Skip to main content
Erschienen in: Current Pain and Headache Reports 2/2015

01.02.2015 | Uncommon and/or Unusual Headaches and Syndromes (J Ailani, Section Editor)

Hemiplegia and Headache: a Review of Hemiplegia in Headache Disorders

verfasst von: J. Ivan Lopez, Ashley Holdridge, John F. Rothrock

Erschienen in: Current Pain and Headache Reports | Ausgabe 2/2015

Einloggen, um Zugang zu erhalten

Abstract

The most common scenario wherein the practicing neurologist is likely to encounter a patient with headache and hemiplegia will vary depending on his/her specific type of practice. A neurologist providing consultative service to an emergency department is far more likely to see patients with “secondary” headache and hemiplegia in the setting of either ischemic or hemorrhagic stroke than hemiplegia as a transient feature of a primary headache disorder. Neurologists subspecializing in headache medicine who practice in a tertiary referral headache clinic are more likely to encounter hemiplegic migraine, but even in that clinical setting hemiplegic migraine is by no means a frequent diagnosis. The acute onset of hemiplegia can be very frightening not only to the patient but also to the medical personnel. Given the abundance of mimicry, practitioners must judiciously ascertain the correct diagnosis as treatment may greatly vary depending on the cause of both headache and hemiplegia. In this review, we will address the most common causes of hemiplegia associated with headache.
Literatur
1.
Zurück zum Zitat Ferro J, Canhao P, Stam J, et al. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke. 2004;35(3):664–70.CrossRefPubMed Ferro J, Canhao P, Stam J, et al. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke. 2004;35(3):664–70.CrossRefPubMed
2.
Zurück zum Zitat Rasmussen BK, Olesen J. Symptomatic and nonsymptomatic headaches in a general population. Neurology. 1992;42:1225–31.CrossRefPubMed Rasmussen BK, Olesen J. Symptomatic and nonsymptomatic headaches in a general population. Neurology. 1992;42:1225–31.CrossRefPubMed
3.
Zurück zum Zitat Mackey J. Evaluation and management of stroke in young adults. Continuum. 2014;20(2):352–69.PubMed Mackey J. Evaluation and management of stroke in young adults. Continuum. 2014;20(2):352–69.PubMed
4.
Zurück zum Zitat Vahedi K, Chabriat H, Levy C, et al. Migraine with aura and brain magnetic resonance imaging abnormalities in patients with CADASIL. Arch Neurol. 2004;61(8):1237–40.PubMed Vahedi K, Chabriat H, Levy C, et al. Migraine with aura and brain magnetic resonance imaging abnormalities in patients with CADASIL. Arch Neurol. 2004;61(8):1237–40.PubMed
5.
Zurück zum Zitat Pavlakis SG, Phillips PC, DiMauro S, et al. Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: a distinctive clinical syndrome. Ann Neurol. 1984;16(4):481–8.CrossRefPubMed Pavlakis SG, Phillips PC, DiMauro S, et al. Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: a distinctive clinical syndrome. Ann Neurol. 1984;16(4):481–8.CrossRefPubMed
6.
Zurück zum Zitat Runchey S, McGee S. Does this patient have a hemorrhagic stroke? Clinical findings distinguishing hemorrhagic stroke from ischemic stroke. JAMA. 2010;30:2280–6.CrossRef Runchey S, McGee S. Does this patient have a hemorrhagic stroke? Clinical findings distinguishing hemorrhagic stroke from ischemic stroke. JAMA. 2010;30:2280–6.CrossRef
7.
Zurück zum Zitat Viana M, Sprenger T, Andelova M, et al. The typical duration of migraine aura: a systematic review. Cephalalgia. 2013;33:483–90.CrossRefPubMed Viana M, Sprenger T, Andelova M, et al. The typical duration of migraine aura: a systematic review. Cephalalgia. 2013;33:483–90.CrossRefPubMed
8.
Zurück zum Zitat Ward T. Migraine diagnosis and pathophysiology. Contin Lifelong Learn Neurol. 2012;18(2):753–4.CrossRef Ward T. Migraine diagnosis and pathophysiology. Contin Lifelong Learn Neurol. 2012;18(2):753–4.CrossRef
9.••
Zurück zum Zitat The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33:629–808. This is the newest classification of headache disorders and everyone interested in headaches should be familiar with this classification. The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33:629–808. This is the newest classification of headache disorders and everyone interested in headaches should be familiar with this classification.
