong Liu, Yong Xie, Tingmo Huang, Chaoran Shi, Yinghe Ding, Chengjun Li, Tian Qin, Shanshan Xie, Fengzhang Zhu, Hongbin Lu, Jianjun Huang, Jianzhong Hu
CD200 in dentate gyrus improves depressive-like behaviors of mice through enhancing hippocampal neurogenesis via alleviation of microglia hyperactivation
Xi Chen, Qian-Qian Cui, Xiao-Hai Hu, Jian Ye, Zi-Cun Liu, Yuan-Xi Mei, Fang Wang, Zhuang-Li Hu, Jian-Guo Chen
Caudal DMN neurons innervate the spleen and release CART peptide to regulate neuroimmune function
Nobuhide Kobori, Anthony N. Moore, John B. Redell, Pramod K. Dash
The aging ovary impairs acute stroke outcomes
Taylor E. Branyan, Jocelyn Aleksa, Esteban Lepe, Kelby Kosel, Farida Sohrabji
Correction: Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway
Ruo-Nan Duan, Chun-Lin Yang, Tong Du, Ai Liu, An-Ran Wang, Wen-Jie Sun, Xi Li, Jiang-Xia Li, Chuan-Zhu Yan, Qi-Ji Liu
Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy
Chong Liu, Xue-Min Zhao, Qiao Wang, Ting-Ting Du, Mo-Xuan Zhang, Hui-Zhi Wang, Ren-Peng Li, Kun Liang, Yuan Gao, Si-Yu Zhou, Tao Xue, Jian-Guo Zhang, Chun-Lei Han, Lin Shi, Liang-Wen Zhang, Fan-Gang Meng
NLRP3–GABA signaling pathway contributes to the pathogenesis of impulsive-like behaviors and cognitive deficits in aged mice
Lu-Ying Wang, Xu-Peng Wang, Jin-Meng Lv, Yu-Dong Shan, Shi-Yan Jia, Zhi-Fang Yu, Hui-Tao Miao, Yue Xin, Dong-Xue Zhang, Li-Min Zhang
Disease-modifying effects of a glial-targeted inducible nitric oxide synthase inhibitor (1400W) in mixed-sex cohorts of a rat soman (GD) model of epilepsy
Suraj S. Vasanthi, Nikhil S. Rao, Manikandan Samidurai, Nyzil Massey, Christina Meyer, Meghan Gage, Mihir Kharate, Aida Almanza, Logan Wachter, Candide Mafuta, Lily Trevino, Adriana M. Carlo, Elijah Bryant, Brooke E. Corson, Morgan Wohlgemuth, Morgan Ostrander, Lucas Showman, Chong Wang, Thimmasettappa Thippeswamy
Transfer of patient’s peripheral blood mononuclear cells (PBMCs) disrupts blood–brain barrier and induces anti-NMDAR encephalitis: a study of novel humanized PBMC mouse model
Yaqing Shu, Fuhua Peng, Bingchu Zhao, Chunxin Liu, Qihui Li, Huilu Li, Yuge Wang, Yanjun Jiang, Tingting Lu, Qin Wang, Jian Sun, Huiyu Feng, Zhengqi Lu, Xiaodong Liu, Jie Wang, Wei Qiu
Tau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation
Yijun Chen, Yang Yu
Gastrointestinal microbiome of ARDS patients induces neuroinflammation and cognitive impairment in mice
Hong Zheng, Qihui Zhao, Jianuo Chen, Jiahui Lu, Yuping Li, Hongchang Gao
Cerebrospinal fluid GFAP is a predictive biomarker for conversion to dementia and Alzheimer’s disease-associated biomarkers alterations among de novo Parkinson’s disease patients: a prospective cohort study
Tingting Liu, Hongzhou Zuo, Di Ma, Dan Song, Yuying Zhao, Oumei Cheng
H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection
Shuo Zhu, Mengying Tao, Yunchuan Li, Xugang Wang, Zikai Zhao, Yixin Liu, Qi Li, Qiuyan Li, Yanbo Lu, Youhui Si, Shengbo Cao, Jing Ye
Alzheimer’s disease-associated complement gene variants influence plasma complement protein levels
Aurora Veteleanu, Joshua Stevenson-Hoare, Samuel Keat, Nikoleta Daskoulidou, Henrik Zetterberg, Amanda Heslegrave, Valentina Escott-Price, Julie Williams, Rebecca Sims, Wioleta M. Zelek, Sarah M. Carpanini, Bryan Paul Morgan
Lipopolysaccharide-binding protein and future Parkinson’s disease risk: a European prospective cohort
Yujia Zhao, Douglas I. Walker, Christina M. Lill, Bastiaan R. Bloem, Sirwan K. L. Darweesh, Brismar Pinto-Pacheco, Brooklyn McNeil, Gary W. Miller, Alicia K. Heath, Myrthe Frissen, Dafina Petrova, Maria-Jose Sánchez, María-Dolores Chirlaque, Marcela Guevara, Maurizio Zibetti, Salvatore Panico, Lefkos Middleton, Verena Katzke, Rudolf Kaaks, Elio Riboli, Giovanna Masala, Sabina Sieri, Raul Zamora-Ros, Pilar Amiano, Mazda Jenab, Susan Peters, Roel Vermeulen
Iron induces B cell pyroptosis through Tom20–Bax–caspase–gasdermin E signaling to promote inflammation post-spinal cord injury
Chengjie Wu, Lining Wang, Sixian Chen, Lei Shi, Mengmin Liu, Pengcheng Tu, Jie Sun, Ruihua Zhao, Yafeng Zhang, Jianwei Wang, Yalan Pan, Yong Ma, Yang Guo
Elevated blood and cerebrospinal fluid biomarkers of microglial activation and blood‒brain barrier disruption in anti-NMDA receptor encephalitis
Haoxiao Chang, Jia Ma, Kai Feng, Ning Feng, Xinxin Wang, Jiali Sun, Tianshu Guo, Yuzhen Wei, Yun Xu, Huabing Wang, Linlin Yin, Xinghu Zhang
Emerging role of non-coding RNAs in neuroinflammation mediated by microglia and astrocytes
Ruicheng Yang, Bo Yang, Wei Liu, Chen Tan, Huanchun Chen, Xiangru Wang
Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice
Dorit Farfara, Meital Sooliman, Limor Avrahami, Tabitha Grace Royal, Shoshik Amram, Lea Rozenstein-Tsalkovich, Dorit Trudler, Shani Blanga-Kanfi, Hagit Eldar-Finkelman, Jens Pahnke, Hanna Rosenmann, Dan Frenkel
Smad7 in the hippocampus contributes to memory impairment in aged mice after anesthesia and surgery
Changliang Liu, Jiahui Wu, Ming Li, Rui Gao, Xueying Zhang, Shixin Ye-Lehmann, Jiangning Song, Tao Zhu, Chan Chen
