Ausgabe 1/2016
Inhalt (307 Artikel)
Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model
Do-Geun Kim, Antje Krenz, Leon E. Toussaint, Kirk J. Maurer, Sudie-Ann Robinson, Angela Yan, Luisa Torres, Margaret S. Bynoe
Interleukin-18 modulation in autism spectrum disorders
Rita Businaro, Mariangela Corsi, Gabriella Azzara, Tania Di Raimo, Giovanni Laviola, Emilia Romano, Lidia Ricci, Mauro Maccarrone, Eleonora Aronica, Andrea Fuso, Serafino Ricci
Modeling leukocyte trafficking at the human blood-nerve barrier in vitro and in vivo geared towards targeted molecular therapies for peripheral neuroinflammation
Kelsey M. Greathouse, Steven P. Palladino, Chaoling Dong, Eric S. Helton, Eroboghene E. Ubogu
Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer’s disease pathology
Andrea F. N. Rosenberger, Tjado H. J. Morrema, Wouter H. Gerritsen, Elise S. van Haastert, Hripsime Snkhchyan, Riet Hilhorst, Annemieke J. M. Rozemuller, Philip Scheltens, Saskia M. van der Vies, Jeroen J. M. Hoozemans
Depressive symptoms are associated with tumor necrosis factor alpha in systemic lupus erythematosus
Mariana Postal, Aline Tamires Lapa, Nailú Angélica Sinicato, Karina de Oliveira Peliçari, Fernando Augusto Peres, Lilian Tereza Lavras Costallat, Paula Teixeira Fernandes, Roberto Marini, Simone Appenzeller
CXCL5 signaling is a shared pathway of neuroinflammation and blood–brain barrier injury contributing to white matter injury in the immature brain
Lin-Yu Wang, Yi-Fang Tu, Yung-Chieh Lin, Chao-Ching Huang
Post-CNS-inflammation expression of CXCL12 promotes the endogenous myelin/neuronal repair capacity following spontaneous recovery from multiple sclerosis-like disease
Rina Zilkha-Falb, Nathali Kaushansky, Naoto Kawakami, Avraham Ben-Nun
Exosomes derived from atorvastatin-modified bone marrow dendritic cells ameliorate experimental autoimmune myasthenia gravis by up-regulated levels of IDO/Treg and partly dependent on FasL/Fas pathway
Xiao-Li Li, Heng Li, Min Zhang, Hua Xu, Long-Tao Yue, Xin-Xin Zhang, Shan Wang, Cong-Cong Wang, Yan-Bin Li, Ying-Chun Dou, Rui-Sheng Duan
Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines
Mousumi Ghosh, Yong Xu, Damien D. Pearse
Neuroprotective effects of bee venom phospholipase A2 in the 3xTg AD mouse model of Alzheimer’s disease
Minsook Ye, Hwan-Suck Chung, Chanju Lee, Moon Sik Yoon, A. Ram Yu, Jin Su Kim, Deok-Sang Hwang, Insop Shim, Hyunsu Bae
Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia
Antonio Carlos Pinheiro de Oliveira, Nizar M. Yousif, Harsharan Singh Bhatia, Julia Hermanek, Michael Huell, Bernd L. Fiebich
Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK
Duy-Khanh Dang, Eun-Joo Shin, Yunsung Nam, Sungwoo Ryoo, Ji Hoon Jeong, Choon-Gon Jang, Toshitaka Nabeshima, Jau-Shyong Hong, Hyoung-Chun Kim
Endogenous adaptation to low oxygen modulates T-cell regulatory pathways in EAE
Nilufer Esen, Vladimir Katyshev, Zakhar Serkin, Svetlana Katysheva, Paula Dore-Duffy
Acute versus chronic phase mechanisms in a rat model of CRPS
Tzuping Wei, Tian-Zhi Guo, Wen-Wu Li, Wade S. Kingery, John David Clark
Tauopathy in transgenic (SHR72) rats impairs function of central noradrenergic system and promotes neuroinflammation
Boris Mravec, Katarina Lejavova, Peter Vargovic, Katarina Ondicova, Lubica Horvathova, Petr Novak, Georg Manz, Peter Filipcik, Michal Novak, Richard Kvetnansky
Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke
R. Zangari, E. R. Zanier, G. Torgano, A. Bersano, S. Beretta, E. Beghi, B. Casolla, N. Checcarelli, S. Lanfranconi, A. Maino, C. Mandelli, G. Micieli, F. Orzi, E. Picetti, M. Silvestrini, N. Stocchetti, B. Zecca, P. Garred, M. G. De Simoni
Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2)
Konstantin Glebov, Patrick Wunderlich, Ilker Karaca, Jochen Walter
Myeloid dendritic cells are decreased in peripheral blood of Alzheimer’s disease patients in association with disease progression and severity of depressive symptoms
Antonio Ciaramella, Francesca Salani, Federica Bizzoni, Maria Donata Orfei, Carlo Caltagirone, Gianfranco Spalletta, Paola Bossù
Urban traffic-derived nanoparticulate matter reduces neurite outgrowth via TNFα in vitro
Hank Cheng, David A. Davis, Sina Hasheminassab, Constantinos Sioutas, Todd E. Morgan, Caleb E. Finch
Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease
Julien Couturier, Ilie-Cosmin Stancu, Olivier Schakman, Nathalie Pierrot, François Huaux, Pascal Kienlen-Campard, Ilse Dewachter, Jean-Noël Octave
Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta
Ryan C. McCarthy, Dah-Yuu Lu, Ahmed Alkhateeb, Andrew M. Gardeck, Chih-Hao Lee, Marianne Wessling-Resnick
Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1
Chaitanya Kurhade, Loreen Zegenhagen, Elvira Weber, Sharmila Nair, Kristin Michaelsen-Preusse, Julia Spanier, Nelson O Gekara, Andrea Kröger, Anna K Överby
Complement component C3a plays a critical role in endothelial activation and leukocyte recruitment into the brain
Fengjiao Wu, Qiang Zou, Xiaodan Ding, Dongyan Shi, Xingxing Zhu, Weiguo Hu, Lixin Liu, Hong Zhou
RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis
Jae-Kyung Lee, George T. Kannarkat, Jaegwon Chung, Hyun Joon Lee, Kareem L. Graham, Malú G. Tansey
The extracellular matrix protein laminin-10 promotes blood–brain barrier repair after hypoxia and inflammation in vitro
Korakoch Kangwantas, Emmanuel Pinteaux, Jeffrey Penny
Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage
Bo Ma, Jason Patrick Day, Harrison Phillips, Bryan Slootsky, Emanuela Tolosano, Sylvain Doré
HSP60 plays a regulatory role in IL-1β-induced microglial inflammation via TLR4-p38 MAPK axis
Shalini Swaroop, Nabonita Sengupta, Amol Ratnakar Suryawanshi, Yogita K Adlakha, Anirban Basu
Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A
Jin Liu, Ding Wang, Shu-Qin Li, Yang Yu, Richard D. Ye
Neuroinflammation and structural injury of the fetal ovine brain following intra-amniotic Candida albicans exposure
Daan R. M. G. Ophelders, Ruth Gussenhoven, Martin Lammens, Benno Küsters, Matthew W. Kemp, John P. Newnham, Matthew S. Payne, Suhas G. Kallapur, Allan H. Jobe, Luc J. Zimmermann, Boris W. Kramer, Tim G. A. M. Wolfs
Brain radiation injury leads to a dose- and time-dependent recruitment of peripheral myeloid cells that depends on CCR2 signaling
Michael J. Moravan, John A. Olschowka, Jacqueline P. Williams, M. Kerry O’Banion
The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures
Catherine O’Sullivan, Anna Schubart, Anis K. Mir, Kumlesh K. Dev
Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseases
Moonhee Lee, Edith G. McGeer, Patrick L. McGeer
Cocaine-mediated induction of microglial activation involves the ER stress-TLR2 axis
Ke Liao, Minglei Guo, Fang Niu, Lu Yang, Shannon E. Callen, Shilpa Buch
Andrographolide attenuates LPS-stimulated up-regulation of C-C and C-X-C motif chemokines in rodent cortex and primary astrocytes
Siew Ying Wong, Michelle G.K. Tan, William A. Banks, W.S. Fred Wong, Peter T.-H. Wong, Mitchell K.P. Lai
Angiotensin-converting enzyme 2 activator diminazene aceturate prevents lipopolysaccharide-induced inflammation by inhibiting MAPK and NF-κB pathways in human retinal pigment epithelium
Lifei Tao, Yiguo Qiu, Xinyu Fu, Ru Lin, Chunyan Lei, Jiaming Wang, Bo Lei
Cerebrospinal fluid lactate is associated with multiple sclerosis disease progression
Maria Albanese, Sara Zagaglia, Doriana Landi, Laura Boffa, Carolina G. Nicoletti, Maria Grazia Marciani, Georgia Mandolesi, Girolama A. Marfia, Fabio Buttari, Francesco Mori, Diego Centonze
TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function
Justin Rustenhoven, Miranda Aalderink, Emma L. Scotter, Robyn L. Oldfield, Peter S. Bergin, Edward W. Mee, E. Scott Graham, Richard L. M. Faull, Maurice A. Curtis, Thomas I-H. Park, Mike Dragunow
Macrophage depletion reduced brain injury following middle cerebral artery occlusion in mice
Yuanyuan Ma, Yaning Li, Lu Jiang, Liping Wang, Zhen Jiang, Yongting Wang, Zhijun Zhang, Guo-Yuan Yang
Virus-mediated EpoR76E gene therapy preserves vision in a glaucoma model by modulating neuroinflammation and decreasing oxidative stress
Jessica Hines-Beard, Wesley S. Bond, Jon R. Backstrom, Tonia S. Rex
Inflammatory cytokine and chemokine profiles are associated with patient outcome and the hyperadrenergic state following acute brain injury
