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Erschienen in: European Radiology 3/2004

01.03.2004 | Pediatric

The role of imaging in the staging and treatment planning of primary malignant bone tumors in children

verfasst von: Harvey E. L. Teo, Wilfred C. G. Peh

Erschienen in: European Radiology | Ausgabe 3/2004

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Abstract

The accurate staging of primary bone tumors in children is critical for treatment planning. Limb salvage operations can now be performed with excellent outcomes in suitable patients. The purpose of this article is to review the current state of imaging techniques and their roles in enabling accurate staging and treatment planning to be performed in pediatric patients with primary bone tumors.
Literatur
1.
Zurück zum Zitat Wolf RE, Enneking WF (1996) The staging and surgery of musculoskeletal neoplasms. Orthop Clin North Am 27:473–481PubMed Wolf RE, Enneking WF (1996) The staging and surgery of musculoskeletal neoplasms. Orthop Clin North Am 27:473–481PubMed
2.
Zurück zum Zitat Grier HE (1997) The Ewing family of tumors. Ewing’s sarcoma and primitive neuroectodermal tumors. Pediatr Clin North Am 44:991–1004PubMed Grier HE (1997) The Ewing family of tumors. Ewing’s sarcoma and primitive neuroectodermal tumors. Pediatr Clin North Am 44:991–1004PubMed
3.
Zurück zum Zitat Veth RP, van Hoesel QGCM, Bökkerink JPM, Hoogenhout J, Pruszczynski M (1995) The art of limb salvage in musculoskeletal oncology. Crit Rev Oncol/Hematol 21:77–103 Veth RP, van Hoesel QGCM, Bökkerink JPM, Hoogenhout J, Pruszczynski M (1995) The art of limb salvage in musculoskeletal oncology. Crit Rev Oncol/Hematol 21:77–103
4.
Zurück zum Zitat Veth RP, Nielsen HKL, Oldhoff J, Schraffordt Koops H, Mehta D, Oosterhuis JW, Kamps WA, Goeken LN (1989) Megaprostheses in the treatment of primary malignant and metastatic tumors in the hip region. J Surg Oncol 40:214–218PubMed Veth RP, Nielsen HKL, Oldhoff J, Schraffordt Koops H, Mehta D, Oosterhuis JW, Kamps WA, Goeken LN (1989) Megaprostheses in the treatment of primary malignant and metastatic tumors in the hip region. J Surg Oncol 40:214–218PubMed
5.
Zurück zum Zitat McDonald DJ (1994) Limb-salvage surgery for treatment of sarcomas of the extremities. Am J Roentgenol 163:509–513 McDonald DJ (1994) Limb-salvage surgery for treatment of sarcomas of the extremities. Am J Roentgenol 163:509–513
6.
Zurück zum Zitat Lodwick GS, Wilson AJ, Farrell C, Virtama P, Dittrich F (1980) Determining growth rates of focal lesions of bones from radiographs. Radiology 134:577–583PubMed Lodwick GS, Wilson AJ, Farrell C, Virtama P, Dittrich F (1980) Determining growth rates of focal lesions of bones from radiographs. Radiology 134:577–583PubMed
7.
Zurück zum Zitat Lodwick GS, Wilson AJ, Farrell C, Virtama P, Smeltzer FM, Dittrich F (1980) Estimating rate of growth in bone lesions: observer performance and error. Radiology 134:585–590PubMed Lodwick GS, Wilson AJ, Farrell C, Virtama P, Smeltzer FM, Dittrich F (1980) Estimating rate of growth in bone lesions: observer performance and error. Radiology 134:585–590PubMed
8.
Zurück zum Zitat Sundaram M, McLeod RA (1990) MR imaging of tumor and tumorlike lesions of bone and soft tissue. Am J Roentgenol 155:817–824PubMed Sundaram M, McLeod RA (1990) MR imaging of tumor and tumorlike lesions of bone and soft tissue. Am J Roentgenol 155:817–824PubMed
9.
Zurück zum Zitat Bloem JL, Taminiau AHM, Eulderink F, Hermans J, Pauwels EK (1988) Radiologic staging of primary bone sarcoma: MR imaging, scintigraphy, angiography, and CT correlated with pathologic examination. Radiology 169:805–810PubMed Bloem JL, Taminiau AHM, Eulderink F, Hermans J, Pauwels EK (1988) Radiologic staging of primary bone sarcoma: MR imaging, scintigraphy, angiography, and CT correlated with pathologic examination. Radiology 169:805–810PubMed
10.
