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Erschienen in: Der Nervenarzt 5/2004

01.05.2004 | Übersicht

Die Bedeutung des Schlafs für gesunde Alkoholkonsumenten und alkoholabhängige Patienten

verfasst von: Priv.-Doz. Dr. H. Gann, D. van Calker, B. Feige, D. Riemann

Erschienen in: Der Nervenarzt | Ausgabe 5/2004

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Zusammenfassung

Die Auswirkungen von Alkohol auf den Schlaf und das Schlaf-EEG bei Gesunden und Alkoholabhängigen in den verschiedenen Phasen der Abhängigkeit werden dargestellt. Gesunde schlafen zunächst besser. Eine höhere Dosis kann aber zur Durchschlafstörung in der 2. Nachthälfte führen. Alkohol interagiert mit einer vorhergehenden Schlafdeprivation oder -restriktion.
Schlafstörungen finden sich häufiger bei Alkoholkranken als bei Gesunden und können die Entwicklung einer Alkoholerkrankung begünstigen. Bei Alkoholkranken finden sich in allen Phasen der Erkrankung Einschlafstörungen und eine verminderte Gesamtschlafzeit sowie überzufällig häufig andere Schlafstörungen, wie Schlafapnoe-Syndrom oder periodische Beinbewegungen im Schlaf. . Es fanden sich Prädiktoren für ein erhöhtes Rückfallrisiko bei abstinenten Alkoholkranken.
Die Neurobiologie des Schlafs und der Alkoholabhängigkeit wird diskutiert. Eine wichtige Bedeutung kommt hierbei dem cholinerg-aminergen reziproken Interaktionsmodell der REM- und Non-REM-Schlafregulation zu. Therapeutische Implikationen werden diskutiert.
Literatur
1.
Zurück zum Zitat Aalto J, Hilakivi L (1986) Differences in the slee-wake patterns of the AA and ANA rat lines developed for high and low alcohol intake. Alcohol 3: 77–79CrossRefPubMed Aalto J, Hilakivi L (1986) Differences in the slee-wake patterns of the AA and ANA rat lines developed for high and low alcohol intake. Alcohol 3: 77–79CrossRefPubMed
2.
Zurück zum Zitat Adamson J, Burdick JA (1973) Sleep of dry alcoholics. Arch Gen Psychiatry 28: 146–149PubMed Adamson J, Burdick JA (1973) Sleep of dry alcoholics. Arch Gen Psychiatry 28: 146–149PubMed
3.
Zurück zum Zitat Aguayo LG, Peoples RW, Yeh HH, Yevenes GE (2002) GABA(A) receptors as molecular sites of ethanol action. Direct or indirect actions? Curr Top Med Chem 2: 869–885PubMed Aguayo LG, Peoples RW, Yeh HH, Yevenes GE (2002) GABA(A) receptors as molecular sites of ethanol action. Direct or indirect actions? Curr Top Med Chem 2: 869–885PubMed
4.
Zurück zum Zitat Aldrich MS (1998) Effects of alcohol on sleep. In: Gomberg ESL, Hegedus AM, Zucker RA (eds) Alcohol problems and aging. National Institute on Alcohol Abuse and Alcoholism Research Monograph No. 33. NIH Publication No. 98–4163. Bethesda/MD: National Institutes of Health, pp 281–300 Aldrich MS (1998) Effects of alcohol on sleep. In: Gomberg ESL, Hegedus AM, Zucker RA (eds) Alcohol problems and aging. National Institute on Alcohol Abuse and Alcoholism Research Monograph No. 33. NIH Publication No. 98–4163. Bethesda/MD: National Institutes of Health, pp 281–300
5.
Zurück zum Zitat Aldrich MS, Brower KJ, Hall JM (1999) Sleep-disordered breathing in alcoholics. Alcohol Clin Exp Res 23: 134–140PubMed Aldrich MS, Brower KJ, Hall JM (1999) Sleep-disordered breathing in alcoholics. Alcohol Clin Exp Res 23: 134–140PubMed
6.
Zurück zum Zitat Allen RP, Wagman AM (1975) Do sleep patterns relate to the desire for alcohol? Adv Exp Med Biol 59: 495–508PubMed Allen RP, Wagman AM (1975) Do sleep patterns relate to the desire for alcohol? Adv Exp Med Biol 59: 495–508PubMed
7.
Zurück zum Zitat Allen RP, Wagman AM, Funderburk FR (1977) Slow wave sleep changes: Alcohol tolerance and treatment implications. Adv Exp Med Biol 85A: 629–640PubMed Allen RP, Wagman AM, Funderburk FR (1977) Slow wave sleep changes: Alcohol tolerance and treatment implications. Adv Exp Med Biol 85A: 629–640PubMed
8.
Zurück zum Zitat Allen RP, Wagman AM, Funderburk FR, Wells DT (1980) Slow wave sleep: A predictor of individual differences in response to drinking? Biol Psychiatry 15: 345–348PubMed Allen RP, Wagman AM, Funderburk FR, Wells DT (1980) Slow wave sleep: A predictor of individual differences in response to drinking? Biol Psychiatry 15: 345–348PubMed
9.
Zurück zum Zitat Aubin HJ, Goldenberg F, Benoit O et al. (1994) Effects of tetrabamate and of diazepam on sleep polygraphy during subacute withdrawal in alcohol-dependent patients. Hum Psychopharmacol 9: 191–195 Aubin HJ, Goldenberg F, Benoit O et al. (1994) Effects of tetrabamate and of diazepam on sleep polygraphy during subacute withdrawal in alcohol-dependent patients. Hum Psychopharmacol 9: 191–195
10.
Zurück zum Zitat Backhaus J, Riemann D (1999) Schlafstörungen. Fortschritte der Psychotherapie Bd 7. Hogrefe, Göttingen Backhaus J, Riemann D (1999) Schlafstörungen. Fortschritte der Psychotherapie Bd 7. Hogrefe, Göttingen
11.
Zurück zum Zitat Baekeland F, Lundwall L, Shanahan TJ, Kissin B (1974) Clinical correlates of reported sleep disturbance in alcoholics. Q J Stud Alc 35: 1230–1241 Baekeland F, Lundwall L, Shanahan TJ, Kissin B (1974) Clinical correlates of reported sleep disturbance in alcoholics. Q J Stud Alc 35: 1230–1241
12.
Zurück zum Zitat Benca RM, Obermeyer WH, Thisted RA, Gillin JC (1992) Sleep and psychiatric disorders: A meta-analysis. Arch Gen Psychiatry 49: 651–668PubMed Benca RM, Obermeyer WH, Thisted RA, Gillin JC (1992) Sleep and psychiatric disorders: A meta-analysis. Arch Gen Psychiatry 49: 651–668PubMed
13.