A brain cytokine-independent switch in cortical activity marks the onset of sickness behavior triggered by acute peripheral inflammation
Samu N. Kurki, Tommi Ala-Kurikka, Arto Lipponen, Alexey S. Pospelov, Taisia Rolova, Jari Koistinaho, Juha Voipio, Kai Kaila
Cellulose ether treatment inhibits amyloid beta aggregation, neuroinflammation and cognitive deficits in transgenic mouse model of Alzheimer’s disease
Tahir Ali, Antonia N. Klein, Keegan McDonald, Lovisa Johansson, Priyanka Ganguli Mukherjee, Martin Hallbeck, Katsumi Doh-ura, Hermann M. Schatzl, Sabine Gilch
Targeted ablation of signal transducer and activator of transduction 1 alleviates inflammation by microglia/macrophages and promotes long-term recovery after ischemic stroke
Wenxuan Han, Hongjian Pu, Sicheng Li, Yaan Liu, Yongfang Zhao, Mingyue Xu, Caixia Chen, Yun Wu, Tuo Yang, Qing Ye, Hong Wang, R. Anne Stetler, Jun Chen, Yejie Shi
Longitudinal positron emission tomography and postmortem analysis reveals widespread neuroinflammation in SARS-CoV-2 infected rhesus macaques
Juliana M. Nieuwland, Erik Nutma, Ingrid H. C. H. M. Philippens, Kinga P. Böszörményi, Edmond J. Remarque, Jaco Bakker, Lisette Meijer, Noor Woerdman, Zahra C. Fagrouch, Babs E. Verstrepen, Jan A. M. Langermans, Ernst J. Verschoor, Albert D. Windhorst, Ronald E. Bontrop, Helga E. de Vries, Marieke A. Stammes, Jinte Middeldorp
ATP-P2X7R-mediated microglia senescence aggravates retinal ganglion cell injury in chronic ocular hypertension
Miao Wei, Guowei Zhang, Zeyu Huang, Xuemeng Ding, Qing Sun, Yujian Zhang, Rongrong Zhu, Huaijin Guan, Min Ji
Transcriptome alterations in peripheral blood B cells of patients with multiple sclerosis receiving immune reconstitution therapy
Michael Hecker, Brit Fitzner, Nina Boxberger, Elena Putscher, Robby Engelmann, Wendy Bergmann, Michael Müller, Isis Ludwig-Portugall, Margit Schwartz, Stefanie Meister, Ales Dudesek, Alexander Winkelmann, Dirk Koczan, Uwe Klaus Zettl
Topographic distribution of inflammation factors in a healing aneurysm
Basil E. Grüter, Gwendoline Canzanella, Joshua Hägler, Jeannine Rey, Stefan Wanderer, Michael von Gunten, José A. Galvan, Rainer Grobholz, Hans-Rudolf Widmer, Luca Remonda, Lukas Andereggen, Serge Marbacher
Prmt5 deficiency inhibits CD4+ T-cell Klf2/S1pr1 expression and ameliorates EAE disease
Yingxia Zheng, Zheyi Chen, Bingqian Zhou, Shiyu Chen, Ningdai Chen, Lisong Shen
Differential effects of SARS-CoV-2 variants on central nervous system cells and blood–brain barrier functions
Alizé Proust, Christophe J. Queval, Ruth Harvey, Lorin Adams, Michael Bennett, Robert J. Wilkinson
Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration
Joseph D. Quick, Cristian Silva, Jia Hui Wong, Kah Leong Lim, Richard Reynolds, Anna M. Barron, Jialiu Zeng, Chih Hung Lo
The mitochondrial protein TSPO in Alzheimer’s disease: relation to the severity of AD pathology and the neuroinflammatory environment
Emma F. Garland, Oliver Dennett, Laurie C. Lau, David S. Chatelet, Michel Bottlaender, James A. R. Nicoll, Delphine Boche
Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation
Sharmistha Banerjee, Taeyeop Park, Yoo Sun Kim, Hee-Yong Kim
Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer’s disease
Sarah R. Ocañas, Kevin D. Pham, Jillian E. J. Cox, Alex W. Keck, Sunghwan Ko, Felix A. Ampadu, Hunter L. Porter, Victor A. Ansere, Adam Kulpa, Collyn M. Kellogg, Adeline H. Machalinski, Manu A. Thomas, Zsabre Wright, Ana J. Chucair-Elliott, Willard M. Freeman
Cerebrospinal fluid levels of neuroinflammatory biomarkers are increased in athletes with persistent post-concussive symptoms following sports-related concussion
Anna Gard, Fredrik Vedung, Fredrik Piehl, Mohsen Khademi, Maria Portonova Wernersson, Ia Rorsman, Yelverton Tegner, Hélène Pessah-Rasmussen, Karsten Ruscher, Niklas Marklund
Influenza A virus infection disrupts oligodendrocyte homeostasis and alters the myelin lipidome in the adult mouse
Allison Y. Louie, Justin S. Kim, Jenny Drnevich, Payam Dibaeinia, Hisami Koito, Saurabh Sinha, Daniel B. McKim, Katiria Soto-Diaz, Romana A. Nowak, Aditi Das, Andrew J. Steelman
The connexin hemichannel inhibitor D4 produces rapid antidepressant-like effects in mice
Huanhuan Li, Anni Guo, Magdiel Salgado, Juan C. Sáez, Chunyue Geoffrey Lau
Biomass smoke inhalation promotes neuroinflammatory and metabolomic temporal changes in the hippocampus of female mice
David Scieszka, Yan Jin, Shahani Noor, Ed Barr, Marcus Garcia, Jessica Begay, Guy Herbert, Russell P. Hunter, Kiran Bhaskar, Rahul Kumar, Rama Gullapalli, Alicia Bolt, Mark A. McCormick, Barry Bleske, Haiwei Gu, Matthew J. Campen
GSDMD knockdown attenuates phagocytic activity of microglia and exacerbates seizure susceptibility in TLE mice
Xiaoxia Yang, Qingqing Cao, Yi Guo, Jingchuan He, Demei Xu, Aolei Lin
Remibrutinib (LOU064) inhibits neuroinflammation driven by B cells and myeloid cells in preclinical models of multiple sclerosis
