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Die Highlights vom Kongress des American College of Cardiology 2024

Im April diskutierten die Herz-Kreislauf-Spezialisten aus der ganzen Welt auf dem  Kongress des American College of Cardiology (ACC) u.a. neue Therapieansätze bei akutem Myokardinfarkt, koronarer Herzerkrankung, kardiogenem Schock oder Aortenklappenstenose. In unserem Kongress-Dossier haben wir für Sie Berichte über die „Late-Breaking Trials“ und andere wichtige Studien zusammengestellt. 
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Heart Failure Reviews
Erschienen in: Heart Failure Reviews 1/2016

01.01.2016

Insulin resistance: an additional risk factor in the pathogenesis of cardiovascular disease in type 2 diabetes

verfasst von: Tushar P. Patel, Komal Rawal, Ashim K. Bagchi, Gauri Akolkar, Nathalia Bernardes, Danielle da Silva Dias, Sarita Gupta, Pawan K. Singal

Erschienen in: Heart Failure Reviews | Ausgabe 1/2016

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Abstract

Sedentary life style and high calorie dietary habits are prominent leading cause of metabolic syndrome in modern world. Obesity plays a central role in occurrence of various diseases like hyperinsulinemia, hyperglycemia and hyperlipidemia, which lead to insulin resistance and metabolic derangements like cardiovascular diseases (CVDs) mediated by oxidative stress. The mortality rate due to CVDs is on the rise in developing countries. Insulin resistance (IR) leads to micro or macro angiopathy, peripheral arterial dysfunction, hampered blood flow, hypertension, as well as the cardiomyocyte and the endothelial cell dysfunctions, thus increasing risk factors for coronary artery blockage, stroke and heart failure suggesting that there is a strong association between IR and CVDs. The plausible linkages between these two pathophysiological conditions are altered levels of insulin signaling proteins such as IR-β, IRS-1, PI3K, Akt, Glut4 and PGC-1α that hamper insulin-mediated glucose uptake as well as other functions of insulin in the cardiomyocytes and the endothelial cells of the heart. Reduced AMPK, PFK-2 and elevated levels of NADP(H)-dependent oxidases produced by activated M1 macrophages of the adipose tissue and elevated levels of circulating angiotensin are also cause of CVD in diabetes mellitus condition. Insulin sensitizers, angiotensin blockers, superoxide scavengers are used as therapeutics in the amelioration of CVD. It evidently becomes important to unravel the mechanisms of the association between IR and CVDs in order to formulate novel efficient drugs to treat patients suffering from insulin resistance-mediated cardiovascular diseases. The possible associations between insulin resistance and cardiovascular diseases are reviewed here.
Literatur
1.
Ceriello A (2005) Postprandial hyperglycemia and diabetes complications is it time to treat? Diabetes 54(1):1–7PubMedCrossRef
2.
Kannel WB, Hjortland M, Castelli WP (1974) Role of diabetes in congestive heart failure: the Framingham study. Am J Cardiol 34(1):29–34PubMedCrossRef
3.
Garcia M, McNamara P, Gordon T, Kannel W (1972) Cardiovascular complications in diabetics. Adv Metab Disord 2(Suppl 2):493–499
4.
Fowler MJ (2008) Microvascular and macrovascular complications of diabetes. Clin Diabetes 26(2):77–82CrossRef
5.
Ceriello A (2003) New insights on oxidative stress and diabetic complications may lead to a “causal” antioxidant therapy. Diabetes Care 26(5):1589–1596PubMedCrossRef
6.
Farahmand F, Lou H, Singal PK (2003) Oxidative stress in cardiovascular complications of diabetes. In: Pierce GN, Nagano M, Zahradka P, Dhalla NS (eds) Atherosclerosis, hypertension and diabetes. Kluwer Academic Publications, Boston, pp 427–437CrossRef
7.
Gyurko R, Siqueira CC, Caldon N, Gao L, Kantarci A, Van Dyke TE (2006) Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice. J Immunol 177(10):7250–7256PubMedPubMedCentralCrossRef
8.