Zurück zum Zitat Brower KJ, Aldrich MS, Hall JM (1998) Polysomnographic and subjective sleep predictors of alcoholic relapse. Alcohol Clin Exp Res 22: 1864–1871PubMed Brower KJ, Aldrich MS, Hall JM (1998) Polysomnographic and subjective sleep predictors of alcoholic relapse. Alcohol Clin Exp Res 22: 1864–1871PubMed
14.
Zurück zum Zitat Brower KJ, Robinson EAR, Zucker RA (2000). Epidemiology of insomnia and alcoholism in the general population. Alcohol Clin Exp Res 24 (suppl. 5): 43A Brower KJ, Robinson EAR, Zucker RA (2000). Epidemiology of insomnia and alcoholism in the general population. Alcohol Clin Exp Res 24 (suppl. 5): 43A
15.
Zurück zum Zitat Brower, KJ, Hall JM (2001) Effects of age and alcoholism on sleep: A controlled study. J Stud Alcohol 62: 335–343PubMed Brower, KJ, Hall JM (2001) Effects of age and alcoholism on sleep: A controlled study. J Stud Alcohol 62: 335–343PubMed
16.
Zurück zum Zitat Brower KJ, Aldrich MS, Robinson EAR, Zucker RA, Greden JF (2001) Insomnia, self-medication, and relapse to alcoholism. Am J Psychiatry 158: 399–404CrossRefPubMed Brower KJ, Aldrich MS, Robinson EAR, Zucker RA, Greden JF (2001) Insomnia, self-medication, and relapse to alcoholism. Am J Psychiatry 158: 399–404CrossRefPubMed
17.
Zurück zum Zitat Caetano R, Clark CL, Greenfield TK (1998) Prevalence, trends, and incidence of alcohol withdrawal symptoms: Analysis of general population and clinical samples. Alcohol Health Res World 22: 73–79 Caetano R, Clark CL, Greenfield TK (1998) Prevalence, trends, and incidence of alcohol withdrawal symptoms: Analysis of general population and clinical samples. Alcohol Health Res World 22: 73–79
18.
Zurück zum Zitat Cagetti E, Liang J, Spigelman I, Olsen RW (2003) Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABA (A) receptors. Mol Pharmacol 63: 53–64CrossRefPubMed Cagetti E, Liang J, Spigelman I, Olsen RW (2003) Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABA (A) receptors. Mol Pharmacol 63: 53–64CrossRefPubMed
19.
Zurück zum Zitat Carmichael FJ, Israel Y, Crawford M, Minhas K, Saldivia V, Sandrin S, Campisi P, Orrego E (1991) Central nervous system effects of acetate: contribution to the central effects of ethanol. Pharmacol Exp Ther 259: 403–408 Carmichael FJ, Israel Y, Crawford M, Minhas K, Saldivia V, Sandrin S, Campisi P, Orrego E (1991) Central nervous system effects of acetate: contribution to the central effects of ethanol. Pharmacol Exp Ther 259: 403–408
20.
Zurück zum Zitat Caron MH, Alling C (2001) Role of nitric oxide in ethanol-induced up-regulation of muscarinic acetylcholine receptors in SH-SY5Y cells. Alcohol Clin Exp Res 25: 1107–1113PubMed Caron MH, Alling C (2001) Role of nitric oxide in ethanol-induced up-regulation of muscarinic acetylcholine receptors in SH-SY5Y cells. Alcohol Clin Exp Res 25: 1107–1113PubMed
21.
Zurück zum Zitat Clark CP, Gillin JC, Golshan S et al. (1998) Increased REM sleep density at admission predicts relapse by three months in primary alcoholics with a lifetime diagnosis of secondary depression. Biol Psychiatry 43: 601–607CrossRefPubMed Clark CP, Gillin JC, Golshan S et al. (1998) Increased REM sleep density at admission predicts relapse by three months in primary alcoholics with a lifetime diagnosis of secondary depression. Biol Psychiatry 43: 601–607CrossRefPubMed
22.
Zurück zum Zitat Diamond I, Nagy L, Mochly-Rosen D, Gordon A (1991) The role of adenosine and adenosine transport in ethanol-induced cellular tolerance and dependence. Possible biologic and genetic markers of alcoholism. Ann N Y Acad Sci 625: 473–487PubMed Diamond I, Nagy L, Mochly-Rosen D, Gordon A (1991) The role of adenosine and adenosine transport in ethanol-induced cellular tolerance and dependence. Possible biologic and genetic markers of alcoholism. Ann N Y Acad Sci 625: 473–487PubMed
23.
Zurück zum Zitat Diamond I, Gordon AS (1997) Cellular and molecular neuroscience of alcoholism. Physiol Rev 77: 1–20PubMed Diamond I, Gordon AS (1997) Cellular and molecular neuroscience of alcoholism. Physiol Rev 77: 1–20PubMed
24.
Zurück zum Zitat Dijk DJ, Brunner DP, Aeschbach D et al. (1992) The effects of ethanol on human sleep EEG power spectra differ from those of benzodiazepine receptor agonists. Neuropsychopharmacology 7: 225–232PubMed Dijk DJ, Brunner DP, Aeschbach D et al. (1992) The effects of ethanol on human sleep EEG power spectra differ from those of benzodiazepine receptor agonists. Neuropsychopharmacology 7: 225–232PubMed
25.
Zurück zum Zitat Drummond SPA, Gillin JC, Smith TL, Demodena A (1998) The sleep of abstinent pure primary alcoholic patients: Natural course and relationship to relapse. Alcohol Clin Exp Res 22: 1796–1802PubMed Drummond SPA, Gillin JC, Smith TL, Demodena A (1998) The sleep of abstinent pure primary alcoholic patients: Natural course and relationship to relapse. Alcohol Clin Exp Res 22: 1796–1802PubMed
26.
Zurück zum Zitat Dunwiddie TV (1999) Adenosine and ethanol: is there a caffeine connection in the actions of ethanol? In: Liu Y, Hunt WA (eds) The „drunken“ synapse: Studies of alcohol-related disorders. Kluwer/Plenum, New York, pp 119–133 Dunwiddie TV (1999) Adenosine and ethanol: is there a caffeine connection in the actions of ethanol? In: Liu Y, Hunt WA (eds) The „drunken“ synapse: Studies of alcohol-related disorders. Kluwer/Plenum, New York, pp 119–133
27.
