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Current Sleep Medicine Reports

Erschienen in:

01.03.2017 | Sleep and Cancer (D Gozal, Section Editor)

Obstructive Sleep Apnea and Cancer: Insights from Intermittent Hypoxia Experimental Models

verfasst von: Isaac Almendros, Miguel Ángel Martinez-Garcia, Ana Obeso, David Gozal

Erschienen in: Current Sleep Medicine Reports | Ausgabe 1/2017

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Abstract

Purpose of the review

This review will provide an updated perspective of the relationship between obstructive sleep apnea (OSA) based on the latest experimental research carried out on animal models subjected to chronic intermittent hypoxia (IH) as a subrogate of OSA.

Recent findings

During the last years, new research linking IH and cancer has emerged. The most recent studies have (1) increased the number of types of tumor investigated in response to IH and (2) explored some of the potential mechanisms modulated by IH which could participate in the increased cancer incidence and malignancy reported under this challenge.

Summary

There are increasing evidences showing that IH mimicking OSA increases tumor incidence, malignancy, and mortality in mice. The mechanisms explored to date are related to the induction of hypoxia-inducible factors, inflammatory and oxidative stress markers, angiogenesis, and IH-induced alterations on the immune system (macrophages and lymphocytes).

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Titel: Obstructive Sleep Apnea and Cancer: Insights from Intermittent Hypoxia Experimental Models
verfasst von: Isaac Almendros
Miguel Ángel Martinez-Garcia
Ana Obeso
David Gozal
Publikationsdatum: 01.03.2017
Verlag: Springer International Publishing
Erschienen in: Current Sleep Medicine Reports / Ausgabe 1/2017
Elektronische ISSN: 2198-6401
DOI: https://doi.org/10.1007/s40675-017-0064-5

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