Barbara Nuesslein-Hildesheim, Enrico Ferrero, Cindy Schmid, Catherine Huck, Paul Smith, Sarah Tisserand, Joelle Rubert, Frederic Bornancin, Denis Eichlisberger, Bruno Cenni
Cortical superficial siderosis is associated with reactive astrogliosis in cerebral amyloid angiopathy
Corinne A. Auger, Valentina Perosa, Steven M. Greenberg, Susanne J. van Veluw, Mariel G. Kozberg
Repeated closed-head mild traumatic brain injury-induced inflammation is associated with nociceptive sensitization
Tyler Nguyen, Natalie Nguyen, Ashlyn G. Cochran, Jared A. Smith, Mohammed Al-Juboori, Andrew Brumett, Saahil Saxena, Sarah Talley, Edward M. Campbell, Alexander G. Obukhov, Fletcher A. White
Sexually dimorphic extracellular vesicle responses after chronic spinal cord injury are associated with neuroinflammation and neurodegeneration in the aged brain
Yun Li, Niaz Khan, Rodney M. Ritzel, Zhuofan Lei, Samantha Allen, Alan I. Faden, Junfang Wu
Chemogenetic activation of locus coeruleus neurons ameliorates the severity of multiple sclerosis
Alejandro Torrillas-de la Cal, Sonia Torres-Sanchez, Lidia Bravo, Meritxell Llorca-Torralba, Jose Antonio Garcia-Partida, Ana I. Arroba, Esther Berrocoso
Atorvastatin rescues hyperhomocysteinemia-induced cognitive deficits and neuroinflammatory gene changes
Erica M. Weekman, Sherika N. Johnson, Colin B. Rogers, Tiffany L. Sudduth, Kevin Xie, Qi Qiao, David W. Fardo, Teodoro Bottiglieri, Donna M. Wilcock
TSLP in DRG neurons causes the development of neuropathic pain through T cells
Yuka Ino, Motoyo Maruyama, Masumi Shimizu, Rimpei Morita, Atsuhiro Sakamoto, Hidenori Suzuki, Atsushi Sakai
Mesenchymal-derived extracellular vesicles enhance microglia-mediated synapse remodeling after cortical injury in aging Rhesus monkeys
Yuxin Zhou, Hrishti Bhatt, Chromewell A. Mojica, Hongqi Xin, Monica A. Pessina, Douglas L. Rosene, Tara L. Moore, Maria Medalla
Microglial SIRT1 activation attenuates synapse loss in retinal inner plexiform layer via mTORC1 inhibition
Ke Yao, Qianxue Mou, Xiaotong Lou, Meng Ye, Bowen Zhao, Yuanyuan Hu, Jing Luo, Hong Zhang, Xing Li, Yin Zhao
RGS5 augments astrocyte activation and facilitates neuroinflammation via TNF signaling
Shu Yin, Xin-yue Ma, Ying-feng Sun, Yan-qing Yin, Ying Long, Chun-lai Zhao, Jun-wei Ma, Sen Li, Yan Hu, Ming-tao Li, Gang Hu, Jia-wei Zhou
Supraphysiologic doses of 17β-estradiol aggravate depression-like behaviors in ovariectomized mice possibly via regulating microglial responses and brain glycerophospholipid metabolism
Ming Li, Jing Zhang, Wendi Chen, Shuang Liu, Xin Liu, Yunna Ning, Yongzhi Cao, Yueran Zhao
GSDMD gene knockout alleviates hyperoxia-induced hippocampal brain injury in neonatal mice
Naga Venkata Divya Challa, Shaoyi Chen, Huijun Yuan, Matthew R. Duncan, William Javier Moreno, Helen Bramlett, W. Dalton Dietrich, Merline Benny, Augusto F. Schmidt, Karen Young, Shu Wu
Assessing the role of T cells in response to retinal injury to uncover new therapeutic targets for the treatment of retinal degeneration
Federica M. Conedera, Judith M. Runnels, Jens V. Stein, Clemens Alt, Volker Enzmann, Charles P. Lin
Transcriptomics and translatomics identify a robust inflammatory gene signature in brain endothelial cells after ischemic stroke
Maria Arbaizar-Rovirosa, Mattia Gallizioli, Juan J. Lozano, Julia Sidorova, Jordi Pedragosa, Sara Figuerola, Nerea Chaparro-Cabanillas, Patricia Boya, Mariona Graupera, Marc Claret, Xabier Urra, Anna M. Planas
H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer's disease through the NFκB signaling pathway
Lin Wei, Xiaowen Yang, Jie Wang, Zhixiao Wang, Qiguang Wang, Yan Ding, Aiqing Yu
N-acetylglucosamine inhibits inflammation and neurodegeneration markers in multiple sclerosis: a mechanistic trial
Michael Sy, Barbara L. Newton, Judy Pawling, Ken L. Hayama, Andres Cordon, Zhaoxia Yu, Jens Kuhle, James W. Dennis, Alexander U. Brandt, Michael Demetriou
Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhages
Dongpei Yin, Chen Wang, Yachao Qi, Ya-Chao Wang, Nina Hagemann, Ayan Mohamud Yusuf, Egor Dzyubenko, Britta Kaltwasser, Tobias Tertel, Bernd Giebel, Matthias Gunzer, Aurel Popa-Wagner, Thorsten R. Doeppner, Dirk M. Hermann
Influence of complement protein C1q or complement receptor C5aR1 on gut microbiota composition in wildtype and Alzheimer’s mouse models
Tiffany J. Petrisko, Matthew Gargus, Shu-Hui Chu, Purnika Selvan, Katrine L. Whiteson, Andrea J. Tenner
Nrf2 regulates iron-dependent hippocampal synapses and functional connectivity damage in depression
Ting Zeng, Junjie Li, Lingpeng Xie, Zhaoyang Dong, Qing Chen, Sha Huang, Shuwen Xie, Yuqi Lai, Jun Li, Weixin Yan, YuHua Wang, Zeping Xie, Changlei Hu, Jiayi Zhang, Shanshan Kuang, Yuhong Song, Lei Gao, Zhiping Lv
Astrocytes evoke a robust IRF7-independent type I interferon response upon neurotropic viral infection
Loreen Weichert, Henning Peter Düsedau, David Fritzsch, Sarah Schreier, Annika Scharf, Martina Grashoff, Kristin Cebulski, Kristin Michaelsen-Preusse, Christian Erck, Stefan Lienenklaus, Ildiko Rita Dunay, Andrea Kröger
