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Erschienen in: European Radiology 1/2013

01.01.2013 | Musculoskeletal

Augmented reality visualisation using an image overlay system for MR-guided interventions: technical performance of spine injection procedures in human cadavers at 1.5 Tesla

verfasst von: Jan Fritz, Paweena U-Thainual, Tamas Ungi, Aaron J. Flammang, Gabor Fichtinger, Iulian I. Iordachita, John A. Carrino

Erschienen in: European Radiology | Ausgabe 1/2013

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Abstract

Objectives

To prospectively assess the technical performance of an augmented reality system for MR-guided spinal injection procedures.

Methods

The augmented reality system was used with a clinical 1.5-T MRI system. A total of 187 lumbosacral spinal injection procedures (epidural injection, spinal nerve root injection, facet joint injection, medial branch block, discography) were performed in 12 human cadavers. Needle paths were planned with the Perk Station module of 3D Slicer software on high-resolution MR images. Needles were placed under augmented reality MRI navigation. MRI was used to confirm needle locations. T1-weighted fat-suppressed MRI was used to visualise the injectant. Outcome variables assessed were needle adjustment rate, inadvertent puncture of non-targeted structures, successful injection rate and procedure time.

Results

Needle access was achieved in 176/187 (94.1 %) targets, whereas 11/187 (5.9 %) were inaccessible. Six of 11 (54.5 %) L5–S1 disks were inaccessible, because of an axial obliquity of 30˚ (27˚–34˚); 5/11 (45.5 %) facet joints were inaccessible because of osteoarthritis or fusion. All accessible targets (176/187, 94.1 %) were successfully injected, requiring 47/176 (26.7 %) needle adjustments. There were no inadvertent punctures of vulnerable structures. Median procedure time was 10.2 min (5–19 min).

Conclusions

Image overlay navigated MR-guided spinal injections were technically accurate. Disks with an obliquity ≥27˚ may be inaccessible.

