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Osteoporosis International
Erschienen in: Osteoporosis International 8/2017

05.04.2017 | Review

Vibrational spectroscopic techniques to assess bone quality

verfasst von: E. P. Paschalis, S. Gamsjaeger, K. Klaushofer

Erschienen in: Osteoporosis International | Ausgabe 8/2017

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Abstract

Although musculoskeletal diseases such as osteoporosis are diagnosed and treatment outcome is evaluated based mainly on routine clinical outcomes of bone mineral density (BMD) by DXA and biochemical markers, it is recognized that these two indicators, as valuable as they have proven to be in the everyday clinical practice, do not fully account for manifested bone strength. Thus, the term bone quality was introduced, to complement considerations based on bone turnover rates and BMD. Bone quality is an “umbrella” term that incorporates the structural and material/compositional characteristics of bone tissue. Vibrational spectroscopic techniques such as Fourier transform infrared microspectroscopy (FTIRM) and imaging (FTIRI), and Raman spectroscopy, are suitable analytical tools for the determination of bone quality as they provide simultaneous, quantitative, and qualitative information on all main bone tissue components (mineral, organic matrix, tissue water), in a spatially resolved manner. Moreover, the results of such analyses may be readily combined with the outcomes of other techniques such as histology/histomorphometry, small angle X-ray scattering, quantitative backscattered electron imaging, and nanoindentation.
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Metadaten
Titel
Vibrational spectroscopic techniques to assess bone quality
verfasst von
E. P. Paschalis
S. Gamsjaeger
K. Klaushofer
Publikationsdatum
05.04.2017
Verlag
Springer London
Erschienen in
Osteoporosis International / Ausgabe 8/2017
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-017-4019-y

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