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01.09.2005 | Original

Relationship between the Arg72Pro Polymorphism of p53 and outcome for patients with traumatic brain injury

verfasst von: Pascual Martínez-Lucas, Jerónimo Moreno-Cuesta, Dolores C. García-Olmo, Francisco Sánchez-Sánchez, Julio Escribano-Martínez, Ana Cuartero del Pozo, Máxima Lizán-García, Damián García-Olmo

Erschienen in: Intensive Care Medicine | Ausgabe 9/2005

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Abstract

Objective

To determine the relationship between the Arg72Pro polymorphism of p53 and the outcome after traumatic brain injury (TBI) in humans.

Design and setting

A prospective study was carried out in a ten-bed surgical intensive care unit (SICU) of a university hospital.

Patients

The study included 90 caucasian patients who had experienced a severe TBI within the previous 24 h. The exclusion criterion was a previous deficit in the central nervous system.

Measurements and results

The main recorded outcomes were values on the Glasgow Outcome Scale (GOS) at discharge from the SICU (GOS-0) and 6 months later (GOS-6). A blood sample was taken from each patient and all samples were analyzed by an allele-specific polymerase chain reaction for detection of Arg72Pro polymorphism of p53. These polymorphisms were tested for their association with values of GOS-0 and GOS-6. A two-tailed value of p<0.05 was considered statistically significant. The frequency of the argine/argine (Arg/Arg) genotype was greater among the patients who had a bad outcome at GOS-0 (69 vs 31% in the bad-outcome group; p=0.029). A multiple logistic regression analysis showed that patients with the Arg/Arg variation had a 2.9-fold greater risk of having a bad outcome at discharge from the SICU (95% confidence interval, 1.05–8.31; p=0.039 ). There was no similar relationship with respect to GOS-6.

Conclusion

The Arg/Arg genotype of the Arg72Pro polymorphism in p53 is associated with increased likelihood of a bad outcome at discharge from the SICU.

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Titel: Relationship between the Arg72Pro Polymorphism of p53 and outcome for patients with traumatic brain injury
verfasst von: Pascual Martínez-Lucas
Jerónimo Moreno-Cuesta
Dolores C. García-Olmo
Francisco Sánchez-Sánchez
Julio Escribano-Martínez
Ana Cuartero del Pozo
Máxima Lizán-García
Damián García-Olmo
Publikationsdatum: 01.09.2005
Verlag: Springer-Verlag
Erschienen in: Intensive Care Medicine / Ausgabe 9/2005
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-005-2715-0

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Relationship between the Arg72Pro Polymorphism of p53 and outcome for patients with traumatic brain injury