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01.03.2008 | Lab Investigation-human/animal tissue

Implicating chromosomal aberrations with meningioma growth and recurrence: results from FISH and MIB-I analysis of grades I and II meningioma tissue

verfasst von: Wolfgang K. Pfisterer, Stephen W. Coons, Fahmy Aboul-Enein, William P. Hendricks, Adrienne C. Scheck, Mark C. Preul

Erschienen in: Journal of Neuro-Oncology | Ausgabe 1/2008

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Abstract

The fluorescence in situ hybridization (FISH) technique was used in 111 WHO grades I and II meningioma patients. Clinical, radiological, pathological, and immunohistochemical data were compared to aberrations of chromosomes 1p, 14q, and 22q determined by FISH. Significant differences for MIB-1 labeling were found between grades I and II tumors (p < 0.001), and between grade I tumors that recurred and those that did not recur (p < 0.001). Chromosomal aberrations were detected with FISH analysis in nearly 50% of grade I, and in 93% of grade II meningiomas. The numbers of chromosomal aberrations correlated significantly to MIB-1 (p < 0.001), with signs of grossly invasive tumor growth (p < 0.001), and with tumor recurrence (p < 0.01). The findings suggest that adding FISH analysis may allow better prediction of possible meningioma recurrence and may be a useful adjunct for therapy decisions.

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Titel: Implicating chromosomal aberrations with meningioma growth and recurrence: results from FISH and MIB-I analysis of grades I and II meningioma tissue
verfasst von: Wolfgang K. Pfisterer
Stephen W. Coons
Fahmy Aboul-Enein
William P. Hendricks
Adrienne C. Scheck
Mark C. Preul
Publikationsdatum: 01.03.2008
Verlag: Springer US
Erschienen in: Journal of Neuro-Oncology / Ausgabe 1/2008
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-007-9498-9

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