Lum H, Roebuck KA (2001) Oxidant stress and endothelial cell dysfunction. Am J Physiol Cell Physiol 280(4):C719–C741PubMed
9.
Versari D, Daghini E, Virdis A, Ghiadoni L, Taddei S (2009) Endothelial dysfunction as a target for prevention of cardiovascular disease. Diabetes Care 32(suppl 2):S314–S321PubMedPubMedCentralCrossRef
10.
Schram MT, Chaturvedi N, Schalkwijk C, Giorgino F, Ebeling P, Fuller JH, Stehouwer CD (2003) Vascular risk factors and markers of endothelial function as determinants of inflammatory markers in type 1 diabetes the EURODIAB Prospective complications study. Diabetes Care 26(7):2165–2173PubMedCrossRef
11.
El-Osta A, Brasacchio D, Yao D, Pocai A, Jones PL, Roeder RG, Cooper ME, Brownlee M (2008) Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J Exp Med 205(10):2409–2417PubMedPubMedCentralCrossRef
12.
Hink U, Li H, Mollnau H, Oelze M, Matheis E, Hartmann M, Skatchkov M, Thaiss F, Stahl RA, Warnholtz A (2001) Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res 88(2):e14–e22PubMedCrossRef
13.
Watts G, Playford D (1998) Dyslipoproteinaemia and hyperoxidative stress in the pathogenesis of endothelial dysfunction in non-insulin dependent diabetes mellitus: an hypothesis. Atherosclerosis 141(1):17–30PubMedCrossRef
14.
Renard CB, Kramer F, Johansson F, Lamharzi N, Tannock LR, von Herrath MG, Chait A, Bornfeldt KE (2004) Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions. J Clin Investig 114(5):659PubMedPubMedCentralCrossRef
15.
Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, Eckel RH (2006) Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss an update of the 1997 American Heart Association Scientific statement on obesity and heart disease from the obesity committee of the council on nutrition, physical activity, and metabolism. Circulation 113(6):898–918PubMedCrossRef
16.
Duncan BB, Schmidt MI, Pankow JS, Ballantyne CM, Couper D, Vigo A, Hoogeveen R, Folsom AR, Heiss G (2003) Low-grade systemic inflammation and the development of type 2 diabetes the atherosclerosis risk in communities study. Diabetes 52(7):1799–1805PubMedCrossRef
17.
Turner R, Holman R, Matthews D, Bassett P, Coster R, Stratton I, Cull C, Peto R, Frighi V, Kennedy I (1993) Hypertension in diabetes study (Hds). 1. Prevalence of hypertension in newly presenting type-2 diabetic-patients and the association with risk-factors for cardiovascular and diabetic complications. J Hypertens 11(3):309–317CrossRef
18.
ADA (1993) Treatment of hypertension in diabetes. Diabetes Care 16:1394–1401CrossRef
19.
Goto A, Arah OA, Goto M, Terauchi Y, Noda M (2013) Severe hypoglycaemia and cardiovascular disease: systematic review and meta-analysis with bias analysis. BMJ 347:F4533PubMedCrossRef
20.
Sommerfield AJ, Wilkinson IB, Webb DJ, Frier BM (2007) Vessel wall stiffness in type 1 diabetes and the central hemodynamic effects of acute hypoglycemia. Am J Physiol Endocrinol Metab 293(5):E1274–E1279PubMedCrossRef
21.
22.
23.
Spallone V, Ziegler D, Freeman R, Bernardi L, Frontoni S, Pop-Busui R, Stevens M, Kempler P, Hilsted J, Tesfaye S (2011) Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management. Diabetes Metab Res Rev 27(7):639–653PubMedCrossRef
24.
Witte D, Tesfaye S, Chaturvedi N, Eaton S, Kempler P, Fuller J, Group EPCS (2005) Risk factors for cardiac autonomic neuropathy in type 1 diabetes mellitus. Diabetologia 48(1):164–171PubMedCrossRef
25.
Astrup AS, Tarnow L, Rossing P, Hansen BV, Hilsted J, Parving H-H (2006) Cardiac autonomic neuropathy predicts cardiovascular morbidity and mortality in type 1 diabetic patients with diabetic nephropathy. Diabetes Care 29(2):334–339PubMedCrossRef
26.