Zurück zum Zitat Dunwiddie TV, Masino SA (2001) The role and regulation of adenosine in the central nervous system. Ann Rev Neurosci 24: 31–55CrossRefPubMed Dunwiddie TV, Masino SA (2001) The role and regulation of adenosine in the central nervous system. Ann Rev Neurosci 24: 31–55CrossRefPubMed
28.
Zurück zum Zitat Ehlers CL (2000) Alcohol and sleep. In: Noronha A, Eckardt M, Warren K (eds) Review of NIAAA’s Neuroscience and Behavioral Research Portfolio. National Institute on Alcohol Abuse and Aldoholism Research Monograph No. 34. NIH Publication No. 00–4520. Bethesda, MD: the Institute, pp 417–433 Ehlers CL (2000) Alcohol and sleep. In: Noronha A, Eckardt M, Warren K (eds) Review of NIAAA’s Neuroscience and Behavioral Research Portfolio. National Institute on Alcohol Abuse and Aldoholism Research Monograph No. 34. NIH Publication No. 00–4520. Bethesda, MD: the Institute, pp 417–433
29.
Zurück zum Zitat Esteban S, Morantaf D, Sastre-Coll A, Miralles A, Garcia-Sevilla JA (2002) Withdrawal from chronic ethanol increases the sensitivity of presynaptic 5-HAT(1A) receptors modulating serotonine and dopamine synthesis in rat brain in vivo. Neurosci Lett 28: 121–124CrossRef Esteban S, Morantaf D, Sastre-Coll A, Miralles A, Garcia-Sevilla JA (2002) Withdrawal from chronic ethanol increases the sensitivity of presynaptic 5-HAT(1A) receptors modulating serotonine and dopamine synthesis in rat brain in vivo. Neurosci Lett 28: 121–124CrossRef
30.
Zurück zum Zitat Faulhaber J, Steiger A, Lancel M (1997) The GABAA agonist THIP produces slow wave sleep and reduces spindling activity in NREM sleep in humans. Psychopharmacology 130: 285–291 Faulhaber J, Steiger A, Lancel M (1997) The GABAA agonist THIP produces slow wave sleep and reduces spindling activity in NREM sleep in humans. Psychopharmacology 130: 285–291
31.
Zurück zum Zitat Feuerlein W (1974) The acute alcohol withdrawal syndrome: Findings and problems. Br J Addict 69: 141–148 Feuerlein W (1974) The acute alcohol withdrawal syndrome: Findings and problems. Br J Addict 69: 141–148
32.
Zurück zum Zitat Fischer J, Mayer G, Peter JH, Riemann D, Sitter H (2001) Nicht-erholsamer Schlaf. Somnologie 5 (Suppl 3): 1–258 Fischer J, Mayer G, Peter JH, Riemann D, Sitter H (2001) Nicht-erholsamer Schlaf. Somnologie 5 (Suppl 3): 1–258
33.
Zurück zum Zitat Foster JH, Peters TJ (1999) Impaired sleep in alcohol misusers and dependent alcoholics and the impact upon outcome. Alcohol Clin Exp Res 23: 1044–1051PubMed Foster JH, Peters TJ (1999) Impaired sleep in alcohol misusers and dependent alcoholics and the impact upon outcome. Alcohol Clin Exp Res 23: 1044–1051PubMed
34.
Zurück zum Zitat Foster JH, Marshall EJ, Peters TJ (2000) Application of a quality of life measure, the life situation survey (LSS), to alcohol-dependent subjects in relapse and remission. Alcohol Clin Exp Res 24: 1687–1692PubMed Foster JH, Marshall EJ, Peters TJ (2000) Application of a quality of life measure, the life situation survey (LSS), to alcohol-dependent subjects in relapse and remission. Alcohol Clin Exp Res 24: 1687–1692PubMed
35.
Zurück zum Zitat Gann H, Kiemen A, Klein T et al. (1997) Schlaf und cholinerger REM-Schlaf-Induktionstest bei Patienten mit primärer Alkoholabhängigkeit. Somnologie 1: 119–125 Gann H, Kiemen A, Klein T et al. (1997) Schlaf und cholinerger REM-Schlaf-Induktionstest bei Patienten mit primärer Alkoholabhängigkeit. Somnologie 1: 119–125
36.
Zurück zum Zitat Gann H, Faulmann A, Kiemen A et al. (1998) Sleep and the cholinergic REM sleep induction test in patients with primary alcoholism. Sleep Research Online 1: 92–95PubMed Gann H, Faulmann A, Kiemen A et al. (1998) Sleep and the cholinergic REM sleep induction test in patients with primary alcoholism. Sleep Research Online 1: 92–95PubMed
37.
Zurück zum Zitat Gann H, Ebersholdt M, Adamovic K, van Calker (1999) Agonist-stimulated Ca2+-response in neutrophils from patients with primary alcoholism and alcoholized healthy subjects. Psychiatry Res 89:189–199CrossRefPubMed Gann H, Ebersholdt M, Adamovic K, van Calker (1999) Agonist-stimulated Ca2+-response in neutrophils from patients with primary alcoholism and alcoholized healthy subjects. Psychiatry Res 89:189–199CrossRefPubMed
38.
Zurück zum Zitat Gann H, Landbrecht M, Feige B, Hohagen F, Riemann D (2001a) Subjektive Parameter des Schlafs bei Patienten mit primärer Alkoholabhängigkeit. Somnologie 5: 65–70CrossRef Gann H, Landbrecht M, Feige B, Hohagen F, Riemann D (2001a) Subjektive Parameter des Schlafs bei Patienten mit primärer Alkoholabhängigkeit. Somnologie 5: 65–70CrossRef
39.
Zurück zum Zitat Gann H, Feige B, Hohagen F et al. (2001b) Sleep and the cholinergic REM sleep induction test in patients with primary alcoholism. Biol Psychiatry 50: 383–390CrossRefPubMed Gann H, Feige B, Hohagen F et al. (2001b) Sleep and the cholinergic REM sleep induction test in patients with primary alcoholism. Biol Psychiatry 50: 383–390CrossRefPubMed
40.
Zurück zum Zitat Gann H, Feige B, Fasihi S et al. (2002) Periodic limb movements during sleep in alcohol dependent patients. Eur Arch Psychiatry Clin Neurosci 252: 124–129PubMed Gann H, Feige B, Fasihi S et al. (2002) Periodic limb movements during sleep in alcohol dependent patients. Eur Arch Psychiatry Clin Neurosci 252: 124–129PubMed
41.
Zurück zum Zitat Gann H, Feige B, Cloot O et al. (2003) Polysomnography during withdrawal with clomethiazole or placebo in alcohol dependent patients—a double-blind and randomized study. Pharmacopsychiatry (in press) Gann H, Feige B, Cloot O et al. (2003) Polysomnography during withdrawal with clomethiazole or placebo in alcohol dependent patients—a double-blind and randomized study. Pharmacopsychiatry (in press)
42.
