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Erschienen in: Intensive Care Medicine 1/2011

01.01.2011 | Editorial

Oxygen: when is more the enemy of good?

verfasst von: Richard D. Branson, Bryce R. H. Robinson

Erschienen in: Intensive Care Medicine | Ausgabe 1/2011

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Excerpt

Oxygen is a drug. As a drug, it is unique in that humans are continuously exposed to a low, homeopathic dose from the atmosphere. Clinically, the primary indication for supplemental oxygen is to reverse hypoxemia. This drug is unique in that it is regularly delivered in unknown doses to patients without indications or attempts at titration. The casual use of oxygen by the health community may simply be secondary to the ease of application via the respiratory tract and the misnomer that too much oxygen is clearly better than too little. However, as with many medical therapies, better can be the enemy of good. …
Literatur
1.
Zurück zum Zitat Servinghaus JW, Astrup PB (1986) History of blood gas analysis: IV Leland Clark’s oxygen electrode. J Clin Monit 2:125–139CrossRef Servinghaus JW, Astrup PB (1986) History of blood gas analysis: IV Leland Clark’s oxygen electrode. J Clin Monit 2:125–139CrossRef
2.
Zurück zum Zitat Bailey TC, Martin EL, Zhao L, Veldhuizen RA (2003) High oxygen concentrations predispose mouse lungs to the deleterious effects of high stretch ventilation. J Appl Physiol 94:975–982PubMed Bailey TC, Martin EL, Zhao L, Veldhuizen RA (2003) High oxygen concentrations predispose mouse lungs to the deleterious effects of high stretch ventilation. J Appl Physiol 94:975–982PubMed
3.
Zurück zum Zitat Davis JM, Penney DP, Notter RH, Metlay L, Dickerson B, Shapiro DL (1989) Lung injury in the neonatal piglet caused by hyperoxia and mechanical ventilation. J Appl Physiol 67:1007–1012PubMed Davis JM, Penney DP, Notter RH, Metlay L, Dickerson B, Shapiro DL (1989) Lung injury in the neonatal piglet caused by hyperoxia and mechanical ventilation. J Appl Physiol 67:1007–1012PubMed
4.
Zurück zum Zitat Quinn DA, Moufarrej RK, Volokhov A, Hales CA (2002) Interactions of lung stretch, hyperoxia, and MIP-2 production in ventilator-induced lung injury. J Appl Physiol 93:517–525PubMed Quinn DA, Moufarrej RK, Volokhov A, Hales CA (2002) Interactions of lung stretch, hyperoxia, and MIP-2 production in ventilator-induced lung injury. J Appl Physiol 93:517–525PubMed
5.
Zurück zum Zitat Sinclair SE, Altemeier WA, Matute-Bello G, Chi EY (2004) Augmented lung injury due to interaction between hyperoxia and mechanical ventilation. Crit Care Med 32:2496–2501CrossRefPubMed Sinclair SE, Altemeier WA, Matute-Bello G, Chi EY (2004) Augmented lung injury due to interaction between hyperoxia and mechanical ventilation. Crit Care Med 32:2496–2501CrossRefPubMed
6.
Zurück zum Zitat Altemeier WA, Scott SE (2007) Hyperoxia in the intensive care unit: why more is not always better. Curr Opin Crit Care 13:73–78CrossRefPubMed Altemeier WA, Scott SE (2007) Hyperoxia in the intensive care unit: why more is not always better. Curr Opin Crit Care 13:73–78CrossRefPubMed
7.
Zurück zum Zitat The Acute Respiratory Distress Syndrome Network (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301–1308CrossRef The Acute Respiratory Distress Syndrome Network (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301–1308CrossRef
8.
Zurück zum Zitat NHLBI Acute Respiratory Distress Syndrome Network (2004) Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 351:327–336CrossRef NHLBI Acute Respiratory Distress Syndrome Network (2004) Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 351:327–336CrossRef
9.
Zurück zum Zitat de Graaff AE, Dongelmans DA, Binnekade JM, de Jonge E (2011) Clinicians response to hyperoxia in ventilated patients in a Dutch ICU depends on the level of FIO2. Intensive Care Med. doi:10.1007/s00134-010-2025-z de Graaff AE, Dongelmans DA, Binnekade JM, de Jonge E (2011) Clinicians response to hyperoxia in ventilated patients in a Dutch ICU depends on the level of FIO2. Intensive Care Med. doi:10.​1007/​s00134-010-2025-z
10.
Zurück zum Zitat Downs JB (2006) Is supplemental oxygen necessary? J Cardiothorac Vasc Surg 20:133–135CrossRef Downs JB (2006) Is supplemental oxygen necessary? J Cardiothorac Vasc Surg 20:133–135CrossRef