miR155, TREM2, INPP5D: Disease stage and cell type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer’s amyloidopathy
Sam Gandy, Michelle E. Ehrlich
Extended interval dosing of ocrelizumab modifies the repopulation of B cells without altering the clinical efficacy in multiple sclerosis
Carla Rodriguez-Mogeda, Zoë Y. G. J. van Lierop, Susanne M. A. van der Pol, Loet Coenen, Laura Hogenboom, Alwin Kamermans, Ernesto Rodriguez, Jack van Horssen, Zoé L. E. van Kempen, Bernard M. J. Uitdehaag, Charlotte E. Teunissen, Maarten E. Witte, Joep Killestein, Helga E. de Vries
Type I/type III IFN and related factors regulate JEV infection and BBB endothelial integrity
Ya-Ge Zhang, Hong-Xin Zhang, Hao-Wei Chen, Penghao Lv, Jie Su, Yan-Ru Chen, Zhen-Fang Fu, Min Cui
Glycolytic shift during West Nile virus infection provides new therapeutic opportunities
Patricia Mingo-Casas, Ana-Belén Blázquez, Marta Gómez de Cedrón, Ana San-Félix, Susana Molina, Estela Escribano-Romero, Eva Calvo-Pinilla, Nereida Jiménez de Oya, Ana Ramírez de Molina, Juan-Carlos Saiz, María-Jesús Pérez-Pérez, Miguel A. Martín-Acebes
Metabolic response to CNS infection with flaviviruses
Marta Dobrzyńska, Anna Moniuszko-Malinowska, Elżbieta Skrzydlewska
Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency
Hong Zeng, Li Cheng, De-zhi Lu, Shuai Fan, Ke-xin Wang, Li-li Xu, Bin Cai, Mou-wang Zhou, Jin-wu Wang
The relationship between systemic inflammation index, systemic immune-inflammatory index, and inflammatory prognostic index and 90-day outcomes in acute ischemic stroke patients treated with intravenous thrombolysis
Fei Ma, Lulu Li, Liang Xu, Jiacheng Wu, Aimei Zhang, Junqi Liao, Jingyi Chen, Yunze Li, Li Li, Zhaoyao Chen, Wenlei Li, Qing Zhu, Yuan Zhu, Minghua Wu
Receptor-interacting protein kinase 2 (RIPK2) profoundly contributes to post-stroke neuroinflammation and behavioral deficits with microglia as unique perpetrators
Jonathan Larochelle, Ryland J. Tishko, Changjun Yang, Yong Ge, Leah T. Phan, Rachel E. Gunraj, Sofia M. Stansbury, Lei Liu, Mansour Mohamadzadeh, Habibeh Khoshbouei, Eduardo Candelario-Jalil
Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1α/ASK1/JNK signaling pathway in mice with traumatic brain injury
Guihong Shi, Liang Liu, Yiyao Cao, Guangshuo Ma, Yanlin Zhu, Jianye Xu, Xu Zhang, Tuo Li, Liang Mi, Haoran Jia, Yanfeng Zhang, Xilei Liu, Yuan Zhou, Shenghui Li, Guili Yang, Xiao Liu, Fanglian Chen, Baolong Wang, Quanjun Deng, Shu Zhang, Jianning Zhang
Noteworthy perspectives on microglia in neuropsychiatric disorders
Hongrui Zhu, Ao Guan, Jiayuan Liu, Li Peng, Zhi Zhang, Sheng Wang
Proteomic profiling identifies novel inflammation-related plasma proteins associated with ischemic stroke outcome
Annelie Angerfors, Cecilia Brännmark, Cecilia Lagging, Kara Tai, Robert Månsby Svedberg, Björn Andersson, Christina Jern, Tara M. Stanne
Distinct features of B cell receptors in neuromyelitis optica spectrum disorder among CNS inflammatory demyelinating diseases
Hyo Jae Kim, Jong-Eun Park, Wangyong Shin, Dayoung Seo, Seungmi Kim, Hyunji Kim, Jinsung Noh, Yonghee Lee, Hyunjin Kim, Young-Min Lim, Hyori Kim, Eun-Jae Lee
Cortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity
Julia Castillo-González, José Luis Ruiz, Ignacio Serrano-Martínez, Irene Forte-Lago, Ana Ubago-Rodriguez, Marta Caro, Jesús Miguel Pérez-Gómez, Alejandro Benítez-Troncoso, Eduardo Andrés-León, Macarena Sánchez-Navarro, Raúl M. Luque, Elena González-Rey
Inhibition of adult hippocampal neurogenesis induced by postoperative CD8 + T-cell infiltration is associated with cognitive decline later following surgery in adult mice
Xiaowei Li, Hong Wang, Qidi Zhang, Xiaobin Sun, Mengyuan Zhang, Gongming Wang
Nisin a probiotic bacteriocin mitigates brain microbiome dysbiosis and Alzheimer’s disease-like neuroinflammation triggered by periodontal disease
Chuanjiang Zhao, Ryutaro Kuraji, Changchang Ye, Li Gao, Allan Radaic, Pachiyappan Kamarajan, Yoshimasa Taketani, Yvonne L. Kapila
BAFF blockade in experimental autoimmune encephalomyelitis reduces inflammation in the meninges and synaptic and neuronal loss in adjacent brain regions
Kanak Gupta, Ajay Kesharwani, Steven Rua, Saumitra Sen Singh, Catherine Siu, Larissa Jank, Matthew D. Smith, Peter A. Calabresi, Pavan Bhargava
Stabilizing histamine release in gut mast cells mitigates peripheral and central inflammation after stroke
Maria P. Blasco Conesa, Frank W. Blixt, Pedram Peesh, Romeesa Khan, Janelle Korf, Juneyoung Lee, Gayathri Jagadeesan, Alexander Andersohn, Tushar K. Das, Chunfeng Tan, Claudia Di Gesu, Gabriela Delevati Colpo, Jose Félix Moruno-Manchón, Louise D. McCullough, Robert Bryan, Bhanu P. Ganesh
Human iPSC-derived glia models for the study of neuroinflammation
Nina Stöberl, Emily Maguire, Elisa Salis, Bethany Shaw, Hazel Hall-Roberts
CD13 facilitates immune cell migration and aggravates acute injury but promotes chronic post-stroke recovery
Justin N. Nguyen, Eric C. Mohan, Gargee Pandya, Uzma Ali, Chunfeng Tan, Julia K. Kofler, Linda Shapiro, Sean P. Marrelli, Anjali Chauhan
Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer’s disease and brain aging
Miriam Corraliza-Gomez, Teresa Bermejo, Jingtao Lilue, Noelia Rodriguez-Iglesias, Jorge Valero, Irene Cozar-Castellano, Eduardo Arranz, Diego Sanchez, Maria Dolores Ganfornina
Astrocyte interferon-gamma signaling dampens inflammation during chronic central nervous system autoimmunity via PD-L1
Brandon C. Smith, Rachel A. Tinkey, Orion D. Brock, Arshiya Mariam, Maria L. Habean, Ranjan Dutta, Jessica L. Williams
Chronic neuroinflammation during aging leads to cholinergic neurodegeneration in the mouse medial septum
Rashmi Gamage, Ilaria Rossetti, Garry Niedermayer, Gerald Münch, Yossi Buskila, Erika Gyengesi
Voltammetry in the spleen assesses real-time immunomodulatory norepinephrine release elicited by autonomic neurostimulation
Ibrahim T. Mughrabi, Michael Gerber, Naveen Jayaprakash, Santhoshi P. Palandira, Yousef Al-Abed, Timir Datta-Chaudhuri, Corey Smith, Valentin A. Pavlov, Stavros Zanos
Downregulation of the glucose transporter GLUT 1 in the cerebral microvasculature contributes to postoperative neurocognitive disorders in aged mice
Ying Chen, Jin Joo, John Man-Tak Chu, Raymond Chuen-Chung Chang, Gordon Tin-Chun Wong
NR4A1 deletion promotes pro-angiogenic polarization of macrophages derived from classical monocytes in a mouse model of neovascular age-related macular degeneration
Steven Droho, Andrew P. Voigt, Jacob K. Sterling, Amrita Rajesh, Kyle S. Chan, Carla M. Cuda, Harris Perlman, Jeremy A. Lavine
Impairing Gasdermin D-mediated pyroptosis is protective against retinal degeneration
Rakshanya Sekar, Yvette Wooff, Adrian V. Cioanca, Melan Kurera, Chinh Ngo, Si Ming Man, Riccardo Natoli
Intermittent hypoxia therapy ameliorates beta-amyloid pathology via TFEB-mediated autophagy in murine Alzheimer's disease
Xueting Wang, Yuqi Xie, Guijuan Chen, Yapeng Lu, Dan Wang, Li Zhu
A systematic review of immune-based interventions for perinatal neuroprotection: closing the gap between animal studies and human trials
Sharmony B. Kelly, Nhi T. Tran, Graeme R. Polglase, Rodney W. Hunt, Marcel F. Nold, Claudia A. Nold-Petry, David M. Olson, Sylvain Chemtob, Gregory A. Lodygensky, Sarah A. Robertson, Alistair J. Gunn, Robert Galinsky
Distinguishing the effects of systemic CSF1R inhibition by PLX3397 on microglia and peripheral immune cells
Akhabue K. Okojie, Joseph O. Uweru, Morgan A. Coburn, Sihan Li, Vivian D. Cao-Dao, Ukpong B. Eyo
Deletion of CD47 from Schwann cells and macrophages hastens myelin disruption/dismantling and scavenging in Schwann cells and augments myelin debris phagocytosis in macrophages
Miri Gitik, Gerard Elberg, Fanny Reichert, Michael Tal, Shlomo Rotshenker
ASK1-K716R reduces neuroinflammation and white matter injury via preserving blood–brain barrier integrity after traumatic brain injury
Shan Meng, Hui Cao, Yichen Huang, Ziyu Shi, Jiaying Li, Yana Wang, Yue Zhang, Shuning Chen, Hong Shi, Yanqin Gao
Complement-membrane regulatory proteins are absent from the nodes of Ranvier in the peripheral nervous system
Netanel Karbian, Yael Eshed-Eisenbach, Marian Zeibak, Adi Tabib, Natasha Sukhanov, Anya Vainshtein, B. Paul Morgan, Yakov Fellig, Elior Peles, Dror Mevorach
Alterations in pathogen-specific cellular and humoral immunity associated with acute peripheral facial palsy of infectious origin
Leyla Mohammad, Mathias Fousse, Gentiana Wenzel, Marina Flotats Bastardas, Klaus Faßbender, Ulrich Dillmann, Bernhard Schick, Michael Zemlin, Barbara C. Gärtner, Urban Sester, David Schub, Tina Schmidt, Martina Sester
Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity
Shuo Kong, Tao-xiang Chen, Xiang-lei Jia, Xue-lei Cheng, Meng-liu Zeng, Jing-yi Liang, Xiao-hua He, Jun Yin, Song Han, Wan-hong Liu, Yuan-teng Fan, Ting Zhou, Yu-min Liu, Bi-wen Peng
IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury
Jonathan C. Vincent, Colleen N. Garnett, James B. Watson, Emma K. Higgins, Teresa Macheda, Lydia Sanders, Kelly N. Roberts, Ryan K. Shahidehpour, Eric M. Blalock, Ning Quan, Adam D. Bachstetter
Recombinant Slit2 suppresses neuroinflammation and Cdc42-mediated brain infiltration of peripheral immune cells via Robo1–srGAP1 pathway in a rat model of germinal matrix hemorrhage
Qian Li, Lei Huang, Yan Ding, Prativa Sherchan, Wenjie Peng, John H. Zhang
Repeated mild traumatic brain injury causes sex-specific increases in cell proliferation and inflammation in juvenile rats
Katie J. Neale, Hannah M. O. Reid, Barbara Sousa, Erin McDonagh, Jamie Morrison, Sandy Shultz, Eric Eyolfson, Brian R. Christie
The novel HS-mimetic, Tet-29, regulates immune cell trafficking across barriers of the CNS during inflammation
Tessa Peck, Connor Davis, Georgia Lenihan-Geels, Maddie Griffiths, Sam Spijkers-Shaw, Olga V. Zubkova, Anne Camille La Flamme
Characterizing the neuroimmune environment of offspring in a novel model of maternal allergic asthma and particulate matter exposure
Juan M. Tamayo, Hadley C. Osman, Jared J. Schwartzer, Kent E. Pinkerton, Paul Ashwood
Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS
