Lung ultrasound predicts the development of bronchopulmonary dysplasia: a prospective observational diagnostic accuracy study

This study aimed to evaluate the predictive ability of lung ultrasound (LU) in the development of bronchopulmonary dysplasia (BPD) in very low birth weight (VLBW) infants. A total of 130 VLBW infants with gestational age < 32 weeks were included; LU was performed at days 1, 2, 3, 6, 9, 12, and 15 postnatally. We calculated the LU score by 12-region, 10-region, and 6-region protocols. The incidence of BPD according to the National Institutes of Health (NIH) 2001 definition and 2019 criteria was 38.5% and 64.6%, respectively. By 12-region and 10-region protocols, LU predicted BPD from the 9^th to 15^th days of life (DOLs) regardless of the criteria used, with an area under the curve (AUC) ranging from 0.826 (95% confidence interval (CI): 0.750–0.887) to 0.877 (95% CI: 0.807–0.928). According to the 2019 BPD definition, the LU score incorporated gestational age, and invasive mechanical ventilation >6 days predicted BPD on the 6^th DOL with an AUC of 0.862 (95% CI: 0.790–0.916). The 6-region protocol had significantly smaller AUC values on the 6^th and 9^th DOLs than the other two protocols.

Conclusion: The 12-region and 10-region LU scoring protocols are superior to the 6-region protocol in the prediction of BPD. LU can predict the development of BPD from the 9^th to 15^th DOLs. With the addition of clinical variables, the earliest prediction time was the 6^th DOL.