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Acta Neurologica Belgica
Erschienen in: Acta Neurologica Belgica 6/2020

11.01.2019 | Original article

White matter microstructural differences between right and left mesial temporal lobe epilepsy

verfasst von: Hossein Sanjari Moghaddam, Farzaneh Rahmani, Mohammad Hadi Aarabi, Mohammad-Reza Nazem-Zadeh, Esmaeil Davoodi-Bojd, Hamid Soltanian-Zadeh

Erschienen in: Acta Neurologica Belgica | Ausgabe 6/2020

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Abstract

Purpose

Mesial temporal lobe epilepsy (mTLE) is a chronic focal epileptic disorder characterized by recalcitrant seizures often necessitating surgical intervention. Identifying the laterality of seizure focus is crucial for pre-surgical planning. We implemented diffusion MRI (DMRI) connectometry to identify differences in white matter connectivity in patients with left and right mTLE relative to healthy control subjects.

Method

We enrolled 12 patients with right mTLE, 12 patients with left mTLE, and 12 age/sex matched healthy controls (HCs). We used DMRI connectometry to identify local connectivity patterns of white matter tracts, based on quantitative anisotropy (QA). We compared QA of white matter to reconstruct tracts with significant difference in connectivity between patients and HCs and then between patients with left and right mTLE.

Results

Right mTLE patients show higher anisotropy in left inferior longitudinal fasciculus (ILF) and forceps minor and lower QA in genu of corpus callosum (CC), bilateral corticospinal tracts (CSTs), and bilateral middle cerebellar peduncles (MCPs) compared to HCs. Left mTLE patients show higher anisotropy in genu of CC, bilateral CSTs, and right MCP and decreased anisotropy in forceps minor compared to HCs. Compared to patients with right mTLE, left mTLE patients showed increased and decreased connectivity in some major tracts.

Conclusions

Our study showed the pattern of microstructural disintegrity in mTLE patients relative to HCs. We demonstrated that left and right mTLE patients have discrepant alternations in their white matter microstructure. These results may indicate that left and right mTLE have different underlying pathologic mechanisms.
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Metadaten
Titel
White matter microstructural differences between right and left mesial temporal lobe epilepsy
verfasst von
Hossein Sanjari Moghaddam
Farzaneh Rahmani
Mohammad Hadi Aarabi
Mohammad-Reza Nazem-Zadeh
Esmaeil Davoodi-Bojd
Hamid Soltanian-Zadeh
Publikationsdatum
11.01.2019
Verlag
Springer International Publishing
Erschienen in
Acta Neurologica Belgica / Ausgabe 6/2020
Print ISSN: 0300-9009
Elektronische ISSN: 2240-2993
DOI
https://doi.org/10.1007/s13760-019-01074-x

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