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2019 | OriginalPaper | Buchkapitel

4. Neoplastische Bildungsstörungen der Hämatopoiese mit erhaltener Ausreifung

verfasst von : Prof. Dr. Hans H. Kreipe

Erschienen in: Pathologie

Verlag: Springer Berlin Heidelberg

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Zusammenfassung

In diesem Kapitel werden nach den neuen Klassifikationskriterien der WHO die myeloproliferativen Neoplasien (MPN), die myelodysplasisch-myeloproliferativen Neoplasien (MDS/MPN) und die myelodysplastischen Syndrome (MDS) behandelt. Systematische Darstellung der Entitäten, ihrer Differenzialdiagnose und Prognose bilden die Basis für die relevante Knochenmarkdiagnostik. Bei den MPN (chronische myeloische Leukämie, Polycythämia vera, essentielle Thrombocythämie, primäre Myelofibrose, chronische Neutrophilenleukämie, die chronische Eosinophilenleukämie) beruht die Diagnose auf dem zytologischen und histologischen Nachweis einer Myeloproliferation in Verbindung mit der Identifikation charakteristischer klonaler genetischer Alterationen; bei den MDS/MPN (chronische myelo-monozytäre Leukämien, atypische chronische myloische Leukämie, refraktäre Anämie mit Ringsideroblasten und Thrombozytose) auf dem Nachweis gleichzeitig vermehrt und vermindert gebildeter Zellreihen; bei der heterogenen Gruppe der MDS als klonale Stammzellerkrankungen auf der die molekulargenetischen Definition der Blasten und deren Gehalt in Blut und Knochenmark.

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Titel: Neoplastische Bildungsstörungen der Hämatopoiese mit erhaltener Ausreifung
verfasst von: Prof. Dr. Hans H. Kreipe
Verlag: Springer Berlin Heidelberg
Buch: Pathologie
Print ISBN: 978-3-540-85183-7

Electronic ISBN: 978-3-540-85184-4

Copyright-Jahr: 2019
DOI: https://doi.org/10.1007/978-3-540-85184-4_4

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

4. Neoplastische Bildungsstörungen der Hämatopoiese mit erhaltener Ausreifung

Zusammenfassung

Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Zusammenfassung

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Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren