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Current Osteoporosis Reports
Erschienen in: Current Osteoporosis Reports 6/2016

06.10.2016 | Bone and Diabetes (A Schwartz and P Vestergaard, Section Editors)

Diabetes and Bone Marrow Adiposity

verfasst von: Tiffany Y. Kim, Anne L. Schafer

Erschienen in: Current Osteoporosis Reports | Ausgabe 6/2016

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Abstract

Purpose of Review

This study aims to describe bone marrow fat changes in diabetes and to discuss the potential role of marrow fat in skeletal fragility.

Recent Findings

Advances in non-invasive imaging have facilitated marrow fat research in humans. In contrast to animal studies which clearly demonstrate higher levels of marrow fat in diabetes, human studies have shown smaller and less certain differences. Marrow fat has been reported to correlate with A1c, and there may be a distinct marrow lipid saturation profile in diabetes.

Summary

Greater marrow fat is associated with impaired skeletal health. Marrow fat may be a mediator of skeletal fragility in diabetes. Circulating lipids, growth hormone alterations, visceral adiposity, and hypoleptinemia have been associated with greater marrow fat and may represent potential mechanisms for the putative effects of diabetes on marrow fat, although other factors likely contribute. Additional research is needed to further define the role of marrow fat in diabetic skeletal fragility and to determine whether marrow fat is a therapeutic target.
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Metadaten
Titel
Diabetes and Bone Marrow Adiposity
verfasst von
Tiffany Y. Kim
Anne L. Schafer
Publikationsdatum
06.10.2016
Verlag
Springer US
Erschienen in
Current Osteoporosis Reports / Ausgabe 6/2016
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-016-0336-x

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