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Erschienen in: Der Nervenarzt 4/2004

01.04.2004 | Übersicht

Risikofaktoren des ischämischen Schlaganfalls

Übersicht über die Evidenz in der Primärprävention

verfasst von: Dr. M. Weih, J. Müller-Nordhorn, N. Amberger, F. Masuhr, F. Lürtzing, J. P. Dreier, A. Hetzel

Erschienen in: Der Nervenarzt | Ausgabe 4/2004

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Zusammenfassung

Risikofaktoren sind Merkmale, die mit einem erhöhten Erkrankungsrisiko assoziiert sind. Risikofaktoren haben sowohl in der Primärprävention des ischämischen Schlaganfalls als auch in der klinischen Praxis und der epidemiologischen Forschung eine große Bedeutung. Die zugrunde liegenden Modelle, Methoden und Studiendesigns sind jedoch oft nicht genügend bekannt. Auf der Basis von Interventionsstudien, Kohortenstudien, Fall-Kontroll-Studien und Metaanalysen geben wir in der vorliegenden Arbeit einen aktuellen Überblick über die Primärprävention der wichtigsten etablierten und potenziell beeinflussbaren Risikofaktoren des ischämischen Schlaganfalls. Jeder Risikofaktor wurde nach einem einheitlichen Schema eingeschätzt und systematisch nach Interventionstyp, Evidenzniveau, Risikoreduktion und Prävalenz ausgewertet.
Literatur
1.
Zurück zum Zitat (1994) Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation. Analysis of pooled data from five randomized controlled trials. Arch Intern Med 154: 1449–1457CrossRefPubMed (1994) Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation. Analysis of pooled data from five randomized controlled trials. Arch Intern Med 154: 1449–1457CrossRefPubMed
2.
Zurück zum Zitat (2002) Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 360: 1903–1913CrossRefPubMed (2002) Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 360: 1903–1913CrossRefPubMed
3.
Zurück zum Zitat (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA 288: 321–333PubMed (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA 288: 321–333PubMed
4.
Zurück zum Zitat Abbott RD, Donahue RP, MacMahon SW et al. (1987) Diabetes and the risk of stroke. The Honolulu Heart Program. JAMA 257: 949–952CrossRefPubMed Abbott RD, Donahue RP, MacMahon SW et al. (1987) Diabetes and the risk of stroke. The Honolulu Heart Program. JAMA 257: 949–952CrossRefPubMed
5.
Zurück zum Zitat Benavente O, Moher D, Pham B (1998) Carotid endarterectomy for asymptomatic carotid stenosis: a meta-analysis. BMJ 317: 1477–1480PubMed Benavente O, Moher D, Pham B (1998) Carotid endarterectomy for asymptomatic carotid stenosis: a meta-analysis. BMJ 317: 1477–1480PubMed
6.
Zurück zum Zitat Blauw GJ, Lagaay AM, Smelt AH et al. (1997) Stroke, statins, and cholesterol. A meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors. Stroke 28: 946–950PubMed Blauw GJ, Lagaay AM, Smelt AH et al. (1997) Stroke, statins, and cholesterol. A meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors. Stroke 28: 946–950PubMed
7.
Zurück zum Zitat Boushey CJ, Beresford SA, Omenn GS et al. (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 274: 1049–1057PubMed Boushey CJ, Beresford SA, Omenn GS et al. (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 274: 1049–1057PubMed
8.
Zurück zum Zitat Bucher HC, Griffith LE, Guyatt GH (1999) Systematic review on the risk and benefit of different cholesterol-lowering interventions. Arterioscler Thromb Vasc Biol 19: 187–195PubMed Bucher HC, Griffith LE, Guyatt GH (1999) Systematic review on the risk and benefit of different cholesterol-lowering interventions. Arterioscler Thromb Vasc Biol 19: 187–195PubMed
9.
Zurück zum Zitat Bushnell CD,Goldstein LB (2000) Diagnostic testing for coagulopathies in patients with ischemic stroke. Stroke 31: 3067–3078PubMed Bushnell CD,Goldstein LB (2000) Diagnostic testing for coagulopathies in patients with ischemic stroke. Stroke 31: 3067–3078PubMed
