nach oben

European Journal of Nutrition

Erschienen in:

01.12.2013 | Original Contribution

Dietary antioxidant capacity is associated with improved serum antioxidant status and decreased serum C-reactive protein and plasma homocysteine concentrations

verfasst von: Meng Yang, Sang-Jin Chung, Anna Floegel, Won O. Song, Sung I. Koo, Ock K. Chun

Erschienen in: European Journal of Nutrition | Ausgabe 8/2013

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To investigate the associations of dietary TAC from diet and supplements with serum antioxidant concentrations and serum C-reactive protein (CRP) and plasma total homocysteine (tHcy) in US adults.

Methods

This was a cross-sectional study. Food consumption data, serum antioxidant levels, and serum CRP and Plasma tHcy concentrations of 4,391 US adults aged ≥19 years in the National Health and Nutrition Examination Survey 2001–2002 were analyzed. The USDA flavonoid and proanthocyanidin databases and dietary supplement data as well as antioxidant capacities of 43 antioxidants were also utilized.

Result

Serum CRP and plasma tHcy concentrations were higher in older adults, smokers, and those with lower non-leisure time physical activity levels (P < 0.05). Energy-adjusted daily total antioxidant capacity (TAC) from diet and supplements was positively associated with serum vitamin E and carotenoid concentrations (P < 0.05). Adjusted odds ratio (OR) for plasma tHcy >13 μmol/L significantly decreased across quartiles of TAC from diet and supplements (Q1 = 2.18 (1.56–2.77); Q2 = 1.30 (1.00–2.07); Q3 = 1.34 (0.84–2.28); Q4 = 1.00; P for linear trend <0.001). A negative trend across quartiles of TAC from diet and supplements was also observed in OR for serum CRP ≥3 mg/L (Q1 = 1.26 (0.97–1.70); Q2 = 1.21 (0.91–1.66); Q3 = 0.97 (0.80–1.24); Q4 = 1.00; P for linear trend <0.05).

Conclusions

These findings indicated that dietary TAC provided an integrated conceptual tool in assessing serum antioxidants and investigating the associations between antioxidant intake and CVD risk. The implicated applicability of dietary TAC needs further validation in prospective cohort studies.

Genkinger JM, Platz EA, Hoffman SC, Comstock GW, Helzlsouer KJ (2004) Fruit, vegetable, and antioxidant intake and all-cause, cancer, and cardiovascular disease mortality in a community-dwelling population in Washington County, Maryland. Am J Epidemiol 160:1223–1233CrossRef

Heidemann C, Schulze MB, Franco OH, van Dam RM, Mantzoros CS, Hu FB (2008) Dietary patterns and risk of mortality from cardiovascular disease, cancer, and all causes in a prospective cohort of women. Circulation 118:230–237CrossRef

Oude Griep LM, Verschuren WM, Kromhout D, Ocke MC, Geleijnse JM (2011) Raw and processed fruit and vegetable consumption and 10-year stroke incidence in a population-based cohort study in the Netherlands. Eur J Clin Nutr 65:791–799CrossRef

Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G et al (2010) Heart disease and stroke statistics-- 2010 update: a report from the American Heart Association. Circulation 121:e46–e215

Singh U, Devaraj S, Jialal I (2005) Vitamin E, oxidative stress, and inflammation. Annu Rev Nutr 25:151–174CrossRef

Pepys MB, Hirschfield GM (2003) C-reactive protein: a critical update. J Clin Invest 111:1805–1812

Nygard O, Vollset SE, Refsum H, Brattstrom L, Ueland PM (1999) Total homocysteine and cardiovascular disease. J Intern Med 246:425–454CrossRef

Ridker PM (2005) C-reactive protein, inflammation, and cardiovascular disease: clinical update. Tex Heart Inst J 32:384–386

Suliman ME, Stenvinkel P, Baranyi P, Heimburger O, Anderstam B, Lindholm B (2003) Hyperhomocysteinemia and its relationship to cardiovascular disease in ESRD: influence of hypoalbuminemia, malnutrition, inflammation, and diabetes mellitus. Am J Kidney Dis 41:S89–S95CrossRef

10.