Alex P. Di Battista, Shawn G. Rhind, Michael G. Hutchison, Syed Hassan, Maria Y. Shiu, Kenji Inaba, Jane Topolovec-Vranic, Antonio Capone Neto, Sandro B. Rizoli, Andrew J. Baker
Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane
Vicente Hernández-Rabaza, Andrea Cabrera-Pastor, Lucas Taoro-González, Michele Malaguarnera, Ana Agustí, Marta Llansola, Vicente Felipo
Protection from experimental autoimmune encephalomyelitis by polyclonal IgG requires adjuvant-induced inflammation
Isaak Quast, Christian W. Keller, Patrick Weber, Christoph Schneider, Stephan von Gunten, Jan D. Lünemann
CD200R1 agonist attenuates glial activation, inflammatory reactions, and hypersensitivity immediately after its intrathecal application in a rat neuropathic pain model
Miriam Hernangómez, Ilona Klusáková, Marek Joukal, Ivana Hradilová-Svíženská, Carmen Guaza, Petr Dubový
Bilateral neuroinflammatory processes in visual pathways induced by unilateral ocular hypertension in the rat
Anaïs Sapienza, Anne-Laure Raveu, Elodie Reboussin, Christophe Roubeix, Céline Boucher, Julie Dégardin, David Godefroy, William Rostène, Annabelle Reaux-Le Goazigo, Christophe Baudouin, Stéphane Melik Parsadaniantz
The expression of the chemokine receptor CCR5 in tick-borne encephalitis
Sambor Grygorczuk, Joanna Osada, Miłosz Parczewski, Anna Moniuszko, Renata Świerzbińska, Maciej Kondrusik, Piotr Czupryna, Justyna Dunaj, Milena Dąbrowska, Sławomir Pancewicz
Sustained TNF production by central nervous system infiltrating macrophages promotes progressive autoimmune encephalomyelitis
Alice Valentin-Torres, Carine Savarin, David R. Hinton, Timothy W. Phares, Cornelia C. Bergmann, Stephen A. Stohlman
The broad-spectrum chemokine inhibitor NR58-3.14.3 modulates macrophage-mediated inflammation in the diseased retina
Nilisha Fernando, Riccardo Natoli, Krisztina Valter, Jan Provis, Matt Rutar
Dual roles of the adenosine A2a receptor in autoimmune neuroinflammation
J. Ingwersen, B. Wingerath, J. Graf, K. Lepka, M. Hofrichter, F. Schröter, F. Wedekind, A. Bauer, J. Schrader, H.-P. Hartung, T. Prozorovski, O. Aktas
Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes
Jeffrey R. Liddell, Sarka Lehtonen, Clare Duncan, Velta Keksa-Goldsteine, Anna-Liisa Levonen, Gundars Goldsteins, Tarja Malm, Anthony R. White, Jari Koistinaho, Katja M. Kanninen
Celastrol protects mouse retinas from bright light-induced degeneration through inhibition of oxidative stress and inflammation
Minjuan Bian, Xiaoye Du, Jingang Cui, Peiwei Wang, Wenjian Wang, Weiliang Zhu, Teng Zhang, Yu Chen
Electroconvulsive therapy suppresses the neurotoxic branch of the kynurenine pathway in treatment-resistant depressed patients
Lilly Schwieler, Martin Samuelsson, Mark A. Frye, Maria Bhat, Ina Schuppe-Koistinen, Oscar Jungholm, Anette G. Johansson, Mikael Landén, Carl M. Sellgren, Sophie Erhardt
Heme oxygenase-1 promotes neuron survival through down-regulation of neuronal NLRP1 expression after spinal cord injury
Wen-Ping Lin, Gong-Peng Xiong, Qing Lin, Xuan-Wei Chen, Li-Qun Zhang, Jin-Xing Shi, Qing-Feng Ke, Jian-Hua Lin
Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia
Yang Cai, Hong Kong, Yin-Bing Pan, Lai Jiang, Xiu-Xiu Pan, Liang Hu, Yan-Ning Qian, Chun-Yi Jiang, Wen-Tao Liu
HIV-tat alters Connexin43 expression and trafficking in human astrocytes: role in NeuroAIDS
Joan W. Berman, Loreto Carvallo, Clarisa M. Buckner, Aimée Luers, Lisa Prevedel, Michael V. Bennett, Eliseo A. Eugenin
Anti-N-methyl-D-aspartate receptor encephalitis: the clinical course in light of the chemokine and cytokine levels in cerebrospinal fluid
Zuzana Liba, Jana Kayserova, Martin Elisak, Petr Marusic, Hana Nohejlova, Jitka Hanzalova, Vladimir Komarek, Anna Sediva
The blockage of the Nogo/NgR signal pathway in microglia alleviates the formation of Aβ plaques and tau phosphorylation in APP/PS1 transgenic mice
Yinquan Fang, Lemeng Yao, Chenhui Li, Jing Wang, Jianing Wang, Shujian Chen, Xin-fu Zhou, Hong Liao
Brain pericytes serve as microglia-generating multipotent vascular stem cells following ischemic stroke
Rika Sakuma, Maiko Kawahara, Akiko Nakano-Doi, Ai Takahashi, Yasue Tanaka, Aya Narita, Sachi Kuwahara-Otani, Tetsu Hayakawa, Hideshi Yagi, Tomohiro Matsuyama, Takayuki Nakagomi
Reciprocal signals between microglia and neurons regulate α-synuclein secretion by exophagy through a neuronal cJUN-N-terminal kinase-signaling axis
Dan Ploug Christensen, Patrick Ejlerskov, Izabela Rasmussen, Frederik Vilhardt
Potential role of microRNA-7 in the anti-neuroinflammation effects of nicorandil in astrocytes induced by oxygen-glucose deprivation
Yin-Feng Dong, Zheng-Zhen Chen, Zhan Zhao, Dan-Dan Yang, Hui Yan, Juan Ji, Xiu-Lan Sun
Role of docosahexaenoic acid in the modulation of glial cells in Alzheimer’s disease
David Heras-Sandoval, José Pedraza-Chaverri, Jazmin M. Pérez-Rojas
Treatment with TO901317, a synthetic liver X receptor agonist, reduces brain damage and attenuates neuroinflammation in experimental intracerebral hemorrhage
Chun-Hu Wu, Chien-Cheng Chen, Chai-You Lai, Tai-Ho Hung, Chao-Chang Lin, Min Chao, Szu-Fu Chen
Systemic pro-inflammatory response facilitates the development of cerebral edema during short hypoxia
Ting-Ting Song, Yan-Hua Bi, Yu-Qi Gao, Rui Huang, Ke Hao, Gang Xu, Jia-Wei Tang, Zhi-Qiang Ma, Fan-Ping Kong, John H. Coote, Xue-Qun Chen, Ji-Zeng Du
Vascular-directed responses of microglia produced by methamphetamine exposure: indirect evidence that microglia are involved in vascular repair?
John F. Bowyer, Sumit Sarkar, Karen M. Tranter, Joseph P. Hanig, Diane B. Miller, James P. O’Callaghan
Microglial migration and interactions with dendrimer nanoparticles are altered in the presence of neuroinflammation
Fan Zhang, Elizabeth Nance, Yossef Alnasser, Rangaramanujam Kannan, Sujatha Kannan
Complex molecular and functional outcomes of single versus sequential cytokine stimulation of rat microglia
Tamjeed A. Siddiqui, Starlee Lively, Lyanne C. Schlichter
Secret talk between adipose tissue and central nervous system via secreted factors—an emerging frontier in the neurodegenerative research
Avinash Parimisetty, Anne-Claire Dorsemans, Rana Awada, Palaniyandi Ravanan, Nicolas Diotel, Christian Lefebvre d’Hellencourt
Morvan’s syndrome and myasthenia gravis related to familial Mediterranean fever gene mutations
Junpei Koge, Shintaro Hayashi, Hiroyuki Murai, Jun Yokoyama, Yuri Mizuno, Taira Uehara, Naoyasu Ueda, Osamu Watanabe, Hiroshi Takashima, Jun-ichi Kira
Glial cell biology in the Great Lakes region
Douglas L. Feinstein, Robert P. Skoff
Erratum to: Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells
Isabella Russo, Giulia Berti, Nicoletta Plotegher, Greta Bernardo, Roberta Filograna, Luigi Bubacco, Elisa Greggio
Activation of the NLRP3 inflammasome in lipopolysaccharide-induced mouse fatigue and its relevance to chronic fatigue syndrome
Zi-Teng Zhang, Xiu-Ming Du, Xiu-Juan Ma, Ying Zong, Ji-Kuai Chen, Chen-Lin Yu, Yan-Gang Liu, Yong-Chun Chen, Li-Jun Zhao, Guo-Cai Lu
Complement activation at the motor end-plates in amyotrophic lateral sclerosis
Nawal Bahia El Idrissi, Sanne Bosch, Valeria Ramaglia, Eleonora Aronica, Frank Baas, Dirk Troost
B cell and/or autoantibody deficiency do not prevent neuropsychiatric disease in murine systemic lupus erythematosus
Jing Wen, Jessica Doerner, Samantha Chalmers, Ariel Stock, Haowei Wang, Maria Gullinello, Mark J. Shlomchik, Chaim Putterman
α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology
Josefine R. Christiansen, Mads N. Olesen, Daniel E. Otzen, Marina Romero-Ramos, Vanesa Sanchez-Guajardo
Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection
Alessandra Cadete Martini, Temugin Berta, Stefânia Forner, Gang Chen, Allisson Freire Bento, Ru-Rong Ji, Giles Alexander Rae
CXCR3 signaling in glial cells ameliorates experimental autoimmune encephalomyelitis by restraining the generation of a pro-Th17 cytokine milieu and reducing CNS-infiltrating Th17 cells
Chen-Yen Chung, Fang Liao
Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice
Lin Yuan, Song Liu, Xuemei Bai, Yan Gao, Guangheng Liu, Xueer Wang, Dexiang Liu, Tong Li, Aijun Hao, Zhen Wang
6-Mercaptopurine attenuates tumor necrosis factor-α production in microglia through Nur77-mediated transrepression and PI3K/Akt/mTOR signaling-mediated translational regulation
Hsin-Yi Huang, Hui-Fen Chang, Ming-Jen Tsai, Jhih-Si Chen, Mei-Jen Wang