10.
Zurück zum Zitat Akerman S, Holland PR, Goadsby PJ. Diencephalic and brainstem mechanisms in migraine. Nat Rev Neurosci. 2011;12:570–84.CrossRefPubMed Akerman S, Holland PR, Goadsby PJ. Diencephalic and brainstem mechanisms in migraine. Nat Rev Neurosci. 2011;12:570–84.CrossRefPubMed
11.
Zurück zum Zitat Zhang X, Levy D, Noseda R, et al. Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. J Neurosci. 2010;30:8807–14.CrossRefPubMedCentralPubMed Zhang X, Levy D, Noseda R, et al. Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. J Neurosci. 2010;30:8807–14.CrossRefPubMedCentralPubMed
12.•
Zurück zum Zitat Eikerman-Haerter K. Spreading depolarizing may link migraine and stroke. Headache. 2014;54:1146–57. Insightful article on the link between migraine and stroke. CrossRef Eikerman-Haerter K. Spreading depolarizing may link migraine and stroke. Headache. 2014;54:1146–57. Insightful article on the link between migraine and stroke. CrossRef
13.
Zurück zum Zitat Tzouri C, Tehindrazanarivelo A, Iglesias S, et al. Case–control study of migraine and risk of ischemic stroke in young women. BMJ. 1995;310:830–3.CrossRef Tzouri C, Tehindrazanarivelo A, Iglesias S, et al. Case–control study of migraine and risk of ischemic stroke in young women. BMJ. 1995;310:830–3.CrossRef
14.
Zurück zum Zitat Buring J, Hebert P, Romero J, et al. Migraine and subsequent risk of stroke in the Physician’s Health Study. Arch Neurol. 1995;52:129–34.CrossRefPubMed Buring J, Hebert P, Romero J, et al. Migraine and subsequent risk of stroke in the Physician’s Health Study. Arch Neurol. 1995;52:129–34.CrossRefPubMed
15.
Zurück zum Zitat Merikangas K, Fenton B, Cheng S, et al. Association between migraine and stroke in a large-scale epidemiological study of the United States. Arch Neurol. 1997;54:362–8.CrossRefPubMed Merikangas K, Fenton B, Cheng S, et al. Association between migraine and stroke in a large-scale epidemiological study of the United States. Arch Neurol. 1997;54:362–8.CrossRefPubMed
16.
Zurück zum Zitat Kurth T, Slomke M, Kase C, et al. Migraine, headache and the risk of stroke in women: a prospective study. Neurology. 2005;64:1020–6.CrossRefPubMed Kurth T, Slomke M, Kase C, et al. Migraine, headache and the risk of stroke in women: a prospective study. Neurology. 2005;64:1020–6.CrossRefPubMed
17.
Zurück zum Zitat Headache Classification Committee of the International Headache Society. ICHD-II abbreviated pocket version. Cephalalgia. 2004;24 Suppl 1:1–160. Headache Classification Committee of the International Headache Society. ICHD-II abbreviated pocket version. Cephalalgia. 2004;24 Suppl 1:1–160.
18.
Zurück zum Zitat Russell MB, Ducros A. Sporadic and familial hemiplegic migraine: pathophysiological mechanisms, clinical characteristics, diagnosis, and management. Lancet Neurol. 2011;10:457–70.CrossRefPubMed Russell MB, Ducros A. Sporadic and familial hemiplegic migraine: pathophysiological mechanisms, clinical characteristics, diagnosis, and management. Lancet Neurol. 2011;10:457–70.CrossRefPubMed
19.
Zurück zum Zitat Heron SE, Dibbens LM. Role of PRRT2 in common paroxysmal neurological disorders: a gene with remarkable pleiotropy. J Med Genet. 2013;50:133–9.CrossRefPubMed Heron SE, Dibbens LM. Role of PRRT2 in common paroxysmal neurological disorders: a gene with remarkable pleiotropy. J Med Genet. 2013;50:133–9.CrossRefPubMed
20.
Zurück zum Zitat Riant F, Roze E, Barbance C, et al. PRRT2 mutations cause hemiplegic migraine. Neurology. 2012;79:2122–4.CrossRefPubMed Riant F, Roze E, Barbance C, et al. PRRT2 mutations cause hemiplegic migraine. Neurology. 2012;79:2122–4.CrossRefPubMed
21.
Zurück zum Zitat Marini C, Conti V, Mei D, et al. PRRT2 mutations in familial infantile seizures, paroxysmal dyskinesia, and hemiplegic migraine. Neurology. 2012;79:2109–14.CrossRefPubMedCentralPubMed Marini C, Conti V, Mei D, et al. PRRT2 mutations in familial infantile seizures, paroxysmal dyskinesia, and hemiplegic migraine. Neurology. 2012;79:2109–14.CrossRefPubMedCentralPubMed
22.
Zurück zum Zitat Pelzer N, de Vries B, Kamphorst J, et al. PRRT2 and hemiplegic migraine: a complex association. Neurology. 2014;83:288–90.CrossRefPubMed Pelzer N, de Vries B, Kamphorst J, et al. PRRT2 and hemiplegic migraine: a complex association. Neurology. 2014;83:288–90.CrossRefPubMed
