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Erschienen in:
01.09.2003 | Brief Report
Cardiac troponin I release and cytokine response during experimental human endotoxaemia
Erschienen in: Intensive Care Medicine | Ausgabe 9/2003
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Objective
To study the relationship between cytokine levels and cardiac troponin I (cTnI).
Design
Prospective experimental study.
Setting
Intensive care unit of a university hospital.
Participants
Six healthy male volunteers.
Interventions
Endotoxin, 4 ng/kg, was given as a 1-min intravenous infusion.
Measurements and results
Circulating cardiac troponin I levels and proinflammatory cytokines tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) were analysed at various time points during a 24-h period. TNF-α appeared in the circulation 30 min after injection (T=0.5 h), reaching peak levels (5,665±1,910 pg/ml) 2 h after infusion. At T=24 h TNF-α was still elevated in the circulation compared to T=0. None of the six volunteers had a cTnI value higher than 0.1 μg/l at T=0, 6 h or 24 h.
Conclusion
The presence of significant amounts of TNF-α, IL-6 and IL-8 in the systemic circulation does not lead to increased levels of cTnI in experimental human endotoxaemia.