Linda T. Nguyen, Andrea Aprico, Eze Nwoke, Alexander D. Walsh, Farrah Blades, Raphael Avneri, Elodie Martin, Bernard Zalc, Trevor J. Kilpatrick, Michele D. Binder
Correction: Gas6 induces infammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer’s disease
Laura D. Owlett, Berke Karaahmet, Linh Le, Elizabeth K. Belcher, Dawling Dionisio-Santos, John A. Olschowka, Michael R. Elliott, M. Kerry O’Banion
β-adrenergic signaling triggers enteric glial reactivity and acute enteric gliosis during surgery
Patrick Leven, Reiner Schneider, Linda Schneider, Shilpashree Mallesh, Pieter Vanden Berghe, Philipp Sasse, Jörg C. Kalff, Sven Wehner
Efferocytosis is restricted by axon guidance molecule EphA4 via ERK/Stat6/MERTK signaling following brain injury
Eman Soliman, John Leonard, Erwin Kristobal Gudenschwager Basso, Ilana Gershenson, Jing Ju, Jatia Mills, Caroline de Jager, Alexandra M. Kaloss, Mohamed Elhassanny, Daniela Pereira, Michael Chen, Xia Wang, Michelle H. Theus
Repeated sleep deprivation decreases the flux into hexosamine biosynthetic pathway/O-GlcNAc cycling and aggravates Alzheimer’s disease neuropathology in adult zebrafish
Jiwon Park, Dong Yeol Kim, Geum-Sook Hwang, Inn-Oc Han
M2 macrophage-derived cathepsin S promotes peripheral nerve regeneration via fibroblast–Schwann cell-signaling relay
Eri Oshima, Yoshinori Hayashi, Zhen Xie, Hitoshi Sato, Suzuro Hitomi, Ikuko Shibuta, Kentaro Urata, Junjun Ni, Koichi Iwata, Tatsuo Shirota, Masamichi Shinoda
Inhibition of UTX/KDM6A improves recovery of spinal cord injury by attenuating BSCB permeability and macrophage infiltration through the MLCK/p-MLC pathway
Yong Xie, Zixiang Luo, Wei Peng, Yudong Liu, Feifei Yuan, Jiaqi Xu, Yi Sun, Hongbin Lu, Tianding Wu, Liyuan Jiang, Jianzhong Hu
Infiltrating myeloid cell-derived properdin markedly promotes microglia-mediated neuroinflammation after ischemic stroke
Pin-yi Liu, Hui-qin Li, Meng-qi Dong, Xin-ya Gu, Si-yi Xu, Sheng-nan Xia, Xin-yu Bao, Yun Xu, Xiang Cao
NeuroD1 administration ameliorated neuroinflammation and boosted neurogenesis in a mouse model of subarachnoid hemorrhage
Ping Chen, Xue-Yan Liu, Mou-Hui Lin, Yu-Xi Li, De-Zhi Kang, Zu-Cheng Ye, Qing-Song Lin
Spatial transcriptomics and neurofilament light chain reveal changes in lesion patterns in murine autoimmune neuroinflammation
Tobias Brummer, Miriam Schillner, Falk Steffen, Flores Kneilmann, Beatrice Wasser, Timo Uphaus, Frauke Zipp, Stefan Bittner
Deletion of voltage-gated calcium channels in astrocytes decreases neuroinflammation and demyelination in a murine model of multiple sclerosis
G. E. Denaroso, Z. Smith, C. G. Angeliu, V. T. Cheli, C. Wang, P. M. Paez
Glyceryl triacetate promotes blood–brain barrier recovery after ischemic stroke through lipogenesis-mediated IL-33 in mice
Haidong Wei, Luming Zhen, Shiquan Wang, Liufei Yang, Shuyue Zhang, Yuanyuan Zhang, Pengyu Jia, Tianyue Wang, Kui Wang, Yan Zhang, Lei Ma, Jianrui Lv, Pengbo Zhang
Erythrocyte–brain endothelial interactions induce microglial responses and cerebral microhemorrhages in vivo
Hai Zhang, Rachita K. Sumbria, Rudy Chang, Jiahong Sun, David H. Cribbs, Todd C. Holmes, Mark J. Fisher, Xiangmin Xu
Contribution of macrophages to neural survival and intracochlear tissue remodeling responses following cochlear implantation
Muhammad Taifur Rahman, Brian J. Mostaert, Bryce Hunger, Utsow Saha, Alexander D. Claussen, Ibrahim Razu, Farjana Nasrin, Nashwaan Ali Khan, Peter Eckard, Sarah Coleman, Jacob Oleson, Jonathon R. Kirk, Keiko Hirose, Marlan R. Hansen
Pericytes are protective in experimental pneumococcal meningitis through regulating leukocyte infiltration and blood–brain barrier function
Nina C. Teske, Susanne Dyckhoff-Shen, Paul Beckenbauer, Jan Philipp Bewersdorf, Joo-Yeon Engelen-Lee, Sven Hammerschmidt, Roland E. Kälin, Hans-Walter Pfister, Matthijs C. Brouwer, Matthias Klein, Rainer Glass, Diederik van de Beek, Uwe Koedel
Cyanidin-3-O-glucoside protects the brain and improves cognitive function in APPswe/PS1ΔE9 transgenic mice model
Hana Baek, Sanjay, Miey Park, Hae-Jeung Lee
Cytokine enrichment in deep cerebellar nuclei is contributed by multiple glial populations and linked to reduced amyloid plaque pathology
Jessica R. Gaunt, Norliyana Zainolabidin, Alaric K. K. Yip, Jia Min Tan, Aloysius Y. T. Low, Albert I. Chen, Toh Hean Ch’ng
Ly6C-high monocytes alleviate brain injury in experimental subarachnoid hemorrhage in mice
Huaijun Chen, Chaoran Xu, Hanhai Zeng, Zhihua Zhang, Ning Wang, Yinghan Guo, Yonghe Zheng, Siqi Xia, Hang Zhou, Xiaobo Yu, Xiongjie Fu, Tianchi Tang, Xinyan Wu, Zihang Chen, Yucong Peng, Jing Cai, Jianru Li, Feng Yan, Chi Gu, Gao Chen, Jingyin Chen
Knockdown and inhibition of hippocampal GPR17 attenuates lipopolysaccharide-induced cognitive impairment in mice
Yusheng Liang, Xu kang, Haiwang Zhang, Heng Xu, Xian Wu
Microglial activation, tau and amyloid deposition in TREM2 p.R47H carriers and mild cognitive impairment patients: a multi-modal/multi-tracer PET/MRI imaging study with influenza vaccine immune challenge
