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Erschienen in: World Journal of Surgery 12/2017

17.07.2017 | Original Scientific Report

Systematic Review and Meta-Analysis of Laparoscopic Versus Open Appendicectomy in Adults with Complicated Appendicitis: an Update of the Literature

verfasst von: Christos Athanasiou, Sonia Lockwood, Georgios A. Markides

Erschienen in: World Journal of Surgery | Ausgabe 12/2017

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Abstract

Aims

To review and compare the outcomes of laparoscopic (LA) versus open appendicectomy (OA) in complicated appendicitis in adult patients, eight years after the last literature review.

Methods

The PRISMA guidelines were adhered to. Pre-defined inclusion and exclusion criteria were used to search the PubMed, Scopus and Cochrane databases and extract relevant data. Methodological and quality assessment was undertaken with outcome meta-analysis and subgroup analyses of methodological quality, type of study and year of study. Assessment of clinical and statistical heterogeneity and publication bias was conducted.

Results

Three randomised control trials (RCTs) (154LA vs 155OA) and 23 case–control trials were included (2034LA vs 2096OA). Methodological quality was low to average but with low statistical heterogeneity. Risk of publication bias was low, and meta-regression indicated shorter length of hospital stay (LOS) in more recent studies, Q = 7.1, P = 0.007. In the combined analysis LA had significantly less surgical site infections [OR = 0.30 (0.22,0.40); p < 0.00001] with reduced time to oral intake [WMD = -0.98 (-1.09,-0.86); P < 0.00001] and LOS [WMD = -3.49(-3.70,-3.29); p < 0.00001]. There was no significant difference in intra-abdominal abscess rates [OR = 1.11(0.85,1.45); p = 0.43]. Operative time was longer during LA [WMD = 10.51 (5.14,15.87); p = 0.0001] but did not reach statistical significance (p = 0.13) in the RCT subgroup analysis.

