Erschienen in:
01.10.2014 | What's New in Intensive Care
What is new in the use of aminoglycosides in critically ill patients?
verfasst von:
Dimitrios K. Matthaiou, Jan De Waele, George Dimopoulos
Erschienen in:
Intensive Care Medicine
|
Ausgabe 10/2014
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Excerpt
When aminoglycosides are used in critically ill patients, it is crucial that their efficacy is maximised. Aminoglycosides are concentration-dependent antibiotics, and the peak concentration over minimum inhibitory concentration (MIC) is the relevant pharmacokinetics/pharmacodynamics (PK/PD) parameter. Studies have shown that aminoglycosides have their maximal effect at
C max/MIC ratio of 8–10. This means that therapeutic drug monitoring (TDM) for efficacy, i.e. monitoring peak levels, may be helpful to guide therapy [
1]. …