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Neurological Sciences

Erschienen in:

01.05.2017 | NEUROBIOLOGY OF HEADACHE

The role of anti-CGRP antibodies in the pathophysiology of primary headaches

verfasst von: Piero Barbanti, Cinzia Aurilia, Luisa Fofi, Gabriella Egeo, Patrizia Ferroni

Erschienen in: Neurological Sciences | Sonderheft 1/2017

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Abstract

Calcitonin gene-related peptide (CGRP), a potent vasodilator and pain-signaling neuropeptide, is a validated therapeutic target for migraine and cluster headache. Four anti-CGRP monoclonal antibodies (mAbs) have been developed, representing the first specific, mechanism-based, migraine prophylactic treatment. CGRP mAbs demonstrated good efficacy coupled to excellent tolerability and safety in 5 phase II clinical trials. Notably, CGRP mAbs induced complete migraine remission in a patients’ subset. To date, more than 20 phase III trials using CGRP mAbs for of episodic and chronic migraine and cluster headache prevention are ongoing. Future investigations will shed light on migraine endophenotypes predictive of good CGRP mAbs responsiveness and provide answers on their long-term cardiovascular safety.

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Titel: The role of anti-CGRP antibodies in the pathophysiology of primary headaches
verfasst von: Piero Barbanti
Cinzia Aurilia
Luisa Fofi
Gabriella Egeo
Patrizia Ferroni
Publikationsdatum: 01.05.2017
Verlag: Springer Milan
Erschienen in: Neurological Sciences / Ausgabe Sonderheft 1/2017
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-017-2907-8

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