Key Points

Augmented reality technology facilitates MR-guided spine injections.
Patient and operator exposure to ionising radiation can be obviated.
MR imaging guidance enabled the procedure without need of a dedicated interventional MRI system.
Various MR-guided spine injection procedures using augmented reality are technically accurate.
Augmented reality has potential to simplify the workflow of MR-guided spine injections.
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Literatur
1.
Zurück zum Zitat Fritz J, Niemeyer T, Clasen S et al (2007) Management of chronic low back pain: rationales, principles, and targets of imaging-guided spinal injections. Radiographics 27:1751–1771PubMedCrossRef Fritz J, Niemeyer T, Clasen S et al (2007) Management of chronic low back pain: rationales, principles, and targets of imaging-guided spinal injections. Radiographics 27:1751–1771PubMedCrossRef
2.
Zurück zum Zitat Carrino JA, Morrison WB, Parker L, Schweitzer ME, Levin DC, Sunshine JH (2002) Spinal injection procedures: volume, provider distribution, and reimbursement in the US Medicare population from 1993 to 1999. Radiology 225:723–729PubMedCrossRef Carrino JA, Morrison WB, Parker L, Schweitzer ME, Levin DC, Sunshine JH (2002) Spinal injection procedures: volume, provider distribution, and reimbursement in the US Medicare population from 1993 to 1999. Radiology 225:723–729PubMedCrossRef
3.
Zurück zum Zitat Krombach GA, Schmitz-Rode T, Wein BB et al (2000) Potential of a new laser target system for percutaneous CT-guided nerve blocks: technical note. Neuroradiology 42:838–841PubMedCrossRef Krombach GA, Schmitz-Rode T, Wein BB et al (2000) Potential of a new laser target system for percutaneous CT-guided nerve blocks: technical note. Neuroradiology 42:838–841PubMedCrossRef
4.
Zurück zum Zitat Nawfel RD, Judy PF, Silverman SG, Hooton S, Tuncali K, Adams DF (2000) Patient and personnel exposure during CT fluoroscopy-guided interventional procedures. Radiology 216:180–184PubMed Nawfel RD, Judy PF, Silverman SG, Hooton S, Tuncali K, Adams DF (2000) Patient and personnel exposure during CT fluoroscopy-guided interventional procedures. Radiology 216:180–184PubMed
5.
Zurück zum Zitat Paulson EK, Sheafor DH, Enterline DS, McAdams HP, Yoshizumi TT (2001) CT fluoroscopy–guided interventional procedures: techniques and radiation dose to radiologists. Radiology 220:161–167PubMed Paulson EK, Sheafor DH, Enterline DS, McAdams HP, Yoshizumi TT (2001) CT fluoroscopy–guided interventional procedures: techniques and radiation dose to radiologists. Radiology 220:161–167PubMed
6.
Zurück zum Zitat Wagner AL (2004) Selective lumbar nerve root blocks with CT fluoroscopic guidance: technique, results, procedure time, and radiation dose. AJNR Am J Neuroradiol 25:1592–1594PubMed Wagner AL (2004) Selective lumbar nerve root blocks with CT fluoroscopic guidance: technique, results, procedure time, and radiation dose. AJNR Am J Neuroradiol 25:1592–1594PubMed
7.
Zurück zum Zitat Wagner LK (2000) CT fluoroscopy: another advancement with additional challenges in radiation management. Radiology 216:9–10PubMed Wagner LK (2000) CT fluoroscopy: another advancement with additional challenges in radiation management. Radiology 216:9–10PubMed
8.
Zurück zum Zitat Blanco SR, Carrino JA (2005) Musculoskeletal interventional MR imaging. Magn Reson Imaging Clin N Am 13:519–532CrossRef Blanco SR, Carrino JA (2005) Musculoskeletal interventional MR imaging. Magn Reson Imaging Clin N Am 13:519–532CrossRef
9.
Zurück zum Zitat Fritz J, Henes JC, Thomas C et al (2008) Diagnostic and interventional MRI of the sacroiliac joints using a 1.5-T open-bore magnet: a one-stop-shopping approach. AJR Am J Roentgenol 191:1717–1724PubMedCrossRef Fritz J, Henes JC, Thomas C et al (2008) Diagnostic and interventional MRI of the sacroiliac joints using a 1.5-T open-bore magnet: a one-stop-shopping approach. AJR Am J Roentgenol 191:1717–1724PubMedCrossRef