Zurück zum Zitat Panicek DM, Gatsonis C, Rosenthal DI, Seeger LL, Huvos AG, Moore SG, Caudry DJ, Palmer WE, McNeil BJ (1997) CT and MR imaging in the local staging of primary malignant musculoskeletal neoplasms: report of the radiology diagnostic oncology group. Radiology 202:237–246PubMed Panicek DM, Gatsonis C, Rosenthal DI, Seeger LL, Huvos AG, Moore SG, Caudry DJ, Palmer WE, McNeil BJ (1997) CT and MR imaging in the local staging of primary malignant musculoskeletal neoplasms: report of the radiology diagnostic oncology group. Radiology 202:237–246PubMed
11.
Zurück zum Zitat Peh WCG (1999) The role of imaging in the staging of bone tumors. Crit Rev Oncol Hematol 31:147–167CrossRefPubMed Peh WCG (1999) The role of imaging in the staging of bone tumors. Crit Rev Oncol Hematol 31:147–167CrossRefPubMed
12.
Zurück zum Zitat Bodner G, Schocke MF, Rachbauer F, Seppi K, Peer S, Fierlinger A, Sununu T, Jaschke WR (2002) Differentiation of malignant and benign musculoskeletal tumors: combined color and power Doppler US and spectral wave analysis. Radiology 223:410–416PubMed Bodner G, Schocke MF, Rachbauer F, Seppi K, Peer S, Fierlinger A, Sununu T, Jaschke WR (2002) Differentiation of malignant and benign musculoskeletal tumors: combined color and power Doppler US and spectral wave analysis. Radiology 223:410–416PubMed
13.
Zurück zum Zitat Saifuddin A (2002) The accuracy of imaging in the local staging of appendicular osteosarcoma. Skeletal Radiol 31:191–201CrossRefPubMed Saifuddin A (2002) The accuracy of imaging in the local staging of appendicular osteosarcoma. Skeletal Radiol 31:191–201CrossRefPubMed
14.
Zurück zum Zitat Onikul E, Fletcher BD, Parham DM, Chen G (1996) Accuracy of MR imaging for estimating intraosseous extent of osteosarcoma. Am J Roentgenol 167:1211–1215PubMed Onikul E, Fletcher BD, Parham DM, Chen G (1996) Accuracy of MR imaging for estimating intraosseous extent of osteosarcoma. Am J Roentgenol 167:1211–1215PubMed
15.
Zurück zum Zitat Verstraete KL, Lang P (2000) Bone and soft tissue tumors: the role of contrast agents for MR imaging. Eur J Radiol 34:229PubMed Verstraete KL, Lang P (2000) Bone and soft tissue tumors: the role of contrast agents for MR imaging. Eur J Radiol 34:229PubMed
16.
Zurück zum Zitat Nomikos GC, Murphey MD, Kransdorf MJ, Bancroft LW, Peterson JJ (2002) Primary bone tumors of the lower extremities. Radiol Clin North Am 40:971–990PubMed Nomikos GC, Murphey MD, Kransdorf MJ, Bancroft LW, Peterson JJ (2002) Primary bone tumors of the lower extremities. Radiol Clin North Am 40:971–990PubMed
17.
Zurück zum Zitat Lang P, Grampp S, Vahlensieck M, Johnston JO, Honda G, Rosenau W, Matthay KK, Peterfy C, Higgins CB, Genant HK (1995) Primary bone tumors: value of MR angiography for preoperative planning and monitoring response to chemotherapy. Am J Roentgenol 165:135–142 Lang P, Grampp S, Vahlensieck M, Johnston JO, Honda G, Rosenau W, Matthay KK, Peterfy C, Higgins CB, Genant HK (1995) Primary bone tumors: value of MR angiography for preoperative planning and monitoring response to chemotherapy. Am J Roentgenol 165:135–142
18.
Zurück zum Zitat Vanel D, Verstraete KL, Shapeero LG (1997) Primary tumors of the musculoskeletal system. Radiol Clin North Am 35:213–237PubMed Vanel D, Verstraete KL, Shapeero LG (1997) Primary tumors of the musculoskeletal system. Radiol Clin North Am 35:213–237PubMed
19.
