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Intensive Care Medicine

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01.03.2015 | Understanding the Disease

Understanding ARDS-associated fibroproliferation

verfasst von: Gianfranco Umberto Meduri, Mahmoud A. Eltorky

Erschienen in: Intensive Care Medicine | Ausgabe 3/2015

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Excerpt

Understanding ARDS-associated lung fibroproliferation requires viewing (1) ARDS as a disease of multifactorial etiology and not as a syndrome and (2) fibroproliferation as an integral part of the disease process and not as a separate temporal component. Although the term “syndrome” (aggregate of symptoms and signs) was applied in its original description [1], ARDS meets all the constitutive elements of a disease process [2]. Translational clinical research has constructed—through a “holistic” level of inquiry—a pathophysiological model of ARDS that fits the pathogenesis (biology—core stratum) with morphological (histology—intermediate stratum) and clinical (physiology—outer stratum) findings observed during the course of the disease [3]. …

Ashbaugh DG, Bigelow DB, Petty TL, Levine BE (1967) Acute respiratory distress in adults. Lancet 2:319–323CrossRefPubMed

Kumar V, Abbas A, Fausto N, Aster J (2010) Cellular response to stress and toxic insults: adaptation, injury and, death. In: Kumar V, Abbas A, Fausto N, Aster J (eds) Robbins and Cotran Pathologic basis of disease. W.B. Saunders, Philadelphia, pp 3–42

Meduri GU, Annane D, Chrousos GP, Marik PE, Sinclair SE (2009) Activation and regulation of systemic inflammation in ARDS: rationale for prolonged glucocorticoid therapy. Chest 136:1631–1643CrossRefPubMed

Friedman R, Hughes AL (2002) Molecular evolution of the NF-kappaB signaling system. Immunogenetics 53:964–974CrossRefPubMed

Meduri GU, Muthiah MP, Carratu P, Eltorky M, Chrousos GP (2005) Nuclear factor-kappaB- and glucocorticoid receptor alpha-mediated mechanisms in the regulation of systemic and pulmonary inflammation during sepsis and acute respiratory distress syndrome. Evidence for inflammation-induced target tissue resistance to glucocorticoids. Neuroimmunomodulation 12:321–338CrossRefPubMed

Meduri GU, Eltorky M, Winer-Muram HT (1995) The fibroproliferative phase of late adult respiratory distress syndrome. Semin Respir Infect 10:154–175PubMed

Katzenstein AL, Bloor CM, Leibow AA (1976) Diffuse alveolar damage—the role of oxygen, shock, and related factors. A review. Am J Pathol 85:209–228PubMedCentralPubMed

Thille AW, Esteban A, Fernandez-Segoviano P, Rodriguez JM, Aramburu JA, Vargas-Errazuriz P, Martin-Pellicer A, Lorente JA, Frutos-Vivar F (2013) Chronology of histological lesions in acute respiratory distress syndrome with diffuse alveolar damage: a prospective cohort study of clinical autopsies. Lancet Respir Med 1:395–401CrossRefPubMed

Ichikado K, Muranaka H, Gushima Y, Kotani T, Nader HM, Fujimoto K, Johkoh T, Iwamoto N, Kawamura K, Nagano J, Fukuda K, Hirata N, Yoshinaga T, Ichiyasu H, Tsumura S, Kohrogi H, Kawaguchi A, Yoshioka M, Sakuma T, Suga M (2012) Fibroproliferative changes on high-resolution CT in the acute respiratory distress syndrome predict mortality and ventilator dependency: a prospective observational cohort study. BMJ open 2:e000545CrossRefPubMedCentralPubMed

10.

Meduri GU, Tolley EA, Chinn A, Stentz F, Postlethwaite A (1998) Procollagen types I and III aminoterminal propeptide levels during acute respiratory distress syndrome and in response to methylprednisolone treatment. Am J Respir Crit Care Med 158:1432–1441CrossRefPubMed

11.

Meduri GU (1996) The role of the host defence response in the progression and outcome of ARDS: pathophysiological correlations and response to glucocorticoid treatment. Eur Respir J 9:2650–2670CrossRefPubMed

12.

Cordier J-F, Peyrol S, Loire R (1994) Bronchiolitis obliterans organizing pneumonia as a model of inflammatory lung disease. In: Epler GR (ed) Diseases of the Bronchioles. Raven Press Ltd, New York, pp 313–345

13.

Burnham EL, Janssen WJ, Riches DW, Moss M, Downey GP (2014) The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance. Eur Respir J 43:276–285CrossRefPubMedCentralPubMed

14.

Conway Morris A, Kefala K, Wilkinson TS, Dhaliwal K, Farrell L, Walsh T, Mackenzie SJ, Reid H, Davidson DJ, Haslett C, Rossi AG, Sallenave JM, Simpson AJ (2009) C5a mediates peripheral blood neutrophil dysfunction in critically ill patients. Am J Respir Crit Care Med 180:19–28CrossRefPubMed

15.

Meduri GU (2002) Clinical review: a paradigm shift: the bidirectional effect of inflammation on bacterial growth. Clinical implications for patients with acute respiratory distress syndrome. Crit Care 6:24–29CrossRefPubMedCentralPubMed

16.

Serhan CN, Savill J (2005) Resolution of inflammation: the beginning programs the end. Nat Immunol 6:1191–1197CrossRefPubMed

17.

Ware LB, Matthay MA (2000) The acute respiratory distress syndrome. N Engl J Med 342:1334–1349CrossRefPubMed

18.

Forel JM, Guervilly C, Hraiech S, Voillet F, Thomas G, Somma C, Secq V, Farnarier C, Payan MJ, Donati SY, Perrin G, Trousse D, Dizier S, Chiche L, Baumstarck K, Roch A, Papazian L, (2015) Type III procollagen is a reliable marker of ARDS-associated lung fibroproliferation. Intensive Care Med 41:1–11CrossRefPubMed

19.

Meduri GU, Kohler G, Headley S, Tolley E, Stentz F, Postlethwaite A (1995) Inflammatory cytokines in the BAL of patients with ARDS. Persistent elevation over time predicts poor outcome. Chest 108:1303–1314CrossRefPubMed

20.

Sinclair SE, Bijoy J, Golden E, Carratu P, Umberger R, Meduri GU (2006) Interleukin-8 and soluble intercellular adhesion molecule-1 during acute respiratory distress syndrome and in response to prolonged methylprednisolone treatment. Minerva Pneumologica 45:93–104

Titel: Understanding ARDS-associated fibroproliferation
verfasst von: Gianfranco Umberto Meduri
Mahmoud A. Eltorky
Publikationsdatum: 01.03.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Intensive Care Medicine / Ausgabe 3/2015
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-014-3613-0

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