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Inflammation Research
Erschienen in: Inflammation Research 9/2020

10.07.2020 | Review

Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome

verfasst von: Xuxin Chen, Jian Tang, Weizheng Shuai, Jiguang Meng, Jian Feng, Zhihai Han

Erschienen in: Inflammation Research | Ausgabe 9/2020

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Abstract

Purpose

Macrophages are highly plastic cells. Under different stimuli, macrophages can be polarized into several different subsets. Two main macrophage subsets have been suggested: classically activated or inflammatory (M1) macrophages and alternatively activated or anti-inflammatory (M2) macrophages. Macrophage polarization is governed by a highly complex set of regulatory networks. Many recent studies have shown that macrophages are key orchestrators in the pathogenesis of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and that regulation of macrophage polarization may improve the prognosis of ALI/ARDS. A further understanding of the mechanisms of macrophage polarization is expected to be helpful in the development of novel therapeutic targets to treat ALI/ARDS. Therefore, we performed a literature review to summarize the regulatory mechanisms of macrophage polarization and its role in the pathogenesis of ALI/ARDS.

Methods

A computer-based online search was performed using the PubMed database and Web of Science database for published articles concerning macrophages, macrophage polarization, and ALI/ARDS.

Results

In this review, we discuss the origin, polarization, and polarization regulation of macrophages as well as the role of macrophage polarization in various stages of ARDS. According to the current literature, regulating the polarized state of macrophages might be a potential therapeutic strategy against ALI/ARDS.
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Metadaten
Titel
Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome
verfasst von
Xuxin Chen
Jian Tang
Weizheng Shuai
Jiguang Meng
Jian Feng
Zhihai Han
Publikationsdatum
10.07.2020
Verlag
Springer International Publishing
Erschienen in
Inflammation Research / Ausgabe 9/2020
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-020-01378-2

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Ob Patienten und Patientinnen mit neu diagnostiziertem Blasenkrebs ein Jahr später Bedauern über die Therapieentscheidung empfinden, wird einer Studie aus England zufolge von der Radikalität und dem Erfolg des Eingriffs beeinflusst.

Costims – das nächste heiße Ding in der Krebstherapie?

28.05.2024 Onkologische Immuntherapie Nachrichten

„Kalte“ Tumoren werden heiß – CD28-kostimulatorische Antikörper sollen dies ermöglichen. Am besten könnten diese in Kombination mit BiTEs und Checkpointhemmern wirken. Erste klinische Studien laufen bereits.

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