Zurück zum Zitat Van Trommel MF, Kroon HM, Bloem JL, Hogendoom PC, Taminiau AH (1997) MR imaging based strategies in limb salvage for osteosarcoma of the distal femur. Skeletal Radiol 26:636–641PubMed Van Trommel MF, Kroon HM, Bloem JL, Hogendoom PC, Taminiau AH (1997) MR imaging based strategies in limb salvage for osteosarcoma of the distal femur. Skeletal Radiol 26:636–641PubMed
20.
Zurück zum Zitat Pettersson H, Gillespy T 3rd, Hamlin DJ, Enneking WF, Springfield DS, Andrew ER, Spanier S, Slone R (1987) Primary musculoskeletal tumors: examination with MR imaging compared with conventional modalities. Radiology 164:237–241PubMed Pettersson H, Gillespy T 3rd, Hamlin DJ, Enneking WF, Springfield DS, Andrew ER, Spanier S, Slone R (1987) Primary musculoskeletal tumors: examination with MR imaging compared with conventional modalities. Radiology 164:237–241PubMed
21.
Zurück zum Zitat Van der Woude HJ, Bloem JL, Holscher HC, Nooy MA, Taminiau AH, Hermans J, Falke TH, Hogendoorn PC (1994) Monitoring the effect of chemotherapy in Ewing sarcoma of bone with MR imaging. Skeletal Radiol 23:493–500PubMed Van der Woude HJ, Bloem JL, Holscher HC, Nooy MA, Taminiau AH, Hermans J, Falke TH, Hogendoorn PC (1994) Monitoring the effect of chemotherapy in Ewing sarcoma of bone with MR imaging. Skeletal Radiol 23:493–500PubMed
22.
Zurück zum Zitat Gronemeyer SA, Kauffman WM, Rocha MS, Steen RG, Fletcher BD (1997) Fat-saturated contrast-enhanced T1-weighted MRI in evaluation of osteosarcoma and Ewing sarcoma. J Magn Reson Imaging 7:585–589PubMed Gronemeyer SA, Kauffman WM, Rocha MS, Steen RG, Fletcher BD (1997) Fat-saturated contrast-enhanced T1-weighted MRI in evaluation of osteosarcoma and Ewing sarcoma. J Magn Reson Imaging 7:585–589PubMed
23.
Zurück zum Zitat Schima W, Amann G, Stiglbauer R, Windhager R, Kramer J, Nicolakis M, Farres MT, Imhof H (1994) Preoperative staging of osteosarcoma: efficacy of MR imaging in detecting joint involvement. Am J Roentgenol 163:1171–1175PubMed Schima W, Amann G, Stiglbauer R, Windhager R, Kramer J, Nicolakis M, Farres MT, Imhof H (1994) Preoperative staging of osteosarcoma: efficacy of MR imaging in detecting joint involvement. Am J Roentgenol 163:1171–1175PubMed
24.
Zurück zum Zitat Murphey MD, Robbin MR, McRae GA, McRae GA, Flemming DJ, Temple HT, Kransdorf MJ (1997) The many faces of osteosarcoma. Radiographics 17:1205–1231PubMed Murphey MD, Robbin MR, McRae GA, McRae GA, Flemming DJ, Temple HT, Kransdorf MJ (1997) The many faces of osteosarcoma. Radiographics 17:1205–1231PubMed
25.
Zurück zum Zitat Panuel M, Gentet JC, Scheiner C, Jouve JL, Bollini G, Petit P, Bourliere-Najean B, Devred P (1993) Physeal and epiphyseal extent of primary malignant tumors in childhood: correlation of preoperative MRI and the pathological examination. Pediatr Radiol 23:421–424PubMed Panuel M, Gentet JC, Scheiner C, Jouve JL, Bollini G, Petit P, Bourliere-Najean B, Devred P (1993) Physeal and epiphyseal extent of primary malignant tumors in childhood: correlation of preoperative MRI and the pathological examination. Pediatr Radiol 23:421–424PubMed
26.
Zurück zum Zitat Eustace S, Tello R, DeCarvalho V, Carey J, Wroblicka JT, Melhem ER, Yucel EK (1997) A comparison of whole-body turboSTIR MR imaging and planar 99mTc-methylene diphosphonate scintigraphy in the examination of patients with suspected skeletal metastases. Am J Roentgenol 169:1655–1661 Eustace S, Tello R, DeCarvalho V, Carey J, Wroblicka JT, Melhem ER, Yucel EK (1997) A comparison of whole-body turboSTIR MR imaging and planar 99mTc-methylene diphosphonate scintigraphy in the examination of patients with suspected skeletal metastases. Am J Roentgenol 169:1655–1661
27.
Zurück zum Zitat Daldrup-Link HE, Franzius C, Link TM, Laukamp D, Sciuk J, Jurgens H, Schober O, Rummeny EJ (2001) Whole-body MR imaging for detection of bone metastases in children and young adults: comparison with skeletal scintigraphy and FDG PET. Am J Roentgenol 177:229–236 Daldrup-Link HE, Franzius C, Link TM, Laukamp D, Sciuk J, Jurgens H, Schober O, Rummeny EJ (2001) Whole-body MR imaging for detection of bone metastases in children and young adults: comparison with skeletal scintigraphy and FDG PET. Am J Roentgenol 177:229–236
28.
Zurück zum Zitat Mazumdar A, Siegel MJ, Narra V, Luchtman-Jones L (2002) Whole-body fast inversion recovery MR imaging of small cell neoplasms in pediatric patients: a pilot study. Am J Roentgenol 179:1261–1266 Mazumdar A, Siegel MJ, Narra V, Luchtman-Jones L (2002) Whole-body fast inversion recovery MR imaging of small cell neoplasms in pediatric patients: a pilot study. Am J Roentgenol 179:1261–1266
29.
Zurück zum Zitat Pastorino U, Gasparini M, Tavecchio L, Azzarelli A, Mapelli S, Zucchi V, Morandi F, Bellani FF, Valente M, Ravasi G (1991) The contribution of salvage surgery to the management of childhood osteosarcoma. J Clin Oncol 9:1357–1362PubMed Pastorino U, Gasparini M, Tavecchio L, Azzarelli A, Mapelli S, Zucchi V, Morandi F, Bellani FF, Valente M, Ravasi G (1991) The contribution of salvage surgery to the management of childhood osteosarcoma. J Clin Oncol 9:1357–1362PubMed
30.
Zurück zum Zitat Meyers PA, Heller G, Healy J, Huvos A, Lane J, Marcove R, Applewhite A, Vlamis V, Rosen G (1992) Chemotherapy for nonmetastatic osteogenic sarcoma: the memorial Sloan–Kettering experience. J Clin Oncol 10:5–15PubMed Meyers PA, Heller G, Healy J, Huvos A, Lane J, Marcove R, Applewhite A, Vlamis V, Rosen G (1992) Chemotherapy for nonmetastatic osteogenic sarcoma: the memorial Sloan–Kettering experience. J Clin Oncol 10:5–15PubMed
31.
Zurück zum Zitat Picci P, Bougraff BT, Bacci G, Neff JR, Sangiorgi L, Cazzola A, Baldini N, Ferrari S, Mercuri M, Ruggieri P (1993) Prognostic significance of histopathologic response to chemotherapy in nonmetastatic Ewing’s sarcoma of the extremities. J Clin Oncol 11:1763–1769PubMed Picci P, Bougraff BT, Bacci G, Neff JR, Sangiorgi L, Cazzola A, Baldini N, Ferrari S, Mercuri M, Ruggieri P (1993) Prognostic significance of histopathologic response to chemotherapy in nonmetastatic Ewing’s sarcoma of the extremities. J Clin Oncol 11:1763–1769PubMed
32.
Zurück zum Zitat Cohen IJ, Hadar H, Schreiber R, Horev G, Katz K, Meller I, Yosipovitch Z, Zaizov R (1994) Primary bone tumor resectability: the value of serial MR studies in the determination of the feasibility, timing, and extent of tumor resection. J Pediatr Orthop 14:781–787PubMed Cohen IJ, Hadar H, Schreiber R, Horev G, Katz K, Meller I, Yosipovitch Z, Zaizov R (1994) Primary bone tumor resectability: the value of serial MR studies in the determination of the feasibility, timing, and extent of tumor resection. J Pediatr Orthop 14:781–787PubMed
33.
Zurück zum Zitat Van der Woude HJ, Bloem JL, Hogendoorn PCW (1998) Preoperative evaluation and monitoring chemotherapy in patients with high-grade osteogenic and Ewing’s sarcoma: review of current imaging modalities. Skeletal Radiol 27:57–71PubMed Van der Woude HJ, Bloem JL, Hogendoorn PCW (1998) Preoperative evaluation and monitoring chemotherapy in patients with high-grade osteogenic and Ewing’s sarcoma: review of current imaging modalities. Skeletal Radiol 27:57–71PubMed
34.