Zurück zum Zitat Gillin JC, Smith TL, Irwin M et al. (1990a) Short REM latency in primary alcoholic patients with secondary depression. Am J Psychiatry 147: 106–109PubMed Gillin JC, Smith TL, Irwin M et al. (1990a) Short REM latency in primary alcoholic patients with secondary depression. Am J Psychiatry 147: 106–109PubMed
43.
Zurück zum Zitat Gillin JC, Smith TL, Irwin M, Kripke DF, Schuckit M (1990b) EEG sleep studies in „pure“ primary alcoholism during subacute withdrawal: Relationships to normal controls, age, and other clinical variables. Biol Psychiatry 27: 477–488CrossRefPubMed Gillin JC, Smith TL, Irwin M, Kripke DF, Schuckit M (1990b) EEG sleep studies in „pure“ primary alcoholism during subacute withdrawal: Relationships to normal controls, age, and other clinical variables. Biol Psychiatry 27: 477–488CrossRefPubMed
44.
Zurück zum Zitat Gillin JC, Smith TL, Irwin M et al. (1994) Increased pressure for rapid eye movement sleep at time of hospital admission predicts relapse in non-depressed patients with primary alcoholism at 3-month follow up. Arch Gen Psychiatry 51: 189–197PubMed Gillin JC, Smith TL, Irwin M et al. (1994) Increased pressure for rapid eye movement sleep at time of hospital admission predicts relapse in non-depressed patients with primary alcoholism at 3-month follow up. Arch Gen Psychiatry 51: 189–197PubMed
45.
Zurück zum Zitat Gillin JC (1998) Are sleep disturbances risk factors for anxiety, depressive and addictive disorders? Acta Psychiatr Scand (Suppl) 393: 39–43 Gillin JC (1998) Are sleep disturbances risk factors for anxiety, depressive and addictive disorders? Acta Psychiatr Scand (Suppl) 393: 39–43
46.
Zurück zum Zitat Gillin JC, Drummond SP (2000) Medication and substance abuse. In: Kryger MH, Roth T, Dement WC (eds) Principles and practice of sleep medicine. 3rd ed. Saunders, Philadelphia/PA, pp 1176–1195 Gillin JC, Drummond SP (2000) Medication and substance abuse. In: Kryger MH, Roth T, Dement WC (eds) Principles and practice of sleep medicine. 3rd ed. Saunders, Philadelphia/PA, pp 1176–1195
47.
Zurück zum Zitat Greeff AP, Conradi WS (1998) Use of progressive relaxation training for chronic alcoholics with insomnia. Psychol Rep 82: 407–412PubMed Greeff AP, Conradi WS (1998) Use of progressive relaxation training for chronic alcoholics with insomnia. Psychol Rep 82: 407–412PubMed
48.
Zurück zum Zitat Greenberg R, Pearlman C (1967) Delirium tremens and dreaming. Am J Psychiatry 124: 133–142PubMed Greenberg R, Pearlman C (1967) Delirium tremens and dreaming. Am J Psychiatry 124: 133–142PubMed
49.
Zurück zum Zitat Gresham SC, Webb WB, Williams RL (1963) Alcohol and caffeine: effect on inferred visual dreaming. Science 140: 1226–1227PubMed Gresham SC, Webb WB, Williams RL (1963) Alcohol and caffeine: effect on inferred visual dreaming. Science 140: 1226–1227PubMed
50.
Zurück zum Zitat Grobin AC, Matthews DB, Devaud LL, Morrow AL (1998) The role of GABA(A) receptors in the acute and chronic effects of ethanol. Psychopharmacology 139: 2–19PubMed Grobin AC, Matthews DB, Devaud LL, Morrow AL (1998) The role of GABA(A) receptors in the acute and chronic effects of ethanol. Psychopharmacology 139: 2–19PubMed
51.
Zurück zum Zitat Gross MM, Goodenough D, Tobin M et al. (1966) Sleep disturbances and hallucinations in the acute alcoholic psychoses. J Nerv Ment Dis 142: 493–514PubMed Gross MM, Goodenough D, Tobin M et al. (1966) Sleep disturbances and hallucinations in the acute alcoholic psychoses. J Nerv Ment Dis 142: 493–514PubMed
52.
Zurück zum Zitat Gross MM, Goodenough DR, Hastey J, Lewis E (1973) Experimental study of sleep in chronic alcoholics before, during and after four days of heavy drinking with a nondrinking comparison. Ann N Y Acad Sci 215: 254–265PubMed Gross MM, Goodenough DR, Hastey J, Lewis E (1973) Experimental study of sleep in chronic alcoholics before, during and after four days of heavy drinking with a nondrinking comparison. Ann N Y Acad Sci 215: 254–265PubMed
53.
Zurück zum Zitat Gross MM, Hastey JM (1975) The relation between baseline slow wave sleep and the slow wave sleep response to alcohol in alcoholics. Adv Exp Med Biol 59: 467–475PubMed Gross MM, Hastey JM (1975) The relation between baseline slow wave sleep and the slow wave sleep response to alcohol in alcoholics. Adv Exp Med Biol 59: 467–475PubMed
54.
Zurück zum Zitat Gross MM, Hastey JM (1976) Sleep disturbances in alcoholism. In: Tarter RE, Sugarman AA (eds) Alcoholism: Interdisciplinary approaches to an enduring problem. Addison-Wesley, Reading/MA, pp 257–307 Gross MM, Hastey JM (1976) Sleep disturbances in alcoholism. In: Tarter RE, Sugarman AA (eds) Alcoholism: Interdisciplinary approaches to an enduring problem. Addison-Wesley, Reading/MA, pp 257–307
55.
Zurück zum Zitat Guizzetti M, Moller T, Costa LG (2003) Ethanol inhibits muscarinic receptor-mediated DANN synthesis and signal transduction in human fetal astrocytes. Neurosci Lett 344: 68–70CrossRefPubMed Guizzetti M, Moller T, Costa LG (2003) Ethanol inhibits muscarinic receptor-mediated DANN synthesis and signal transduction in human fetal astrocytes. Neurosci Lett 344: 68–70CrossRefPubMed
56.
Zurück zum Zitat Hajak G, Rodenbeck A, Voderholzer U et al. (2001) Doxepin in the treatment of primary insomnia- a placebo-controlled, double-blind, polysomnographic study. J Clin Psychiatry 62: 453–463PubMed Hajak G, Rodenbeck A, Voderholzer U et al. (2001) Doxepin in the treatment of primary insomnia- a placebo-controlled, double-blind, polysomnographic study. J Clin Psychiatry 62: 453–463PubMed
57.