10.
Zurück zum Zitat Fritz J, Clasen S, Boss A et al (2008) Real-time MR fluoroscopy-navigated lumbar facet joint injections: feasibility and technical properties. Eur Radiol 18:1513–1518PubMedCrossRef Fritz J, Clasen S, Boss A et al (2008) Real-time MR fluoroscopy-navigated lumbar facet joint injections: feasibility and technical properties. Eur Radiol 18:1513–1518PubMedCrossRef
11.
Zurück zum Zitat Fritz J, Thomas C, Tzaribachev N et al (2009) MRI-guided injection procedures of the temporomandibular joints in children and adults: technique, accuracy, and safety. AJR Am J Roentgenol 193:1148–1154PubMedCrossRef Fritz J, Thomas C, Tzaribachev N et al (2009) MRI-guided injection procedures of the temporomandibular joints in children and adults: technique, accuracy, and safety. AJR Am J Roentgenol 193:1148–1154PubMedCrossRef
12.
Zurück zum Zitat Fritz J, Thomas C, Clasen S, Claussen CD, Lewin JS, Pereira PL (2009) Freehand real-time MRI-guided lumbar spinal injection procedures at 1.5 T: feasibility, accuracy, and safety. AJR Am J Roentgenol 192:W161–W167PubMedCrossRef Fritz J, Thomas C, Clasen S, Claussen CD, Lewin JS, Pereira PL (2009) Freehand real-time MRI-guided lumbar spinal injection procedures at 1.5 T: feasibility, accuracy, and safety. AJR Am J Roentgenol 192:W161–W167PubMedCrossRef
13.
Zurück zum Zitat Fritz J, Tzaribachev N, Thomas C et al (2010) Evaluation of MR imaging guided steroid injection of the sacroiliac joints for the treatment of children with refractory enthesitis-related arthritis. Eur Radiol 21:1050–1057PubMedCrossRef Fritz J, Tzaribachev N, Thomas C et al (2010) Evaluation of MR imaging guided steroid injection of the sacroiliac joints for the treatment of children with refractory enthesitis-related arthritis. Eur Radiol 21:1050–1057PubMedCrossRef
14.
Zurück zum Zitat Ojala R, Vahala E, Karppinen J et al (2000) Nerve root infiltration of the first sacral root with MRI guidance. J Magn Reson Imaging 12:556–561PubMedCrossRef Ojala R, Vahala E, Karppinen J et al (2000) Nerve root infiltration of the first sacral root with MRI guidance. J Magn Reson Imaging 12:556–561PubMedCrossRef
15.
Zurück zum Zitat Ojala R, Klemola R, Karppinen J, Sequeiros RB, Tervonen O (2001) Sacro-iliac joint arthrography in low back pain: feasibility of MRI guidance. Eur J Radiol 40:236–239PubMedCrossRef Ojala R, Klemola R, Karppinen J, Sequeiros RB, Tervonen O (2001) Sacro-iliac joint arthrography in low back pain: feasibility of MRI guidance. Eur J Radiol 40:236–239PubMedCrossRef
16.
Zurück zum Zitat Smith KA, Carrino J (2008) MRI-guided interventions of the musculoskeletal system. J Magn Reson Imaging 27:339–346PubMedCrossRef Smith KA, Carrino J (2008) MRI-guided interventions of the musculoskeletal system. J Magn Reson Imaging 27:339–346PubMedCrossRef
17.
Zurück zum Zitat Hushek SG, Martin AJ, Steckner M, Bosak E, Debbins J, Kucharzyk W (2008) MR systems for MRI-guided interventions. J Magn Reson Imaging 27:253–266PubMedCrossRef Hushek SG, Martin AJ, Steckner M, Bosak E, Debbins J, Kucharzyk W (2008) MR systems for MRI-guided interventions. J Magn Reson Imaging 27:253–266PubMedCrossRef
18.
Zurück zum Zitat Lewin JS, Petersilge CA, Hatem SF et al (1998) Interactive MR imaging-guided biopsy and aspiration with a modified clinical C-arm system. AJR Am J Roentgenol 170:1593–1601PubMed Lewin JS, Petersilge CA, Hatem SF et al (1998) Interactive MR imaging-guided biopsy and aspiration with a modified clinical C-arm system. AJR Am J Roentgenol 170:1593–1601PubMed
19.