Blockage of indoleamine 2,3-dioxygenase regulates Japanese encephalitis via enhancement of type I/II IFN innate and adaptive T-cell responses
Seong Bum Kim, Jin Young Choi, Erdenebileg Uyangaa, Ajit Mahadev Patil, Ferdaus Mohd Altaf Hossain, Jin Hur, Sang-Youel Park, John-Hwa Lee, Koanhoi Kim, Seong Kug Eo
Age exacerbates the CCR2/5-mediated neuroinflammatory response to traumatic brain injury
Josh M. Morganti, Lara-Kirstie Riparip, Austin Chou, Sharon Liu, Nalin Gupta, Susanna Rosi
Multiallelic copy number variation in the complement component 4A (C4A) gene is associated with late-stage age-related macular degeneration (AMD)
Felix Grassmann, Stuart Cantsilieris, Anja-Sabrina Schulz-Kuhnt, Stefan J. White, Andrea J Richardson, Alex W Hewitt, Brendan J. Vote, Denise Schmied, Robyn H Guymer, Bernhard H.F. Weber, Paul N. Baird
Immune response after intermittent minimally invasive intraocular pressure elevations in an experimental animal model of glaucoma
Oliver W. Gramlich, Julia Teister, Mareike Neumann, Xue Tao, Sabine Beck, Harald D. von Pein, Norbert Pfeiffer, Franz H. Grus
Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia
Vicente Hernandez-Rabaza, Andrea Cabrera-Pastor, Lucas Taoro-Gonzalez, Alba Gonzalez-Usano, Ana Agusti, Tiziano Balzano, Marta Llansola, Vicente Felipo
Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK
Yan-jing Yang, Liang Hu, Ye-peng Xia, Chun-yi Jiang, Chen Miao, Chun-qing Yang, Miao Yuan, Lin Wang
Downregulation of CD47 and CD200 in patients with focal cortical dysplasia type IIb and tuberous sclerosis complex
Fei-Ji Sun, Chun-Qing Zhang, Xin Chen, Yu-Jia Wei, Song Li, Shi-Yong Liu, Zhen-le Zang, Jiao-Jiang He, Wei Guo, Hui Yang
A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation
Gyun Jee Song, Myungsu Jung, Jong-Heon Kim, Hana Park, Md Habibur Rahman, Sheng Zhang, Zhong-Yin Zhang, Dong Ho Park, Hyun Kook, In-Kyu Lee, Kyoungho Suk
Tumor necrosis factor superfamily member APRIL contributes to fibrotic scar formation after spinal cord injury
Lucy H. Funk, Amber R. Hackett, Mary Bartlett Bunge, Jae K. Lee
A novel antagonist of p75NTR reduces peripheral expansion and CNS trafficking of pro-inflammatory monocytes and spares function after traumatic brain injury
Sangmi Lee, Aaron Mattingly, Amity Lin, Jeffrey Sacramento, Leda Mannent, Marie-Noelle Castel, Benoit Canolle, Sandrine Delbary-Gossart, Badia Ferzaz, Josh M. Morganti, Susanna Rosi, Adam R. Ferguson, Geoffrey T. Manley, Jacqueline C. Bresnahan, Michael S. Beattie
Aquaporin 11, a regulator of water efflux at retinal Müller glial cell surface decreases concomitant with immune-mediated gliosis
Cornelia A. Deeg, Barbara Amann, Konstantin Lutz, Sieglinde Hirmer, Karina Lutterberg, Elisabeth Kremmer, Stefanie M. Hauck
The effect of concomitant peripheral injury on traumatic brain injury pathobiology and outcome
Stuart J. McDonald, Mujun Sun, Denes V. Agoston, Sandy R. Shultz
Methamphetamine alters microglial immune function through P2X7R signaling
Nicole C. Fernandes, Uma Sriram, Larisa Gofman, Jonathan M. Cenna, Servio H. Ramirez, Raghava Potula
Role of transient receptor potential ankyrin 1 channels in Alzheimer’s disease
Kuan-I Lee, Hsueh-Te Lee, Hui-Ching Lin, Huey-Jen Tsay, Feng-Chuan Tsai, Song-Kun Shyue, Tzong-Shyuan Lee
Retinal glial responses to optic nerve crush are attenuated in Bax-deficient mice and modulated by purinergic signaling pathways
Caitlin E. Mac Nair, Cassandra L. Schlamp, Angela D. Montgomery, Valery I. Shestopalov, Robert W. Nickells
A monoclonal natural human IgM protects axons in the absence of remyelination
Bharath Wootla, Aleksandar Denic, Arthur E. Warrington, Moses Rodriguez
Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain
Raffaella Moretti, Pierre-Louis Leger, Valérie C. Besson, Zsolt Csaba, Julien Pansiot, Lorena Di Criscio, Andrea Gentili, Luigi Titomanlio, Philippe Bonnin, Olivier Baud, Christiane Charriaut-Marlangue
Neuron-immune mechanisms contribute to pain in early stages of arthritis
Francisco R. Nieto, Anna K. Clark, John Grist, Gareth J. Hathway, Victoria Chapman, Marzia Malcangio
Dimethyl fumarate attenuates experimental autoimmune neuritis through the nuclear factor erythroid-derived 2-related factor 2/hemoxygenase-1 pathway by altering the balance of M1/M2 macrophages
Ranran Han, Jinting Xiao, Hui Zhai, Junwei Hao
Interactions between inflammatory mediators and corticosteroids regulate transcription of genes within the Kynurenine Pathway in the mouse hippocampus
Alexandra K. Brooks, Marcus A. Lawson, Robin A. Smith, Tiffany M. Janda, Keith W. Kelley, Robert H. McCusker
A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system
Takuya Iizumi, Shinichi Takahashi, Kyoko Mashima, Kazushi Minami, Yoshikane Izawa, Takato Abe, Takako Hishiki, Makoto Suematsu, Mayumi Kajimura, Norihiro Suzuki
Differential expression of P2X7 receptor and IL-1β in nociceptive and neuropathic pain
Benjamin Luchting, Jens Heyn, Tobias Woehrle, Banafscheh Rachinger-Adam, Simone Kreth, Ludwig C Hinske, Shahnaz C Azad
Interleukin-25 is detrimental for recovery after spinal cord injury in mice
Dearbhaile Dooley, Evi Lemmens, Peter Ponsaerts, Sven Hendrix
TLR7-mediated skin inflammation remotely triggers chemokine expression and leukocyte accumulation in the brain
Alison McColl, Carolyn A. Thomson, Louis Nerurkar, Gerard J. Graham, Jonathan Cavanagh
Decreased neuroinflammation correlates to higher vagus nerve activity fluctuations in near-term ovine fetuses: a case for the afferent cholinergic anti-inflammatory pathway?
M. G. Frasch, M. Szynkaruk, A. P. Prout, K. Nygard, M. Cao, R. Veldhuizen, R. Hammond, B. S. Richardson
Induction of the type I interferon response in neurological forms of Gaucher disease
Einat B. Vitner, Tamar Farfel-Becker, Natalia Santos Ferreira, Dena Leshkowitz, Piyush Sharma, Karl S. Lang, Anthony H. Futerman
Pro-inflammatory cytokines and their epistatic interactions in genetic susceptibility to schizophrenia
Lekshmy Srinivas, Neetha N. Vellichirammal, Ann Mary Alex, Chandrasekharan Nair, Indu V. Nair, Moinak Banerjee
Retraction Note: Alteration of astrocytes and Wnt/β-catenin signaling in the frontal cortex of autistic subjects
Fujiang Cao, Ailan Yin, Guang Wen, Ashfaq M. Sheikh, Zujaja Tauqeer, Mazhar Malik, Amenah Nagori, Michael Schirripa, Frank Schirripa, George Merz, Shiqing Feng, W. Ted Brown, Xiaohong Li
Interferon gamma protects neonatal neural stem/progenitor cells during measles virus infection of the brain
Kristen N. Fantetti, Erica L. Gray, Priya Ganesan, Apurva Kulkarni, Lauren A. O’Donnell
Low-dose lipopolysaccharide (LPS) inhibits aggressive and augments depressive behaviours in a chronic mild stress model in mice
Yvonne Couch, Alexander Trofimov, Natalyia Markova, Vladimir Nikolenko, Harry W. Steinbusch, Vladimir Chekhonin, Careen Schroeter, Klaus-Peter Lesch, Daniel C. Anthony, Tatyana Strekalova
Neonatal inflammatory pain and systemic inflammatory responses as possible environmental factors in the development of autism spectrum disorder of juvenile rats
Jin Hwan Lee, Alyssa R. Espinera, Dongdong Chen, Ko-Eun Choi, Asha Yoshiko Caslin, Soonmi Won, Valentina Pecoraro, Guang-Yin Xu, Ling Wei, Shan Ping Yu
Clozapine metabolites protect dopaminergic neurons through inhibition of microglial NADPH oxidase
Lulu Jiang, Xuefei Wu, Shuo Wang, Shih-Heng Chen, Hui Zhou, Belinda Wilson, Chun-Yang Jin, Ru-Band Lu, Keqin Xie, Qingshan Wang, Jau-Shyong Hong
Neuromyelitis optica study model based on chronic infusion of autoantibodies in rat cerebrospinal fluid
R. Marignier, A. Ruiz, S. Cavagna, A. Nicole, C. Watrin, M. Touret, S. Parrot, G. Malleret, C. Peyron, C. Benetollo, N. Auvergnon, S. Vukusic, P. Giraudon
Early life overfeeding impairs spatial memory performance by reducing microglial sensitivity to learning
Simone N. De Luca, Ilvana Ziko, Luba Sominsky, Jason C. D. Nguyen, Tara Dinan, Alyson A. Miller, Trisha A. Jenkins, Sarah J. Spencer
Cryopreserved vitamin D3-tolerogenic dendritic cells pulsed with autoantigens as a potential therapy for multiple sclerosis patients
María José Mansilla, Raian Contreras-Cardone, Juan Navarro-Barriuso, Nathalie Cools, Zwi Berneman, Cristina Ramo-Tello, Eva María Martínez-Cáceres
Glial cell activation, recruitment, and survival of B-lineage cells following MCMV brain infection
James R. Lokensgard, Manohar B. Mutnal, Sujata Prasad, Wen Sheng, Shuxian Hu