Zurück zum Zitat Harris RA, Allan AM (1989) Alcohol intoxication: ion channels and genetics. FASEB J 3: 1689–1695PubMed Harris RA, Allan AM (1989) Alcohol intoxication: ion channels and genetics. FASEB J 3: 1689–1695PubMed
58.
Zurück zum Zitat Hobson JA, Lydic R, Baghdoyan HA (1986) Evolving concepts of sleep cycle generation: From brain centers to neuronal populations. Behav Brain Sci 9: 371–448 Hobson JA, Lydic R, Baghdoyan HA (1986) Evolving concepts of sleep cycle generation: From brain centers to neuronal populations. Behav Brain Sci 9: 371–448
59.
Zurück zum Zitat Imatoh N, Nakazawa Y, Ohshima H, Ishibashi M, Yokoyama T (1986) Circadian rhythm of REM sleep of chronic alcoholics during alcohol withdrawal. Drug Alcohol Depend 18: 77–85PubMed Imatoh N, Nakazawa Y, Ohshima H, Ishibashi M, Yokoyama T (1986) Circadian rhythm of REM sleep of chronic alcoholics during alcohol withdrawal. Drug Alcohol Depend 18: 77–85PubMed
60.
Zurück zum Zitat Irwin M, Miller C, Gillin JC, Demodena A, Ehlers CL (2000) Polysomnographic and spectral sleep EEG in primary alcoholics: An interaction between alcohol dependence and Africa-American ethnicity. Alcohol Clin Exp Res 24: 1376–1384PubMed Irwin M, Miller C, Gillin JC, Demodena A, Ehlers CL (2000) Polysomnographic and spectral sleep EEG in primary alcoholics: An interaction between alcohol dependence and Africa-American ethnicity. Alcohol Clin Exp Res 24: 1376–1384PubMed
61.
Zurück zum Zitat Ishibashi M, Nakazawa Y, Yokoyama T et al. (1987) Cerebral atrophy and slow wave sleep of abstinent chronic alcoholics. Drug Alcohol Depend 19: 325–332PubMed Ishibashi M, Nakazawa Y, Yokoyama T et al. (1987) Cerebral atrophy and slow wave sleep of abstinent chronic alcoholics. Drug Alcohol Depend 19: 325–332PubMed
62.
Zurück zum Zitat Johnson LC, Burdick JA, Smith J (1970) Sleep during alcohol intake and withdrawal in the chronic alcoholic. Arch Gen Psychiatry 22: 406–418PubMed Johnson LC, Burdick JA, Smith J (1970) Sleep during alcohol intake and withdrawal in the chronic alcoholic. Arch Gen Psychiatry 22: 406–418PubMed
63.
Zurück zum Zitat Johnson BA, Jasinski DR, Galloway GP et al. (1996) Ritanserin in the treatment of alcohol dependence—a multi-center clinical trial. Ritanserin Study Group. Psychopharmacology 128: 206–215 Johnson BA, Jasinski DR, Galloway GP et al. (1996) Ritanserin in the treatment of alcohol dependence—a multi-center clinical trial. Ritanserin Study Group. Psychopharmacology 128: 206–215
64.
Zurück zum Zitat Johnson EO, Roehrs T, Roth T, Breslau N (1998) Epidemiology of alcohol and medication as aids to sleep in early adulthood. Sleep 21: 178–186PubMed Johnson EO, Roehrs T, Roth T, Breslau N (1998) Epidemiology of alcohol and medication as aids to sleep in early adulthood. Sleep 21: 178–186PubMed
65.
Zurück zum Zitat Jones BE (2003) Arousal systems. Front Biosci 8: 438–451 Jones BE (2003) Arousal systems. Front Biosci 8: 438–451
66.
Zurück zum Zitat Karam-Hage M, Brower KJ (2000) Gabapentin treatment for insomnia associated with alcohol dependence (letter) Am J Psychiatry 157: 151 Karam-Hage M, Brower KJ (2000) Gabapentin treatment for insomnia associated with alcohol dependence (letter) Am J Psychiatry 157: 151
67.
Zurück zum Zitat Knowles JB, Laverty SG, Kuechler HA (1968) Effects of alcohol on REM sleep. Q J Stud Alcohol 29: 342–349PubMed Knowles JB, Laverty SG, Kuechler HA (1968) Effects of alcohol on REM sleep. Q J Stud Alcohol 29: 342–349PubMed
68.
Zurück zum Zitat Kotorie T, Nakazawa Y, Yokoyama T et al. (1982) Terminal sleep following delirium tremens in chronic alcoholics—Polysomnographic and behavioral study. Drug Alcohol Depend 10: 125–134PubMed Kotorie T, Nakazawa Y, Yokoyama T et al. (1982) Terminal sleep following delirium tremens in chronic alcoholics—Polysomnographic and behavioral study. Drug Alcohol Depend 10: 125–134PubMed
69.
Zurück zum Zitat Kumari M, Ticku MK (2000) Regulation of NMDA receptors by ethanol. Prog Drug Res 54: 152–189PubMed Kumari M, Ticku MK (2000) Regulation of NMDA receptors by ethanol. Prog Drug Res 54: 152–189PubMed
70.
Zurück zum Zitat Landolt HP, Roth C, Dijk DJ et al. (1996) Late-afternoon ethanol intake affects nocturnal sleep and the sleep EEG in middle-aged men. J Clin Psychopharmacol 16: 428–436CrossRefPubMed Landolt HP, Roth C, Dijk DJ et al. (1996) Late-afternoon ethanol intake affects nocturnal sleep and the sleep EEG in middle-aged men. J Clin Psychopharmacol 16: 428–436CrossRefPubMed
71.
Zurück zum Zitat Landolt HP, Gillin JC (2001) Sleep abnormalities during abstinence in alcohol-dependent patients. CNS Drugs 15: 413–425PubMed Landolt HP, Gillin JC (2001) Sleep abnormalities during abstinence in alcohol-dependent patients. CNS Drugs 15: 413–425PubMed
72.
Zurück zum Zitat Le Bon O, Verbanck P, Hoffmann G et al. (1997) Sleep in detoxified alcoholics: Impairment of most standard sleep parameters and increased risk for sleep apnea, but not myoclonias—A controlled study. J Stud Alcohol 58: 30–36PubMed Le Bon O, Verbanck P, Hoffmann G et al. (1997) Sleep in detoxified alcoholics: Impairment of most standard sleep parameters and increased risk for sleep apnea, but not myoclonias—A controlled study. J Stud Alcohol 58: 30–36PubMed
73.