Kaptoge S, Di Angelantonio E, Lowe G, Pepys MB, Thompson SG, Collins R, Danesh J (2010) C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet 375:132–140CrossRef

11.

de Ferranti SD, Rifai N (2007) C-reactive protein: a nontraditional serum marker of cardiovascular risk. Cardiovasc Pathol 16:14–21CrossRef

12.

van’t Veer P, Jansen MC, Klerk M, Kok FJ (2000) Fruits and vegetables in the prevention of cancer and cardiovascular disease. Public Health Nutr 3:103–107

13.

Hermsdorff HH, Zulet MA, Puchau B, Martinez JA (2010) Fruit and vegetable consumption and proinflammatory gene expression from peripheral blood mononuclear cells in young adults: a translational study. Nutr Metab (Lond) 7:42CrossRef

14.

Pellegrini N, Salvatore S, Valtuena S, Bedogni G, Porrini M, Pala V, Del Rio D, Sieri S, Miglio C, Krogh V, Zavaroni I, Brighenti F (2007) Development and validation of a food frequency questionnaire for the assessment of dietary total antioxidant capacity. J Nutr 137:93–98

15.

Martin K, Wu D, Meydani M (2000) The effect of carotenoids on the expression of cell surface adhesion molecules and binding of monocytes to human aortic endothelial cells. Atherosclerosis 150:265–274CrossRef

16.

Kaur G, Rao LV, Agrawal A, Pendurthi UR (2007) Effect of wine phenolics on cytokine-induced C-reactive protein expression. J Thromb Haemost 5:1309–1317CrossRef

17.

Libinaki R, Tesanovic S, Heal A, Nikolovski B, Vinh A, Widdop RE, Gaspari TA, Devaraj S, Ogru E (2010) Effect of tocopheryl phosphate on key biomarkers of inflammation: implication in the reduction of atherosclerosis progression in a hypercholesterolaemic rabbit model. Clin Exp Pharmacol Physiol 37:587–592CrossRef

18.

El-Mowafy AM, El-Mesery ME, Salem HA, Al-Gayyar MM, Darweish MM (2010) Prominent chemopreventive and chemoenhancing effects for resveratrol: unraveling molecular targets and the role of C-reactive protein. Chemotherapy 56:60–65CrossRef

19.

Suzuki K, Inoue T, Hashimoto S, Ochiai J, Kusuhara Y, Ito Y, Hamajima N (2010) Association of serum carotenoids with high molecular weight adiponectin and inflammation markers among Japanese subjects. Clin Chim Acta 411:1330–1334CrossRef

20.

Scheurig AC, Thorand B, Fischer B, Heier M, Koenig W (2008) Association between the intake of vitamins and trace elements from supplements and C-reactive protein: results of the MONICA/KORA Augsburg study. Eur J Clin Nutr 62:127–137CrossRef

21.

Vivekananthan D, Penn M, Sapp S, Hsu A, Topol E (2003) Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet 361:2017–2023CrossRef

22.

Kushi LH, Folsom AR, Prineas RJ, Mink PJ, Wu Y, Bostick RM (1996) Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women. N Engl J Med 334:1156–1162CrossRef

23.

Serafini M, Del Rio D (2004) Understanding the association between dietary antioxidants, redox status and disease: is the total antioxidant capacity the right tool? Redox Rep 9:145–152CrossRef

24.

Brighenti F, Valtuena S, Pellegrini N, Ardigo D, Del Rio D, Salvatore S, Piatti P, Serafini M, Zavaroni I (2005) Total antioxidant capacity of the diet is inversely and independently related to plasma concentration of high-sensitivity C-reactive protein in adult Italian subjects. Br J Nutr 93:619–625CrossRef

25.

Yang M, Chung S-J, Chung C, Kim D-O, Song WO, Koo SI, Chun OK (2010) Estimation of total antioxidant capacity from diet and supplements in U.S. adults. Br J Nutr 106:254–263CrossRef

26.

National Center for Health Statistics (2004) National Health and Nutrition Examination Survey, 2001-2002 Data Files. Hyattsville, MD: Centers for Disease Control. http://www.cdc.gov/nchs/nhanes/nhanes2001-2002/nhanes01_02.htm. Accessed by May, 2004

27.

Botman S, Moore T, Moriarity C, Parsons V (2000) Design and estimation for the national health interview survey, 1995-2004. National Center for Health Statistics. Vital Health Stat 2(130). http://www.cdc.gov/nchs/data/series/sr_02/sr02_130.pdf

28.

