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01.01.2014 | Original Article

Metabolism of the newly encountered designer drug α-pyrrolidinovalerophenone in humans: identification and quantitation of urinary metabolites

verfasst von: Noriaki Shima, Munehiro Katagi, Hiroe Kamata, Shuntaro Matsuta, Keiko Sasaki, Tohru Kamata, Hiroshi Nishioka, Akihiro Miki, Michiaki Tatsuno, Kei Zaitsu, Akira Ishii, Takako Sato, Hitoshi Tsuchihashi, Koichi Suzuki

Erschienen in: Forensic Toxicology | Ausgabe 1/2014

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Abstract

Urinary metabolites of α-pyrrolidinovalerophenone (α-PVP) in humans were investigated by analyzing urine specimens obtained from abusers. Unambiguous identification and accurate quantification of major metabolites were realized using gas chromatography–mass spectrometry and liquid chromatography-tandem mass spectrometry with newly synthesized authentic standards. Two major metabolic pathways were revealed: (1) the reduction of the β-keto moiety to 1-phenyl-2-(pyrrolidin-1-yl)pentan-1-ol (OH-α-PVP, diastereomers) partly followed by conjugation to its glucuronide, and (2) the oxidation at the 2″-position of the pyrrolidine ring to α-(2″-oxo-pyrrolidino)valerophenone (2″-oxo-α-PVP) via the putative intermediate α-(2″-hydroxypyrrolidino)valerophenone (2″-OH-α-PVP). Of the metabolites retaining the structural characteristics of the parent drug, OH-α-PVP was most abundant in most of the specimens examined.

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Titel: Metabolism of the newly encountered designer drug α-pyrrolidinovalerophenone in humans: identification and quantitation of urinary metabolites
verfasst von: Noriaki Shima
Munehiro Katagi
Hiroe Kamata
Shuntaro Matsuta
Keiko Sasaki
Tohru Kamata
Hiroshi Nishioka
Akihiro Miki
Michiaki Tatsuno
Kei Zaitsu
Akira Ishii
Takako Sato
Hitoshi Tsuchihashi
Koichi Suzuki
Publikationsdatum: 01.01.2014
Verlag: Springer Japan
Erschienen in: Forensic Toxicology / Ausgabe 1/2014
Print ISSN: 1860-8965
Elektronische ISSN: 1860-8973
DOI: https://doi.org/10.1007/s11419-013-0202-9

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Metabolism of the newly encountered designer drug α-pyrrolidinovalerophenone in humans: identification and quantitation of urinary metabolites

Abstract

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Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

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