DeFronzo RA, Tripathy D (2009) Skeletal muscle insulin resistance is the primary defect in type 2 diabetes. Diabetes Care 32(suppl 2):S157–S163PubMedPubMedCentralCrossRef
27.
Groop L, Bonadonna R, Del Prato S, Ratheiser K, Zyck K, DeFronzo R (1989) Effect of insulin on oxidative and non-oxidative pathways of glucose and FFA metabolism in NIDDM. Evidence for multiple sites of insulin resistance. J Clin Invest 84:205–213PubMedPubMedCentralCrossRef
28.
Morino K, Petersen KF, Shulman GI (2006) Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. Diabetes 55(Supplement 2):S9–S15PubMedPubMedCentralCrossRef
29.
Langin D, Dicker A, Tavernier G, Hoffstedt J, Mairal A, Rydén M, Arner E, Sicard A, Jenkins CM, Viguerie N (2005) Adipocyte lipases and defect of lipolysis in human obesity. Diabetes 54(11):3190–3197PubMedCrossRef
30.
Kern PA (1997) Potential role of TNFα and lipoprotein lipase as candidate genes for obesity. J Nutr 127(9):1917S–1922SPubMed
31.
Bugianesi E, McCullough AJ, Marchesini G (2005) Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 42(5):987–1000PubMedCrossRef
32.
Dröge W (2002) Free radicals in the physiological control of cell function. Physiol Rev 82(1):47–95PubMedCrossRef
33.
Brownlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414(6865):813–820PubMedCrossRef
34.
Greene DA, Stevens MJ, Obrosova I, Feldman EL (1999) Glucose-induced oxidative stress and programmed cell death in diabetic neuropathy. Eur J Pharmacol 375(1):217–223PubMedCrossRef
35.
Wolff SP, Dean R (1987) Glucose autoxidation and protein modification. The potential role of ‘autoxidative glycosylation’ in diabetes. Biochem J 245:243–250PubMedPubMedCentralCrossRef
36.
Yan S, Stern D, Schmidt A (1997) What’s the RAGE? The receptor for advanced glycation end products (RAGE) and the dark side of glucose. Eur J Clin Invest 27(3):179–181PubMedCrossRef
37.
Stojiljkovic MP, Lopes HF, Zhang D, Morrow JD, Goodfriend TL, Egan BM (2002) Increasing plasma fatty acids elevates F2-isoprostanes in humans: implications for the cardiovascular risk factor cluster. J Hypertens 20(6):1215–1221PubMedCrossRef
38.
S-i Yamagishi, Edelstein D, X-l Du, Kaneda Y, Guzmán M, Brownlee M (2001) Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J Biol Chem 276(27):25096–25100CrossRef
39.
Paz K, Hemi R, LeRoith D, Karasik A, Elhanany E, Kanety H, Zick Y (1997) A Molecular Basis for Insulin Resistance elevated serine/threonine phosphorylation of irs-1 and irs-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation. J Biol Chem 272(47):29911–29918PubMedCrossRef
40.
Potashnik R, Bloch-Damti A, Bashan N, Rudich A (2003) IRS1 degradation and increased serine phosphorylation cannot predict the degree of metabolic insulin resistance induced by oxidative stress. Diabetologia 46(5):639–648PubMed
41.
Ogihara T, Asano T, Katagiri H, Sakoda H, Anai M, Shojima N, Ono H, Fujishiro M, Kushiyama A, Fukushima Y (2004) Oxidative stress induces insulin resistance by activating the nuclear factor-κB pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase. Diabetologia 47(5):794–805PubMedCrossRef
42.
Khamaisi M, Potashnik R, Tirosh A, Demshchak E, Rudich A, Trischler H, Wessel K, Bashan N (1997) Lipoic acid reduces glycemia and increases muscle GLUT4 content in streptozotocin-diabetic rats. Metabolism 46(7):763–768PubMedCrossRef
43.
Pessler D, Rudich A, Bashan N (2001) Oxidative stress impairs nuclear proteins binding to the insulin responsive element in the GLUT4 promoter. Diabetologia 44(12):2156–2164PubMedCrossRef
44.