Zurück zum Zitat Erlemann R, Reiser MF, Peters PE, Vasallo P, Nommensen B, Kusnierz-Glaz CR, Ritter J, Roessner A (1989) Musculoskeletal neoplasms: static and dynamic Gd-DTPA-enhanced MR imaging. Radiology 171:767–773PubMed Erlemann R, Reiser MF, Peters PE, Vasallo P, Nommensen B, Kusnierz-Glaz CR, Ritter J, Roessner A (1989) Musculoskeletal neoplasms: static and dynamic Gd-DTPA-enhanced MR imaging. Radiology 171:767–773PubMed
35.
Zurück zum Zitat Lang P, Honda G, Roberts T, Vahlensieck M, Johnston JO, Rosenau W, Mathur A, Peterfy C, Gooding CA, Genant HK (1995) Musculoskeletal neoplasm: perineoplastic edema versus tumor on dynamic postcontrast MR images with spatial mapping of instantaneous enhancement rates. Radiology 197:831–839PubMed Lang P, Honda G, Roberts T, Vahlensieck M, Johnston JO, Rosenau W, Mathur A, Peterfy C, Gooding CA, Genant HK (1995) Musculoskeletal neoplasm: perineoplastic edema versus tumor on dynamic postcontrast MR images with spatial mapping of instantaneous enhancement rates. Radiology 197:831–839PubMed
36.
Zurück zum Zitat De Baere T, Vanel D, Shapeero LG, Charpentier A, Terrier P, di Paola M (1992) Osteosarcoma after chemotherapy: evaluation with contrast material-enhanced subtraction MR imaging. Radiology 185:587–592PubMed De Baere T, Vanel D, Shapeero LG, Charpentier A, Terrier P, di Paola M (1992) Osteosarcoma after chemotherapy: evaluation with contrast material-enhanced subtraction MR imaging. Radiology 185:587–592PubMed
37.
Zurück zum Zitat Moller HE, Vermathen P, Rummeny E, Wortler K, Wuisman P, Rossner A, Wormann B, Ritter J, Peters PE (1996) In vivo 31P NMR spectroscopy of human musculoskeletal tumors as a measure of response to chemotherapy. NMR Biomed. 9:347–358 Moller HE, Vermathen P, Rummeny E, Wortler K, Wuisman P, Rossner A, Wormann B, Ritter J, Peters PE (1996) In vivo 31P NMR spectroscopy of human musculoskeletal tumors as a measure of response to chemotherapy. NMR Biomed. 9:347–358
38.
Zurück zum Zitat Sijens PE (1998) Phosphorus MR spectroscopy in the treatment of human extremity sarcomas. NMR Biomed 11:341–353CrossRefPubMed Sijens PE (1998) Phosphorus MR spectroscopy in the treatment of human extremity sarcomas. NMR Biomed 11:341–353CrossRefPubMed
39.
Zurück zum Zitat Fletcher BD, Hanna SL, Fairclough DL, Gronemeyer SA (1992) Pediatric musculoskeletal tumors: use of dynamic, contrast-enhanced MR imaging to monitor response to chemotherapy. Radiology 184:243–248PubMed Fletcher BD, Hanna SL, Fairclough DL, Gronemeyer SA (1992) Pediatric musculoskeletal tumors: use of dynamic, contrast-enhanced MR imaging to monitor response to chemotherapy. Radiology 184:243–248PubMed
40.
Zurück zum Zitat Glazer HS, Lee JKT, Levitt RG, Heiken JP, Ling D, Totty WG, Balfe DM, Emani B, Wasserman TH, Murphy WA (1985) Radiation fibrosis: differentiation from recurrent tumor by MR imaging. Radiology 156:721–726PubMed Glazer HS, Lee JKT, Levitt RG, Heiken JP, Ling D, Totty WG, Balfe DM, Emani B, Wasserman TH, Murphy WA (1985) Radiation fibrosis: differentiation from recurrent tumor by MR imaging. Radiology 156:721–726PubMed
41.
Zurück zum Zitat Griffiths HJ, Thompson RC, Nitke SJ, Olson PN, Thielen KR, Amundson P (1997) Use of MRI in evaluating postoperative changes in patients with bone and soft tissue tumors. Orthopedics 20:215–220PubMed Griffiths HJ, Thompson RC, Nitke SJ, Olson PN, Thielen KR, Amundson P (1997) Use of MRI in evaluating postoperative changes in patients with bone and soft tissue tumors. Orthopedics 20:215–220PubMed
42.
