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Clinical Neuroradiology

Erschienen in:

01.06.2014 | Review Article

Differential Diagnosis of White Matter Lesions: Nonvascular Causes—Part II

verfasst von: S. Weidauer, M. Nichtweiß, E. Hattingen

Erschienen in: Clinical Neuroradiology | Ausgabe 2/2014

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Abstract

The knowledge of characteristic lesion patterns is important in daily practice imaging, as the radiologist increasingly is required to provide precise differential diagnosis despite unspecific clinical symptoms like cognitive impairment and missed elaborated neurological workup. This part II dealing with nonvascular white matter changes of proven cause and diagnostic significance aimed to assist the evaluation of diseases exhibiting lesions exclusively or predominantly located in the white matter. The etiologies commented on are classified as follows: (a) toxic–metabolic, (b) leukodystrophies and mitochondriopathies, (c) infectious, (d) neoplastic, and (e) immune mediated. The respective mode of lesion formation is characterized, and typical radiological findings are displayed. More or less symmetrical lesion patterns on the one hand as well as focal and multifocal ones on the other are to be analyzed with reference to clinical data and knowledge of predilection sites characterizing major disease categories. Complementing spinal cord imaging may be useful not only in acute and relapsing demyelinating diseases but in certain leukodystrophies as well. In neuromyelitis optica (NMO), the detection of a specific antibody and some recently published observations may lead to a new understanding of certain deep white matter lesions occasionally complicating systemic autoimmune disease.

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Titel: Differential Diagnosis of White Matter Lesions: Nonvascular Causes—Part II
verfasst von: S. Weidauer
M. Nichtweiß
E. Hattingen
Publikationsdatum: 01.06.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Neuroradiology / Ausgabe 2/2014
Print ISSN: 1869-1439
Elektronische ISSN: 1869-1447
DOI: https://doi.org/10.1007/s00062-013-0267-1

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Springer Medizin

Differential Diagnosis of White Matter Lesions: Nonvascular Causes—Part II

Abstract

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