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Clinical Reviews in Allergy & Immunology

Erschienen in:

01.10.2014

The Mechanisms and Applications of T Cell Vaccination for Autoimmune Diseases: a Comprehensive Review

verfasst von: Xin Huang, Haijing Wu, Qianjin Lu

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 2/2014

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Abstract

Autoimmune diseases (ADs) are a spectrum of diseases originating from loss of immunologic self-tolerance and T cell abnormal autoreactivity, causing organ damage and death. However, the pathogenic mechanism of ADs remains unclear. The current treatments of ADs include nonsteroidal anti-inflammatory drugs (NSAIDS), antimalarials, corticosteroids, immunosuppressive drugs, and biological therapies. With the need to prevent side effects resulting from current treatments and acquire better clinical remission, developing a novel pharmaceutical treatment is extremely urgent. The concept of T cell vaccination (TCV) has been raised as the finding that immunization with attenuated autoreactive T cells is capable of inducing T cell-dependent inhibition of autoimmune responses. TCV may act as an approach to control unwanted adaptive immune response through eliminating the autoreactive T cells. Over the past decades, the effect of TCV has been justified in several animal models of autoimmune diseases including experimental autoimmune encephalomyelitis (EAE), murine autoimmune diabetes in nonobese diabetic (NOD) mice, collagen-induced arthritis (CIA), and so on. Meanwhile, clinical trials of TCV have confirmed the safety and efficacy in corresponding autoimmune diseases ranging from multiple sclerosis (MS) to systemic lupus erythematosus (SLE). This review aims to summarize the ongoing experimental and clinical trials and elucidate possible molecule mechanisms of TCV.

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Titel: The Mechanisms and Applications of T Cell Vaccination for Autoimmune Diseases: a Comprehensive Review
verfasst von: Xin Huang
Haijing Wu
Qianjin Lu
Publikationsdatum: 01.10.2014
Verlag: Springer US
Erschienen in: Clinical Reviews in Allergy & Immunology / Ausgabe 2/2014
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-014-8439-6

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Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.

Betalaktam-Allergie: praxisnahes Vorgehen beim Delabeling

16.05.2024 Pädiatrische Allergologie Nachrichten

Die große Mehrheit der vermeintlichen Penicillinallergien sind keine. Da das „Etikett“ Betalaktam-Allergie oft schon in der Kindheit erworben wird, kann ein frühzeitiges Delabeling lebenslange Vorteile bringen. Ein Team von Pädiaterinnen und Pädiatern aus Kanada stellt vor, wie sie dabei vorgehen.

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Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

The Mechanisms and Applications of T Cell Vaccination for Autoimmune Diseases: a Comprehensive Review

Abstract

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Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

Hörschwäche erhöht Demenzrisiko unabhängig von Beta-Amyloid

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

Betalaktam-Allergie: praxisnahes Vorgehen beim Delabeling

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Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

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Weitere Artikel der Ausgabe 2/2014

Molecular Mechanisms in Autoimmune Type 1 Diabetes: a Critical Review

Erratum to: Molecular Mechanisms in Autoimmune Type 1 Diabetes: a Critical Review

Alteration of Regulatory T Cells in Type 1 Diabetes Mellitus: A Comprehensive Review

NK Cell Trafficking in Health and Autoimmunity:A Comprehensive Review

Stem Cell Therapy in Autoimmune Rheumatic Diseases: a Comprehensive Review

Molecular Biology of Atopic Dermatitis

Neu im Fachgebiet HNO

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

Hörschwäche erhöht Demenzrisiko unabhängig von Beta-Amyloid

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

Betalaktam-Allergie: praxisnahes Vorgehen beim Delabeling

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