10.
Zurück zum Zitat Chambers BR, You RX, Donnan GA (2000) Carotid endarterectomy for asymptomatic carotid stenosis. Cochrane Database Syst Rev CD001923 Chambers BR, You RX, Donnan GA (2000) Carotid endarterectomy for asymptomatic carotid stenosis. Cochrane Database Syst Rev CD001923
11.
Zurück zum Zitat Cina CS, Clase CM, Haynes BR (1999) Refining the indications for carotid endarterectomy in patients with symptomatic carotid stenosis: A systematic review. J Vasc Surg 30: 606–617PubMed Cina CS, Clase CM, Haynes BR (1999) Refining the indications for carotid endarterectomy in patients with symptomatic carotid stenosis: A systematic review. J Vasc Surg 30: 606–617PubMed
12.
Zurück zum Zitat Collins R, Peto R, MacMahon S et al. (1990) Blood pressure, stroke, and coronary heart disease. Part 2, Short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Neurol Clin 335: 827–838CrossRef Collins R, Peto R, MacMahon S et al. (1990) Blood pressure, stroke, and coronary heart disease. Part 2, Short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Neurol Clin 335: 827–838CrossRef
13.
Zurück zum Zitat Corrao G, Bagnardi V, Zambon A et al. (1999) Exploring the dose-response relationship between alcohol consumption and the risk of several alcohol-related conditions: a meta-analysis. Addiction 94: 1551–1573CrossRefPubMed Corrao G, Bagnardi V, Zambon A et al. (1999) Exploring the dose-response relationship between alcohol consumption and the risk of several alcohol-related conditions: a meta-analysis. Addiction 94: 1551–1573CrossRefPubMed
14.
Zurück zum Zitat Corvol JC, Bouzamondo A, Sirol M et al. (2003) Differential effects of lipid-lowering therapies on stroke prevention: a meta-analysis of randomized trials. Arch Intern Med 163: 669–676CrossRefPubMed Corvol JC, Bouzamondo A, Sirol M et al. (2003) Differential effects of lipid-lowering therapies on stroke prevention: a meta-analysis of randomized trials. Arch Intern Med 163: 669–676CrossRefPubMed
15.
Zurück zum Zitat Djousse L, Ellison RC, Beiser A et al. (2002) Alcohol consumption and risk of ischemic stroke: The Framingham Study. Stroke 33: 907–912CrossRefPubMed Djousse L, Ellison RC, Beiser A et al. (2002) Alcohol consumption and risk of ischemic stroke: The Framingham Study. Stroke 33: 907–912CrossRefPubMed
16.
Zurück zum Zitat Donahue RP, Abbott RD, Reed DM et al. (1986) Alcohol and hemorrhagic stroke. The Honolulu Heart Program. JAMA 255: 2311–2314CrossRefPubMed Donahue RP, Abbott RD, Reed DM et al. (1986) Alcohol and hemorrhagic stroke. The Honolulu Heart Program. JAMA 255: 2311–2314CrossRefPubMed
17.
Zurück zum Zitat Ernst E,Resch KL (1993) Fibrinogen as a cardiovascular risk factor: a meta-analysis and review of the literature. Ann Intern Med 118: 956–963PubMed Ernst E,Resch KL (1993) Fibrinogen as a cardiovascular risk factor: a meta-analysis and review of the literature. Ann Intern Med 118: 956–963PubMed
18.
Zurück zum Zitat Gillum LA, Mamidipudi SK, Johnston SC (2000) Ischemic stroke risk with oral contraceptives: A meta-analysis. JAMA 284: 72–78CrossRefPubMed Gillum LA, Mamidipudi SK, Johnston SC (2000) Ischemic stroke risk with oral contraceptives: A meta-analysis. JAMA 284: 72–78CrossRefPubMed
19.
Zurück zum Zitat Hart RG, Benavente O, McBride R et al. (1999) Antithrombotic therapy to prevent stroke in patients with atrial fibrillation: a meta-analysis. Ann Intern Med 131: 492–501PubMed Hart RG, Benavente O, McBride R et al. (1999) Antithrombotic therapy to prevent stroke in patients with atrial fibrillation: a meta-analysis. Ann Intern Med 131: 492–501PubMed
20.
Zurück zum Zitat Heinzlef O, Cohen A, Amarenco P (1997) An update on aortic causes of ischemic stroke. Curr Opin Neurol 10: 64–72PubMed Heinzlef O, Cohen A, Amarenco P (1997) An update on aortic causes of ischemic stroke. Curr Opin Neurol 10: 64–72PubMed