23.
Zurück zum Zitat Fedak EM, Zumberge NA, Heyer GL. The diagnostic role for susceptibility-weighted MRI during sporadic hemiplegic migraine. Cephalalgia. 2013;0(0):1–6. Fedak EM, Zumberge NA, Heyer GL. The diagnostic role for susceptibility-weighted MRI during sporadic hemiplegic migraine. Cephalalgia. 2013;0(0):1–6.
24.
Zurück zum Zitat Hansen JM, Schytz HW, Larsen VA, et al. Hemiplegic migraine aura with cerebral hypoperfusion: imaging in the acute phase. Headache. 2011;51:1289–96.CrossRefPubMed Hansen JM, Schytz HW, Larsen VA, et al. Hemiplegic migraine aura with cerebral hypoperfusion: imaging in the acute phase. Headache. 2011;51:1289–96.CrossRefPubMed
25.
Zurück zum Zitat Lizuka T, Takahashi Y, Sato M, et al. Neurovascular changes in prolonged migraine aura in FHM with a novel ATP1A2 gene mutation. J Neurol Neurosurg Psychiatry. 2011. doi:10.1136/jnnp-2011-300843. Lizuka T, Takahashi Y, Sato M, et al. Neurovascular changes in prolonged migraine aura in FHM with a novel ATP1A2 gene mutation. J Neurol Neurosurg Psychiatry. 2011. doi:10.​1136/​jnnp-2011-300843.
26.
Zurück zum Zitat Mourand I, Menjot de Champfleur N, Carra-Dalleiere C, et al. Perfusion-weighted imaging in persistent hemiplegic migraine. Neuroradiology. 2012;54:255–60.CrossRefPubMed Mourand I, Menjot de Champfleur N, Carra-Dalleiere C, et al. Perfusion-weighted imaging in persistent hemiplegic migraine. Neuroradiology. 2012;54:255–60.CrossRefPubMed
27.
Zurück zum Zitat Sugrue G, Bolster F, Crosbie I, Kavanagh E. Hemiplegic migraine: neuroimaging findings during a hemiplegic migraine attack. Headache. 2014;54:716–8.CrossRefPubMed Sugrue G, Bolster F, Crosbie I, Kavanagh E. Hemiplegic migraine: neuroimaging findings during a hemiplegic migraine attack. Headache. 2014;54:716–8.CrossRefPubMed
29.
Zurück zum Zitat Shevel E. Arterial surgery for sporadic hemiplegic migraine: preliminary results. Br J Oral Maxillofac Surg. 2014;52:405–8.CrossRefPubMed Shevel E. Arterial surgery for sporadic hemiplegic migraine: preliminary results. Br J Oral Maxillofac Surg. 2014;52:405–8.CrossRefPubMed
30.
Zurück zum Zitat Tentschert S, Wimmer R, Greisenegger S, Lang W, Lalouschek W. Headache at stroke onset in 2196 patients with ischemic stroke or transient ischemic attack. Stroke. 2005;36:e1–3.CrossRefPubMed Tentschert S, Wimmer R, Greisenegger S, Lang W, Lalouschek W. Headache at stroke onset in 2196 patients with ischemic stroke or transient ischemic attack. Stroke. 2005;36:e1–3.CrossRefPubMed
31.
Zurück zum Zitat Gorelick P, Hier D, Caplan L, et al. Headache in acute cerebrovascular disease. Neurology. 1986;36:1445–50.CrossRefPubMed Gorelick P, Hier D, Caplan L, et al. Headache in acute cerebrovascular disease. Neurology. 1986;36:1445–50.CrossRefPubMed
32.
33.
Zurück zum Zitat Jorgenson H, Jespersen H, Nakayama H, et al. Headache and stroke: the Copenhagen stroke study. Neurology. 1994;44:1793–7.CrossRef Jorgenson H, Jespersen H, Nakayama H, et al. Headache and stroke: the Copenhagen stroke study. Neurology. 1994;44:1793–7.CrossRef
34.
Zurück zum Zitat Evans R, Mitsias P. Headache at the onset of acute cerebral ischemia. Headache. 2009;49:902–8.CrossRefPubMed Evans R, Mitsias P. Headache at the onset of acute cerebral ischemia. Headache. 2009;49:902–8.CrossRefPubMed
35.
Zurück zum Zitat Fisher C. Headache in cerebrovascular disease. In: Vinken P, Bruyn G, editors. Handbook of clinical neurology, vol. 5. Amsterdam: North Holland Publishing; 1968. p. 124. Fisher C. Headache in cerebrovascular disease. In: Vinken P, Bruyn G, editors. Handbook of clinical neurology, vol. 5. Amsterdam: North Holland Publishing; 1968. p. 124.
36.
Zurück zum Zitat Medina J, Diamond S, Rubino S. Headaches in patients with transient ischemic attacks. Headache. 1975;15:194.CrossRefPubMed Medina J, Diamond S, Rubino S. Headaches in patients with transient ischemic attacks. Headache. 1975;15:194.CrossRefPubMed
37.
38.
Zurück zum Zitat Ferro J, Melo T, Oliveiro A, et al. A multivariate study of headache associated with ischemic stroke. Headache. 1995;35:315–9.CrossRefPubMed Ferro J, Melo T, Oliveiro A, et al. A multivariate study of headache associated with ischemic stroke. Headache. 1995;35:315–9.CrossRefPubMed
39.
