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Clinical Reviews in Allergy & Immunology
Erschienen in: Clinical Reviews in Allergy & Immunology 3/2012

01.06.2012

Cutting Edge Issues in Autoimmune Gastritis

verfasst von: Ban-Hock Toh, James Chan, Tin Kyaw, Frank Alderuccio

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 3/2012

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Abstract

Autoimmune gastritis is the outcome of a pathological CD4 T cell-mediated autoimmune response directed against the gastric H/K-ATPase. Silent initially, the gastric lesion becomes manifest in humans by the development of megaloblastic pernicious anemia arising from vitamin B12 deficiency. Cutting edge issues in this disease relate to its epidemiology, immunogenetics, a role for Helicobacter pylori as an infective trigger through molecular mimicry, its immunopathogenesis, associated organ-specific autoimmune diseases, laboratory diagnosis, and approaches to curative therapy.
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Metadaten
Titel
Cutting Edge Issues in Autoimmune Gastritis
verfasst von
Ban-Hock Toh
James Chan
Tin Kyaw
Frank Alderuccio
Publikationsdatum
01.06.2012
Verlag
Humana Press Inc
Erschienen in
Clinical Reviews in Allergy & Immunology / Ausgabe 3/2012
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI
https://doi.org/10.1007/s12016-010-8218-y

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