21.
Zurück zum Zitat Iso H, Jacobs DR Jr, Wentworth D et al. (1989) Serum cholesterol levels and six-year mortality from stroke in 350,977 men screened for the multiple risk factor intervention trial. N Engl J Med 320: 904–910PubMed Iso H, Jacobs DR Jr, Wentworth D et al. (1989) Serum cholesterol levels and six-year mortality from stroke in 350,977 men screened for the multiple risk factor intervention trial. N Engl J Med 320: 904–910PubMed
22.
Zurück zum Zitat Kawachi I, Colditz GA, Stampfer MJ et al. (1993) Smoking cessation and decreased risk of stroke in women. JAMA 269: 232–236CrossRefPubMed Kawachi I, Colditz GA, Stampfer MJ et al. (1993) Smoking cessation and decreased risk of stroke in women. JAMA 269: 232–236CrossRefPubMed
23.
Zurück zum Zitat Kelly PJ, Rosand J, Kistler JP et al. (2002) Homocysteine, MTHFR 677C-T polymorphism, and risk of ischemic stroke: results of a meta-analysis. Neurology 59: 529–536PubMed Kelly PJ, Rosand J, Kistler JP et al. (2002) Homocysteine, MTHFR 677C-T polymorphism, and risk of ischemic stroke: results of a meta-analysis. Neurology 59: 529–536PubMed
24.
Zurück zum Zitat Kiely DK, Wolf PA, Cupples LA et al. (1994) Physical activity and stroke risk: the Framingham Study. Am J Epidemiol 140: 608–620PubMed Kiely DK, Wolf PA, Cupples LA et al. (1994) Physical activity and stroke risk: the Framingham Study. Am J Epidemiol 140: 608–620PubMed
25.
Zurück zum Zitat Law MR, Wald NJ, Rudnicka AR (2003) Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. BMJ 326: 1423CrossRefPubMed Law MR, Wald NJ, Rudnicka AR (2003) Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. BMJ 326: 1423CrossRefPubMed
26.
Zurück zum Zitat MacMahon S, Peto R, Cutler J et al. (1990) Blood pressure, stroke, and coronary heart disease. Part 1, Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Neurol Clin 335: 765–774CrossRef MacMahon S, Peto R, Cutler J et al. (1990) Blood pressure, stroke, and coronary heart disease. Part 1, Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Neurol Clin 335: 765–774CrossRef
27.
Zurück zum Zitat Mulrow CD, Cornell JA, Herrera CR et al. (1994) Hypertension in the elderly. Implications and generalizability of randomized trials. JAMA 272: 1932–1938CrossRefPubMed Mulrow CD, Cornell JA, Herrera CR et al. (1994) Hypertension in the elderly. Implications and generalizability of randomized trials. JAMA 272: 1932–1938CrossRefPubMed
28.
Zurück zum Zitat Neal B, MacMahon S, Chapman N (2000) Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomised trials. Blood Pressure Lowering Treatment Trialists‘ Collaboration. Neurol Clin 356: 1955–1964 Neal B, MacMahon S, Chapman N (2000) Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomised trials. Blood Pressure Lowering Treatment Trialists‘ Collaboration. Neurol Clin 356: 1955–1964
29.
Zurück zum Zitat Overell JR, Bone I, Lees KR (2000) Interatrial septal abnormalities and stroke: a meta-analysis of case-control studies. Neurology 55: 1172–1179PubMed Overell JR, Bone I, Lees KR (2000) Interatrial septal abnormalities and stroke: a meta-analysis of case-control studies. Neurology 55: 1172–1179PubMed
30.
Zurück zum Zitat Pahor M, Psaty BM, Alderman MH et al. (2000) Health outcomes associated with calcium antagonists compared with other first-line antihypertensive therapies: a meta-analysis of randomised controlled trials. Neurol Clin 356: 1949–1954CrossRef Pahor M, Psaty BM, Alderman MH et al. (2000) Health outcomes associated with calcium antagonists compared with other first-line antihypertensive therapies: a meta-analysis of randomised controlled trials. Neurol Clin 356: 1949–1954CrossRef
31.