Zurück zum Zitat Pickard J, Mackenzie E, Harper A. Serotonin and prostaglandins: intracranial and extracranial effects with reference to migraine. In: Green R, editor. Current concepts in migraine research. New York: Raven; 1978. p. 101. Pickard J, Mackenzie E, Harper A. Serotonin and prostaglandins: intracranial and extracranial effects with reference to migraine. In: Green R, editor. Current concepts in migraine research. New York: Raven; 1978. p. 101.
40.
Zurück zum Zitat Murinova N, Krashin D, Lucas S. Vascular risk in migraineurs: interaction of endothelial and cortical excitability factors. Headache. 2012;54:583–90.CrossRef Murinova N, Krashin D, Lucas S. Vascular risk in migraineurs: interaction of endothelial and cortical excitability factors. Headache. 2012;54:583–90.CrossRef
41.
Zurück zum Zitat Silbert P, Mokri B, Schievink W. Headache and neck pain in spontaneous internal carotid and vertebral artery dissections. Neurology. 1995;45:1517–22.CrossRefPubMed Silbert P, Mokri B, Schievink W. Headache and neck pain in spontaneous internal carotid and vertebral artery dissections. Neurology. 1995;45:1517–22.CrossRefPubMed
42.
Zurück zum Zitat Mokri B, Sundt T, House O. Spontaneous internal carotid dissection, hemicrania and Horner’s syndrome. Mokri B, Sundt T, House O. Spontaneous internal carotid dissection, hemicrania and Horner’s syndrome.
43.
Zurück zum Zitat Girot M, Ferro JM, Canhao P, et al. Predictors of outcome in patients with cerebral venous thrombosis and intracerebral hemorrhage. Stroke. 2007;38(2):337–42.CrossRefPubMed Girot M, Ferro JM, Canhao P, et al. Predictors of outcome in patients with cerebral venous thrombosis and intracerebral hemorrhage. Stroke. 2007;38(2):337–42.CrossRefPubMed
44.
Zurück zum Zitat Bousser M, Barnett H. Cerebral venous thrombosis. In: Barnett H, Mohr J, Stein B, et al., editors. Stroke: pathology, diagnosis and management. 2nd ed. New York: Churchill and Livingston; 1992. p. 522. Bousser M, Barnett H. Cerebral venous thrombosis. In: Barnett H, Mohr J, Stein B, et al., editors. Stroke: pathology, diagnosis and management. 2nd ed. New York: Churchill and Livingston; 1992. p. 522.
45.
Zurück zum Zitat Bousser M, Chiras J, Sauron B, et al. Cerebral venous thrombosis: a review of 38 cases. Stroke. 1985;16:199–213.CrossRefPubMed Bousser M, Chiras J, Sauron B, et al. Cerebral venous thrombosis: a review of 38 cases. Stroke. 1985;16:199–213.CrossRefPubMed
46.
Zurück zum Zitat Levine S, Twyman R, Gilman S. The role of anticoagulation in cavernous sinus thrombosis. Neurology. 1988;38:517–22.CrossRefPubMed Levine S, Twyman R, Gilman S. The role of anticoagulation in cavernous sinus thrombosis. Neurology. 1988;38:517–22.CrossRefPubMed
47.
Zurück zum Zitat Kelly AG. Unruptured intracranial aneurysms: screening and management. Continuum. 2014;20(2):387–98.PubMed Kelly AG. Unruptured intracranial aneurysms: screening and management. Continuum. 2014;20(2):387–98.PubMed
48.
Zurück zum Zitat Green MW. Secondary headaches. Contin Lifelong Learn Neurol. 2012;18(4):783–95.CrossRef Green MW. Secondary headaches. Contin Lifelong Learn Neurol. 2012;18(4):783–95.CrossRef
49.
Zurück zum Zitat Barrett KM, Meschia JF. Genetic stroke syndromes. Continuum. 2014;20(2):339–411. Barrett KM, Meschia JF. Genetic stroke syndromes. Continuum. 2014;20(2):339–411.
50.
Zurück zum Zitat Lu-Emerson C, Eichler AF. Brain metastases. Contin Lifelong Learn Neurol. 2012;18(2):295–311.CrossRef Lu-Emerson C, Eichler AF. Brain metastases. Contin Lifelong Learn Neurol. 2012;18(2):295–311.CrossRef
51.
Zurück zum Zitat Rosenfeld MR, Pruit AA. Management of malignant gliomas and primary CNS lymphoma: standard care and future directions. Contin Lifelong Learn Neurol. 2012;18(2):406–15.CrossRef Rosenfeld MR, Pruit AA. Management of malignant gliomas and primary CNS lymphoma: standard care and future directions. Contin Lifelong Learn Neurol. 2012;18(2):406–15.CrossRef
Metadaten
Titel
Hemiplegia and Headache: a Review of Hemiplegia in Headache Disorders
verfasst von
J. Ivan Lopez
Ashley Holdridge
John F. Rothrock
Publikationsdatum
01.02.2015
Verlag
Springer US
Erschienen in
Current Pain and Headache Reports / Ausgabe 2/2015
Print ISSN: 1531-3433
Elektronische ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-014-0471-y

