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Neurological Sciences

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01.12.2018 | Original Article

Serum NT-pro CNP levels in epileptic seizure, psychogenic non-epileptic seizure, and healthy subjects

verfasst von: Mustafa Ceylan, Ahmet Yalcin, Omer Faruk Bayraktutan, Esra Laloglu

Erschienen in: Neurological Sciences | Ausgabe 12/2018

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Abstract

Purpose

Epileptic seizure is the result of uncontrollable neural excitation in the brain. The C-type natriuretic peptide is a member of natriuretic peptide hormone family and is synthesized by brain and blood vessels in CNS. NT-pro CNP is an amino-terminal fragment of C-type natriuretic peptide and is more stable compared to its predecessor. In this study, we aimed to evaluate the role of NT-pro CNP in psychogenic non-epileptic seizures, epileptic seizures, and normal subjects.

Methods

Thirty-three patients with epilepsy and 43 patients with psychogenic non-epileptic seizures were enrolled in this study. The control group consisted of 28 healthy subjects. Post-ictal serum levels of NT-pro CNP were acquired from all participants. Statistically significant differences between patient groups and controls regarding serum levels of NT-pro CNP were sought.

Results

NT-pro CNP levels were significantly lower in the epilepsy group than the psychogenic non-epileptic seizure group and control group with no significant difference between the psychogenic non-epileptic seizure and control group (p < 0.05).

Conclusion

Post-ictal serum NT-pro CNP levels were lower in epileptic seizures compared to psychogenic non-epileptic seizures as well as healthy controls. We think that such a difference is associated with C-type natriuretic peptide-related neural mechanisms such as altered microcirculation, increased brain-blood barrier permeability, and synaptic stabilization.

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Titel: Serum NT-pro CNP levels in epileptic seizure, psychogenic non-epileptic seizure, and healthy subjects
verfasst von: Mustafa Ceylan
Ahmet Yalcin
Omer Faruk Bayraktutan
Esra Laloglu
Publikationsdatum: 01.12.2018
Verlag: Springer Milan
Erschienen in: Neurological Sciences / Ausgabe 12/2018
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-018-3562-4

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