Oliver Cousins, Julia J. Schubert, Avinash Chandra, Mattia Veronese, Polena Valkimadi, Byron Creese, Zunera Khan, Ryan Arathimos, Adam Hampshire, Ivana Rosenzweig, Clive Ballard, Anne Corbett, Dag Aasland, Latha Velayudhan, Michael O’Neill, David Collier, Ramla Awais, Kerstin Sander, Erik Årstad, Oliver Howes, Federico Turkheimer, Angela Hodges
Microglia/macrophages are ultrastructurally altered by their proximity to spinal cord injury in adult female mice
Marie-Kim St-Pierre, Fernando González Ibáñez, Antje Kroner, Marie-Ève Tremblay
The role of Nurr1-miR-30e-5p-NLRP3 axis in inflammation-mediated neurodegeneration: insights from mouse models and patients’ studies in Parkinson’s disease
Tianbai Li, Xiang Tan, Lulu Tian, Congcong Jia, Cheng Cheng, Xi Chen, Min Wei, Yuanyuan Wang, Yiying Hu, Qiqi Jia, Yang Ni, Murad Al-Nusaif, Song Li, Weidong Le
Temporal changes in regulatory T cell subsets defined by the transcription factor Helios in stroke and their potential role in stroke-associated infection: a prospective case–control study
Maria Lukasik, Magdalena Telec, Radoslaw Kazmierski, Izabela Wojtasz, Natalia Andrzejewska-Gorczyńska, Wojciech Kociemba, Grzegorz Dworacki, Wojciech P. Kozubski, Magdalena Frydrychowicz
Naïve Huntington’s disease microglia mount a normal response to inflammatory stimuli but display a partially impaired development of innate immune tolerance that can be counteracted by ganglioside GM1
Noam Steinberg, Danny Galleguillos, Asifa Zaidi, Melanie Horkey, Simonetta Sipione
PSMC5 regulates microglial polarization and activation in LPS-induced cognitive deficits and motor impairments by interacting with TLR4
Wei Bi, Keyao Bao, Xinqi Zhou, Yihui Deng, Xiaoting Li, Jiawei Zhang, Xin Lan, Jiayi Zhao, Daxiang Lu, Yezi Xu, Yanmei Cen, Rui Cao, Mengyang Xu, Wenbin Zhong, Lihong Zhu
14-3-3 -reported early synaptic injury in Alzheimer’s disease is independently mediated by sTREM2
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Hypothermia combined with extracellular vesicles from clonally expanded immortalized mesenchymal stromal cells improves neurodevelopmental impairment in neonatal hypoxic-ischemic brain injury
Nicole Labusek, Parnian Ghari, Yanis Mouloud, Christian Köster, Eva Diesterbeck, Martin Hadamitzky, Ursula Felderhoff-Müser, Ivo Bendix, Bernd Giebel, Josephine Herz
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Shengnan Zheng, Yiquan Li, Xiaomeng Song, Mengting Wu, Lu Yu, Gan Huang, Tengfei Liu, Lei Zhang, Mingmei Shang, Qingfen Zhu, Chengjiang Gao, Lin Chen, Huiqing Liu
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Namkwon Kim, In Gyoung Ju, Seung Ho Jeon, Yeongae Lee, Min-Ji Jung, Min Sung Gee, Jae Seok Cho, Kyung-Soo Inn, Lee Ann Garrett-Sinha, Myung Sook Oh, Jong Kil Lee
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Anbiao Wu, Jiyan Zhang
TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy
Xuliang Huang, Changzhou Ye, Xinyu Zhao, Yao Tong, Wen Lin, Qingqing Huang, Yuhao Zheng, Junlu Wang, Anqi Zhang, Yunchang Mo
Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia‒reperfusion injury by modulating various cells
Zhaohui Ruan, Guosheng Cao, Yisong Qian, Longsheng Fu, Jinfang Hu, Tiantian Xu, Yaoqi Wu, Yanni Lv
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Drew A. Gillett, Rebecca L. Wallings, Oihane Uriarte Huarte, Malú Gámez Tansey
Correction : IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury
Jonathan C. Vincent, Colleen N. Garnett, James B. Watson, Emma K. Higgins, Teresa Macheda, Lydia Sanders, Kelly N. Roberts, Ryan K. Shahidehpour, Eric M. Blalock, Ning Quan, Adam D. Bachstetter
Correction: miR155, TREM2, INPP5D: Disease stage and cell-type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer’s amyloidopathy
Sam Gandy, Michelle E. Ehrlich
Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis
Nils Mein, Nikolai von Stackelberg, Jonathan Wickel, Christian Geis, Ha-Yeun Chung
Astrocyte-specific knockout of YKL-40/Chi3l1 reduces Aβ burden and restores memory functions in 5xFAD mice
Xiaoyan Zeng, Stanley K. K. Cheung, Mengqi Shi, Penelope M. Y. Or, Zhining Li, Julia Y. H. Liu, Wayne L. H. Ho, Tian Liu, Kun Lu, John A. Rudd, Yubing Wang, Andrew M. Chan
An engineered Fc fusion protein that targets antigen-specific T cells and autoantibodies mitigates autoimmune disease
Mathangi Janakiraman, Alexei Leliavski, Jeeva Varadarajulu, Dieter Jenne, Gurumoorthy Krishnamoorthy
Design, synthesis, and characterization of novel system xC− transport inhibitors: inhibition of microglial glutamate release and neurotoxicity
Mariusz P. Gajewski, Steven W. Barger
The hypothalamic steroidogenic pathway mediates susceptibility to inflammation-evoked depression in female mice
Fu-Rong Xu, Zhen-Hong Wei, Xiao-Xia Xu, Xiao-Gang Zhang, Chao-Jun Wei, Xiao-Ming Qi, Yong-Hong Li, Xiao-Ling Gao, Yu Wu
Lateralized response of skull bone marrow via osteopontin signaling in mice after ischemia reperfusion
Chaoran Xu, Qia Zhang, Yi Zhang, Huaijun Chen, Tianchi Tang, Junjie Wang, Siqi Xia, Gao Chen, Jianmin Zhang