Castelló A, Rodríguez-Manzaneque JC, Camps M, Perez-Castillo A, Testar X, Palacin M, Santos A, Zorzano A (1994) Perinatal hypothyroidism impairs the normal transition of GLUT4 and GLUT1 glucose transporters from fetal to neonatal levels in heart and brown adipose tissue. Evidence for tissue-specific regulation of GLUT4 expression by thyroid hormone. J Biol Chem 269(8):5905–5912PubMed
45.
Randle PJ, Kerbey AL, Espinal J (1988) Mechanisms decreasing glucose oxidation in diabetes and starvation: role of lipid fuels and hormones. Diabetes Metab Rev 4(7):623–638PubMedCrossRef
46.
47.
Stalder M, Pometta D, Suenram A (1981) Relationship between plasma insulin levels and high density lipoprotein cholesterol levels in healthy men. Diabetologia 21(6):544–548PubMed
48.
Sadur UN, Yost TJ, Eckel RH (1984) Insulin responsiveness of adipose tissue lipoprotein lipase is delayed but preserved in obesity*. J Clin Endocrinol Metab 59(6):1176–1182PubMedCrossRef
49.
Golay A, Zech L, Shi M-Z, Chiou Y-A, Reaven G, Chen Y-D (1987) High density lipoprotein (HDL) metabolism in noninsulin-dependent diabetes mellitus: measurement of HDL turnover using tritiated HDL*. J Clin Endocrinol Metab 65(3):512–518PubMedCrossRef
50.
Eriksson P, Nilsson L, Karpe F, Hamsten A (1998) Very-low-density lipoprotein response element in the promoter region of the human plasminogen activator inhibitor-1 gene implicated in the impaired fibrinolysis of hypertriglyceridemia. Arterioscler Thromb Vasc Biol 18(1):20–26PubMedCrossRef
51.
Nishikawa T, Edelstein D, Du XL, S-i Yamagishi, Matsumura T, Kaneda Y, Yorek MA, Beebe D, Oates PJ, Hammes H-P (2000) Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404(6779):787–790PubMedCrossRef
52.
Pyörälä K (1979) Relationship of glucose tolerance and plasma insulin to the incidence of coronary heart disease: results from two population studies in Finland. Diabetes Care 2(2):131–141PubMedCrossRef
53.
Després J-P, Lamarche B, Mauriège P, Cantin B, Dagenais GR, Moorjani S, Lupien P-J (1996) Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 334(15):952–958PubMedCrossRef
54.
Suzuki M, Shinozaki K, Kanazawa A, Hara Y, Hattori Y, Tsushima M, Harano Y (1996) Insulin resistance as an independent risk factor for carotid wall thickening. Hypertension 28(4):593–598PubMedCrossRef
55.
Shen D-C, Shieh S-M, Fuh M-T, Wu D-A, Chen Y-D, Reaven G (1988) Resistance to insulin-stimulated-glucose uptake in patients with hypertension*. J Clin Endocrinol Metab 66(3):580–583PubMedCrossRef
56.
Reaven GM, Chang H (1991) Relationship between blood pressure, plasma insulin ana triglyceride concentration, and insulin action in spontaneous hypertensive and Wistar-Kyoto rats. Am J Hypertens 4(1 Pt 1):34–38PubMed
57.
Sechi LA, Melis A, Tedde R (1992) Insulin hypersecretion: a distinctive feature between essential and secondary hypertension. Metabolism 41(11):1261–1266PubMedCrossRef
58.
Reaven G (1996) Hypertension and associated metabolic abnormalities—the role of insulin resistance and the sympathoadrenal system. N Engl J Med 334:374–381PubMedCrossRef
59.
Mitchell TH, Nolan B, Henry M, Cronin C, Baker H, Greely G (1997) Microalbuminuria in patients with non-insulin-dependent diabetes mellitus relates to nocturnal systolic blood pressure. Am J Med 102(6):531–535PubMedCrossRef
60.