Zurück zum Zitat Longo LP, Johnson B (1998) Treatment of insomnia in substance abusing patients. Psychiatr Ann 28: 154–159 Longo LP, Johnson B (1998) Treatment of insomnia in substance abusing patients. Psychiatr Ann 28: 154–159
74.
Zurück zum Zitat Lovinger DM (1999) 5-HT3 receptors and the neural actions of alcohol: an increasingly exciting topic. Neurochem Int 35: 125–130CrossRefPubMed Lovinger DM (1999) 5-HT3 receptors and the neural actions of alcohol: an increasingly exciting topic. Neurochem Int 35: 125–130CrossRefPubMed
75.
Zurück zum Zitat MacLean AW, Cairns J (1982) Dose-response effects of ethanol on the sleep of young men. J Stud Alcohol 43: 434–444PubMed MacLean AW, Cairns J (1982) Dose-response effects of ethanol on the sleep of young men. J Stud Alcohol 43: 434–444PubMed
76.
Zurück zum Zitat Madsen BW, Rossi L (1980) Sleep and Michaelis-Menten elimination of ethanol. Clin Pharmacol Ther 27: 114–119PubMed Madsen BW, Rossi L (1980) Sleep and Michaelis-Menten elimination of ethanol. Clin Pharmacol Ther 27: 114–119PubMed
77.
Zurück zum Zitat Mandani M, Hollyfield R, Ravi RD, Dorus W, Borge GF (1989) Prevalence of sleep apnea among abstinent chronic alcoholic men (abstract). Sleep Res 18: 349 Mandani M, Hollyfield R, Ravi RD, Dorus W, Borge GF (1989) Prevalence of sleep apnea among abstinent chronic alcoholic men (abstract). Sleep Res 18: 349
78.
Zurück zum Zitat Maxion H, Schneider E (1970) Der Einfluss von Clomethiazol (Distraneurin) auf das Schlaf-Elektroenzephalogramm nach Alkoholdelir. Pharmakopsychiatrie, Neuro-Psychopharmakologie 3: 233–238 Maxion H, Schneider E (1970) Der Einfluss von Clomethiazol (Distraneurin) auf das Schlaf-Elektroenzephalogramm nach Alkoholdelir. Pharmakopsychiatrie, Neuro-Psychopharmakologie 3: 233–238
79.
Zurück zum Zitat Mello NK, Mendelson JH (1970) Behavioral studies of sleep patterns in alcoholics during intoxication and withdrawal. J Pharmacol Exp Ther 175: 94–112PubMed Mello NK, Mendelson JH (1970) Behavioral studies of sleep patterns in alcoholics during intoxication and withdrawal. J Pharmacol Exp Ther 175: 94–112PubMed
80.
Zurück zum Zitat Moeller FG, Gillin JC, Irwin M et al. (1993) A comparison of sleep EEGs in patients with primary major depression and major depression secondary to alcoholism. J Affect Disord 27: 39–42CrossRefPubMed Moeller FG, Gillin JC, Irwin M et al. (1993) A comparison of sleep EEGs in patients with primary major depression and major depression secondary to alcoholism. J Affect Disord 27: 39–42CrossRefPubMed
81.
Zurück zum Zitat Monti JM, Alterwain P (1991) Ritanserin decreases alcohol intake in chronic alcoholics (letter) Lancet 337 (8732): 60 Monti JM, Alterwain P (1991) Ritanserin decreases alcohol intake in chronic alcoholics (letter) Lancet 337 (8732): 60
82.
Zurück zum Zitat Monti JM, Alterwain P, Estevez F et al. (1993) The effects of ritanserin on mood and sleep in abstinent alcoholic patients. Sleep 16: 647–654PubMed Monti JM, Alterwain P, Estevez F et al. (1993) The effects of ritanserin on mood and sleep in abstinent alcoholic patients. Sleep 16: 647–654PubMed
83.
Zurück zum Zitat Morin C, Culbert JP, Schwartz SM (1994) Nonpharmacological interventions for insomnia: a meta-analysis. Am J Psychiatry 151: 1172–1180.PubMed Morin C, Culbert JP, Schwartz SM (1994) Nonpharmacological interventions for insomnia: a meta-analysis. Am J Psychiatry 151: 1172–1180.PubMed
84.
Zurück zum Zitat Murtagh DR, Greenwood KM (1995) Identifying effective psychological treatments for insomnia: a meta-analysis. J Clin Consult Psychol 63: 79–89CrossRef Murtagh DR, Greenwood KM (1995) Identifying effective psychological treatments for insomnia: a meta-analysis. J Clin Consult Psychol 63: 79–89CrossRef
85.
Zurück zum Zitat National Institute on Alcohol Abuse and Alcoholism (1998) Alcohol Alert No. 41: Alcohol and sleep. Bethesda MD: the Institute National Institute on Alcohol Abuse and Alcoholism (1998) Alcohol Alert No. 41: Alcohol and sleep. Bethesda MD: the Institute
86.
Zurück zum Zitat National Sleep Foundation. 2000 Omnibus sleep in America poll. (Web page available in year 2000 at www.sleepfoundation.org/publications/2000poll.html [accessed on January 9, 2001]) National Sleep Foundation. 2000 Omnibus sleep in America poll. (Web page available in year 2000 at www.sleepfoundation.org/publications/2000poll.html [accessed on January 9, 2001])
87.
Zurück zum Zitat Pandey SC, Piano MR, Schwertz DW, Davis JM, Pandey GN (1992) Effect of ethanol administration and withdrawal on serotonin receptor subtypes and receptor-mediated phosphoinositide hydrolysis in rat brain. Alcohol Clin Exp Res 16: 1110–1116PubMed Pandey SC, Piano MR, Schwertz DW, Davis JM, Pandey GN (1992) Effect of ethanol administration and withdrawal on serotonin receptor subtypes and receptor-mediated phosphoinositide hydrolysis in rat brain. Alcohol Clin Exp Res 16: 1110–1116PubMed
88.
Zurück zum Zitat Papineau K, Roehrs T, Petrucelli N, Rosenthal L, Roth T (1988) Electrophysiological assessment (Multiple Sleep Latency Test) of the biphasic effects of ethanol in humans. Alcohol Clin Exp Res 22: 231–235 Papineau K, Roehrs T, Petrucelli N, Rosenthal L, Roth T (1988) Electrophysiological assessment (Multiple Sleep Latency Test) of the biphasic effects of ethanol in humans. Alcohol Clin Exp Res 22: 231–235
89.