National Center for Health Statistics (2004) General information about the NHANES 2001-2002, laboratory methodology and public data files. Hyattsville, MD: Centers for Disease Control. http://www.cdc.gov/nchs/data/nhanes/nhanes_01_02/l36_b_doc.pdf. Accessed May, 2004

29.

Chun OK, Floegel A, Chung S-J, Chung C, Song WO, Koo SI (2010) Estimation of antioxidant intakes from diet and supplements in U.S. adults. J Nutr 140:317–324CrossRef

30.

Agricultural Research Service, US Department of Agriculture (2003) Database for the flavonoid content of selected foods. Agricultural Research Service, Beltsville. http://www.nal.usda.gov/fnic/foodcomp/Data/Flav/flav.pdf. Accessed March, 2003

31.

Agricultural Research Service, US Department of Agriculture (2002) USDA-Iowa State University database on the isoflavone content of foods, release 1.3. Agricultural Research Service, Beltsville. http://www.nal.usda.gov/fnic/foodcomp/Data/isoflav/isoflav.html. Accessed 2002

32.

Agricultural Research Service, US Department of Agriculture (2004) Database for the Proanthocyanidin Content of Selected Foods. Agricultural Research Service, Beltsville. http://www.nal.usda.gov/fnic/foodcomp/Data/PA/PA.html. Accessed 2004

33.

Floegel A, Kim D-O, Chung SJ, Song WO, Fernandez ML, Bruno RS, Koo SI, Chun OK (2010) Development and validation of an algorithm to establish a total antioxidant capacity database of the US diet. Int J Food Sci Nutr 61:600–623CrossRef

34.

Kim D-O, Chun OK, Kim YJ, Moon HY, Lee CY (2003) Quantification of polyphenolics and their antioxidant capacity in fresh plums. J Agric Food Chem 51:6509–6515CrossRef

35.

Kim D-O, Lee KW, Lee HJ, Lee CY (2002) Vitamin C equivalent antioxidant capacity (VCEAC) of phenolic phytochemicals. J Agric Food Chem 50:3713–3717CrossRef

36.

Chun OK, Kim D-O, Smith N, Schroeder D, Han JT, Lee CY (2005) Daily consumption of phenolics and total antioxidant capacity from fruits and vegetables in the American diet. J Sci Food Agric 85:1715–1724CrossRef

37.

Blake GJ, Rifai N, Buring JE, Ridker PM (2003) Blood pressure, C-reactive protein, and risk of future cardiovascular events: a prospective study among 15,215 women. Circulation 108:2993–2999CrossRef

38.

de Luis DA, Fernandez N, Arranz ML, Aller R, Izaola O, Romero E (2005) Total homocysteine levels relation with chronic complications of diabetes, body composition, and other cardiovascular risk factors in a population of patients with diabetes mellitus type 2. J Diabetes Complicat 19:42–46CrossRef

39.

Detopoulou P, Panagiotakos DB, Chrysohoou C, Fragopoulou E, Nomikos T, Antonopoulou S, Pitsavos C, Stefanadis C (2010) Dietary antioxidant capacity and concentration of adiponectin in apparently healthy adults: the ATTICA study. Eur J Clin Nutr 64:161–168CrossRef

40.

Puchau B, Zulet MA, de Echavarri AG, Hermsdorff HHM, Martinez JA (2010) Dietary total antioxidant capacity is negatively associated with some metabolic syndrome features in healthy young adults. Nutrition 26:534–541CrossRef

41.

Kim D-O, Lee CY (2004) Comprehensive study on vitamin C equivalent antioxidant capacity (VCEAC) of various polyphenolics in scavenging a free radical and its structural relationship. Crit Rev Food Sci Nutr 44:253–273CrossRef

42.

Wang Y, Yang M, Lee SG, Davis CG, Kenny A, Koo SI, Chun OK (2012) Plasma total antioxidant capacity is associated with dietary intake and plasma level of antioxidants in postmenopausal women. J Nutr Biochem 23:1725–1731

43.

Wang Y, Yang M, Lee SG, Davis CG, Masterjohn C, Kenny A, Bruno R, Chun OK (2010) Total antioxidant capacity: a useful tool in assessing antioxidant intake status. In: Diederich M (ed) Natural compounds and apoptosis. Springer, New York

44.