Laine H, Yki-Jarvinen H, Kirvela O, Tolvanen T, Raitakari M, Solin O, Haaparanta M, Knuuti J, Nuutila P (1998) Insulin resistance of glucose uptake in skeletal muscle cannot be ameliorated by enhancing endothelium-dependent blood flow in obesity. J Clin Investig 101(5):1156PubMedPubMedCentralCrossRef
61.
62.
Seidell JC, Pérusse L, Després J-P, Bouchard C (2001) Waist and hip circumferences have independent and opposite effects on cardiovascular disease risk factors: the Quebec Family Study. Am J Clin Nutr 74(3):315–321PubMed
63.
Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH (1997) Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 336(14):973–979PubMedCrossRef
64.
Brown NJ, Kim K-S, Chen Y-Q, Blevins LS, Nadeau JH, Meranze SG, Vaughan DE (2000) Synergistic effect of adrenal steroids and angiotensin II on plasminogen activator inhibitor-1 production 1. J Clin Endocrinol Metab 85(1):336–344PubMed
65.
Sowers JR, Sowers PS, Peuler JD (1994) Role of insulin resistance and hyperinsulinemia in development of hypertension and atherosclerosis. J Lab Clin Med 123(5):647–652PubMed
66.
Chen Y-Q, Su M, Walia RR, Hao Q, Covington JW, Vaughan DE (1998) Sp1 sites mediate activation of the plasminogen activator inhibitor-1 promoter by glucose in vascular smooth muscle cells. J Biol Chem 273(14):8225–8231PubMedCrossRef
67.
Westerbacka J, Vehkavaara S, Bergholm R, Wilkinson I, Cockcroft J, Yki-Järvinen H (1999) Marked resistance of the ability of insulin to decrease arterial stiffness characterizes human obesity. Diabetes 48(4):821–827PubMedCrossRef
68.
Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD (1996) Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Investig 97(11):2601PubMedPubMedCentralCrossRef
69.
Després J-P (2006) Abdominal obesity: the most prevalent cause of the metabolic syndrome and related cardiometabolic risk. Eur Heart J Suppl 8(suppl B):B4–B12CrossRef
70.
Steinberger J, Daniels SR (2003) Obesity, insulin resistance, diabetes, and cardiovascular risk in children an American Heart Association scientific statement from the atherosclerosis, hypertension, and obesity in the Young Committee (Council on Cardiovascular Disease in the Young) and the Diabetes Committee (Council on Nutrition, Physical Activity, and Metabolism). Circulation 107(10):1448–1453PubMedCrossRef
71.
Van Gaal LF, Mertens IL, Christophe E (2006) Mechanisms linking obesity with cardiovascular disease. Nature 444(7121):875–880PubMedCrossRef
72.
Turer AT, Hill JA, Elmquist JK, Scherer PE (2012) Adipose tissue biology and cardiomyopathy translational implications. Circ Res 111(12):1565–1577PubMedPubMedCentralCrossRef
73.
Ramkhelawon B, Hennessy EJ, Ménager M, Ray TD, Sheedy FJ, Hutchison S, Wanschel A, Oldebeken S, Geoffrion M, Spiro W (2014) Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity. Nat Med 20(4):377–384PubMedPubMedCentralCrossRef
74.
Sell H, Habich C, Eckel J (2012) Adaptive immunity in obesity and insulin resistance. Nat Rev Endocrinol 8(12):709–716PubMedCrossRef
75.
76.
Borén J, Taskinen MR, Olofsson SO, Levin M (2013) Ectopic lipid storage and insulin resistance: a harmful relationship. J Intern Med 274(1):25–40PubMedCrossRef
77.
Yang R, Barouch LA (2007) Leptin signaling and obesity cardiovascular consequences. Circ Res 101(6):545–559PubMedCrossRef
78.
Lumeng CN, Bodzin JL, Saltiel AR (2007) Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Investig 117(1):175PubMedPubMedCentralCrossRef
79.
Ruan H, Hacohen N, Golub TR, Van Parijs L, Lodish HF (2002) Tumor necrosis factor-α suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes nuclear factor-κB activation by TNF-α is obligatory. Diabetes 51(5):1319–1336PubMedCrossRef
80.