11.
Zurück zum Zitat Johannigman JA, Branson RD, Edwards MG (2009) Closed loop control of inspired oxygen concentration in trauma patients. J Am Coll Surg 208:763–768CrossRefPubMed Johannigman JA, Branson RD, Edwards MG (2009) Closed loop control of inspired oxygen concentration in trauma patients. J Am Coll Surg 208:763–768CrossRefPubMed
12.
Zurück zum Zitat Kilgannon JH, Jones AE, Shapiro NI, Angelos MG, Milcarek B, Hunter K, Parrillo JE, Trzeciak S, Emergency Medicine Shock Research Network (EMShockNet) Investigators (2010) Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA 202:2165–2171CrossRef Kilgannon JH, Jones AE, Shapiro NI, Angelos MG, Milcarek B, Hunter K, Parrillo JE, Trzeciak S, Emergency Medicine Shock Research Network (EMShockNet) Investigators (2010) Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA 202:2165–2171CrossRef
13.
Zurück zum Zitat Wijesinghe M, Perrin K, Ranchord A, Simmonds M, Weatherall M, Beasley R (2009) Routine use of oxygen in the treatment of myocardial infarction: systematic review. Heart 95:198–202CrossRefPubMed Wijesinghe M, Perrin K, Ranchord A, Simmonds M, Weatherall M, Beasley R (2009) Routine use of oxygen in the treatment of myocardial infarction: systematic review. Heart 95:198–202CrossRefPubMed
14.
Zurück zum Zitat Verecki V, Martin E, Rosenthal RE, Hof PR, Hoffman GE, Fiskum G (2006) Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, metabolic dysfunction and neuronal death. J Cereb Blood Flow Metab 26:821–835CrossRef Verecki V, Martin E, Rosenthal RE, Hof PR, Hoffman GE, Fiskum G (2006) Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, metabolic dysfunction and neuronal death. J Cereb Blood Flow Metab 26:821–835CrossRef
15.
Zurück zum Zitat Balan IS, Fiskum G, Hazelton J, Cotto-Cumba C, Rosenthal RE (2006) Oximetry guided reoxygenation improves neurologic outcome after experimental cardiac arrest. Stroke 37:3008–3013CrossRefPubMed Balan IS, Fiskum G, Hazelton J, Cotto-Cumba C, Rosenthal RE (2006) Oximetry guided reoxygenation improves neurologic outcome after experimental cardiac arrest. Stroke 37:3008–3013CrossRefPubMed
16.
Zurück zum Zitat McNulty PH, King N, Scott S, Hartman G, McCann J, Kozak M, Chambers CE, Demers LM, Sinoway LI (2005) Effects of supplemental oxygen administration on coronary blood flow in patients undergoing cardiac catheterization. Am J Physiol Heart Circ Physiol 288:H1057–H1062CrossRefPubMed McNulty PH, King N, Scott S, Hartman G, McCann J, Kozak M, Chambers CE, Demers LM, Sinoway LI (2005) Effects of supplemental oxygen administration on coronary blood flow in patients undergoing cardiac catheterization. Am J Physiol Heart Circ Physiol 288:H1057–H1062CrossRefPubMed
17.
Zurück zum Zitat Davidson RM, Ramo BW, Wallace AG, Whalen RE, Starmer CF (1973) Blood gas and hemodynamic responses to oxygen in acute myocardial infarction. Circulation 47:704–711PubMed Davidson RM, Ramo BW, Wallace AG, Whalen RE, Starmer CF (1973) Blood gas and hemodynamic responses to oxygen in acute myocardial infarction. Circulation 47:704–711PubMed
18.
Zurück zum Zitat Davis DP, Meade W, Sise MJ (2009) Both hypoxemia and extreme hyperoxemia may be detrimental in patients with severe traumatic brain injury. J Neurotrauma 26:2217–2223CrossRefPubMed Davis DP, Meade W, Sise MJ (2009) Both hypoxemia and extreme hyperoxemia may be detrimental in patients with severe traumatic brain injury. J Neurotrauma 26:2217–2223CrossRefPubMed
19.
Zurück zum Zitat Severinghaus JW (2002) Priestly, the furious free thinker of the enlightenment, and Scheele, the taciturn apothecary of Uppsala. Acta Anesth Scand 46:2–9CrossRef Severinghaus JW (2002) Priestly, the furious free thinker of the enlightenment, and Scheele, the taciturn apothecary of Uppsala. Acta Anesth Scand 46:2–9CrossRef
Metadaten
Titel
Oxygen: when is more the enemy of good?
verfasst von
Richard D. Branson
Bryce R. H. Robinson
Publikationsdatum
01.01.2011
Verlag
Springer-Verlag
Erschienen in
Intensive Care Medicine / Ausgabe 1/2011
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-010-2034-y

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