Complement system activation contributes to the ependymal damage induced by microbial neuraminidase
Pablo Granados-Durán, María Dolores López-Ávalos, Timothy R. Hughes, Krista Johnson, B. Paul Morgan, Paul P. Tamburini, Pedro Fernández-Llebrez, Jesús M. Grondona
Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells
Marie-Eve Tremblay, Issan Zhang, Kanchan Bisht, Julie C. Savage, Cynthia Lecours, Martin Parent, Vladimir Titorenko, Dusica Maysinger
Brain trauma elicits non-canonical macrophage activation states
Charles C. Kim, Mary C. Nakamura, Christine L. Hsieh
Impairment of toll-like receptors 2 and 4 leads to compensatory mechanisms after sciatic nerve axotomy
C. M. Freria, D. Bernardes, G. L. Almeida, G. F. Simões, G. O. Barbosa, A. L. R. Oliveira
Inhibition of myeloperoxidase oxidant production by N-acetyl lysyltyrosylcysteine amide reduces brain damage in a murine model of stroke
Guoliang Yu, Ye Liang, Ziming Huang, Deron W. Jones, Kirkwood A. Pritchard Jr., Hao Zhang
Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity
Jerel A. Fields, Cassia Overk, Anthony Adame, Jazmin Florio, Michael Mante, Andrea Pineda, Paula Desplats, Edward Rockenstein, Cristian Achim, Eliezer Masliah
Intraperitoneally administered IgG from patients with amyotrophic lateral sclerosis or from an immune-mediated goat model increase the levels of TNF-α, IL-6, and IL-10 in the spinal cord and serum of mice
Izabella Obál, Gergely Klausz, Yvette Mándi, Mária Deli, László Siklós, József I. Engelhardt
Inflammatory profile in LRRK2-associated prodromal and clinical PD
Kathrin Brockmann, Anja Apel, Claudia Schulte, Nicole Schneiderhan-Marra, Claustre Pont-Sunyer, Dolores Vilas, Javier Ruiz-Martinez, Markus Langkamp, Jean-Christophe Corvol, Florence Cormier, Thomas Knorpp, Thomas O. Joos, Thomas Gasser, Birgitt Schüle, Jan O. Aasly, Tatiana Foroud, Jose Felix Marti-Masso, Alexis Brice, Eduardo Tolosa, Connie Marras, Daniela Berg, Walter Maetzler
Chronic administration of AMD3100 increases survival and alleviates pathology in SOD1G93A mice model of ALS
Inna Rabinovich-Nikitin, Assaf Ezra, Beka Barbiro, Polina Rabinovich-Toidman, Beka Solomon
Kynurenine metabolic balance is disrupted in the hippocampus following peripheral lipopolysaccharide challenge
Jennifer M. Parrott, Laney Redus, Jason C. O’Connor
Chronic spinal cord injury attenuates influenza virus-specific antiviral immunity
Valerie Bracchi-Ricard, Ji Zha, Annalise Smith, Darlah M. Lopez-Rodriguez, John R. Bethea, Samita Andreansky
STIMs and Orai1 regulate cytokine production in spinal astrocytes
Xinghua Gao, Jingsheng Xia, Frances M. Munoz, Melissa T. Manners, Rong Pan, Olimpia Meucci, Yue Dai, Huijuan Hu
Activated brain mast cells contribute to postoperative cognitive dysfunction by evoking microglia activation and neuronal apoptosis
Xiang Zhang, Hongquan Dong, Nana Li, Susu Zhang, Jie Sun, Shu Zhang, Yanning Qian
Erratum to: A new co-ultramicronized composite including palmitoylethanolamide and luteolin to prevent neuroinflammation in spinal cord injury
Irene Paterniti, Daniela Impellizzeri, Rosanna Di Paola, Michele Navarra, Salvatore Cuzzocrea, Emanuela Esposito
Erratum to: Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain
Daniela Impellizzeri, Giuseppe Bruschetta, Marika Cordaro, Rosalia Crupi, Rosalba Siracusa, Emanuela Esposito, Salvatore Cuzzocrea
The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia
David B. Kurland, Volodymyr Gerzanich, Jason K. Karimy, Seung Kyoon Woo, Rudi Vennekens, Marc Freichel, Bernd Nilius, Joseph Bryan, J. Marc Simard
Reduced levels of alpha-1-antitrypsin in cerebrospinal fluid of amyotrophic lateral sclerosis patients: a novel approach for a potential treatment
Uri Wormser, Jessica Mandrioli, Marco Vinceti, Nicola Fini, Amnon Sintov, Berta Brodsky, Elena Proskura, Yoram Finkelstein
Endogenous analgesia mediated by CD4+ T lymphocytes is dependent on enkephalins in mice
Lilian Basso, Jérôme Boué, Karim Mahiddine, Catherine Blanpied, Sébastien Robiou-du-Pont, Nathalie Vergnolle, Céline Deraison, Gilles Dietrich
Transgenic expression of non-structural genes of Theiler’s virus suppresses initial viral replication and pathogenesis of demyelination
Hyun Seok Kang, Jinjong Myoung, Eui Young So, Young Yil Bahk, Byung S. Kim
Reduction of cytosolic phospholipase A2α upregulation delays the onset of symptoms in SOD1G93A mouse model of amyotrophic lateral sclerosis
Yulia Solomonov, Nurit Hadad, Rachel Levy
Microglial immunophenotype in dementia with Alzheimer’s pathology
Thais Minett, John Classey, Fiona E. Matthews, Marie Fahrenhold, Mariko Taga, Carol Brayne, Paul G. Ince, James A. R. Nicoll, Delphine Boche
Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells
Ewa Kozela, Ana Juknat, Fuying Gao, Nathali Kaushansky, Giovanni Coppola, Zvi Vogel
Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation
Sandra M. Rocha, Tatiana Saraiva, Ana C. Cristóvão, Raquel Ferreira, Tiago Santos, Marta Esteves, Cláudia Saraiva, Goun Je, Luísa Cortes, Jorge Valero, Gilberto Alves, Alexander Klibanov, Yoon-Seong Kim, Liliana Bernardino
Expression of IL-1β in rhesus EAE and MS lesions is mainly induced in the CNS itself
Saskia Maria Burm, Laura Anna Norma Peferoen, Ella Alwine Zuiderwijk-Sick, Krista Geraldine Haanstra, Bert Adriaan ‘t Hart, Paul van der Valk, Sandra Amor, Jan Bauer, Jeffrey John Bajramovic
IL4 induces IL6-producing M2 macrophages associated to inhibition of neuroinflammation in vitro and in vivo
Giacomo Casella, Livia Garzetti, Alberto T. Gatta, Annamaria Finardi, Chiara Maiorino, Francesca Ruffini, Gianvito Martino, Luca Muzio, Roberto Furlan
Combined [18F]DPA-714 micro-positron emission tomography and autoradiography imaging of microglia activation after closed head injury in mice
Ina Israel, Andrea Ohsiek, Ehab Al-Momani, Christiane Albert-Weissenberger, Christian Stetter, Stine Mencl, Andreas K. Buck, Christoph Kleinschnitz, Samuel Samnick, Anna-Leena Sirén
Interleukin-6: an emerging regulator of pathological pain
Ya-Qun Zhou, Zheng Liu, Zhi-Heng Liu, Shu-Ping Chen, Man Li, Allahverdi Shahveranov, Da-Wei Ye, Yu-Ke Tian
Altered excitatory-inhibitory balance within somatosensory cortex is associated with enhanced plasticity and pain sensitivity in a mouse model of multiple sclerosis
Liam E. Potter, John W. Paylor, Jee Su Suh, Gustavo Tenorio, Jayalakshmi Caliaperumal, Fred Colbourne, Glen Baker, Ian Winship, Bradley J. Kerr
Fingolimod promotes peripheral nerve regeneration via modulation of lysophospholipid signaling
Fabian Szepanowski, Angelika Derksen, Irina Steiner, Gerd Meyer zu Hörste, Thomas Daldrup, Hans-Peter Hartung, Bernd C. Kieseier
Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity
Shamsudheen Moidunny, Marco Matos, Evelyn Wesseling, Santanu Banerjee, David J. Volsky, Rodrigo A. Cunha, Paula Agostinho, Hendrikus W. Boddeke, Sabita Roy
Neuronal seipin knockout facilitates Aβ-induced neuroinflammation and neurotoxicity via reduction of PPARγ in hippocampus of mouse
Yun Qian, Jun Yin, Juan Hong, Guoxi Li, Baofeng Zhang, George Liu, Qi Wan, Ling Chen
Alteration of colonic excitatory tachykininergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration
Carolina Pellegrini, Matteo Fornai, Rocchina Colucci, Erika Tirotta, Fabio Blandini, Giovanna Levandis, Silvia Cerri, Cristina Segnani, Chiara Ippolito, Nunzia Bernardini, Karolina Cseri, Corrado Blandizzi, György Haskó, Luca Antonioli
Anti-inflammatory effect of cholera toxin B subunit in experimental stroke
Lei Zhang, Yanxia Huang, Yinyao Lin, Yilong Shan, Sha Tan, Wei Cai, Haiyan Li, Bingjun Zhang, Xuejiao Men, Zhengqi Lu
Rice bran derivatives alleviate microglia activation: possible involvement of MAPK pathway
Harsharan S. Bhatia, Julian Baron, Stephanie Hagl, Gunter P. Eckert, Bernd L. Fiebich
Prenatal exposure to the organophosphate insecticide chlorpyrifos enhances brain oxidative stress and prostaglandin E2 synthesis in a mouse model of idiopathic autism
Alessia De Felice, Anita Greco, Gemma Calamandrei, Luisa Minghetti
Repetitive transcranial magnetic stimulation reduces remote apoptotic cell death and inflammation after focal brain injury
Valeria Sasso, Elisa Bisicchia, Laura Latini, Veronica Ghiglieri, Fabrizio Cacace, Valeria Carola, Marco Molinari, Maria Teresa Viscomi
Augmented expression of TSPO after intracerebral hemorrhage: a role in inflammation?