Zurück zum Zitat Weiss CR, Nour SG, Lewin JS (2008) MR-guided biopsy: a review of current techniques and applications. J Magn Reson Imaging 27:311–325PubMedCrossRef Weiss CR, Nour SG, Lewin JS (2008) MR-guided biopsy: a review of current techniques and applications. J Magn Reson Imaging 27:311–325PubMedCrossRef
20.
Zurück zum Zitat Weiss CR, Marker DR, Fischer GS, Fichtinger G, Machado AJ, Carrino JA (2011) Augmented reality visualization using image-overlay for MR-guided interventions: system description, feasibility, and initial evaluation in a spine phantom. AJR Am J Roentgenol 196:W305–W307PubMedCrossRef Weiss CR, Marker DR, Fischer GS, Fichtinger G, Machado AJ, Carrino JA (2011) Augmented reality visualization using image-overlay for MR-guided interventions: system description, feasibility, and initial evaluation in a spine phantom. AJR Am J Roentgenol 196:W305–W307PubMedCrossRef
21.
Zurück zum Zitat Fischer GS, Deguet A, Schlattman D et al (2006) MRI image overlay: applications to arthrography needle insertion. Stud Health Technol Inform 119:150–155PubMed Fischer GS, Deguet A, Schlattman D et al (2006) MRI image overlay: applications to arthrography needle insertion. Stud Health Technol Inform 119:150–155PubMed
22.
Zurück zum Zitat Fichtinger G, Deguet A, Masamune K et al (2005) Image overlay guidance for needle insertion in CT scanner. IEEE Trans Biomed Eng 52:1415–1424PubMedCrossRef Fichtinger G, Deguet A, Masamune K et al (2005) Image overlay guidance for needle insertion in CT scanner. IEEE Trans Biomed Eng 52:1415–1424PubMedCrossRef
23.
Zurück zum Zitat Fritz J, U-Thainual P, Ungi T et al (2011) Augmented reality visualization using image-overlay for MR-guided interventions: accuracy for lumbar spinal procedures with a 1.5-Tesla MRI scanner. AJR Am J Roentgenol 198:W266–W273CrossRef Fritz J, U-Thainual P, Ungi T et al (2011) Augmented reality visualization using image-overlay for MR-guided interventions: accuracy for lumbar spinal procedures with a 1.5-Tesla MRI scanner. AJR Am J Roentgenol 198:W266–W273CrossRef
24.
Zurück zum Zitat Vikal S, Thainual P, Carrino JA, Iordachita I, Fischer GS, Fichtinger G (2010) Perk Station–Percutaneous surgery training and performance measurement platform. Comput Med Imaging Graph 34:19–32PubMedCrossRef Vikal S, Thainual P, Carrino JA, Iordachita I, Fischer GS, Fichtinger G (2010) Perk Station–Percutaneous surgery training and performance measurement platform. Comput Med Imaging Graph 34:19–32PubMedCrossRef
25.
Zurück zum Zitat Gering DT, Nabavi A, Kikinis R et al (2001) An integrated visualization system for surgical planning and guidance using image fusion and an open MR. J Magn Reson Imaging 13:967–975PubMedCrossRef Gering DT, Nabavi A, Kikinis R et al (2001) An integrated visualization system for surgical planning and guidance using image fusion and an open MR. J Magn Reson Imaging 13:967–975PubMedCrossRef
26.
Zurück zum Zitat Obesity: preventing and managing the global epidemic. Report of a WHO consultation (2000) World Health Organ Tech Rep Ser 894:i–253 Obesity: preventing and managing the global epidemic. Report of a WHO consultation (2000) World Health Organ Tech Rep Ser 894:i–253
27.
Zurück zum Zitat Carrino JA, Lurie JD, Tosteson AN et al (2009) Lumbar spine: reliability of MR imaging findings. Radiology 250:161–170PubMedCrossRef Carrino JA, Lurie JD, Tosteson AN et al (2009) Lumbar spine: reliability of MR imaging findings. Radiology 250:161–170PubMedCrossRef
28.
Zurück zum Zitat Streitparth F, Walter T, Wonneberger U et al (2010) Image-guided spinal injection procedures in open high-field MRI with vertical field orientation: feasibility and technical features. Eur Radiol 20:395–403PubMedCrossRef Streitparth F, Walter T, Wonneberger U et al (2010) Image-guided spinal injection procedures in open high-field MRI with vertical field orientation: feasibility and technical features. Eur Radiol 20:395–403PubMedCrossRef