Conclusions

LA appears to have significant benefits with improved morbidity compared to OA in complicated appendicitis (level of evidence II).
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Literatur
1.
Zurück zum Zitat Anderson JE, Bickler SW, Chang DC et al (2012) Examining a common disease with unknown etiology: trends in epidemiology and surgical management of appendicitis in California, 1995–2009. World J Surg 36:2787–2794CrossRefPubMed Anderson JE, Bickler SW, Chang DC et al (2012) Examining a common disease with unknown etiology: trends in epidemiology and surgical management of appendicitis in California, 1995–2009. World J Surg 36:2787–2794CrossRefPubMed
2.
Zurück zum Zitat Buckius MT, McGrath B, Monk J et al (2012) Changing epidemiology of acute appendicitis in the United States: study period 1993–2008. J Surg Res 175:185–190CrossRefPubMed Buckius MT, McGrath B, Monk J et al (2012) Changing epidemiology of acute appendicitis in the United States: study period 1993–2008. J Surg Res 175:185–190CrossRefPubMed
3.
Zurück zum Zitat Masoomi H, Nguyen NT, Dolich MO et al (2014) Laparoscopic Appendectomy Trends and Outcomes in the United States: data from the Nationwide Inpatient Sample (NIS), 2004‐2011. Am Surg 80:1074–1077PubMed Masoomi H, Nguyen NT, Dolich MO et al (2014) Laparoscopic Appendectomy Trends and Outcomes in the United States: data from the Nationwide Inpatient Sample (NIS), 2004‐2011. Am Surg 80:1074–1077PubMed
4.
Zurück zum Zitat Markides G, Subar D, Riyad K (2010) Laparoscopic versus open appendectomy in adults with complicated appendicitis: systematic review and meta-analysis. World J Surg 34:2026–2040CrossRefPubMed Markides G, Subar D, Riyad K (2010) Laparoscopic versus open appendectomy in adults with complicated appendicitis: systematic review and meta-analysis. World J Surg 34:2026–2040CrossRefPubMed
5.
Zurück zum Zitat Moher D, Liberati A, Tetzlaff J et al (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 151:264–269CrossRefPubMed Moher D, Liberati A, Tetzlaff J et al (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 151:264–269CrossRefPubMed
6.
Zurück zum Zitat Quezada F, Quezada N, Mejia R et al (2015) Laparoscopic versus open approach in the management of appendicitis complicated exclusively with peritonitis: a single center experience. Int J Surg 13:80–83CrossRefPubMed Quezada F, Quezada N, Mejia R et al (2015) Laparoscopic versus open approach in the management of appendicitis complicated exclusively with peritonitis: a single center experience. Int J Surg 13:80–83CrossRefPubMed
7.
Zurück zum Zitat Taguchi Y, Komatsu S, Sakamoto E et al (2016) Laparoscopic versus open surgery for complicated appendicitis in adults: a randomized controlled trial. Surg Endosc 30:1705–1712CrossRefPubMed Taguchi Y, Komatsu S, Sakamoto E et al (2016) Laparoscopic versus open surgery for complicated appendicitis in adults: a randomized controlled trial. Surg Endosc 30:1705–1712CrossRefPubMed
8.
Zurück zum Zitat Thomson J-E, Kruger D, Jann-Kruger C et al (2015) Laparoscopic versus open surgery for complicated appendicitis: a randomized controlled trial to prove safety. Surg Endosc 29:2027–2032CrossRefPubMed Thomson J-E, Kruger D, Jann-Kruger C et al (2015) Laparoscopic versus open surgery for complicated appendicitis: a randomized controlled trial to prove safety. Surg Endosc 29:2027–2032CrossRefPubMed
9.
Zurück zum Zitat Yeom S, Kim MS, Park S et al (2014) Comparison of the outcomes of laparoscopic and open approaches in the treatment of periappendiceal abscess diagnosed by radiologic investigation. J Laparoendosc Adv Surg Tech 24:762–769CrossRef Yeom S, Kim MS, Park S et al (2014) Comparison of the outcomes of laparoscopic and open approaches in the treatment of periappendiceal abscess diagnosed by radiologic investigation. J Laparoendosc Adv Surg Tech 24:762–769CrossRef
10.
