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Current Osteoporosis Reports
Erschienen in: Current Osteoporosis Reports 3/2012

01.09.2012 | Bone Genetics (S Ferrari, Section Editor)

Genetics and the Individualized Prediction of Fracture

verfasst von: Tuan V. Nguyen, John A. Eisman

Erschienen in: Current Osteoporosis Reports | Ausgabe 3/2012

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Abstract

Recent genome-wide association studies have identified many genetic variants associated with fracture risk. These genetic variants are common in the general population but have very modest effect sizes. A remaining challenge is to translate these genetic variant discoveries to better predict the risk of fracture based on an individual’s genetic profile (ie, individualized risk assessment). Empirical and simulation studies have shown that 1) the utility of a single genetic variant for fracture risk assessment is very limited; but 2) a profile of 50 genetic variants, each with odds ratio ranging from 1.02 to 1.15, can improve the accuracy of fracture prediction and classification beyond that obtained by conventional clinical risk factors. These results are consistent with the view that genetic profiling, when integrated in existing risk assessment models, can inform a more accurate prediction of fracture risk in an individual.
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Metadaten
Titel
Genetics and the Individualized Prediction of Fracture
verfasst von
Tuan V. Nguyen
John A. Eisman
Publikationsdatum
01.09.2012
Verlag
Current Science Inc.
Erschienen in
Current Osteoporosis Reports / Ausgabe 3/2012
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-012-0113-4

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