Zurück zum Zitat Prospective studies collaboration (1995) Cholesterol, diastolic blood pressure, and stroke: 13,000 strokes in 450,000 people in 45 prospective cohorts. Prospective studies collaboration. Neurol Clin 346: 1647–1653 Prospective studies collaboration (1995) Cholesterol, diastolic blood pressure, and stroke: 13,000 strokes in 450,000 people in 45 prospective cohorts. Prospective studies collaboration. Neurol Clin 346: 1647–1653
32.
Zurück zum Zitat Psaty BM, Lumley T, Furberg CD et al. (2003) Health outcomes associated with various antihypertensive therapies used as first-line agents: a network meta-analysis. JAMA 289: 2534–2544CrossRefPubMed Psaty BM, Lumley T, Furberg CD et al. (2003) Health outcomes associated with various antihypertensive therapies used as first-line agents: a network meta-analysis. JAMA 289: 2534–2544CrossRefPubMed
33.
Zurück zum Zitat Psaty BM, Smith NL, Siscovick DS et al. (1997) Health outcomes associated with antihypertensive therapies used as first-line agents. A systematic review and meta-analysis. JAMA 277: 739–745CrossRefPubMed Psaty BM, Smith NL, Siscovick DS et al. (1997) Health outcomes associated with antihypertensive therapies used as first-line agents. A systematic review and meta-analysis. JAMA 277: 739–745CrossRefPubMed
34.
Zurück zum Zitat Reynolds K, Lewis LB, Nolen JD et al. (2003) Alcohol consumption and risk of stroke: a meta-analysis. JAMA 289: 579–588CrossRefPubMed Reynolds K, Lewis LB, Nolen JD et al. (2003) Alcohol consumption and risk of stroke: a meta-analysis. JAMA 289: 579–588CrossRefPubMed
35.
Zurück zum Zitat Ross SD, Allen IE, Connelly JE et al. (1999) Clinical outcomes in statin treatment trials: a meta-analysis. Arch Intern Med 159: 1793–1802CrossRefPubMed Ross SD, Allen IE, Connelly JE et al. (1999) Clinical outcomes in statin treatment trials: a meta-analysis. Arch Intern Med 159: 1793–1802CrossRefPubMed
36.
Zurück zum Zitat Shinton R,Beevers G (1989) Meta-analysis of relation between cigarette smoking and stroke. BMJ 298: 789–794PubMed Shinton R,Beevers G (1989) Meta-analysis of relation between cigarette smoking and stroke. BMJ 298: 789–794PubMed
37.
Zurück zum Zitat Wald DS, Law M, Morris JK (2002) Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ 325: 1202PubMed Wald DS, Law M, Morris JK (2002) Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ 325: 1202PubMed
38.
Zurück zum Zitat Weih M, Junge-Hulsing J, Mehraein S et al. (2000) Hereditary thrombophilia with ischemic stroke and sinus thrombosis. Diagnosis, therapy and meta-analysis. Nervenarzt 71: 936–945CrossRefPubMed Weih M, Junge-Hulsing J, Mehraein S et al. (2000) Hereditary thrombophilia with ischemic stroke and sinus thrombosis. Diagnosis, therapy and meta-analysis. Nervenarzt 71: 936–945CrossRefPubMed
39.
Zurück zum Zitat Whisnant JP (1997) Modeling of risk factors for ischemic stroke; The Willis lecture. Stroke 28: 1839–1843 Whisnant JP (1997) Modeling of risk factors for ischemic stroke; The Willis lecture. Stroke 28: 1839–1843
40.
Zurück zum Zitat Wolf PA, D’Agostino RB, Belanger AJ et al. (1991) Probability of stroke: a risk profile from the Framingham Study. Stroke 22: 312–318PubMed Wolf PA, D’Agostino RB, Belanger AJ et al. (1991) Probability of stroke: a risk profile from the Framingham Study. Stroke 22: 312–318PubMed
41.
Zurück zum Zitat Wolf PA, D’Agostino RB, Kannel WB et al. (1988) Cigarette smoking as a risk factor for stroke. The Framingham Study. JAMA 19: 1025–1029 Wolf PA, D’Agostino RB, Kannel WB et al. (1988) Cigarette smoking as a risk factor for stroke. The Framingham Study. JAMA 19: 1025–1029
Metadaten
Titel
Risikofaktoren des ischämischen Schlaganfalls
Übersicht über die Evidenz in der Primärprävention
verfasst von
Dr. M. Weih
J. Müller-Nordhorn
N. Amberger
F. Masuhr
F. Lürtzing
J. P. Dreier
A. Hetzel
Publikationsdatum
01.04.2004
Verlag
Springer-Verlag
Erschienen in
Der Nervenarzt / Ausgabe 4/2004
Print ISSN: 0028-2804
Elektronische ISSN: 1433-0407
DOI
https://doi.org/10.1007/s00115-003-1639-6

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