Frederick Bonsack IV, Cargill H. Alleyne Jr, Sangeetha Sukumari-Ramesh
Phenotypic clustering: a novel method for microglial morphology analysis
Franck Verdonk, Pascal Roux, Patricia Flamant, Laurence Fiette, Fernando A. Bozza, Sébastien Simard, Marc Lemaire, Benoit Plaud, Spencer L. Shorte, Tarek Sharshar, Fabrice Chrétien, Anne Danckaert
Targeting inflammation as a treatment modality for neuropathic pain in spinal cord injury: a randomized clinical trial
David J. Allison, Aysha Thomas, Kayleigh Beaudry, David S. Ditor
The immunomodulator decoy receptor 3 improves locomotor functional recovery after spinal cord injury
Chuan-Wen Chiu, Wen-Hung Huang, Shao-Ji Lin, May-Jywan Tsai, Hsu Ma, Shie-Liang Hsieh, Henrich Cheng
Immune response in the eye following epileptic seizures
Matilda Ahl, Una Avdic, Cecilia Skoug, Idrish Ali, Deepti Chugh, Ulrica Englund Johansson, Christine T Ekdahl
Combining systemic and stereotactic MEMRI to detect the correlation between gliosis and neuronal connective pathway at the chronic stage after stroke
Xiao-zhu Hao, Le-kang Yin, Xiao-xue Zhang, Jia-qi Tian, Chan-chan Li, Xiao-yuan Feng, Min Jiang, Yan-mei Yang
Multivariate projection method to investigate inflammation associated with secondary insults and outcome after human traumatic brain injury: a pilot study
Anna Teresa Mazzeo, Claudia Filippini, Rosalba Rosato, Vito Fanelli, Barbara Assenzio, Ian Piper, Timothy Howells, Ilaria Mastromauro, Maurizio Berardino, Alessandro Ducati, Luciana Mascia
Identification of a specific α-synuclein peptide (α-Syn 29-40) capable of eliciting microglial superoxide production to damage dopaminergic neurons
Shijun Wang, Chun-Hsien Chu, Mingri Guo, Lulu Jiang, Hui Nie, Wei Zhang, Belinda Wilson, Li Yang, Tessandra Stewart, Jau-Shyong Hong, Jing Zhang
IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system
Rafael F. O. Franca, Renata S. Costa, Jaqueline R. Silva, Raphael S. Peres, Leila R. Mendonça, David F. Colón, José Carlos Alves-Filho, Fernando Q. Cunha
Thalamocortical-auditory network alterations following cuprizone‐induced demyelination
Nikoo Ghaffarian, Masoud Mesgari, Manuela Cerina, Kerstin Göbel, Thomas Budde, Erwin-Josef Speckmann, Sven G. Meuth, Ali Gorji
Complement is activated in progressive multiple sclerosis cortical grey matter lesions
Lewis M. Watkins, James W. Neal, Sam Loveless, Iliana Michailidou, Valeria Ramaglia, Mark I. Rees, Richard Reynolds, Neil P. Robertson, B. Paul Morgan, Owain W. Howell
C-C motif chemokine ligand 20 regulates neuroinflammation following spinal cord injury via Th17 cell recruitment
Jianzhong Hu, Zhiming Yang, Xiaoning Li, Hongbin Lu
A critical time window for the analgesic effect of central histamine in the partial sciatic ligation model of neuropathic pain
Jie Yu, Ying-Ying Tang, Ran-Ran Wang, Guo-Dong Lou, Ting-Ting Hu, Wei-Wei Hou, Jia-Xing Yue, Hiroshi Ohtsu, Li-Yun Shi, Shi-Hong Zhang, Zhong Chen
New insights into the pharmacokinetics and pharmacodynamics of natalizumab treatment for patients with multiple sclerosis, obtained from clinical and in vitro studies
T. Sehr, U. Proschmann, K. Thomas, M. Marggraf, E. Straube, H. Reichmann, A. Chan, T. Ziemssen
Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats
Masaaki Korai, Keiko T. Kitazato, Yoshiteru Tada, Takeshi Miyamoto, Kenji Shimada, Nobuhisa Matsushita, Yasuhisa Kanematsu, Junichiro Satomi, Tomoki Hashimoto, Shinji Nagahiro
Erratum to: Inhibition of myeloperoxidase oxidant production by N-acetyl lysyltyrosylcysteine amide reduces brain damage in a murine model of stroke
Guoliang Yu, Ye Liang, Ziming Huang, Deron W. Jones, Kirkwood A. Pritchard Jr, Hao Zhang
MT5-MMP, just a new APP processing proteinase in Alzheimer’s disease?
Kévin Baranger, Michel Khrestchatisky, Santiago Rivera
Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat
Jing-Ya Wang, Ya-Ni Huang, Chong-Chi Chiu, David Tweedie, Weiming Luo, Chaim G. Pick, Szu-Yi Chou, Yu Luo, Barry J. Hoffer, Nigel H. Greig, Jia-Yi Wang
VPAC1 receptor (Vipr1)-deficient mice exhibit ameliorated experimental autoimmune encephalomyelitis, with specific deficits in the effector stage
Catalina Abad, Bhavaani Jayaram, Laurine Becquet, Yuqi Wang, M Sue O’Dorisio, James A. Waschek, Yossan-Var Tan
Cerebrospinal fluid levels of neopterin are elevated in delirium after hip fracture
Roanna J. Hall, Leiv Otto Watne, Ane-Victoria Idland, Johan Raeder, Frede Frihagen, Alasdair M. J. MacLullich, Anne Cathrine Staff, Torgeir Bruun Wyller, Durk Fekkes
Adult obese mice suffer from chronic secondary brain injury after mild TBI
Matthew Sherman, Ming-Mei Liu, Shari Birnbaum, Steven E. Wolf, Joseph P. Minei, Joshua W. Gatson
Minocycline attenuates interferon-α-induced impairments in rat fear extinction
Qiang Bi, Lijuan Shi, Pingting Yang, Jianing Wang, Ling Qin
Interleukin-1β has trophic effects in microglia and its release is mediated by P2X7R pore
Mastura Monif, Christopher A. Reid, Kim L. Powell, Katherine J. Drummond, Terrence J. O’Brien, David A. Williams
Infiltrating T lymphocytes reduce myeloid phagocytosis activity in synucleinopathy model
Annika Sommer, Tanja Fadler, Eva Dorfmeister, Anna-Carin Hoffmann, Wei Xiang, Beate Winner, Iryna Prots
Long-term trihexyphenidyl exposure alters neuroimmune response and inflammation in aging rat: relevance to age and Alzheimer’s disease
Yuqi Huang, Zhe Zhao, Xiaoli Wei, Yong Zheng, Jianqiang Yu, Jianquan Zheng, Liyun Wang
Characterization of the binding pattern of human aquaporin-4 autoantibodies in patients with neuromyelitis optica spectrum disorders
Friederike Tuller, Hannah Holzer, Kathrin Schanda, Fahmy Aboulenein-Djamshidian, Romana Höftberger, Michael Khalil, Thomas Seifert-Held, Fritz Leutmezer, Thomas Berger, Markus Reindl
Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis
Emiliano Trias, Sofía Ibarburu, Romina Barreto-Núñez, Joël Babdor, Thiago T. Maciel, Matthias Guillo, Laurent Gros, Patrice Dubreuil, Pablo Díaz-Amarilla, Patricia Cassina, Laura Martínez-Palma, Ivan C. Moura, Joseph S. Beckman, Olivier Hermine, Luis Barbeito
Antibodies to the RNA-binding protein hnRNP A1 contribute to neurodegeneration in a model of central nervous system autoimmune inflammatory disease
Joshua N. Douglas, Lidia A. Gardner, Hannah E. Salapa, Stephen J. Lalor, Sangmin Lee, Benjamin M. Segal, Paul E. Sawchenko, Michael C. Levin
Circulating microRNAs as biomarkers for rituximab therapy, in neuromyelitis optica (NMO)
Adi Vaknin-Dembinsky, Hanna Charbit, Livnat Brill, Oded Abramsky, Devorah Gur-Wahnon, Iddo Z. Ben-Dov, Iris Lavon
Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models
Xiao-Long Sun, Bei-Yu Chen, Hai-Kang Zhao, Ying-Ying Cheng, Min-Hua Zheng, Li Duan, Wen Jiang, Liang-Wei Chen
Long-term exposure to PGE2 causes homologous desensitization of receptor-mediated activation of protein kinase A
Ramy Habashy Malty, Andy Hudmon, Jill C. Fehrenbacher, Michael R. Vasko
Transcriptome sequencing reveals that LPS-triggered transcriptional responses in established microglia BV2 cell lines are poorly representative of primary microglia
Amitabh Das, Sun Hwa Kim, Sarder Arifuzzaman, Taeho Yoon, Jin Choul Chai, Young Seek Lee, Kyoung Sun Park, Kyoung Hwa Jung, Young Gyu Chai
Chemokine CXCL13 mediates orofacial neuropathic pain via CXCR5/ERK pathway in the trigeminal ganglion of mice
Qian Zhang, De-Li Cao, Zhi-Jun Zhang, Bao-Chun Jiang, Yong-Jing Gao
The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-β degradation
Weiguo Dong, Christine M. Embury, Yaman Lu, Sarah M. Whitmire, Bhagyalaxmi Dyavarshetty, Harris A. Gelbard, Howard E. Gendelman, Tomomi Kiyota
Lymphocytes influence intracranial aneurysm formation and rupture: role of extracellular matrix remodeling and phenotypic modulation of vascular smooth muscle cells
David M. Sawyer, Lauren A. Pace, Crissey L. Pascale, Alexander C. Kutchin, Brannan E. O’Neill, Robert M. Starke, Aaron S. Dumont
Erratum to: P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite
Liang Feng, Yizhao Chen, Rui Ding, Zhenghao Fu, Shuo Yang, Xinqing Deng, Jun Zeng
TLR2 and TLR9 modulate enteric nervous system inflammatory responses to lipopolysaccharide
Joan F. Burgueño, Albert Barba, Elena Eyre, Carolina Romero, Michel Neunlist, Ester Fernández
Infection of zebrafish embryos with live fluorescent Streptococcus pneumoniae as a real-time pneumococcal meningitis model
Kin Ki Jim, JooYeon Engelen-Lee, Astrid M. van der Sar, Wilbert Bitter, Matthijs C. Brouwer, Arie van der Ende, Jan-Willem Veening, Diederik van de Beek, Christina M. J. E. Vandenbroucke-Grauls
Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes
Sinead A. O’Sullivan, Fabrizio Gasparini, Anis K. Mir, Kumlesh K. Dev
Cuprizone demyelination induces a unique inflammatory response in the subventricular zone
James M. Hillis, Julie Davies, Mayara Vieira Mundim, Osama Al-Dalahmah, Francis G. Szele
Actions of the antihistaminergic clemastine on presymptomatic SOD1-G93A mice ameliorate ALS disease progression
Savina Apolloni, Paola Fabbrizio, Susanna Amadio, Cinzia Volonté
Class I PI3K inhibitor ZSTK474 mediates a shift in microglial/macrophage phenotype and inhibits inflammatory response in mice with cerebral ischemia/reperfusion injury