Zurück zum Zitat Dimitriou I, Reckmann B, Nephuth O et al (2013) Single institution’s experience in laparoscopic appendectomy as a suitable therapy for complicated appendicitis. Langen Arch Surg 398:147–152CrossRef Dimitriou I, Reckmann B, Nephuth O et al (2013) Single institution’s experience in laparoscopic appendectomy as a suitable therapy for complicated appendicitis. Langen Arch Surg 398:147–152CrossRef
11.
Zurück zum Zitat Galli R, Banz V, Fenner H et al (2013) Laparoscopic approach in perforated appendicitis: increased incidence of surgical site infection? Surg Endosc 27:2928–2933CrossRefPubMed Galli R, Banz V, Fenner H et al (2013) Laparoscopic approach in perforated appendicitis: increased incidence of surgical site infection? Surg Endosc 27:2928–2933CrossRefPubMed
13.
Zurück zum Zitat Wilson DG, Bond AK, Ladwa N et al (2013) Intra-abdominal collections following laparoscopic versus open appendicectomy: an experience of 516 consecutive cases at a district general hospital. Surg Endosc 27:2351–2356CrossRefPubMed Wilson DG, Bond AK, Ladwa N et al (2013) Intra-abdominal collections following laparoscopic versus open appendicectomy: an experience of 516 consecutive cases at a district general hospital. Surg Endosc 27:2351–2356CrossRefPubMed
14.
Zurück zum Zitat Ferranti F, Corona F, Siani L et al (2012) Laparoscopic versus open appendectomy for the treatment of complicated appendicitis. G Chir 33:263–267PubMed Ferranti F, Corona F, Siani L et al (2012) Laparoscopic versus open appendectomy for the treatment of complicated appendicitis. G Chir 33:263–267PubMed
15.
Zurück zum Zitat Schietroma M, Piccione F, Carlei F et al (2012) Peritonitis from perforated appendicitis: stress response after laparoscopic or open treatment. Am Surg 78:582–590PubMed Schietroma M, Piccione F, Carlei F et al (2012) Peritonitis from perforated appendicitis: stress response after laparoscopic or open treatment. Am Surg 78:582–590PubMed
16.
Zurück zum Zitat Lim SG, Ahn EJ, Kim SY et al (2011) A clinical comparison of laparoscopic versus open appendectomy for complicated appendicitis. J Korean Soc Coloproctol 27:293–297CrossRefPubMedPubMedCentral Lim SG, Ahn EJ, Kim SY et al (2011) A clinical comparison of laparoscopic versus open appendectomy for complicated appendicitis. J Korean Soc Coloproctol 27:293–297CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Garg CP, Vaidya BB, Chengalath MM (2009) Efficacy of laparoscopy in complicated appendicitis. Int J Surg 7:250–252CrossRefPubMed Garg CP, Vaidya BB, Chengalath MM (2009) Efficacy of laparoscopy in complicated appendicitis. Int J Surg 7:250–252CrossRefPubMed
18.
Zurück zum Zitat Kehagias I, Karamanakos SN, Panagiotopoulos S et al (2008) Laparoscopic versus open appendectomy: which way to go. World J Gastroenterol 14:4909–4914CrossRefPubMedPubMedCentral Kehagias I, Karamanakos SN, Panagiotopoulos S et al (2008) Laparoscopic versus open appendectomy: which way to go. World J Gastroenterol 14:4909–4914CrossRefPubMedPubMedCentral
19.
Zurück zum Zitat Park H-C, Yang D-H, Lee B-H (2009) The laparoscopic approach for perforated appendicitis, including cases complicated by abscess formation. J Laparoendosc Adv Surg Tech 19:727–730CrossRef Park H-C, Yang D-H, Lee B-H (2009) The laparoscopic approach for perforated appendicitis, including cases complicated by abscess formation. J Laparoendosc Adv Surg Tech 19:727–730CrossRef
20.
Zurück zum Zitat Sleem R, Fisher S, Gestring M et al (2009) Perforated appendicitis: is early laparoscopic appendectomy appropriate? Surgery 146:731–738CrossRefPubMed Sleem R, Fisher S, Gestring M et al (2009) Perforated appendicitis: is early laparoscopic appendectomy appropriate? Surgery 146:731–738CrossRefPubMed
22.
Zurück zum Zitat So JB, Chiong E-C, Chiong E et al (2002) Laparoscopic appendectomy for perforated appendicitis. World J Surg 26:1485–1488CrossRefPubMed So JB, Chiong E-C, Chiong E et al (2002) Laparoscopic appendectomy for perforated appendicitis. World J Surg 26:1485–1488CrossRefPubMed
23.
Zurück zum Zitat Kirshtein B, Bayme M, Domchik S et al (2007) Complicated appendicitis: laparoscopic or conventional surgery? World J Surg 31:744–749CrossRefPubMed Kirshtein B, Bayme M, Domchik S et al (2007) Complicated appendicitis: laparoscopic or conventional surgery? World J Surg 31:744–749CrossRefPubMed