Zurück zum Zitat Lang P, Johnston JO, Arenal-Romero F, Gooding CA. (1998) Advances in MR imaging of pediatric musculoskeletal neoplasms. MRI Clin North Am 6:579–604 Lang P, Johnston JO, Arenal-Romero F, Gooding CA. (1998) Advances in MR imaging of pediatric musculoskeletal neoplasms. MRI Clin North Am 6:579–604
43.
Zurück zum Zitat Ryan SP, Weinberger E, White KS, Shaw DW, Patterson K, Nazar-Stewart V, Miser J (1995) MR imaging of bone marrow in children with osteosarcoma: effect of granulocytic colony-stimulating factor. Am J Roentgenol 165:915–920PubMed Ryan SP, Weinberger E, White KS, Shaw DW, Patterson K, Nazar-Stewart V, Miser J (1995) MR imaging of bone marrow in children with osteosarcoma: effect of granulocytic colony-stimulating factor. Am J Roentgenol 165:915–920PubMed
44.
Zurück zum Zitat Schulte M, Brecht-Krauss D, Werner M, Hartwig E, Sarkar MR, Keppler P, Kotzerke J, Guhlmann A, Delling G, Reske SN (1999) Evaluation of neoadjuvant therapy response of osteogenic sarcoma using FDG PET. J Nucl Med 40:1637–1643PubMed Schulte M, Brecht-Krauss D, Werner M, Hartwig E, Sarkar MR, Keppler P, Kotzerke J, Guhlmann A, Delling G, Reske SN (1999) Evaluation of neoadjuvant therapy response of osteogenic sarcoma using FDG PET. J Nucl Med 40:1637–1643PubMed
45.
Zurück zum Zitat Bredella MA, Caputo GR, Steinbach LS (2002) Value of FDG positron emission tomography in conjunction with MR imaging for evaluating therapy response in patients with musculoskeletal sarcomas. Am J Roentgenol 179:1145–1150PubMed Bredella MA, Caputo GR, Steinbach LS (2002) Value of FDG positron emission tomography in conjunction with MR imaging for evaluating therapy response in patients with musculoskeletal sarcomas. Am J Roentgenol 179:1145–1150PubMed
46.
Zurück zum Zitat Jones DN, McCowage GB, Sostman HD, Brizel DM, Layfield L, Charles HC, Dewhirst MW, Prescott DM, Friedman HS, Harrelson JM, Scully SP, Coleman RE (1996) Monitoring of neoadjuvant therapy response of soft-tissue and musculoskeletal sarcoma using fluorine-18-FDG PET. J Nucl Med 37:1438–1444PubMed Jones DN, McCowage GB, Sostman HD, Brizel DM, Layfield L, Charles HC, Dewhirst MW, Prescott DM, Friedman HS, Harrelson JM, Scully SP, Coleman RE (1996) Monitoring of neoadjuvant therapy response of soft-tissue and musculoskeletal sarcoma using fluorine-18-FDG PET. J Nucl Med 37:1438–1444PubMed
47.
Zurück zum Zitat Cook GJ, Houston S, Rubens R, Maisey MN, Fogelman I (1998) Detection of bone metastases in breast cancer by 18FDG PET: differing metabolic activity in osteoblastic and osteolytic lesions. J Clin Oncol 16:3375–3379PubMed Cook GJ, Houston S, Rubens R, Maisey MN, Fogelman I (1998) Detection of bone metastases in breast cancer by 18FDG PET: differing metabolic activity in osteoblastic and osteolytic lesions. J Clin Oncol 16:3375–3379PubMed
48.
Zurück zum Zitat Cook GJ, Fogelman I (2000) The role of positron emission tomography in the management of bone metastases. Cancer 15(12 Suppl):2927–2933CrossRef Cook GJ, Fogelman I (2000) The role of positron emission tomography in the management of bone metastases. Cancer 15(12 Suppl):2927–2933CrossRef
Metadaten
Titel
The role of imaging in the staging and treatment planning of primary malignant bone tumors in children
verfasst von
Harvey E. L. Teo
Wilfred C. G. Peh
Publikationsdatum
01.03.2004
Erschienen in
European Radiology / Ausgabe 3/2004
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-003-2211-2

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