Valtuena S, Del Rio D, Pellegrini N, Ardigo D, Franzini L, Salvatore S, Piatti PM, Riso P, Zavaroni I, Brighenti F (2007) The total antioxidant capacity of the diet is an independent predictor of plasma beta-carotene. Eur J Clin Nutr 61:69–76CrossRef

45.

Puchau B, Zulet MA, de Echavarri AG, Hermsdorff HH, Martinez JA (2009) Dietary total antioxidant capacity: a novel indicator of diet quality in healthy young adults. J Am Coll Nutr 28:648–656CrossRef

46.

Jansen MC, Van Kappel AL, Ocke MC, Van’t Veer P, Boshuizen HC, Riboli E, Bueno-de-Mesquita HB (2004) Plasma carotenoid levels in Dutch men and women, and the relation with vegetable and fruit consumption. Eur J Clin Nutr 58:1386–1395CrossRef

47.

Baldrick FR, Woodside JV, Elborn JS, Young IS, McKinley MC (2011) Biomarkers of fruit and vegetable intake in human intervention studies: a systematic review. Crit Rev Food Sci Nutr 51:795–815CrossRef

48.

Del Rio D, Valtuena S, Pellegrini N, Bianchi MA, Ardigo D, Franzini L, Scazzina F, Monti L, Zavaroni I, Brighenti F (2009) Intervention study with a high or low antioxidant capacity diet: effects on circulating beta-carotene. Eur J Clin Nutr 63:1220–1225CrossRef

49.

McNaughton SA, Marks GC, Gaffney P, Williams G, Green A (2005) Validation of a food-frequency questionnaire assessment of carotenoid and vitamin E intake using weighed food records and plasma biomarkers: the method of triads model. Eur J Clin Nutr 59:211–218CrossRef

50.

Dixon LB, Subar AF, Wideroff L, Thompson FE, Kahle LL, Potischman N (2006) Carotenoid and tocopherol estimates from the NCI diet history questionnaire are valid compared with multiple recalls and serum biomarkers. J Nutr 136:3054–3061

51.

Satia JA, Watters JL, Galanko JA (2009) Validation of an antioxidant nutrient questionnaire in whites and African Americans. J Am Diet Assoc 109:502–508CrossRef

52.

Yang M, Wang Y, Davis CG, Lee SG, Fernandez ML, Koo SI, Cho E, Song WO, Chun OK (2012) Validation of an FFQ to assess short-term antioxidant intake against 30d food records and plasma biomarkers. Public Health Nutr. doi:10.1017/S1368980012005071

53.

Wang Y, Yang M, Lee SG, Davis CG, Koo SI, Chun OK (2012) Dietary total antioxidant capacity is associated with diet and plasma antioxidant status in healthy young adults. J Acad Nutr Diet 112:1626–1635CrossRef

54.

Carr AC, Zhu BZ, Frei B (2000) Potential antiatherogenic mechanisms of ascorbate (vitamin C) and alpha-tocopherol (vitamin E). Circ Res 87:349–354CrossRef

55.

Berliner JA, Heinecke JW (1996) The role of oxidized lipoproteins in atherogenesis. Free Radic Biol Med 20:707–727CrossRef

56.

Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC (1993) Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 328:1450–1456CrossRef

57.

Stampfer MJ, Hennekens CH, Manson JE, Colditz GA, Rosner B, Willett WC (1993) Vitamin E consumption and the risk of coronary disease in women. N Engl J Med 328:1444–1449CrossRef

58.

van Herpen-Broekmans WMR, Klopping-Ketelaars IAA, Bots ML, Kluft C, Princen H, Hendriks HFJ, Tijburg LBM, van Poppel G, Kardinaal AFM (2004) Serum carotenoids and vitamins in relation to markers of endothelial function and inflammation. Eur J Epidemiol 19:915–921CrossRef

59.

Ito Y, Kurata M, Suzuki K, Hamajima N, Hishida H, Aoki K (2006) Cardiovascular disease mortality and serum carotenoid concentrations: a Japanese population-based follow-up study. J Epidemiol 16:154–160CrossRef

60.

Rissanen TH, Voutilainen S, Nyyssonen K, Lakka TA, Sivenius J, Salonen R, Kaplan GA, Salonen JT (2001) Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. Brit J Nutr 85:749–754CrossRef

61.

