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Journal of Neural Transmission

Erschienen in:

01.08.2012 | Movement Disorders - Review article

The significance of neuronal lateralisation in Parkinson’s disease

verfasst von: P. Riederer, J. Sian-Hülsmann

Erschienen in: Journal of Neural Transmission | Ausgabe 8/2012

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Abstract

The destruction of the dopaminergic neurons in the substantia nigra (SN) and consequent depletion of striatal dopamine elicits the main movement deficits related to Parkinson’s disease (PD). In the early stages of the illness, the motor symptoms are often exhibited asymmetrically. Thus, the onset of PD features starts on either the right or left side. The side of onset appears to determine the prognosis of the disorder and other features, such as right-side tremor dominance has a better prognosis in contrast to left-side dominant bradykinesia-rigidity. In addition, left-side onset of motor features is associated with cognitive decline. Therefore, an intricate relation appears to exist between the side of disease onset and progression/severity and other non-motor symptoms. Unilateral PD in turn corresponds to neuronal nigrostriatal degeneration in the contralateral hemisphere. Indeed positron emission tomography has demonstrated a positive correlation between symptom asymmetry and brain function (Hoorn et al. Parkinsonism Relat Disord 17:58–60, 2011), which corresponds to a unilateral pattern of degeneration. This phenomenon appears to be exclusive to PD. Additionally, the variation in motor symptom(s) dominance exhibited in the disorder conforms to the notion that PD is a spectrum disease with many sub-groups. Thus, clinical and post mortem studies on “lateralisation” may serve as a vital tool in understanding the mechanism(s) eliciting the characteristic destruction of the SN neurons. Additionally, it may be employed as a predictive indicator for the symptomology and prognosis of the illness thus allowing selective treatment strategies targeted at the pronounced hemispheric degeneration.

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Titel: The significance of neuronal lateralisation in Parkinson’s disease
verfasst von: P. Riederer
J. Sian-Hülsmann
Publikationsdatum: 01.08.2012
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 8/2012
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-012-0775-1

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Weitere Artikel der Ausgabe 8/2012

Influence of sildenafil on the anticonvulsant action of selected antiepileptic drugs against pentylenetetrazole-induced clonic seizures in mice

Modulation of in vivo GABA-evoked responses by nitric oxide-active compounds in the globus pallidus of rat

Age-related decline in motor behavior and striatal dopamine transporter in cynomolgus monkeys

Reactive oxygen/nitrogen species and their functional correlations in neurodegenerative diseases

(−)-Epigallocatechin-3-gallate increases the number of neural stem cells around the damaged area after rat traumatic brain injury