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Journal of Neuro-Oncology

Erschienen in:

01.07.2015 | Editors' Invited Manuscript

The role of checkpoints in the treatment of GBM

verfasst von: Jennifer E. Kim, Michael Lim

Erschienen in: Journal of Neuro-Oncology | Ausgabe 3/2015

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Abstract

Targeted immunotherapy is founded on the principle that augmentation of effector T cell activity in the tumor microenvironment can translate to tumor regression. Targeted checkpoint inhibitors in the form of agonist or antagonist monoclonal antibodies have come to the fore as a promising strategy to activate systemic immunity and enhance T cell activity by blocking negative signals, enhancing positive signals, or altering the cytokine milieu. This review will examine several immune checkpoints and checkpoint modulators that play a role in cancer pathogenesis, with an emphasis on malignant gliomas.

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Titel: The role of checkpoints in the treatment of GBM
verfasst von: Jennifer E. Kim
Michael Lim
Publikationsdatum: 01.07.2015
Verlag: Springer US
Erschienen in: Journal of Neuro-Oncology / Ausgabe 3/2015
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-015-1747-8

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