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21.03.2016 | Original Article

Incidence of contrast-induced acute kidney injury in a pediatric setting: a cohort study

verfasst von: Aymeric Cantais, Zeineb Hammouda, Olivier Mory, Hugues Patural, Jean-Louis Stephan, Lyudmyla Gulyaeva, Michael Darmon

Erschienen in: Pediatric Nephrology | Ausgabe 8/2016

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Abstract

Background

Contrast-induced acute kidney injury (CI-AKI) is a common pathology among adult patients, with an incidence ranging from 3–25 % depending on risk factors. Little information is available regarding CI-AKI incidence, risk factors, and prognostic impact in the pediatric population.

Methods

We performed a retrospective study of pediatric patients who underwent computed tomography (CT) scan with iodinated contrast media injection between 2005 and 2014 in five pediatric units of a university hospital. CI-AKI was defined according to Kidney Disease/Improving Global Outcomes (KDIGO) criteria.

Results

Of 346 identified patients, 233 had renal function follow-up and were included in our analyses. CI-AKI incidence was 10.3 % [95 % confidence interval (CI) 6.4–14.2 %]. CI-AKI was associated with 30-day unfavorable outcome before (45.8 % vs. 19.7 %, P = 0.007) and after [odds ratio (OR) 3.6; 95 % CI 1.4–9.5] adjustment for confounders. No independent risk factors of CI-AKI were identified.

Conclusions

CI-AKI incidence was as high as 10.3 % following intravenous contrast media administration in the pediatric setting. As reported among adults, CI-AKI was associated with unfavorable outcome after adjustment for confounders. Although additional studies are needed in the pediatric setting, our data suggest that physicians should maintain a high degree of suspicion toward this complication among pediatric patients.

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Titel: Incidence of contrast-induced acute kidney injury in a pediatric setting: a cohort study
verfasst von: Aymeric Cantais
Zeineb Hammouda
Olivier Mory
Hugues Patural
Jean-Louis Stephan
Lyudmyla Gulyaeva
Michael Darmon
Publikationsdatum: 21.03.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 8/2016
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-016-3313-9

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Incidence of contrast-induced acute kidney injury in a pediatric setting: a cohort study