24.
Zurück zum Zitat Stöltzing H, Thon K (2001) Perforated appendicitis: is laparoscopic operation advisable? Dig Surg 17:610–616CrossRef Stöltzing H, Thon K (2001) Perforated appendicitis: is laparoscopic operation advisable? Dig Surg 17:610–616CrossRef
25.
Zurück zum Zitat Piksun G, Kozic D, Rajpal S et al (2001) Comparison of laparoscopic, open and converted appendectomy for perforated appendicitis. Surg Endosc 15:660–662CrossRef Piksun G, Kozic D, Rajpal S et al (2001) Comparison of laparoscopic, open and converted appendectomy for perforated appendicitis. Surg Endosc 15:660–662CrossRef
26.
Zurück zum Zitat Fukami Y, Hasegawa H, Sakamoto E et al (2007) Value of laparoscopic appendectomy in perforated appendicitis. World J Surg 31:93–97CrossRefPubMed Fukami Y, Hasegawa H, Sakamoto E et al (2007) Value of laparoscopic appendectomy in perforated appendicitis. World J Surg 31:93–97CrossRefPubMed
27.
Zurück zum Zitat Yau KK, Siu WT, Tang CN et al (2007) Laparoscopic versus open appendectomy for complicated appendicitis. J Am Coll Surg 205:60–65CrossRefPubMed Yau KK, Siu WT, Tang CN et al (2007) Laparoscopic versus open appendectomy for complicated appendicitis. J Am Coll Surg 205:60–65CrossRefPubMed
28.
Zurück zum Zitat Pokala N, Sadhasivam S, Kiran RP et al (2007) Complicated appendicitis—is the laparoscopic approach appropriate? A comparative study with the open approach: outcome in a community hospital setting. Am Surg 73:737–742PubMed Pokala N, Sadhasivam S, Kiran RP et al (2007) Complicated appendicitis—is the laparoscopic approach appropriate? A comparative study with the open approach: outcome in a community hospital setting. Am Surg 73:737–742PubMed
29.
Zurück zum Zitat Kim H, Lee I, Lee Y et al (2009) A comparative study on the short-term clinicopathologic outcomes of laparoscopic surgery versus conventional open surgery for transverse colon cancer. Surg Endosc 23:1812–1817CrossRefPubMed Kim H, Lee I, Lee Y et al (2009) A comparative study on the short-term clinicopathologic outcomes of laparoscopic surgery versus conventional open surgery for transverse colon cancer. Surg Endosc 23:1812–1817CrossRefPubMed
30.
Zurück zum Zitat Khalili TM, Hiatt JR, Savar A et al (1999) Perforated appendicitis is not a contraindication to laparoscopy. Am Surg 65:965–967PubMed Khalili TM, Hiatt JR, Savar A et al (1999) Perforated appendicitis is not a contraindication to laparoscopy. Am Surg 65:965–967PubMed
31.
Zurück zum Zitat Wullstein C, Barkhausen S, Gross E (2001) Results of laparoscopic vs. conventional appendectomy in complicated appendicitis. Dis Colon Rectum 44:1700–1705CrossRefPubMed Wullstein C, Barkhausen S, Gross E (2001) Results of laparoscopic vs. conventional appendectomy in complicated appendicitis. Dis Colon Rectum 44:1700–1705CrossRefPubMed
32.
Zurück zum Zitat Lin H-F, Wu J-M, Tseng L-M et al (2006) Laparoscopic versus open appendectomy for perforated appendicitis. J Gastrointest Surg 10:906–910CrossRefPubMed Lin H-F, Wu J-M, Tseng L-M et al (2006) Laparoscopic versus open appendectomy for perforated appendicitis. J Gastrointest Surg 10:906–910CrossRefPubMed
33.
Zurück zum Zitat Katsuno G, Nagakari K, Yoshikawa S et al (2009) Laparoscopic appendicectomy for complicated appendicitis: a comparison with open appendicectomy. World J Surg 33:208–214CrossRefPubMed Katsuno G, Nagakari K, Yoshikawa S et al (2009) Laparoscopic appendicectomy for complicated appendicitis: a comparison with open appendicectomy. World J Surg 33:208–214CrossRefPubMed
34.
Zurück zum Zitat Masoomi H, Nguyen NT, Dolich MO et al (2011) Comparison of laparoscopic versus open appendectomy for acute nonperforated and perforated appendicitis in the obese population. Am J Surg 202:733–739CrossRefPubMed Masoomi H, Nguyen NT, Dolich MO et al (2011) Comparison of laparoscopic versus open appendectomy for acute nonperforated and perforated appendicitis in the obese population. Am J Surg 202:733–739CrossRefPubMed
35.