Po Wang, Yating He, Daojing Li, Ranran Han, Guiyou Liu, Dexin Kong, Junwei Hao
Aqueous extract from the Withania somnifera leaves as a potential anti-neuroinflammatory agent: a mechanistic study
Muskan Gupta, Gurcharan Kaur
HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer’s disease
Barry W. Festoff, Ravi K. Sajja, Patrick van Dreden, Luca Cucullo
Decreased haemodynamic response and decoupling of cortical gamma-band activity and tissue oxygen perfusion after striatal interleukin-1 injection
Natasha Bray, Fiona E. Burrows, Myles Jones, Jason Berwick, Stuart M. Allan, Ingo Schiessl
Type-1 angiotensin receptor signaling in central nervous system myeloid cells is pathogenic during fatal alphavirus encephalitis in mice
Pennelope K. Blakely, Amanda K. Huber, David N. Irani
Cortisol-induced immune suppression by a blockade of lymphocyte egress in traumatic brain injury
Tingting Dong, Liang Zhi, Brijesh Bhayana, Mei X. Wu
Fractalkine suppression during hepatic encephalopathy promotes neuroinflammation in mice
Matthew McMillin, Stephanie Grant, Gabriel Frampton, Sarah Andry, Adam Brown, Sharon DeMorrow
Dynamic change of neutrophil to lymphocyte ratio and hemorrhagic transformation after thrombolysis in stroke
Zhiliang Guo, Shuhong Yu, Lulu Xiao, Xin Chen, Ruidong Ye, Ping Zheng, Qiliang Dai, Wen Sun, Changsheng Zhou, Shuiping Wang, Wusheng Zhu, Xinfeng Liu
Red LED photobiomodulation reduces pain hypersensitivity and improves sensorimotor function following mild T10 hemicontusion spinal cord injury
Di Hu, Shuyu Zhu, Jason Robert Potas
α-Synuclein deficiency promotes neuroinflammation by increasing Th1 cell-mediated immune responses
Benjamin Ettle, Kristina Kuhbandner, Stefanie Jörg, Alana Hoffmann, Jürgen Winkler, Ralf A. Linker
Dysregulation of the (immuno)proteasome pathway in malformations of cortical development
J. van Scheppingen, D. W. M. Broekaart, T. Scholl, M. R. J. Zuidberg, J. J. Anink, W. G. Spliet, P. C. van Rijen, T. Czech, J. A. Hainfellner, M. Feucht, A. Mühlebner, E. A. van Vliet, E. Aronica
Etifoxine improves sensorimotor deficits and reduces glial activation, neuronal degeneration, and neuroinflammation in a rat model of traumatic brain injury
Emmanuelle Simon-O’Brien, Delphine Gauthier, Véronique Riban, Marc Verleye
The glucagon-like peptide-1 receptor agonist exendin-4 ameliorates warfarin-associated hemorrhagic transformation after cerebral ischemia
Fangzhe Chen, Weifeng Wang, Hongyan Ding, Qi Yang, Qiang Dong, Mei Cui
1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype
Ioanna Plastira, Eva Bernhart, Madeleine Goeritzer, Helga Reicher, Vishwanath Bhat Kumble, Nora Kogelnik, Andrea Wintersperger, Astrid Hammer, Stefanie Schlager, Katharina Jandl, Akos Heinemann, Dagmar Kratky, Ernst Malle, Wolfgang Sattler
High-fat diet feeding differentially affects the development of inflammation in the central nervous system
Owein Guillemot-Legris, Julien Masquelier, Amandine Everard, Patrice D. Cani, Mireille Alhouayek, Giulio G. Muccioli
Siponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis
Antonietta Gentile, Alessandra Musella, Silvia Bullitta, Diego Fresegna, Francesca De Vito, Roberta Fantozzi, Eleonora Piras, Francesca Gargano, Giovanna Borsellino, Luca Battistini, Anna Schubart, Georgia Mandolesi, Diego Centonze
miR-17-92 facilitates neuronal differentiation of transplanted neural stem/precursor cells under neuroinflammatory conditions
Susu Mao, Xiuhua Li, Jin Wang, Xin Ding, Chenyu Zhang, Liang Li
Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway
Xiaowei Zhang, Zhenhua Zheng, Xijuan Liu, Bo Shu, Panyong Mao, Bingke Bai, Qinxue Hu, Minhua Luo, Xiaohe Ma, Zongqiang Cui, Hanzhong Wang
Secreted herpes simplex virus-2 glycoprotein G alters thermal pain sensitivity by modifying NGF effects on TRPV1
Jorge Rubén Cabrera, Abel Viejo-Borbolla, Antonio Alcamí, Francisco Wandosell
Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery
Jan Hirsch, Susana Vacas, Niccolo Terrando, Miao Yuan, Laura P. Sands, Joel Kramer, Kevin Bozic, Mervyn M. Maze, Jacqueline M. Leung
Astroglia acquires a toxic neuroinflammatory role in response to the cerebrospinal fluid from amyotrophic lateral sclerosis patients
Pooja-Shree Mishra, Dinesh K. Dhull, A. Nalini, K. Vijayalakshmi, T. N. Sathyaprabha, Phalguni Anand Alladi, Trichur R. Raju
Mannan binding lectin-associated serine protease-2 (MASP-2) critically contributes to post-ischemic brain injury independent of MASP-1
Franca Orsini, Elvina Chrysanthou, Thomas Dudler, W. Jason Cummings, Minoru Takahashi, Teizo Fujita, Gregory Demopulos, Maria-Grazia De Simoni, Wilhelm Schwaeble
Bullatine A stimulates spinal microglial dynorphin A expression to produce anti-hypersensitivity in a variety of rat pain models
Qian Huang, Xiao-Fang Mao, Hai-Yun Wu, Teng-Fei Li, Ming-Li Sun, Hao Liu, Yong-Xiang Wang
Colony-stimulating factor 1 receptor blockade prevents fractionated whole-brain irradiation-induced memory deficits
Xi Feng, Timothy D. Jopson, Maria Serena Paladini, Sharon Liu, Brian L. West, Nalin Gupta, Susanna Rosi
Erratum to: IFN-gamma signaling in the central nervous system controls the course of experimental autoimmune encephalomyelitis independently of the localization and composition of inflammatory foci
Eunyoung Lee, Sarah Chamanara, David Pleasure, Athena M. Soulika
Interleukin-6, MCP-1, IP-10, and MIG are sequentially expressed in cerebrospinal fluid after subarachnoid hemorrhage
Aichi Niwa, Koji Osuka, Takahiro Nakura, Naoki Matsuo, Takeya Watabe, Masakazu Takayasu
A murine model of inflammation-induced cerebral microbleeds
Rachita K. Sumbria, Mher Mahoney Grigoryan, Vitaly Vasilevko, Tatiana B. Krasieva, Miriam Scadeng, Alexandra K. Dvornikova, Annlia Paganini-Hill, Ronald Kim, David H. Cribbs, Mark J. Fisher
Mapping autoantigen epitopes: molecular insights into autoantibody-associated disorders of the nervous system
Nese Sinmaz, Tina Nguyen, Fiona Tea, Russell C. Dale, Fabienne Brilot
Erratum to: Exacerbation of blast-induced ocular trauma by an immune response
Courtney Bricker-Anthony, Jessica Hines-Beard, Lauren D’Surney, Tonia S. Rex
Assessment of neuroinflammation in a mouse model of obesity and β-amyloidosis using PET
Anna M. Barron, Masaki Tokunaga, Ming-Rong Zhang, Bin Ji, Tetsuya Suhara, Makoto Higuchi
Modulatory effects of perforin gene dosage on pathogen-associated blood-brain barrier (BBB) disruption
Robin C. Willenbring, Fang Jin, David J. Hinton, Mike Hansen, Doo-Sup Choi, Kevin D. Pavelko, Aaron J. Johnson
CCR5 ameliorates Japanese encephalitis via dictating the equilibrium of regulatory CD4+Foxp3+ T and IL-17+CD4+ Th17 cells
Jin Hyoung Kim, Ajit Mahadev Patil, Jin Young Choi, Seong Bum Kim, Erdenebelig Uyangaa, Ferdaus Mohd Altaf Hossain, Sang-Youel Park, John Hwa Lee, Seong Kug Eo
Social defeat induces depressive-like states and microglial activation without involvement of peripheral macrophages
Michael L. Lehmann, Hannah A. Cooper, Dragan Maric, Miles Herkenham
SPARC expression by cerebral microvascular endothelial cells in vitro and its influence on blood-brain barrier properties
Samir Alkabie, Jayasree Basivireddy, Lixin Zhou, Jane Roskams, Peter Rieckmann, Jacqueline A. Quandt
Cellular investigations with human antibodies associated with the anti-IgLON5 syndrome
Lidia Sabater, Jesús Planagumà, Josep Dalmau, Francesc Graus
Cerebral ischemia-induced angiogenesis is dependent on tumor necrosis factor receptor 1-mediated upregulation of α5β1 and αVβ3 integrins
Heng Huang, Qijuan Huang, Fuxin Wang, Richard Milner, Longxuan Li
Erratum to: Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat
Jing-Ya Wang, Ya-Ni Huang, Chong-Chi Chiu, David Tweedie, Weiming Luo, Chaim G. Pick, Szu-Yi Chou, Yu Luo, Barry J. Hoffer, Nigel H. Greig, Jia-Yi Wang
Erratum to: NT-020 treatment reduces inflammation and augments Nrf-2 and Wnt signaling in aged rats
Antwoine Flowers, Jea-Young Lee, Bethany Grimmig, Sandra Acosta, Charles Hudson, Brent Small, Cyndy D. Sanberg, Paula C. Bickford
Electroconvulsive shock attenuated microgliosis and astrogliosis in the hippocampus and ameliorated schizophrenia-like behavior of Gunn rat
Erlyn Limoa, Sadayuki Hashioka, Tsuyoshi Miyaoka, Keiko Tsuchie, Ryosuke Arauchi, Ilhamuddin A. Azis, Rei Wake, Maiko Hayashida, Tomoko Araki, Motohide Furuya, Kristian Liaury, Andi J. Tanra, Jun Horiguchi
Interaction between interleukin-1β and type-1 cannabinoid receptor is involved in anxiety-like behavior in experimental autoimmune encephalomyelitis
Antonietta Gentile, Diego Fresegna, Alessandra Musella, Helena Sepman, Silvia Bullitta, Francesca De Vito, Roberta Fantozzi, Alessandro Usiello, Mauro Maccarrone, Nicola B. Mercuri, Beat Lutz, Georgia Mandolesi, Diego Centonze
Metabolic determinants of the immune modulatory function of neural stem cells
Denise Drago, Veronica Basso, Edoardo Gaude, Giulio Volpe, Luca Peruzzotti-Jametti, Angela Bachi, Giovanna Musco, Annapaola Andolfo, Christian Frezza, Anna Mondino, Stefano Pluchino
Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models
Pongsatorn Meesawatsom, James Burston, Gareth Hathway, Andrew Bennett, Victoria Chapman