29.
Zurück zum Zitat Sequeiros RB, Ojala RO, Klemola R, Vaara TJ, Jyrkinen L, Tervonen OA (2002) MRI-guided periradicular nerve root infiltration therapy in low-field (0.23-T) MRI system using optical instrument tracking. Eur Radiol 12:1331–1337PubMedCrossRef Sequeiros RB, Ojala RO, Klemola R, Vaara TJ, Jyrkinen L, Tervonen OA (2002) MRI-guided periradicular nerve root infiltration therapy in low-field (0.23-T) MRI system using optical instrument tracking. Eur Radiol 12:1331–1337PubMedCrossRef
30.
Zurück zum Zitat Sequeiros RB, Klemola R, Ojala R, Jyrkinen L, Vaara T, Tervonen O (2003) Percutaneous MR-guided discography in a low-field system using optical instrument tracking: a feasibility study. J Magn Reson Imaging 17:214–219PubMedCrossRef Sequeiros RB, Klemola R, Ojala R, Jyrkinen L, Vaara T, Tervonen O (2003) Percutaneous MR-guided discography in a low-field system using optical instrument tracking: a feasibility study. J Magn Reson Imaging 17:214–219PubMedCrossRef
31.
Zurück zum Zitat Streitparth F, Hartwig T, Schnackenburg B et al (2011) MR-guided discography using an open 1 Tesla MRI system. Eur Radiol 21:1043–1049PubMedCrossRef Streitparth F, Hartwig T, Schnackenburg B et al (2011) MR-guided discography using an open 1 Tesla MRI system. Eur Radiol 21:1043–1049PubMedCrossRef
32.
Zurück zum Zitat Fritz J, Pereira PL (2007) MR-Guided pain therapy: principles and clinical applications. Rofo 179:914–924PubMedCrossRef Fritz J, Pereira PL (2007) MR-Guided pain therapy: principles and clinical applications. Rofo 179:914–924PubMedCrossRef
33.
Zurück zum Zitat Moche M, Trampel R, Kahn T, Busse H (2008) Navigation concepts for MR image-guided interventions. J Magn Reson Imaging 27:276–291PubMedCrossRef Moche M, Trampel R, Kahn T, Busse H (2008) Navigation concepts for MR image-guided interventions. J Magn Reson Imaging 27:276–291PubMedCrossRef
34.
Zurück zum Zitat Sullivan WJ, Willick SE, Chira-Adisai W et al (2000) Incidence of intravascular uptake in lumbar spinal injection procedures. Spine (Phila Pa 1976) 25:481–486CrossRef Sullivan WJ, Willick SE, Chira-Adisai W et al (2000) Incidence of intravascular uptake in lumbar spinal injection procedures. Spine (Phila Pa 1976) 25:481–486CrossRef
35.
Zurück zum Zitat Furman MB, O'Brien EM, Zgleszewski TM (2000) Incidence of intravascular penetration in transforaminal lumbosacral epidural steroid injections. Spine (Phila Pa 1976) 25:2628–2632CrossRef Furman MB, O'Brien EM, Zgleszewski TM (2000) Incidence of intravascular penetration in transforaminal lumbosacral epidural steroid injections. Spine (Phila Pa 1976) 25:2628–2632CrossRef
36.
Zurück zum Zitat Manchikanti L, Cash KA, Pampati V, Damron KS, McManus CD (2004) Evaluation of lumbar transforaminal epidural injections with needle placement and contrast flow patterns: a prospective, descriptive report. Pain Physician 7:217–223PubMed Manchikanti L, Cash KA, Pampati V, Damron KS, McManus CD (2004) Evaluation of lumbar transforaminal epidural injections with needle placement and contrast flow patterns: a prospective, descriptive report. Pain Physician 7:217–223PubMed
37.
Zurück zum Zitat Goodman BS, Lincoln CE, Deshpande KK, Poczatek RB, Lander PH, Devivo MJ (2005) Incidence of intravascular uptake during fluoroscopically guided lumbar disc injections: a prospective observational study. Pain Physician 8:263–266PubMed Goodman BS, Lincoln CE, Deshpande KK, Poczatek RB, Lander PH, Devivo MJ (2005) Incidence of intravascular uptake during fluoroscopically guided lumbar disc injections: a prospective observational study. Pain Physician 8:263–266PubMed
38.