Dalgård C, Nielsen F, Morrow J, Enghusen-Poulsen H, Jonung T, Hørder M, de Maat M (2009) Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease. Br J Nutr 101:263–269CrossRef

62.

Lee IM, Cook NR, Gaziano JM, Gordon D, Ridker PM, Manson JE, Hennekens CH, Buring JE (2005) Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women’s Health Study: a randomized controlled trial. JAMA 294:56–65CrossRef

63.

Redberg RF (2005) Vitamin E and cardiovascular health: does sex matter? JAMA 294:107–109CrossRef

64.

Sesso HD, Buring JE, Christen WG, Kurth T, Belanger C, MacFadyen J, Bubes V, Manson JE, Glynn RJ, Gaziano JM (2008) Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians’ Health Study II randomized controlled trial. JAMA 300:2123–2133CrossRef

65.

Miller ER III, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E (2005) Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 142:37–46CrossRef

66.

Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH, Barnhart S, Hammar S (1996) Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 334:1150–1155CrossRef

67.

Cummings DM, King DE, Mainous AG, Geesey ME (2006) Combining serum biomarkers: the association of C-reactive protein, insulin sensitivity, and homocysteine with cardiovascular disease history in the general US population. Eur J Cardiovasc Prev Rehabil 13:180–185CrossRef

68.

Esmaillzadeh A, Kimiagar M, Mehrabi Y, Azadbakht L, Hu FB, Willett WC (2007) Dietary patterns and markers of systemic inflammation among Iranian women. J Nutr 137:992–998

69.

Ford ES, Liu S, Mannino DM, Giles WH, Smith SJ (2003) C-reactive protein concentration and concentrations of blood vitamins, carotenoids, and selenium among United States adults. Eur J Clin Nutr 57:1157–1163CrossRef

70.

Bertran N, Camps J, Fernandez-Ballart J, Arija V, Ferre N, Tous M, Simo D, Murphy MM, Vilella E, Joven J (2005) Diet and lifestyle are associated with serum C-reactive protein concentrations in a population-based study. J Lab Clin Med 145:41–46CrossRef

71.

Block G, Jensen C, Dietrich M, Norkus EP, Hudes M, Packer L (2004) Plasma C-reactive protein concentrations in active and passive smokers: influence of antioxidant supplementation. J Am Coll Nutr 23:141–147CrossRef

72.

Nanri A, Moore MA, Kono S (2007) Impact of C-reactive protein on disease risk and its relation to dietary factors. Asian Pac J Cancer Prev 8:167–177

Titel: Dietary antioxidant capacity is associated with improved serum antioxidant status and decreased serum C-reactive protein and plasma homocysteine concentrations
verfasst von: Meng Yang
Sang-Jin Chung
Anna Floegel
Won O. Song
Sung I. Koo
Ock K. Chun
Publikationsdatum: 01.12.2013
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 8/2013
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-012-0491-5

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Dietary antioxidant capacity is associated with improved serum antioxidant status and decreased serum C-reactive protein and plasma homocysteine concentrations

Abstract

Purpose

Methods

Result

Conclusions

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

15% bedauern gewählte Blasenkrebs-Therapie

Costims – das nächste heiße Ding in der Krebstherapie?

Update Innere Medizin

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Purpose

Methods

Result

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 8/2013

Effects of a dietetic treatment in older, undernourished, community-dwelling individuals in primary care: a randomized controlled trial

Yeast (1,3)-(1,6)-beta-glucan helps to maintain the body’s defence against pathogens: a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects

Effect on LDL-cholesterol of a large dose of a dietary supplement with plant extracts in subjects with untreated moderate hypercholesterolaemia: a randomised, double-blind, placebo-controlled study

Effect of Maillard reaction on biochemical properties of peanut 7S globulin (Ara h 1) and its interaction with a human colon cancer cell line (Caco-2)

Dietary, anthropometric, and lifestyle correlates of serum carotenoids in postmenopausal women

Beneficial effects of omega-3 fatty acids on the consequences of a fructose diet are not mediated by PPAR delta or PGC1 alpha

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

15% bedauern gewählte Blasenkrebs-Therapie

Costims – das nächste heiße Ding in der Krebstherapie?

Update Innere Medizin