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01.11.2009 | Original

Assessment of pro-vasopressin and pro-adrenomedullin as predictors of 28-day mortality in septic shock patients

verfasst von: Caroline Guignant, Nicolas Voirin, Fabienne Venet, Françoise Poitevin, Christophe Malcus, Julien Bohé, Alain Lepape, Guillaume Monneret

Erschienen in: Intensive Care Medicine | Ausgabe 11/2009

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Abstract

Purpose

Improvements in survival after septic shock will most likely rely on our capacity to manage individualized therapies based on the measurement of rapidly accessible biomarkers. As the early phase of septic shock is dominated by severe alterations of the cardiovascular system, the predictive value for mortality of pro-vasopressin (pro-AVP) and pro-adrenomedullin (pro-ADM), two vasoactive pro-hormones, was assessed.

Methods

In 99 consecutive patients, pro-hormone concentrations were measured (immunoluminometric assay) three times within the first week after the onset of septic shock.

Results

Pro-AVP and pro-ADM concentrations were significantly increased in non-survivors in comparison with survivors and were significantly associated with mortality after both univariate and multivariate analysis. Importantly, when assessed as a pair, pro-ADM and pro-AVP were even more informative.

Conclusions

Both Pro-ADM and pro-AVP appear to be good biomarkers for the prediction of 28-day mortality after septic shock. However, their association in a single variable tends to improve their predictive capacity.

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Titel: Assessment of pro-vasopressin and pro-adrenomedullin as predictors of 28-day mortality in septic shock patients
verfasst von: Caroline Guignant
Nicolas Voirin
Fabienne Venet
Françoise Poitevin
Christophe Malcus
Julien Bohé
Alain Lepape
Guillaume Monneret
Publikationsdatum: 01.11.2009
Verlag: Springer-Verlag
Erschienen in: Intensive Care Medicine / Ausgabe 11/2009
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-009-1610-5

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Assessment of pro-vasopressin and pro-adrenomedullin as predictors of 28-day mortality in septic shock patients