Zurück zum Zitat Lee CJ, Kim YC, Shin JH et al (2008) Intravascular injection in lumbar medial branch block: a prospective evaluation of 1433 injections. Anesth Analg 106:1274–1278, tablePubMedCrossRef Lee CJ, Kim YC, Shin JH et al (2008) Intravascular injection in lumbar medial branch block: a prospective evaluation of 1433 injections. Anesth Analg 106:1274–1278, tablePubMedCrossRef
39.
Zurück zum Zitat Kennedy DJ, Dreyfuss P, Aprill CN, Bogduk N (2009) Paraplegia following image-guided transforaminal lumbar spine epidural steroid injection: two case reports. Pain Med 10:1389–1394PubMedCrossRef Kennedy DJ, Dreyfuss P, Aprill CN, Bogduk N (2009) Paraplegia following image-guided transforaminal lumbar spine epidural steroid injection: two case reports. Pain Med 10:1389–1394PubMedCrossRef
40.
Zurück zum Zitat Lyders EM, Morris PP (2009) A case of spinal cord infarction following lumbar transforaminal epidural steroid injection: MR imaging and angiographic findings. AJNR Am J Neuroradiol 30:1691–1693PubMedCrossRef Lyders EM, Morris PP (2009) A case of spinal cord infarction following lumbar transforaminal epidural steroid injection: MR imaging and angiographic findings. AJNR Am J Neuroradiol 30:1691–1693PubMedCrossRef
41.
Zurück zum Zitat Glaser SE, Falco F (2005) Paraplegia following a thoracolumbar transforaminal epidural steroid injection. Pain Physician 8:309–314PubMed Glaser SE, Falco F (2005) Paraplegia following a thoracolumbar transforaminal epidural steroid injection. Pain Physician 8:309–314PubMed
42.
Zurück zum Zitat Houten JK, Errico TJ (2002) Paraplegia after lumbosacral nerve root block: report of three cases. Spine J 2:70–75PubMedCrossRef Houten JK, Errico TJ (2002) Paraplegia after lumbosacral nerve root block: report of three cases. Spine J 2:70–75PubMedCrossRef
43.
Zurück zum Zitat Thefenne L, Dubecq C, Zing E et al (2010) A rare case of paraplegia complicating a lumbar epidural infiltration. Ann Phys Rehabil Med 53:575–583PubMed Thefenne L, Dubecq C, Zing E et al (2010) A rare case of paraplegia complicating a lumbar epidural infiltration. Ann Phys Rehabil Med 53:575–583PubMed
44.
Zurück zum Zitat Lenoir T, Deloin X, Dauzac C, Rillardon L, Guigui P (2008) Paraplegia after interlaminar epidural steroid injection: a case report. Rev Chir Orthop Reparatrice Appar Mot 94:697–701PubMedCrossRef Lenoir T, Deloin X, Dauzac C, Rillardon L, Guigui P (2008) Paraplegia after interlaminar epidural steroid injection: a case report. Rev Chir Orthop Reparatrice Appar Mot 94:697–701PubMedCrossRef
45.
Zurück zum Zitat Shetty SK, Nelson EN, Lawrimore TM, Palmer WE (2007) Use of gadolinium chelate to confirm epidural needle placement in patients with an iodinated contrast reaction. Skeletal Radiol 36:301–307PubMedCrossRef Shetty SK, Nelson EN, Lawrimore TM, Palmer WE (2007) Use of gadolinium chelate to confirm epidural needle placement in patients with an iodinated contrast reaction. Skeletal Radiol 36:301–307PubMedCrossRef
46.
Zurück zum Zitat Sharma SK, Jones JO, Zeballos PP, Irwin SA, Martin TW (2009) The prevention of discitis during discography. Spine J 9:936–943PubMedCrossRef Sharma SK, Jones JO, Zeballos PP, Irwin SA, Martin TW (2009) The prevention of discitis during discography. Spine J 9:936–943PubMedCrossRef
Metadaten
Titel
Augmented reality visualisation using an image overlay system for MR-guided interventions: technical performance of spine injection procedures in human cadavers at 1.5 Tesla
verfasst von
Jan Fritz
Paweena U-Thainual
Tamas Ungi
Aaron J. Flammang
Gabor Fichtinger
Iulian I. Iordachita
John A. Carrino
Publikationsdatum
01.01.2013
Verlag
Springer-Verlag
Erschienen in
European Radiology / Ausgabe 1/2013
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-012-2569-0

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