Permana PA, Menge C, Reaven PD (2006) Macrophage-secreted factors induce adipocyte inflammation and insulin resistance. Biochem Biophys Res Commun 341(2):507–514PubMedCrossRef
81.
Schächinger V, Britten MB, Zeiher AM (2000) Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 101(16):1899–1906PubMedCrossRef
82.
Bugiardini R, Manfrini O, Pizzi C, Fontana F, Morgagni G (2004) Endothelial function predicts future development of coronary artery disease a study of women with chest pain and normal coronary angiograms. Circulation 109(21):2518–2523PubMedCrossRef
83.
Han S, Liang C-P, DeVries-Seimon T, Ranalletta M, Welch CL, Collins-Fletcher K, Accili D, Tabas I, Tall AR (2006) Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions. Cell Metab 3(4):257–266PubMedCrossRef
84.
Kuboki K, Jiang ZY, Takahara N, Ha SW, Igarashi M, Yamauchi T, Feener EP, Herbert TP, Rhodes CJ, King GL (2000) Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo a specific vascular action of insulin. Circulation 101(6):676–681PubMedCrossRef
85.
Hamsten A, Wiman B, de Faire U, Blombäck M (1985) Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction. N Engl J Med 313(25):1557–1563PubMedCrossRef
86.
Wiman B, Andersson T, Hallqvist J, Reuterwall C, Ahlbom A (2000) Plasma levels of tissue plasminogen activator/plasminogen activator inhibitor-1 complex and von Willebrand factor are significant risk markers for recurrent myocardial infarction in the Stockholm Heart Epidemiology Program (SHEEP) study. Arterioscler Thromb Vasc Biol 20(8):2019–2023PubMedCrossRef
87.
Calles-Escandon J, Mirza SA, Sobel BE, Schneider DJ (1998) Induction of hyperinsulinemia combined with hyperglycemia and hypertriglyceridemia increases plasminogen activator inhibitor 1 in blood in normal human subjects. Diabetes 47(2):290–293PubMedCrossRef
88.
Bertrand L, Horman S, Beauloye C, Vanoverschelde J-L (2008) Insulin signalling in the heart. Cardiovasc Res 79(2):238–248PubMedCrossRef
89.
Randle P, Garland P, Hales C, Newsholme E (1963) The glucose fatty-acid cycle its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 281(7285):785–789CrossRef
90.
Proud C (2007) Signalling to translation: how signal transduction pathways control the protein synthetic machinery. Biochem J 403:217–234PubMedCrossRef
91.
Heineke J, Molkentin JD (2006) Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol 7(8):589–600PubMedCrossRef
92.
Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM (1999) Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399(6736):601–605PubMedCrossRef
93.
McFarlane SI, Banerji M, Sowers JR (2001) Insulin resistance and cardiovascular disease. J Clin Endocrinol Metab 86(2):713–718PubMed
94.
Mehta PK, Griendling KK (2007) Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol 292(1):C82–C97PubMedCrossRef
95.
Lowell BB, Shulman GI (2005) Mitochondrial dysfunction and type 2 diabetes. Science 307(5708):384–387PubMedCrossRef
96.
Kim YJ, Park T (2008) Genes are differentially expressed in the epididymal fat of rats rendered obese by a high-fat diet. Nutr Res 28(6):414–422PubMedCrossRef
97.
Dong F, Li Q, Sreejayan N, Nunn JM, Ren J (2007) Metallothionein prevents high-fat diet-induced cardiac contractile dysfunction role of peroxisome proliferator-activated receptor γ coactivator 1α and mitochondrial biogenesis. Diabetes 56(9):2201–2212PubMedCrossRef
98.
Garcia-Roves P, Huss JM, Han D-H, Hancock CR, Iglesias-Gutierrez E, Chen M, Holloszy JO (2007) Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle. Proc Natl Acad Sci 104(25):10709–10713PubMedPubMedCentralCrossRef
99.
Hancock CR, Han D-H, Chen M, Terada S, Yasuda T, Wright DC, Holloszy JO (2008) High-fat diets cause insulin resistance despite an increase in muscle mitochondria. Proc Natl Acad Sci 105(22):7815–7820PubMedPubMedCentralCrossRef
100.
Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI (2004) Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 350(7):664–671PubMedPubMedCentralCrossRef
101.
Huo L, Scarpulla RC (2001) Mitochondrial DNA instability and peri-implantation lethality associated with targeted disruption of nuclear respiratory factor 1 in mice. Mol Cell Biol 21(2):644–654PubMedPubMedCentralCrossRef
102.
Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R (2003) Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc Natl Acad Sci 100(14):8466–8471PubMedPubMedCentralCrossRef
103.
Mootha VK, Lindgren CM, Eriksson K-F, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstråle M, Laurila E (2003) PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34(3):267–273PubMedCrossRef
104.
Russell LK, Mansfield CM, Lehman JJ, Kovacs A, Courtois M, Saffitz JE, Medeiros DM, Valencik ML, McDonald JA, Kelly DP (2004) Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1α promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner. Circ Res 94(4):525–533PubMedCrossRef
105.
Lehman JJ, Barger PM, Kovacs A, Saffitz JE, Medeiros DM, Kelly DP (2000) Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Investig 106(7):847PubMedPubMedCentralCrossRef
106.
Huss JM, Kelly DP (2004) Nuclear receptor signaling and cardiac energetics. Circ Res 95(6):568–578PubMedCrossRef
107.
Kelly DP, Scarpulla RC (2004) Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev 18(4):357–368PubMedCrossRef
108.
Garnier A, Fortin D, Delomenie C, Momken I, Veksler V, Ventura-Clapier R (2003) Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles. J Physiol 551(2):491–501PubMedPubMedCentralCrossRef
109.
Ritz P, Berrut G (2005) Mitochondrial function, energy expenditure, aging and insulin resistance. Diabetes Metab 31:5S67–65S73PubMedCrossRef
110.
Savage DB, Petersen KF, Shulman GI (2005) Mechanisms of insulin resistance in humans and possible links with inflammation. Hypertension 45(5):828–833PubMedCrossRef
111.
J-a Kim, Wei Y, Sowers JR (2008) Role of mitochondrial dysfunction in insulin resistance. Circ Res 102(4):401–414CrossRef
112.
113.
Mather KJ, Lteif A, Steinberg HO, Baron AD (2004) Interactions between endothelin and nitric oxide in the regulation of vascular tone in obesity and diabetes. Diabetes 53(8):2060–2066PubMedCrossRef
114.
Ting HH, Timimi FK, Boles KS, Creager SJ, Ganz P, Creager MA (1996) Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Investig 97(1):22PubMedPubMedCentralCrossRef
115.
Chen H, Montagnani M, Funahashi T, Shimomura I, Quon MJ (2003) Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem 278(45):45021–45026PubMedCrossRef
116.
Whaley-Connell A, Govindarajan G, Habibi J, Hayden MR, Cooper SA, Wei Y, Ma L, Qazi M, Link D, Karuparthi PR (2007) Angiotensin II-mediated oxidative stress promotes myocardial tissue remodeling in the transgenic (mRen2) 27 Ren2 rat. Am J Physiol Endocrinol Metab 293(1):E355–E363PubMedCrossRef
117.
Koh KK, Quon MJ, Han SH, Chung W-J, Ahn JY, Seo Y-H, Choi IS, Shin EK (2005) Additive beneficial effects of fenofibrate combined with atorvastatin in the treatment of combined hyperlipidemia. J Am Coll Cardiol 45(10):1649–1653PubMedCrossRef
Metadaten
Titel
Insulin resistance: an additional risk factor in the pathogenesis of cardiovascular disease in type 2 diabetes
verfasst von
Tushar P. Patel
Komal Rawal
Ashim K. Bagchi
Gauri Akolkar
Nathalia Bernardes
Danielle da Silva Dias
Sarita Gupta
Pawan K. Singal
Publikationsdatum
01.01.2016
Verlag
Springer US
Erschienen in
Heart Failure Reviews / Ausgabe 1/2016
Print ISSN: 1382-4147
Elektronische ISSN: 1573-7322
DOI
https://doi.org/10.1007/s10741-015-9515-6

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