The anti-inflammatory Annexin A1 induces the clearance and degradation of the amyloid-β peptide
Miriam Ries, Rodrigo Loiola, Urvi N. Shah, Steve M. Gentleman, Egle Solito, Magdalena Sastre
The crucial role of Erk2 in demyelinating inflammation in the central nervous system
Rentaro Okazaki, Toru Doi, Kentaro Hayakawa, Kazuhito Morioka, Osamu Imamura, Kunio Takishima, Makoto Hamanoue, Yasuhiro Sawada, Motoshi Nagao, Sakae Tanaka, Toru Ogata
Excess cerebral TNF causing glutamate excitotoxicity rationalizes treatment of neurodegenerative diseases and neurogenic pain by anti-TNF agents
Ian A. Clark, Bryce Vissel
Regulation of inflammatory responses by neuregulin-1 in brain ischemia and microglial cells in vitro involves the NF-kappa B pathway
Lauren J. Simmons, Monique C. Surles-Zeigler, Yonggang Li, Gregory D. Ford, Gale D. Newman, Byron D. Ford
Intra-amniotic LPS causes acute neuroinflammation in preterm rhesus macaques
Augusto F. Schmidt, Paranthaman S. Kannan, Claire A. Chougnet, Steve C. Danzer, Lisa A. Miller, Alan H. Jobe, Suhas G. Kallapur
Latitude and HLA-DRB1*04:05 independently influence disease severity in Japanese multiple sclerosis: a cross-sectional study
Yuri Nakamura, Takuya Matsushita, Shinya Sato, Masaaki Niino, Toshiyuki Fukazawa, Satoshi Yoshimura, Shin Hisahara, Noriko Isobe, Shun Shimohama, Mitsuru Watanabe, Kazuto Yoshida, Hideki Houzen, Yusei Miyazaki, Ryo Yamasaki, Seiji Kikuchi, Jun-ichi Kira
MicroRNA-155 enhances T cell trafficking and antiviral effector function in a model of coronavirus-induced neurologic disease
Laura L. Dickey, Colleen L. Worne, Jessica L. Glover, Thomas E. Lane, Ryan M. O’Connell
Glycyrrhizin protects against focal cerebral ischemia via inhibition of T cell activity and HMGB1-mediated mechanisms
Xiaoxing Xiong, Lijuan Gu, Yan Wang, Ying Luo, Hongfei Zhang, Jessica Lee, Sheri Krams, Shengmei Zhu, Heng Zhao
β-Catenin signaling positively regulates glutamate uptake and metabolism in astrocytes
Victoria Lutgen, Srinivas D. Narasipura, Amit Sharma, Stephanie Min, Lena Al-Harthi
Antibody profiling identifies novel antigenic targets in spinal cord injury patients
Ilse Palmers, Elke Ydens, Eric Put, Bart Depreitere, Helma Bongers-Janssen, Peter Pickkers, Sven Hendrix, Veerle Somers
Heme oxygenase-1-mediated neuroprotection in subarachnoid hemorrhage via intracerebroventricular deferoxamine
Robert H. LeBlanc III, Ruiya Chen, Magdy H. Selim, Khalid A. Hanafy
Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy
Sherry Dadsetan, Tiziano Balzano, Jerónimo Forteza, Ana Agusti, Andrea Cabrera-Pastor, Lucas Taoro-Gonzalez, Vicente Hernandez-Rabaza, Belen Gomez-Gimenez, Nisrin ElMlili, Marta Llansola, Vicente Felipo
Oxidative damage and chemokine production dominate days before immune cell infiltration and EAE disease debut
Henrik Hasseldam, Rune Skovgaard Rasmussen, Flemming Fryd Johansen
HIV-1 Tat-shortened neurite outgrowth through regulation of microRNA-132 and its target gene expression
Pejman Rahimian, Johnny J. He
miR-124a and miR-155 enhance differentiation of regulatory T cells in patients with neuropathic pain
Jens Heyn, Benjamin Luchting, Ludwig C. Hinske, Max Hübner, Shahnaz C. Azad, Simone Kreth
Interferon-γ blocks signalling through PDGFRβ in human brain pericytes
Deidre Jansson, Emma L. Scotter, Justin Rustenhoven, Natacha Coppieters, Leon C. D. Smyth, Robyn L. Oldfield, Peter S. Bergin, Edward W. Mee, E. Scott Graham, Richard L. M. Faull, Mike Dragunow
In vitro evaluation of physiologically relevant concentrations of teriflunomide on activation and proliferation of primary rodent microglia
Tanja Wostradowski, Chittappen Kandiyil Prajeeth, Viktoria Gudi, Jessica Kronenberg, Sina Witte, Marina Brieskorn, Martin Stangel
Andrographolide induces Nrf2 and heme oxygenase 1 in astrocytes by activating p38 MAPK and ERK
Siew Ying Wong, Michelle G. K. Tan, Peter T. H. Wong, Deron R. Herr, Mitchell K. P. Lai
CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and l-type Ca2+ channels upstream of p38 MAPK
Ana B. Sanchez, Kathryn E. Medders, Ricky Maung, Paloma Sánchez-Pavón, Daniel Ojeda-Juárez, Marcus Kaul
Reduced acute neuroinflammation and improved functional recovery after traumatic brain injury by α-linolenic acid supplementation in mice
Abhishek Desai, Taeyeop Park, Jaquel Barnes, Karl Kevala, Huazhen Chen, Hee-Yong Kim
PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier
Slava Rom, Viviana Zuluaga-Ramirez, Nancy L. Reichenbach, Holly Dykstra, Sachin Gajghate, Pal Pacher, Yuri Persidsky
Loss of Schwann cell plasticity in chronic inflammatory demyelinating polyneuropathy (CIDP)
Abhijeet R. Joshi, Laura Holtmann, Ilja Bobylev, Christian Schneider, Christian Ritter, Joachim Weis, Helmar C. Lehmann
Immunomodulatory effects of nicotine on interleukin 1β activated human astrocytes and the role of cyclooxygenase 2 in the underlying mechanism
Priya Revathikumar, Filip Bergqvist, Srividya Gopalakrishnan, Marina Korotkova, Per-Johan Jakobsson, Jon Lampa, Erwan Le Maître
Brain omega-3 polyunsaturated fatty acids modulate microglia cell number and morphology in response to intracerebroventricular amyloid-β 1-40 in mice
Kathryn E. Hopperton, Marc-Olivier Trépanier, Vanessa Giuliano, Richard P. Bazinet
Upregulation of neuronal zinc finger protein A20 expression is required for electroacupuncture to attenuate the cerebral inflammatory injury mediated by the nuclear factor-kB signaling pathway in cerebral ischemia/reperfusion rats
Jian Zhan, Wenyi Qin, Ying Zhang, Jing Jiang, Hongmei Ma, Qiongli Li, Yong Luo
The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPARγ-mediated alteration of microglial activation phenotypes
Qiuying Zhao, Xiaohui Wu, Shuo Yan, Xiaofang Xie, Yonghua Fan, Jinqiang Zhang, Cheng Peng, Zili You
Multiple organ dysfunction and systemic inflammation after spinal cord injury: a complex relationship
Xin Sun, Zachary B. Jones, Xiao-ming Chen, Libing Zhou, Kwok-Fai So, Yi Ren
Immune response in peripheral axons delays disease progression in SOD1G93A mice
Giovanni Nardo, Maria Chiara Trolese, Giuseppe de Vito, Roberta Cecchi, Nilo Riva, Giorgia Dina, Paul R. Heath, Angelo Quattrini, Pamela J. Shaw, Vincenzo Piazza, Caterina Bendotti
Adoptive transfer of M2 macrophages reduces neuropathic pain via opioid peptides
Maria Pannell, Dominika Labuz, Melih Ö. Celik, Jacqueline Keye, Arvind Batra, Britta Siegmund, Halina Machelska
Sinomenine activates astrocytic dopamine D2 receptors and alleviates neuroinflammatory injury via the CRYAB/STAT3 pathway after ischemic stroke in mice
Jing Qiu, Zhongjun Yan, Kai Tao, Yansong Li, Yuqian Li, Jingchen Li, Yushu Dong, Dayun Feng, Huisheng Chen
Neurogenic inflammation after traumatic brain injury and its potentiation of classical inflammation
Frances Corrigan, Kimberley A. Mander, Anna V. Leonard, Robert Vink
Nogo receptor complex expression dynamics in the inflammatory foci of central nervous system experimental autoimmune demyelination
Paschalis Theotokis, Olga Touloumi, Roza Lagoudaki, Evangelia Nousiopoulou, Evangelia Kesidou, Spyridon Siafis, Theodoros Tselios, Athanasios Lourbopoulos, Dimitrios Karacostas, Nikolaos Grigoriadis, Constantina Simeonidou
Activation of the hypothalamic-pituitary-adrenal (HPA) axis contributes to the immunosuppression of mice infected with Angiostrongylus cantonensis
Ai-ling Chen, Xi Sun, Wei Wang, Jin-feng Liu, Xin Zeng, Jing-fan Qiu, Xin-jian Liu, Yong Wang
Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication
Brenna M. Flannery, Donald A. Bruun, Douglas J. Rowland, Christopher N. Banks, Adam T. Austin, David L. Kukis, Yonggang Li, Byron D. Ford, Daniel J. Tancredi, Jill L. Silverman, Simon R. Cherry, Pamela J. Lein
Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction
Yuping Li, Ke Pan, Lin Chen, Jiao-lin Ning, Xiaojun Li, Ting Yang, Niccolò Terrando, Jianteng Gu, Guocai Tao
Fumarate modulates the immune/inflammatory response and rescues nerve cells and neurological function after stroke in rats
Ruihe Lin, Jingli Cai, Eric W. Kostuk, Robert Rosenwasser, Lorraine Iacovitti
Brain region and epilepsy-associated differences in inflammatory mediator levels in medically refractory mesial temporal lobe epilepsy
Kenneth I. Strauss, Kost V. Elisevich
IL-10 plays an important role in the control of inflammation but not in the bacterial burden in S. epidermidis CNS catheter infection
Yenis M. Gutierrez-Murgas, Gwenn Skar, Danielle Ramirez, Matthew Beaver, Jessica N. Snowden
Loss of cerebellar neurons in the progression of lentiviral disease: effects of CNS-permeant antiretroviral therapy
Christian Wächter, Lee E. Eiden, Nedye Naumann, Candan Depboylu, Eberhard Weihe
Cerebrospinal fluid cytokines in Lyme neuroborreliosis
Annukka Pietikäinen, Mikael Maksimow, Tommi Kauko, Saija Hurme, Marko Salmi, Jukka Hytönen
EGFR transactivation contributes to neuroinflammation in Streptococcus suis meningitis
Xiao-Pei Yang, Ji-Yang Fu, Rui-Cheng Yang, Wen-Tong Liu, Tao Zhang, Bo Yang, Ling Miao, Bei-Bei Dou, Chen Tan, Huan-Chun Chen, Xiang-Ru Wang
Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G
Christian M. Felix, Marc H. Levin, Alan S. Verkman