Zurück zum Zitat Poelchen W, Proctor WR, Dunwiddie TV (2000) The in vitro ethanol sensitivity of hippocampal synaptic gamma-aminobutyric acid (A) responses differs in lines of mice and rats genetically selected for behavioral sensitivity or insensitivity to ethanol. J Pharmacol Exp Ther 295: 741–746PubMed Poelchen W, Proctor WR, Dunwiddie TV (2000) The in vitro ethanol sensitivity of hippocampal synaptic gamma-aminobutyric acid (A) responses differs in lines of mice and rats genetically selected for behavioral sensitivity or insensitivity to ethanol. J Pharmacol Exp Ther 295: 741–746PubMed
90.
Zurück zum Zitat Pohorecky LA (1977) Biphasic action of ethanol. Biobehavior Reviews 1: 231–240CrossRef Pohorecky LA (1977) Biphasic action of ethanol. Biobehavior Reviews 1: 231–240CrossRef
91.
Zurück zum Zitat Proctor WR, Poelchen W, Bowers BJ, Wehner JM, Messing RO, Dunwiddie TV (2003) Ethanol differenzially enhances hippocampal GABA A receptor-mediated responses in protein kinase C gamma (PKC gamma) and PKC epsilon null mice. J Pharmacol Exp Ther 305: 264–270CrossRefPubMed Proctor WR, Poelchen W, Bowers BJ, Wehner JM, Messing RO, Dunwiddie TV (2003) Ethanol differenzially enhances hippocampal GABA A receptor-mediated responses in protein kinase C gamma (PKC gamma) and PKC epsilon null mice. J Pharmacol Exp Ther 305: 264–270CrossRefPubMed
92.
Zurück zum Zitat Rechtschaffen A, Kales A (1968) A manual of standardized terminology, techniques and scoring system for sleep stages of human sleep. Washington DC: National Institute of Health Publications, US Government Printin Office Rechtschaffen A, Kales A (1968) A manual of standardized terminology, techniques and scoring system for sleep stages of human sleep. Washington DC: National Institute of Health Publications, US Government Printin Office
93.
Zurück zum Zitat Riemann D, Backhaus J (1996) Schlafstörungen bewältigen—ein psychologisches Gruppenprogramm. Beltz PVU, Weinheim Riemann D, Backhaus J (1996) Schlafstörungen bewältigen—ein psychologisches Gruppenprogramm. Beltz PVU, Weinheim
94.
Zurück zum Zitat Riemann D, Voderholzer U, Cohrs S et al. (2002) Trimipramine in primary insomnia: results of a polysomnographic double-blind controlled study. Pharmacopsychiatry 35: 165–174CrossRefPubMed Riemann D, Voderholzer U, Cohrs S et al. (2002) Trimipramine in primary insomnia: results of a polysomnographic double-blind controlled study. Pharmacopsychiatry 35: 165–174CrossRefPubMed
95.
Zurück zum Zitat Roehrs T, Yoon J, Roth T (1991) Nocturnal and next-day effects of ethanol and basal level of sleepiness. Hum Psychopharmacology 6: 307–311 Roehrs T, Yoon J, Roth T (1991) Nocturnal and next-day effects of ethanol and basal level of sleepiness. Hum Psychopharmacology 6: 307–311
96.
Zurück zum Zitat Roehrs T, Beare D, Zorick F et al. (1994) Sleepiness and ethanol effects on simulated driving. Alcohol Clin Exp Res 18: 154–156PubMed Roehrs T, Beare D, Zorick F et al. (1994) Sleepiness and ethanol effects on simulated driving. Alcohol Clin Exp Res 18: 154–156PubMed
97.
Zurück zum Zitat Roehrs T, Roth T (1995) Alcohol-induced sleepiness and memory function. Alcohol Health Res World 19: 130–135 Roehrs T, Roth T (1995) Alcohol-induced sleepiness and memory function. Alcohol Health Res World 19: 130–135
98.
Zurück zum Zitat Roehrs T, Roth T (1998) State-altering actions of ethanol, caffeine, and nicotine. In: Lydic R, Baghdoyan HA (eds) Handbook of Behavioral State Control—Cellular and Molecular Mechanisms. CRC Press, New York, pp 421–432 Roehrs T, Roth T (1998) State-altering actions of ethanol, caffeine, and nicotine. In: Lydic R, Baghdoyan HA (eds) Handbook of Behavioral State Control—Cellular and Molecular Mechanisms. CRC Press, New York, pp 421–432
99.
Zurück zum Zitat Roehrs T, Papineau K, Rosenthal L, Roth T (1999) Ethanol as a hypnotic in insomniacs: Self administration and effects of sleep and mood. Neuropsychopharmacology 20: 279–286CrossRefPubMed Roehrs T, Papineau K, Rosenthal L, Roth T (1999) Ethanol as a hypnotic in insomniacs: Self administration and effects of sleep and mood. Neuropsychopharmacology 20: 279–286CrossRefPubMed
100.
Zurück zum Zitat Roth T, Ancoli-Israel S (1999) Daytime consequences and correlates of insomnia in the United States: Results of the 1991 National Sleep Foundation Survey. II. Sleep 22 (suppl. 2): S354-S358 Roth T, Ancoli-Israel S (1999) Daytime consequences and correlates of insomnia in the United States: Results of the 1991 National Sleep Foundation Survey. II. Sleep 22 (suppl. 2): S354-S358
101.
Zurück zum Zitat Rundell OH, Lester BK, Griffiths WJ et al. (1972) Alcohol and sleep in young adults. Psychopharmacologia 26: 201–218PubMed Rundell OH, Lester BK, Griffiths WJ et al. (1972) Alcohol and sleep in young adults. Psychopharmacologia 26: 201–218PubMed
102.
Zurück zum Zitat Sapru MK, Diamond I, Gordon AS (1994) Adenosine receptors mediate cellular adaptation to ethanol in NG 108–15 cells. J Pharmacol Exp Ther 27: 542–548 Sapru MK, Diamond I, Gordon AS (1994) Adenosine receptors mediate cellular adaptation to ethanol in NG 108–15 cells. J Pharmacol Exp Ther 27: 542–548
103.
Zurück zum Zitat Satel SL, Kosten TR, Schuckit MA, Fischman MW (1993) Should protracted withdrawal from drugs be included in DSM-IV? Am J Psychiatry 150: 695–704PubMed Satel SL, Kosten TR, Schuckit MA, Fischman MW (1993) Should protracted withdrawal from drugs be included in DSM-IV? Am J Psychiatry 150: 695–704PubMed
104.
Zurück zum Zitat Schiavi RC, Stimmel BB, Mandelli J, White D (1995) Chronic alcoholism and male sexual function. Am J Psychiatry 152: 1045–1051PubMed Schiavi RC, Stimmel BB, Mandelli J, White D (1995) Chronic alcoholism and male sexual function. Am J Psychiatry 152: 1045–1051PubMed
105.