Vesicular HMGB1 release from neurons stressed with spreading depolarization enables confined inflammatory signaling to astrocytes
Zeynep Kaya, Nevin Belder, Melike Sever-Bahcekapili, Buket Donmez-Demir, Şefik Evren Erdener, Naz Bozbeyoglu, Canan Bagci, Emine Eren-Kocak, Muge Yemisci, Hulya Karatas, Esra Erdemli, Ihsan Gursel, Turgay Dalkara
Empagliflozin targets Mfn1 and Opa1 to attenuate microglia-mediated neuroinflammation in retinal ischemia and reperfusion injury
Zhenlan Yang, Yidan Liu, Xuhao Chen, Shaofen Huang, Yangyang Li, Guitong Ye, Xu Cao, Wenru Su, Yehong Zhuo
Extracellular vesicles from hiPSC-NSCs can prevent peripheral inflammation-induced cognitive dysfunction with inflammasome inhibition and improved neurogenesis in the hippocampus
Gunel Ayyubova, Maheedhar Kodali, Raghavendra Upadhya, Leelavathi N. Madhu, Sahithi Attaluri, Yogish Somayaji, Bing Shuai, Shama Rao, Goutham Shankar, Ashok K. Shetty
Longitudinal cerebrospinal fluid measurements show glial hypo- and hyperactivation in predementia Alzheimer’s disease
Kaja Nordengen, Bjørn-Eivind Kirsebom, Grit Richter, Lene Pålhaugen, Berglind Gísladóttir, Nikias Siafarikas, Arne Nakling, Arvid Rongve, Geir Bråthen, Gøril Rolfseng Grøntvedt, Fernando Gonzalez, Knut Waterloo, Kulbhushan Sharma, Thomas Karikari, Eleonora M. Vromen, Betty M. Tijms, Pieter J. Visser, Per Selnes, Milicia G. Kramberger, Bengt Winblad, Kaj Blennow, Tormod Fladby
Human-derived air–liquid interface cultures decipher Alzheimer’s disease–SARS-CoV-2 crosstalk in the olfactory mucosa
Muhammad Ali Shahbaz, Suvi Kuivanen, Riikka Lampinen, Laura Mussalo, Tomáš Hron, Táňa Závodná, Ravi Ojha, Zdeněk Krejčík, Liudmila Saveleva, Numan Ahmad Tahir, Juho Kalapudas, Anne M. Koivisto, Elina Penttilä, Heikki Löppönen, Prateek Singh, Jan Topinka, Olli Vapalahti, Sweelin Chew, Giuseppe Balistreri, Katja M. Kanninen
CSF-1R inhibitor PLX3397 attenuates peripheral and brain chronic GVHD and improves functional outcomes in mice
Samreen N. Shaikh, Emily F. Willis, Max Dierich, Yi Xu, Samuel J. S. Stuart, Glenda C. Gobe, Abate A. Bashaw, Oliver Rawashdeh, Seung Jae Kim, Jana Vukovic
Inhaled nitric oxide suppresses neuroinflammation in experimental ischemic stroke
Rebecca I. Sienel, Uta Mamrak, Janina Biller, Stefan Roth, Andreas Zellner, Tipparat Parakaw, Rayomand S. Khambata, Arthur Liesz, Christof Haffner, Amrita Ahluwalia, Burcu F. Seker, Nikolaus Plesnila
Central activation of the fatty acid sensor GPR120 suppresses microglia reactivity and alleviates sickness- and anxiety-like behaviors
Shingo Nakajima, Geneviève Demers, Arturo Israel Machuca-Parra, Zahra Dashtehei Pour, Diane Bairamian, Khalil Bouyakdan, Alexandre Fisette, Anita Kabahizi, Josephine Robb, Demetra Rodaros, Cyril Laurent, Guillaume Ferreira, Nathalie Arbour, Thierry Alquier, Stephanie Fulton
Oxygen therapy attenuates neuroinflammation after spinal cord injury
Michael D. Sunshine, Victoria E. Bindi, Branden L. Nguyen, Vivian Doerr, Franccesco P. Boeno, Vijayendran Chandran, Ashley J. Smuder, David D. Fuller
Targeting CB2R in astrocytes for Parkinson's disease therapy: unraveling the Foxg1-mediated neuroprotective mechanism through autophagy-mediated NLRP3 degradation
Hong Zhu, Feng Xiao, Yao Xiao, Yun Guo, Xuesong Shan, Zhe Zhang, Lieliang Zhang, Hua Guo
27-hydroxycholesterol causes cognitive deficits by disturbing Th17/Treg balance and the related immune responses in mild cognitive impairment patients and C57BL/6J mice
Tao Wang, Wenjing Feng, Mengwei Ju, Huiyan Yu, Zhiting Guo, Xuejing Sun, Kexin Yang, Miao Liu, Rong Xiao
TNFR1 signaling converging on FGF14 controls neuronal hyperactivity and sickness behavior in experimental cerebral malaria
Nolan M. Dvorak, Nadia D. Domingo, Cynthia M. Tapia, Paul A. Wadsworth, Mate Marosi, Yosef Avchalumov, Chanida Fongsaran, Leandra Koff, Jessica Di Re, Catherine M. Sampson, Timothy J. Baumgartner, Pingyuan Wang, Paula P. Villarreal, Olivia D. Solomon, Sonja J. Stutz, Aditi, Jacob Porter, Komi Gbedande, Brendan Prideaux, Thomas A. Green, Erin H. Seeley, Parimal Samir, Kelley T. Dineley, Gracie Vargas, Jia Zhou, Irma Cisneros, Robin Stephens, Fernanda Laezza
Amelioration of experimental autoimmune encephalomyelitis by in vivo reprogramming of macrophages using pro-resolving factors
Thierry Gauthier, Omayra Martin-Rodriguez, Cécile Chagué, Anna Daoui, Adam Ceroi, Alexis Varin, Francis Bonnefoy, Séverine Valmary-Degano, Mélanie Couturier, Susanne Behlke, Philippe Saas, Pierre-François Cartron, Sylvain Perruche
Succinate-induced macrophage polarization and RBP4 secretion promote vascular sprouting in ocular neovascularization
Tianyi Shen, Ruoyi Lin, Chengyu Hu, Donghui Yu, Chengda Ren, Tingting Li, Meijiang Zhu, Zhongqi Wan, Tu Su, Yan Wu, Wenting Cai, Jing Yu
Bruton’s tyrosine kinase-bearing B cells and microglia in neuromyelitis optica spectrum disorder
Ye Liu, Zhenning Huang, Tian-Xiang Zhang, Bin Han, Guili Yang, Dongmei Jia, Li Yang, Qiang Liu, Alexander Y. L. Lau, Friedemann Paul, Alexei Verkhratsky, Fu-Dong Shi, Chao Zhang