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13.03.2019 | Clinical Study

Fertility treatment is associated with multiple meningiomas and younger age at diagnosis

verfasst von: Maryam N. Shahin, Stephen T. Magill, Cecilia L. Dalle Ore, Jennifer A. Viner, Pamela N. Peters, David A. Solomon, Michael W. McDermott

Erschienen in: Journal of Neuro-Oncology | Ausgabe 1/2019

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Abstract

Purpose

Meningiomas are more common in females and 70–80% express the progesterone receptor, raising the possibility that highdose exogenous estrogen/progesterone exposure, such as occurs during fertility treatments, may increase the risk of developing a meningioma. The goal of this study was to report the incidence of prior fertility treatment in a consecutive series of female meningioma patients.

Methods

A retrospective review (2015–2018) was performed of female patients with meningioma, and those with prior fertility treatment were compared to those without fertility treatment using standard statistical methods.

Results

Of 206 female patients with meningioma, 26 (12.6%) had a history of fertility treatments. Patients underwent various forms of assisted reproductive technology including: in vitro fertilization (50.0%), clomiphene with or without intrauterine insemination (34.6%), and unspecified (19.2%). Median follow up was 1.8 years. Tumors were WHO grade I (78.6%) or grade II (21.4%). Patients who underwent fertility treatments presented at significantly younger mean age compared to those who had not (51.8 vs. 57.3 years, p = 0.0135, 2tailed Ttest), and on multivariate analysis were more likely to have multiple meningiomas (OR 4.97, 95% CI 1.4–18.1, p = 0.0154) and convexity/falx meningiomas (OR 4.45, 95% CI 1.7–11.5, p = 0.0021).

Conclusions

Patients in this cohort with a history of fertility treatment were more likely to present at a younger age and have multiple and convexity/falx meningiomas, emphasizing the importance of taking estrogen/progesterone exposure history when evaluating patients with meningioma. Future clinical studies at other centers in larger populations and laboratory investigations are needed to determine the role of fertility treatment in meningioma development.

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Titel: Fertility treatment is associated with multiple meningiomas and younger age at diagnosis
verfasst von: Maryam N. Shahin
Stephen T. Magill
Cecilia L. Dalle Ore
Jennifer A. Viner
Pamela N. Peters
David A. Solomon
Michael W. McDermott
Publikationsdatum: 13.03.2019
Verlag: Springer US
Erschienen in: Journal of Neuro-Oncology / Ausgabe 1/2019
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-019-03147-6

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