Weitere Artikel der Ausgabe 2/2015

Current Pain and Headache Reports 2/2015 Zur Ausgabe

Antibodies and Other Biological Treatments (M Bigal, Section Editor)

The Development of Therapeutic Monoclonal Antibodies: Overview of the Nonclinical Safety Assessment

Häusliche Gewalt in der orthopädischen Notaufnahme oft nicht erkannt

28.05.2024 Traumatologische Notfälle Nachrichten

In der Notaufnahme wird die Chance, Opfer von häuslicher Gewalt zu identifizieren, von Orthopäden und Orthopädinnen offenbar zu wenig genutzt. Darauf deuten die Ergebnisse einer Fragebogenstudie an der Sahlgrenska-Universität in Schweden hin.

Fehlerkultur in der Medizin – Offenheit zählt!

Darüber reden und aus Fehlern lernen, sollte das Motto in der Medizin lauten. Und zwar nicht nur im Sinne der Patientensicherheit. Eine negative Fehlerkultur kann auch die Behandelnden ernsthaft krank machen, warnt Prof. Dr. Reinhard Strametz. Ein Plädoyer und ein Leitfaden für den offenen Umgang mit kritischen Ereignissen in Medizin und Pflege.

Mehr Frauen im OP – weniger postoperative Komplikationen

21.05.2024 Allgemeine Chirurgie Nachrichten

Ein Frauenanteil von mindestens einem Drittel im ärztlichen Op.-Team war in einer großen retrospektiven Studie aus Kanada mit einer signifikanten Reduktion der postoperativen Morbidität assoziiert.

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

17.05.2024 Klinik aktuell Nachrichten

Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.