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Immunologic Research
Erschienen in: Immunologic Research 1/2021

23.01.2021 | Review

Effects of functionally diverse calpain system on immune cells

verfasst von: Yueqi Chen, Zhaoliang Su, Fang Liu

Erschienen in: Immunologic Research | Ausgabe 1/2021

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Abstract

Calpains are a family of nonlysosomal cysteine proteases, which play important roles in numerous physiological and pathological processes. Locations of them dictates the functions so that they are classified as ubiquitously expressed calpains and tissue-specific calpains. Recent studies are mainly focused on conventional calpains (calpain-1,2) in development and diseases, and increasing people pay attention to other subtypes of calpains but may not been summarized appropriately. Growing evidence suggests that calpains are also involved in immune regulation. However, seldom articles review the regulation of calpains on immune cells. The aim of this article is to review the research progress of each calpain isozyme and the effect of calpains on immune cells, especially the promotion effect of calpains on the immune response of macrophage, neutrophils, dendritic cells, mast cells, natural killed cells, and lymphocytes. These effects would hold great promise for the clinical application of calpains as a practicable therapeutic option in the treatment of immune related diseases.
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Metadaten
Titel
Effects of functionally diverse calpain system on immune cells
verfasst von
Yueqi Chen
Zhaoliang Su
Fang Liu
Publikationsdatum
23.01.2021
Verlag
Springer US
Erschienen in
Immunologic Research / Ausgabe 1/2021
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-021-09177-5

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