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01.08.2004 | Original Article

Toxicological data and growth characteristics of single post-feeding larvae and puparia of Calliphora vicina (Diptera: Calliphoridae) obtained from a controlled nordiazepam study

verfasst von: Karen Pien, Marleen Laloup, Miriam Pipeleers-Marichal, Patrick Grootaert, Gert De Boeck, Nele Samyn, Tom Boonen, Kathy Vits, Michelle Wood

Erschienen in: International Journal of Legal Medicine | Ausgabe 4/2004

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Abstract

Larvae of the Calliphora vicina (Diptera: Calliphoridae) were reared on artificial food spiked with different concentrations of nordiazepam. The dynamics of the accumulation and conversion of nordiazepam to its metabolite oxazepam in post-feeding larvae and empty puparia were studied. Analysis was performed using a previously developed liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. This method enabled the detection and quantitation of nordiazepam and oxazepam in single larvae and puparia. Both drugs could be detected in post-feeding larvae and empty puparia. In addition, the influence of nordiazepam on the development and growth of post-feeding larvae was studied. However, no major differences were observed for these parameters between the larvae fed on food containing nordiazepam and the control group. To our knowledge, this is the first report describing the presence of nordiazepam and its metabolite, oxazepam, in single Calliphora vicina larvae and puparia.

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Titel: Toxicological data and growth characteristics of single post-feeding larvae and puparia of Calliphora vicina (Diptera: Calliphoridae) obtained from a controlled nordiazepam study
verfasst von: Karen Pien
Marleen Laloup
Miriam Pipeleers-Marichal
Patrick Grootaert
Gert De Boeck
Nele Samyn
Tom Boonen
Kathy Vits
Michelle Wood
Publikationsdatum: 01.08.2004
Verlag: Springer-Verlag
Erschienen in: International Journal of Legal Medicine / Ausgabe 4/2004
Print ISSN: 0937-9827
Elektronische ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-004-0441-8

Springer Medizin

Toxicological data and growth characteristics of single post-feeding larvae and puparia of Calliphora vicina (Diptera: Calliphoridae) obtained from a controlled nordiazepam study

Abstract

Neu im Fachgebiet Rechtsmedizin

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Springer Medizin

Abstract

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