Complement component 3 (C3) expression in the hippocampus after excitotoxic injury: role of C/EBPβ
Elena Hernandez-Encinas, Diana Aguilar-Morante, Jose A. Morales-Garcia, Elena Gine, Marina Sanz-SanCristobal, Angel Santos, Ana Perez-Castillo
Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects
Richard Lindqvist, Filip Mundt, Jonathan D. Gilthorpe, Silke Wölfel, Nelson O. Gekara, Andrea Kröger, Anna K. Överby
Inositol 1,4,5-trisphosphate receptor type 1 autoantibodies in paraneoplastic and non-paraneoplastic peripheral neuropathy
Sven Jarius, Marius Ringelstein, Jürgen Haas, Irina I. Serysheva, Lars Komorowski, Kai Fechner, Klaus-Peter Wandinger, Philipp Albrecht, Harald Hefter, Andreas Moser, Eva Neuen-Jacob, Hans-Peter Hartung, Brigitte Wildemann, Orhan Aktas
MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin
Sven Jarius, Klemens Ruprecht, Ingo Kleiter, Nadja Borisow, Nasrin Asgari, Kalliopi Pitarokoili, Florence Pache, Oliver Stich, Lena-Alexandra Beume, Martin W. Hümmert, Corinna Trebst, Marius Ringelstein, Orhan Aktas, Alexander Winkelmann, Mathias Buttmann, Alexander Schwarz, Hanna Zimmermann, Alexander U. Brandt, Diego Franciotta, Marco Capobianco, Joseph Kuchling, Jürgen Haas, Mirjam Korporal-Kuhnke, Soeren Thue Lillevang, Kai Fechner, Kathrin Schanda, Friedemann Paul, Brigitte Wildemann, Markus Reindl
MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome
Sven Jarius, Klemens Ruprecht, Ingo Kleiter, Nadja Borisow, Nasrin Asgari, Kalliopi Pitarokoili, Florence Pache, Oliver Stich, Lena-Alexandra Beume, Martin W. Hümmert, Marius Ringelstein, Corinna Trebst, Alexander Winkelmann, Alexander Schwarz, Mathias Buttmann, Hanna Zimmermann, Joseph Kuchling, Diego Franciotta, Marco Capobianco, Eberhard Siebert, Carsten Lukas, Mirjam Korporal-Kuhnke, Jürgen Haas, Kai Fechner, Alexander U. Brandt, Kathrin Schanda, Orhan Aktas, Friedemann Paul, Markus Reindl, Brigitte Wildemann
MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 3: Brainstem involvement - frequency, presentation and outcome
Sven Jarius, Ingo Kleiter, Klemens Ruprecht, Nasrin Asgari, Kalliopi Pitarokoili, Nadja Borisow, Martin W. Hümmert, Corinna Trebst, Florence Pache, Alexander Winkelmann, Lena-Alexandra Beume, Marius Ringelstein, Oliver Stich, Orhan Aktas, Mirjam Korporal-Kuhnke, Alexander Schwarz, Carsten Lukas, Jürgen Haas, Kai Fechner, Mathias Buttmann, Judith Bellmann-Strobl, Hanna Zimmermann, Alexander U. Brandt, Diego Franciotta, Kathrin Schanda, Friedemann Paul, Markus Reindl, Brigitte Wildemann
MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 4: Afferent visual system damage after optic neuritis in MOG-IgG-seropositive versus AQP4-IgG-seropositive patients
Florence Pache, Hanna Zimmermann, Janine Mikolajczak, Sophie Schumacher, Anna Lacheta, Frederike C. Oertel, Judith Bellmann-Strobl, Sven Jarius, Brigitte Wildemann, Markus Reindl, Amy Waldman, Kerstin Soelberg, Nasrin Asgari, Marius Ringelstein, Orhan Aktas, Nikolai Gross, Mathias Buttmann, Thomas Ach, Klemens Ruprecht, Friedemann Paul, Alexander U. Brandt
Acute neuroinflammation provokes intracellular acidification in mouse hippocampus
Anna A. Tyrtyshnaia, Larisa V. Lysenko, Francisco Madamba, Igor V. Manzhulo, Maxim Y. Khotimchenko, Alexander M. Kleschevnikov
N-Docosahexaenoylethanolamine ameliorates LPS-induced neuroinflammation via cAMP/PKA-dependent signaling
Taeyeop Park, Huazhen Chen, Karl Kevala, Ji-Won Lee, Hee-Yong Kim
Spatio-temporal profile, phenotypic diversity, and fate of recruited monocytes into the post-ischemic brain
Lidia Garcia-Bonilla, Giuseppe Faraco, Jamie Moore, Michelle Murphy, Gianfranco Racchumi, Jayashree Srinivasan, David Brea, Costantino Iadecola, Josef Anrather
Anthocyanins abrogate glutamate-induced AMPK activation, oxidative stress, neuroinflammation, and neurodegeneration in postnatal rat brain
Shahid Ali Shah, Faiz Ul Amin, Mehtab Khan, Muhammad Noman Abid, Shafiq Ur Rehman, Tae Hyun Kim, Min Woo Kim, Myeong Ok Kim
In vivo inhibition of miR-155 significantly alters post-stroke inflammatory response
Juan Carlos Pena-Philippides, Ernesto Caballero-Garrido, Tamar Lordkipanidze, Tamara Roitbak
Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model
Debbie Le Blon, Caroline Guglielmetti, Chloé Hoornaert, Alessandra Quarta, Jasmijn Daans, Dearbhaile Dooley, Evi Lemmens, Jelle Praet, Nathalie De Vocht, Kristien Reekmans, Eva Santermans, Niel Hens, Herman Goossens, Marleen Verhoye, Annemie Van der Linden, Zwi Berneman, Sven Hendrix, Peter Ponsaerts
Sex-specific variation in signaling pathways and gene expression patterns in human leukocytes in response to endotoxin and exercise
Asghar Abbasi, Rodolfo de Paula Vieira, Felix Bischof, Michael Walter, Masoud Movassaghi, Nicole C. Berchtold, Andreas M. Niess, Carl W. Cotman, Hinnak Northoff
Gene expression comparison reveals distinct basal expression of HOX members and differential TNF-induced response between brain- and spinal cord-derived microvascular endothelial cells
Yves Molino, Françoise Jabès, Amandine Bonnet, Nicolas Gaudin, Anne Bernard, Philippe Benech, Michel Khrestchatisky
Cytokine and chemokine alterations in tissue, CSF, and plasma in early presymptomatic phase of experimental allergic encephalomyelitis (EAE), in a rat model of multiple sclerosis
Nozha Borjini, Mercedes Fernández, Luciana Giardino, Laura Calzà
Appearance of claudin-5+ leukocytes in the central nervous system during neuroinflammation: a novel role for endothelial-derived extracellular vesicles
Debayon Paul, Valentina Baena, Shujun Ge, Xi Jiang, Evan R. Jellison, Timothy Kiprono, Dritan Agalliu, Joel S. Pachter
Human class I major histocompatibility complex alleles determine central nervous system injury versus repair
Bharath Wootla, Aleksandar Denic, Jens O. Watzlawik, Arthur E. Warrington, Laurie J. Zoecklein, Louisa M. Papke-Norton, Chella David, Moses Rodriguez
Metformin reduces morphine tolerance by inhibiting microglial-mediated neuroinflammation
Yinbing Pan, Xiaodi Sun, Lai Jiang, Liang Hu, Hong Kong, Yuan Han, Cheng Qian, Chao Song, Yanning Qian, Wentao Liu
Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons
Rakel López de Maturana, Valérie Lang, Amaia Zubiarrain, Amaya Sousa, Nerea Vázquez, Ana Gorostidi, Julio Águila, Adolfo López de Munain, Manuel Rodríguez, Rosario Sánchez-Pernaute
Inhibition of STAT3- and MAPK-dependent PGE2 synthesis ameliorates phagocytosis of fibrillar β-amyloid peptide (1-42) via EP2 receptor in EMF-stimulated N9 microglial cells
Gen-Lin He, Zhen Luo, Ting-Ting Shen, Ping Li, Ju Yang, Xue Luo, Chun-Hai Chen, Peng Gao, Xue-Sen Yang
Balancing the immune response in the brain: IL-10 and its regulation
Diogo Lobo-Silva, Guilhermina M. Carriche, A. Gil Castro, Susana Roque, Margarida Saraiva
Brain inflammation is accompanied by peripheral inflammation in Cstb −/− mice, a model for progressive myoclonus epilepsy
Olesya Okuneva, Zhilin Li, Inken Körber, Saara Tegelberg, Tarja Joensuu, Li Tian, Anna-Elina Lehesjoki
Cell cycle inhibition reduces inflammatory responses, neuronal loss, and cognitive deficits induced by hypobaria exposure following traumatic brain injury
Jacob W. Skovira, Junfang Wu, Jessica J. Matyas, Alok Kumar, Marie Hanscom, Shruti V. Kabadi, Raymond Fang, Alan I. Faden
The histone deacetylase inhibitor, sodium butyrate, exhibits neuroprotective effects for ischemic stroke in middle-aged female rats
Min Jung Park, Farida Sohrabji
Variable sensitivity to complement-dependent cytotoxicity in murine models of neuromyelitis optica
Yiting Liu, Danielle E. Harlow, Katherine S. Given, Gregory P. Owens, Wendy B. Macklin, Jeffrey L. Bennett
Regulation of effector function of CNS autoreactive CD4 T cells through inhibitory receptors and IL-7Rα
Patrick K Nuro-Gyina, Elizabeth L Rieser, Marissa C Granitto, Wei Pei, Yue Liu, Priscilla W Lee, Saba Aqel, Jian Zhang, Amy E Lovett-Racke, Michael K Racke, Yuhong Yang
Tollip, an early regulator of the acute inflammatory response in the substantia nigra
Marie Humbert-Claude, D. Duc, D. Dwir, L. Thieren, J. Sandström von Tobel, C. Begka, F. Legueux, D. Velin, M. H. Maillard, K. Q. Do, F. Monnet-Tschudi, L. Tenenbaum
LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways
Longyu Yang, Chia-Chen Liu, Honghua Zheng, Takahisa Kanekiyo, Yuka Atagi, Lin Jia, Daxin Wang, Aurelie N’songo, Dan Can, Huaxi Xu, Xiao-Fen Chen, Guojun Bu
miR-15a/16 reduces retinal leukostasis through decreased pro-inflammatory signaling
Eun-Ah Ye, Li Liu, Youde Jiang, Jenny Jan, Subhash Gaddipati, Susmit Suvas, Jena J. Steinle
Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit
Jacquelyn A. Brown, Simona G. Codreanu, Mingjian Shi, Stacy D. Sherrod, Dmitry A. Markov, M. Diana Neely, Clayton M. Britt, Orlando S. Hoilett, Ronald S. Reiserer, Philip C. Samson, Lisa J. McCawley, Donna J. Webb, Aaron B. Bowman, John A. McLean, John P. Wikswo
Pro-epileptogenic effects of viral-like inflammation in both mature and immature brains
Nina Dupuis, Andrey Mazarati, Béatrice Desnous, Vibol Chhor, Bobbi Fleiss, Tifenn Le Charpentier, Sophie Lebon, Zsolt Csaba, Pierre Gressens, Pascal Dournaud, Stéphane Auvin