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06.05.2019 | Schock | CME

Hitzeschockproteine als forensisch und klinisch bedeutende Stressmarker

Teil 1: Allgemeines und klinische Relevanz

verfasst von: PD Dr. med. E. Doberentz, B. Madea

Erschienen in: Rechtsmedizin | Ausgabe 3/2019

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Zusammenfassung

Hitzeschockproteine (HSP) sind hochkonservierte Proteine mit großer Bedeutung für die Proteinhomöostase. Sie finden sich in allen Organismen und sind Bestandteil aller Zellen und Zellkompartimente. Bei Zellstress werden HSP zur Zellprotektion verstärkt exprimiert und unterstützen v. a. die Neufaltung oder Degradation denaturierter Proteine. Hitzeschockproteine werden auf variable zelltoxische Faktoren hin verstärkt exprimiert, v. a. auf Hitzestress. Sie nehmen wesentlichen Einfluss auf verschiedene Erkrankungen wie Tumor- oder Autoimmunerkrankungen; entsprechend fokussieren sich therapeutisch ausgerichtete Forschungsprojekte z. B. auf die Inaktivierung bzw. Induktion einer intrazellulären HSP-Expression.

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Titel: Hitzeschockproteine als forensisch und klinisch bedeutende Stressmarker
Teil 1: Allgemeines und klinische Relevanz
verfasst von: PD Dr. med. E. Doberentz
B. Madea
Publikationsdatum: 06.05.2019
Verlag: Springer Medizin
Schlagwörter: Schock
Schock
Erschienen in: Rechtsmedizin / Ausgabe 3/2019
Print ISSN: 0937-9819
Elektronische ISSN: 1434-5196
DOI: https://doi.org/10.1007/s00194-019-0317-3

Springer Medizin

Hitzeschockproteine als forensisch und klinisch bedeutende Stressmarker

Teil 1: Allgemeines und klinische Relevanz

Zusammenfassung

Neu im Fachgebiet Rechtsmedizin

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Zusammenfassung

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