Erschienen in:
12.09.2016 | Editorial
Improved survival in critically ill patients: are large RCTs more useful than personalized medicine? We are not sure
verfasst von:
Luciano Gattinoni, Tommaso Tonetti, Michael Quintel
Erschienen in:
Intensive Care Medicine
|
Ausgabe 11/2016
Einloggen, um Zugang zu erhalten
Excerpt
At first sight, personalized medicine and large randomized clinical trials (RCTs) seem to reflect opposite approaches to medicine: one focusing on the single individual, the other on the population of individuals. Accordingly, in critically ill patients, does the “best” therapy depend on the unique characteristics of the patient or does it derive from the outcome analysis of a large population in which a given therapy has been tested? Actually, we believe that comparing personalized medicine and large RCTs is like comparing apples and oranges. Indeed, which are the essences of personalized medicine and which those of the RCTs? …