Zurück zum Zitat Skoloda TE, Alterman AI, Gottheil EL (1979) Sleep quality reported by drinking and non-drinking alcoholics. In: Gottheil EL (ed) Addiction Research and Treatment: Converging Trends. Pergamon, Elmsford, NY, pp 102–112 Skoloda TE, Alterman AI, Gottheil EL (1979) Sleep quality reported by drinking and non-drinking alcoholics. In: Gottheil EL (ed) Addiction Research and Treatment: Converging Trends. Pergamon, Elmsford, NY, pp 102–112
106.
Zurück zum Zitat Smith ML, Perlis ML, Park A et al. (2002) Comparative meta-analysis of pharmacotherapy and behavior therapy for persistent insomnia. Am J Psychiatry 159: 5–11CrossRefPubMed Smith ML, Perlis ML, Park A et al. (2002) Comparative meta-analysis of pharmacotherapy and behavior therapy for persistent insomnia. Am J Psychiatry 159: 5–11CrossRefPubMed
107.
Zurück zum Zitat Stoller MK (1994) Economic effects of insomnia. Clin Ther 16: 873–897PubMed Stoller MK (1994) Economic effects of insomnia. Clin Ther 16: 873–897PubMed
108.
Zurück zum Zitat Tan ET, Lambie DG, Johnson RH, Robinson BJ, Whiteside EA (1985) Sleep apnea in alcoholic patients after withdrawal. Clin Sci 69: 655–661PubMed Tan ET, Lambie DG, Johnson RH, Robinson BJ, Whiteside EA (1985) Sleep apnea in alcoholic patients after withdrawal. Clin Sci 69: 655–661PubMed
109.
Zurück zum Zitat VanCauter E, Plat L, Scharf MB et al. (1997) Simultaneous stimulation of slow-wave sleep and growth hormone secretion by gamma-hydroxybutyrate in normal young men. J Clin Invest 100: 745–753PubMed VanCauter E, Plat L, Scharf MB et al. (1997) Simultaneous stimulation of slow-wave sleep and growth hormone secretion by gamma-hydroxybutyrate in normal young men. J Clin Invest 100: 745–753PubMed
110.
Zurück zum Zitat Vitiello MV, Prinz PN, Personius JP et al. (1990) Nighttime hypoxemia is increased in abstaining chronic alcoholic men. Alcohol Clin Exp Res 14: 38–41PubMed Vitiello MV, Prinz PN, Personius JP et al. (1990) Nighttime hypoxemia is increased in abstaining chronic alcoholic men. Alcohol Clin Exp Res 14: 38–41PubMed
111.
Zurück zum Zitat Wagman AM, Allen RP (1975) Effects of alcohol ingestion and abstinence on slow wave sleep of alcoholics. Adv Exp Med Biol 59: 453–466PubMed Wagman AM, Allen RP (1975) Effects of alcohol ingestion and abstinence on slow wave sleep of alcoholics. Adv Exp Med Biol 59: 453–466PubMed
112.
Zurück zum Zitat Weissman MM, Greenwald S, Nino-Murcia G, Dement WC (1997) The morbidity of insomnia uncomplicated by psychiatric disorders. Gen Hosp Psychiatry 19: 245–250CrossRefPubMed Weissman MM, Greenwald S, Nino-Murcia G, Dement WC (1997) The morbidity of insomnia uncomplicated by psychiatric disorders. Gen Hosp Psychiatry 19: 245–250CrossRefPubMed
113.
Zurück zum Zitat Wetter DW, Young TB (1994) The relation between cigarette smoking and sleep disturbance. Prev Med 23: 328–334CrossRefPubMed Wetter DW, Young TB (1994) The relation between cigarette smoking and sleep disturbance. Prev Med 23: 328–334CrossRefPubMed
114.
Zurück zum Zitat Williams HL, Rundell OH (1981) Altered sleep physiology in chronic alcoholics: Reversal with abstinence. Alcohol Clin Exp Res 2: 318–325 Williams HL, Rundell OH (1981) Altered sleep physiology in chronic alcoholics: Reversal with abstinence. Alcohol Clin Exp Res 2: 318–325
115.
Zurück zum Zitat Williams DL, MacLean AW, Cairns J (1983) Dose-response effects of ethanol on the sleep of young women. J Stud Alcohol 44: 515–523PubMed Williams DL, MacLean AW, Cairns J (1983) Dose-response effects of ethanol on the sleep of young women. J Stud Alcohol 44: 515–523PubMed
116.
Zurück zum Zitat Wirkner K, Poelchen W, Koles L et al. (1999) Ethanol-induced inhibition of NMDA receptor channels. Neurochem Int 35: 153–162PubMed Wirkner K, Poelchen W, Koles L et al. (1999) Ethanol-induced inhibition of NMDA receptor channels. Neurochem Int 35: 153–162PubMed
117.
Zurück zum Zitat Yao L, Asai K, Jiang Z et al. (2001) Dopamine D2 receptor inhibition of adenyl cyclase is abolished by acute ethanol but restored after chronic ethanol exposure. J Pharmacol Exp Ther 298: 833–839PubMed Yao L, Asai K, Jiang Z et al. (2001) Dopamine D2 receptor inhibition of adenyl cyclase is abolished by acute ethanol but restored after chronic ethanol exposure. J Pharmacol Exp Ther 298: 833–839PubMed
118.
Zurück zum Zitat Yules RB, Freedman DX, Chandler KA (1966) The effect of ethyl alcohol on man’s electroencephalographic sleep cycle. Electroencephalogr Clin Neurophysiol 20: 109–111CrossRefPubMed Yules RB, Freedman DX, Chandler KA (1966) The effect of ethyl alcohol on man’s electroencephalographic sleep cycle. Electroencephalogr Clin Neurophysiol 20: 109–111CrossRefPubMed
119.
Zurück zum Zitat Zarcone V (1978) Alcoholism and sleep. Adv Biosci 21: 29–38PubMed Zarcone V (1978) Alcoholism and sleep. Adv Biosci 21: 29–38PubMed
Metadaten
Titel
Die Bedeutung des Schlafs für gesunde Alkoholkonsumenten und alkoholabhängige Patienten
verfasst von
Priv.-Doz. Dr. H. Gann
D. van Calker
B. Feige
D. Riemann
Publikationsdatum
01.05.2004
Verlag
Springer-Verlag
Erschienen in
Der Nervenarzt / Ausgabe 5/2004
Print ISSN: 0028-2804
Elektronische ISSN: 1433-0407
DOI
https://doi.org/10.1007/s00115-003-1637-8

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