Zurück zum Zitat Ukai T, Shikata S, Takeda H et al (2016) Evidence of surgical outcomes fluctuates over time: results from a cumulative meta-analysis of laparoscopic versus open appendectomy for acute appendicitis. BMC Gastroenterol 16:1–12CrossRef Ukai T, Shikata S, Takeda H et al (2016) Evidence of surgical outcomes fluctuates over time: results from a cumulative meta-analysis of laparoscopic versus open appendectomy for acute appendicitis. BMC Gastroenterol 16:1–12CrossRef
36.
Zurück zum Zitat Masoomi H, Mills S, Dolich M et al (2012) Comparison of outcomes of laparoscopic versus open appendectomy in children: data from the Nationwide Inpatient Sample (NIS), 2006–2008. World J Surg 36:573–578CrossRefPubMed Masoomi H, Mills S, Dolich M et al (2012) Comparison of outcomes of laparoscopic versus open appendectomy in children: data from the Nationwide Inpatient Sample (NIS), 2006–2008. World J Surg 36:573–578CrossRefPubMed
37.
Zurück zum Zitat Tiwari MM, Reynoso JF, Tsang AW et al (2011) Comparison of outcomes of laparoscopic and open appendectomy in management of uncomplicated and complicated appendicitis. Ann Surg 254:927–932CrossRefPubMed Tiwari MM, Reynoso JF, Tsang AW et al (2011) Comparison of outcomes of laparoscopic and open appendectomy in management of uncomplicated and complicated appendicitis. Ann Surg 254:927–932CrossRefPubMed
38.
Zurück zum Zitat Tuggle KR-M, Ortega G, Bolorunduro OB et al (2010) Laparoscopic versus open appendectomy in complicated appendicitis: a review of the NSQIP database. J Surg Res 163:225–228CrossRefPubMed Tuggle KR-M, Ortega G, Bolorunduro OB et al (2010) Laparoscopic versus open appendectomy in complicated appendicitis: a review of the NSQIP database. J Surg Res 163:225–228CrossRefPubMed
39.
Zurück zum Zitat Yeh C, Wu S, Liao C et al (2011) Laparoscopic appendectomy for acute appendicitis is more favorable for patients with comorbidities, the elderly, and those with complicated appendicitis: a nationwide population-based study. Surg Endosc 25:2932–2942CrossRefPubMed Yeh C, Wu S, Liao C et al (2011) Laparoscopic appendectomy for acute appendicitis is more favorable for patients with comorbidities, the elderly, and those with complicated appendicitis: a nationwide population-based study. Surg Endosc 25:2932–2942CrossRefPubMed
40.
Zurück zum Zitat Markar SR, Penna M AH (2014) Laparoscopic approach to appendectomy reduces the incidence of short- and long-term post-operative bowel obstruction: systematic review and pooled analysis. J Gastrointest Surg 18:1683–1692CrossRefPubMed Markar SR, Penna M AH (2014) Laparoscopic approach to appendectomy reduces the incidence of short- and long-term post-operative bowel obstruction: systematic review and pooled analysis. J Gastrointest Surg 18:1683–1692CrossRefPubMed
41.
Zurück zum Zitat Werkgartner G, Cerwenka H, El Shabrawi A et al (2015) Laparoscopic versus open appendectomy for complicated appendicitis in high risk patients. Int J Colorectal Dis 30:397–401CrossRefPubMed Werkgartner G, Cerwenka H, El Shabrawi A et al (2015) Laparoscopic versus open appendectomy for complicated appendicitis in high risk patients. Int J Colorectal Dis 30:397–401CrossRefPubMed
42.
Zurück zum Zitat Bulian DR (2015) Invited commentary on” Werkgartner G. et al.: laparoscopic versus open appendectomy for complicated appendicitis in high risk patients”. Int J Colorectal Dis 30:567CrossRefPubMed Bulian DR (2015) Invited commentary on” Werkgartner G. et al.: laparoscopic versus open appendectomy for complicated appendicitis in high risk patients”. Int J Colorectal Dis 30:567CrossRefPubMed
Metadaten
Titel
Systematic Review and Meta-Analysis of Laparoscopic Versus Open Appendicectomy in Adults with Complicated Appendicitis: an Update of the Literature
verfasst von
Christos Athanasiou
Sonia Lockwood
Georgios A. Markides
Publikationsdatum
17.07.2017
Verlag
Springer International Publishing
Erschienen in
World Journal of Surgery / Ausgabe 12/2017
Print ISSN: 0364-2313
Elektronische ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-017-4123-3

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